Cryo-EM Structural Biology Facility Opened in San Diego by FairJourney Bio
FairJourney Bio has launched an advanced cryo‑electron microscopy (cryo‑EM) structural biology facility in San Diego, featuring two 300 kV ThermoFisher Titan Krios 5 systems. The lab brings atomic‑resolution imaging directly into the company’s antibody discovery platform, supporting everything from epitope mapping to lead optimization. Services began in January 2026, expanding FairJourney’s U.S. presence beyond San Francisco into the biotech hub of San Diego. The move aims to shift structural biology from a late‑stage validation tool to an early‑stage decision engine.
Drugs From a Text Prompt, Wegovy Pill Competition Dampens Lilly’s Surge
Agentic AI is revolutionizing drug discovery, allowing scientists to generate candidates from simple text prompts and run extended‑reality guided experiments. In parallel, Gilead announced a deal to acquire Tubulis for up to $5 billion, strengthening its antibody‑drug conjugate portfolio. Eli Lilly and...
BBB Access Route via Proteomic Vascular Mapping
Researchers led by Jiefu Li at the Howard Hughes Medical Institute have unveiled an in‑vivo proteomic method that tags and isolates proteins on the luminal surface of blood vessels. By perfusing a lectin‑conjugated peroxidase, they biotinylate adjacent proteins, enabling mass‑spectrometry...
DNA Uptake in Cholera May Increase Defense Mechanisms
Researchers at EPFL discovered that Vibrio cholerae can take up extracellular DNA when grown on chitin, inserting new gene cassettes into the first position of its sedentary chromosomal integron (SCI). About 10% of these cassettes encode antiviral defenses, instantly boosting...
Seer to Apply Deep Proteomics Tech to Singapore Population Cohort Study
Seer announced that its Proteograph® platform will profile the plasma proteome of about 10,000 participants in Singapore’s PRECISE‑SG100K cohort. The proteomic data will be merged with Thermo Fisher Scientific’s Olink® Reveal sequencing‑based results and Orbitrap Astral mass‑spectrometry outputs. PRECISE‑SG100K, the...
Labguru Customer Portal Launched for CRO/CDMO and Client Collaboration
Cenevo has unveiled the Labguru Customer Portal, a digital hub that extends its ELN and LIMS platforms to external partners. The portal lets CROs and CDMOs centralize visibility across projects, standardize workflows, and manage multiple client programs at scale. Clients...
Single-Cell Atlas of Maternal–Fetal Interface Sheds Light on Pregnancy Complications
Scientists at UCSF have produced a comprehensive single‑cell atlas of the human maternal–fetal interface, analyzing about 200,000 cells from early gestation to term. The study combined single‑nucleus transcriptomics, chromatin accessibility, spatial transcriptomics and multiplex protein imaging to map cell types...
Organ-on-Chip Integrated Into Preclinical Glioblastoma Research
German biotech Dynamic42 and oncology firm EPO have formed a strategic partnership to embed organ‑on‑chip technology into preclinical glioblastoma research. The collaboration merges Dynamic42’s human‑based blood‑brain barrier‑on‑chip platform with EPO’s tumor models and translational expertise, targeting more predictive drug testing....
Neuroblastoma Tumor Growth in Mice Suppressed by Blocking Enzyme to Inhibit mTOR Signaling
Researchers at The Hebrew University of Jerusalem identified neuronal nitric oxide synthase (nNOS) as a driver of neuroblastoma growth and showed that its inhibition suppresses mTOR signaling. Using the selective inhibitor BA-101 and siRNA knock‑down, they reduced nitric oxide production,...
Forecasting Protein Aggregation with an Improved Algorithm
Scientists at the Autonomous University of Barcelona have released the fourth generation of their protein‑aggregation forecasting algorithm, which leverages AlphaFold structural data and molecular‑dynamics simulations. The tool lets users evaluate aggregation risk, explore mutations, scan protein families, and assess pH...
Faster Process Development via “Transfer Learning”
Transfer learning—a form of AI that reuses models trained on historic data—promises to accelerate biopharmaceutical process development. By applying existing predictive models to new, related fermentations, companies can forecast critical metrics such as viable cell density and product titre from...
Redefining Bioprocessing Using Reservoirs of Biochemical Diversity
Scientists have uncovered a trove of heat‑tolerant glycosyltransferase enzymes in the rhizosphere soils of desert plants in Saudi Arabia. These extremophile enzymes, identified through metagenomic analysis, could improve glycosylation steps in biologics manufacturing by operating under high‑temperature, low‑moisture conditions. The...
Plant Molecular Farming Comes of Age
Plant molecular farming (PMF) has evolved into a scalable, GMP‑compatible platform for producing complex biologics, leveraging low‑energy plant growth and advanced transient‑expression systems. Recent advances in sensor technology, AI‑enabled host engineering, and digital manufacturing have lowered infrastructure costs and accelerated...
Childhood Dementia Explained by Synaptic Dysfunction, Opens New Therapies
Researchers at Flinders University used human iPSC-derived cortical neurons to model Sanfilippo syndrome, revealing that excitatory synapses become hyperactive early in development. This chronic overactivity mirrors the hyperactivity and sleep disturbances observed in affected children and appears to drive cognitive...
Neurocrine Grows in Endocrinology, Rare Disease with $2.9B Soleno Buyout
Neurocrine Biosciences announced a $2.9 billion cash acquisition of Soleno Therapeutics, adding the FDA‑approved Vykat XR for Prader‑Willi syndrome to its portfolio. The deal also brings together Neurocrine’s existing marketed drugs Ingrezza and Crenessity, which together generated roughly $2.8 billion in 2025 sales....
High-Throughput Platform for Fast-Acting Covalent Protein Therapies
Researchers at Westlake University unveiled a high‑throughput yeast‑surface‑display platform to engineer fast‑acting covalent protein therapeutics. The system screens diverse crosslinkers and millions of protein variants, enabling precise spatial positioning of warheads that dramatically speeds covalent bond formation. Using the platform,...
Gilead to Acquire Tubulis for Up to $5B, Expanding Cancer ADC Capabilities
U.S. drugmaker Gilead Sciences announced a definitive agreement to acquire German ADC specialist Tubulis for up to $5 billion, including $3.15 billion upfront cash and up to $1.85 billion in milestones. The acquisition brings Tubulis’ next‑generation antibody‑drug conjugate platform, highlighted by the TUB‑040...
Autoimmune Disease-Related Inflammation Reduced with ENDOtollins Drug
A study in *Nature Chemical Biology* reports a new class of compounds called ENDOtollins that selectively block the Munc13‑4–syntaxin 7 interaction, dampening endosomal Toll‑like receptor activation and systemic inflammation. Screening of roughly 32,000 molecules identified ENDO12 as the most potent candidate,...
Microplastics in Human Bile Drive Mitochondrial Dysfunction and Senescence
Researchers have identified microplastics in the bile of all 14 patients studied, revealing six polymer types dominated by PET and polyethylene. Patients with gallstones carried significantly higher microplastic loads, suggesting bile stasis may promote retention. Laboratory exposure of cholangiocytes to...
Immunotherapy Enhanced by Restoring Mitochondrial Function in Dendritic Cells
A new study in Science by St. Jude researchers reveals that tumors suppress dendritic cell function by crippling mitochondrial fitness, undermining the body’s antitumor immunity. Restoring mitochondrial activity in dendritic cells reactivates their ability to prime immune responses and dramatically...
Low-Cost, Single Sample Blood Test Detects Different Cancers, Liver Disorders, and Other Diseases
UCLA researchers unveiled MethylScan, a low‑cost blood test that analyzes cell‑free DNA methylation to detect multiple cancers and liver disorders in a single sample. By using methylation‑sensitive enzymes to strip away background DNA, the assay reduces sequencing needs to about...
Machine Learning and Single-Cell Technology Combined to Drive High-Performance Cell Line Development
OneCyte and Kemp Proteins have formed a strategic partnership that fuses OneCyte’s high‑throughput single‑cell cloning platform with Kemp’s machine‑learning‑driven protein design system, PROTiQ. The combined workflow uses in‑silico sequence evaluation to flag developability risks, then rapidly screens thousands of clones...
Nanotube Injector Boosts Mitochondrial Performance Through Cytoplasmic Transfer
Researchers at Waseda University unveiled a gold‑membrane nanotube injector that can extract and deliver cytoplasmic material—including intact mitochondria—between living cells. By fine‑tuning nanotube dimensions and internal air pressure, the system achieves over 90% transfer efficiency while preserving roughly 95% cell...
Epigenetic Strategy Restores Tumor Suppressor in Acute Myeloid Leukemia Models
Researchers at The Jackson Laboratory have demonstrated that inhibiting KDM4 enzymes can reactivate the silenced tumor‑suppressor gene ZBTB7A in acute myeloid leukemia (AML) models. Using a novel FISHnCRISP platform that combines fluorescence in‑situ hybridization, flow cytometry and CRISPR editing, they...
Hydrogel-Based Axon Model Improves Early Testing for MS Remyelination Therapies
University College London researchers have created a hydrogel‑based axon model that mimics the ~5 kPa softness and three‑dimensional geometry of real brain axons. The tunable micropillar arrays enable human oligodendrocytes to form compact, multilayered myelin, a first for fully hydrogel systems....
Combining Novel Dual HIF Inhibitors with Immunotherapy Erases Multiple Tumor Types in Mice
Researchers at Johns Hopkins and the University of Maryland have created first‑in‑class small‑molecule inhibitors that simultaneously block hypoxia‑inducible factors 1 and 2. In mouse models, the dual HIF‑1/2 inhibitors eradicated breast, colorectal, melanoma and prostate tumors when paired with checkpoint antibodies such...
Cell Line Development Has to Evolve
Cell line development (CLD) remains a hidden bottleneck that dictates speed to clinic, manufacturability, and long‑term product performance. Traditional random‑integration and lengthy clone screening are giving way to engineered platforms, especially glutamine synthetase (GS) knockout systems, which reduce heterogeneity and...
Text Mining Culture Conditions and Glycosylation Relationships
Researchers at the University of Delaware and Waters have created an automated text‑mining pipeline that extracts relationships between cell‑culture conditions and protein glycosylation with 88% accuracy. The extracted data are normalized and stored in a Bioprocess Knowledge Graph, enabling a...
Peptonics Solves Cell Culture Defoaming Debacle
Researchers have demonstrated that the peptide‑based surfactant Peptonic ih‑T1010 performs on par with the industry‑standard poloxamer 188 in CHO and HEK293 fed‑batch cultures for monoclonal antibodies and AAV vectors. The new surfactant dramatically reduces foam formation, allowing manufacturers to skip...
Prolonged Transfection Complex Stability for Reliable Large-Scale AAV Manufacturing
Gene‑therapy manufacturers face a bottleneck when adding large volumes of AAV transfection complex to bioreactors within a narrow time window. Mirus Bio’s VirusGEN Transfection Complex Stabilizer, used with TransIT‑VirusGEN reagent, cuts the required complex volume from roughly five percent to...
Can AI Agents Automate Scientific Discovery?
Nvidia’s GTC keynote highlighted a new wave of agentic AI systems—OpenClaw, Kosmos, LabOS, Latent‑Y and Dyno Psi‑Phi—designed to automate and accelerate scientific discovery. These agents combine large‑language models, XR interfaces and robotic labs to compress months of research into days while...
Detecting Disease at Its Molecular Origin
Garage Brain Science (GBS), a Taiwan biotech, announced new clinical collaborations to develop rapid, at‑home screening tools for early metabolic stress linked to prediabetes and structural abnormalities of the TDP‑43 protein associated with neurodegenerative diseases. The company is leveraging blood‑based...
Common Ancestry Limits Protein Sequence Exploration, Computational Study Shows
Researchers from OIST, ISTA, Vienna and CAB published a computational study in PNAS showing that common ancestry, rather than selection or epistasis, is the primary constraint on protein sequence diversification. By estimating the effective dimensionality of protein families and simulating...
Autism Risk Genes Largely Shared Across Global Populations
Scientists have long identified autism risk genes mainly in European‑ancestry cohorts, leaving gaps for other populations. The GALA Consortium sequenced over 15,000 Latin American individuals, including 4,700 with autism, and found 35 genome‑wide significant risk genes. These genes show substantial...
Link Between Ceramide Transport and Cell Senescence Could Inform Aging Biology Research
University at Buffalo researchers discovered that impairment of the ceramide transfer protein (CERT) blocks ER‑to‑Golgi ceramide transport, causing ceramide buildup in the endoplasmic reticulum and triggering ER stress that drives replicative senescence. Pharmacological inhibition of CERT reproduced the senescent phenotype...
African Trypanosomes Use a Molecular Shredder to Avoid Detection in the Bloodstream
Researchers at the University of York have identified ESB2, an RNA endonuclease that acts as a molecular shredder within Trypanosoma brucei. By selectively degrading transcripts, ESB2 fine‑tunes Variant Surface Glycoprotein expression, allowing the parasite to evade host immunity. The finding,...
Gut-Immune Link Identified in Multiple Sclerosis-Related Neuroinflammation
Researchers at Keio University discovered that intestinal epithelial cells (IECs) expressing MHC class II trigger the expansion of pathogenic Th17 cells that migrate to the spinal cord and drive neuroinflammation in multiple sclerosis (MS) mouse models. Examination of intestinal biopsies from...
Agentic AI, Virtual Cell, LNP Vaccine Boosters, Engineered Organs, and Mergers
Agentic AI is emerging as a pivotal technology in healthcare, building on generative AI momentum. Xaira Therapeutics unveiled the largest virtual cell model to date, enhancing complex biology simulations. Researchers redesigned lipid nanoparticles to avoid the liver and concentrate in...
Lonza Media Development Lab Set Up in Singapore
Lonza has opened a dedicated media development laboratory at its Singapore campus to help bioprocessing customers fine‑tune cell‑culture media and smoothly transition formulations to GMP manufacturing. The facility applies a systematic, early‑stage optimization workflow that evaluates scalability, raw‑material readiness, and...
Blocking TIE2 Protein May Prevent Blood Vessel Defects in the Brain
Researchers at the University of Pennsylvania identified the endothelial receptor TIE2 as a pivotal link between the MEKK3‑KLF2/4 and PI3K signaling cascades that drive cerebral cavernous malformations (CCMs). In mouse models, oral inhibition of TIE2 with the tyrosine‑kinase inhibitor rebastinib...
Egg-Based Biologics Drive Neion Bio Pharma Deal
Neion Bio, fresh from stealth mode, signed its first co‑development and supply agreement with a major global pharmaceutical company to produce recombinant biologics using its egg‑based Raptor™ platform. The deal provides upfront and milestone payments plus profit‑sharing after commercialization, delivering...
Nanoplastics Released by ‘Eco-Friendly’ Bioplastics May Slow Fetal Development in Mice
A study by Anhui Medical University and Fudan University shows that polylactic acid (PLA), a widely used biodegradable bioplastic, breaks down into oligomeric lactic acid (OLA) nanoplastics that cross the placental barrier in mice. Exposure to environmentally relevant OLA doses...
Antibodies Connect Cancer with Autoimmune Brain Disease
Researchers at Cold Spring Harbor Laboratory published a Nature paper showing that antibodies generated against NMDA‑receptor‑expressing tumors can both boost anti‑cancer immunity and trigger autoimmune encephalitis. In mouse models, strong anti‑NMDA antibody responses correlated with robust tumor control, yet the...
Leveraging the Full Potential of Regenerative Medicine Requires a Proactive Approach
Regenerative medicine promises to shift healthcare from a reactive model to proactive disease modification by targeting early biological drivers of chronic degeneration. Cell‑based therapies such as mesenchymal stromal/stem cells (MSCs) can modulate inflammation, immune signaling, and tissue repair, showing benefits...
Parasites Prompt Gut-Brain Communication to Trigger Appetite Loss
UCSF researchers have mapped a gut‑brain signaling cascade that explains why parasitic worm infections cause loss of appetite. They discovered that tuft cells detect parasite‑derived succinate and release acetylcholine, which prompts nearby enterochromaffin cells to secrete serotonin. The serotonin then...
Scout-Triggered Proteomics Sharpens HCP Control
Host-cell proteins (HCPs) remain a persistent impurity risk in biomanufacturing, with regulators demanding levels below 100 ppm in final drug products. Traditional ELISAs measure total HCPs but cannot identify individual proteins, while conventional multiple reaction monitoring (MRM) suffers from retention‑time shifts...
Rentschler Highlights Milford Site Progress and Growth
Rentsc hler Biopharma announced that its Milford, Massachusetts CDMO site has entered a new growth phase, adding a 22,000‑square‑foot cleanroom and four 2,000‑liter single‑use bioreactors. The expansion, the largest in the company’s 150‑year history, brings the U.S. facility to the...
Xaira’s First Virtual Cell Model Is Largest To-Date, Toward Complex Biology
Xaira Therapeutics unveiled X-Cell, a 4.9‑billion‑parameter virtual cell model that predicts transcriptome‑level responses to genetic perturbations. The model leverages the company’s 25.6 million‑cell X‑Atlas/Pisces CRISPRi Perturb‑seq dataset and demonstrates zero‑shot performance on unseen T‑cell and iPSC contexts. X-Cell uses a diffusion...
Genomic Mapping of E. Coli Capsules Identifies High-Risk Types for Vaccines
A genomic survey of over 18,000 *Escherichia coli* genomes has mapped 90 capsular K‑loci, revealing that five capsule types (K1, K5, K52, K2, K14) cause more than half of bloodstream and urinary‑tract infections in Europe. The study links these high‑risk...
Synthetic DNA Manufacturing Hub Set Up in Boston by Artis BioSolutions
Artis BioSolutions, a San Diego‑based advanced therapies firm, has launched a synthetic DNA manufacturing hub in Boston using Syngoi Technologies' proprietary enzymatic platform. The new site complements its GMP manufacturing facility in Watertown, creating a bi‑continental network with an existing...
