Polynomially Efficient Quantum Enabled Variational Monte Carlo for Training Neural-Network Quantum States for Physico-Chemical Applications
Researchers propose a polynomially efficient, quantum‑enabled variational Monte Carlo (VMC) method to train neural‑network quantum states (NQS). The algorithm scales linearly with circuit width and depth, requires only constant measurements, and avoids mid‑circuit reads, while simultaneously handling amplitude and phase components. Benchmarks on local spin models and non‑local electronic‑structure Hamiltonians demonstrate accurate ground‑state learning, even for distorted geometries with strong multi‑reference correlation. Results suggest near‑term quantum hardware can accelerate Monte‑Carlo sampling, offering a quantum‑assisted advantage for chemistry and condensed‑matter simulations.
Network-Based Prediction of Drug Combinations with Quantum Annealing
The study introduces a quantum‑annealing algorithm that predicts effective drug combinations by casting the problem as a quadratic unconstrained binary optimisation (QUBO). It leverages the network‑medicine concept of disease modules and the “Complementary Exposure” principle, which seeks drugs that hit...
Real-Time PCR–Based Detection of Mycoplasma Agalactiae in Sheep Bulk Tank Milk to Support Flock-Level Epidemiology
A real‑time PCR assay for detecting Mycoplasma agalactiae in sheep bulk‑tank milk was developed and validated, showing high specificity and sensitivity. The test was deployed across more than 900 dairy sheep farms in Sardinia, revealing widespread but generally low‑level prevalence...
How Do Genetic Diversity, Gene Flow, and Divergent Haplotypes Drive Population Differentiation in the Invasive Red Palm Weevil (Rhynchophorus Ferrugineus)...
Researchers examined the invasive red palm weevil in Saudi Arabia’s Qassim region using mitochondrial COI and nuclear ITS markers. COI analysis revealed near‑identical haplotypes and strong genetic links to populations in Egypt, Al‑Ahsa, Pakistan and the UAE. ITS sequencing, with...
Modular Meta-Evolutionary AI Architecture Enables Interpretable Stratification in Heterogeneous Clinical Trials
The paper introduces a modular, meta‑evolutionary AI system that couples an interpretable dynamical‑systems learner (NetraAI) with a literature‑grounded LLM Strategist. NetraAI uses a long‑range memory to discover compact Model‑Derived Subgroups (MDS) and abstains when evidence is weak, while the LLM...
Health-Related Quality of Life and Its Influence Factors in Chinese Patients with Phenylketonuria
A 2025 cross‑sectional survey assessed health‑related quality of life (HRQoL) in 196 Chinese phenylketonuria (PKU) patients using the EQ‑5D instrument. The cohort, average age 9.5 years, was predominantly rural (62%) with low educational attainment and modest household incomes. Mean EQ‑5D...
Neurodevelopmental Outcomes of Mild Neonatal Encephalopathy Treated with Therapeutic Hypothermia
A recent cohort study of 220 infants with mild neonatal encephalopathy compared therapeutic hypothermia (TH) to standard care. The TH group experienced more arrhythmia, delayed first feeding, and higher hospitalization costs, yet neurodevelopmental assessments at two years showed no statistically...
Factors Associated with Rapid Repeat Pregnancies in Women at High Risk for Adverse Birth Outcomes
A prospective cohort of 894 women in Indiana’s WeCare community health worker (CHW) program found that 26% experienced rapid repeat pregnancy (RRP), defined as a live birth within 27 months of a prior delivery. Adjusted analyses linked younger age at...
Quantifying Pathway Identifiability Under Partial Metabolomics for Measurement Prioritization
The study introduces an operator‑based framework to assess pathway identifiability when metabolite coverage is incomplete. It aligns condition‑specific pathway graphs using a Johnson‑Lindenstrauss stabilized fused Gromov‑Wasserstein (JL‑FGW) operator and quantifies ambiguity via a composite functional that blends transport entropy, alignment...
Reproductive Isolation and Differential Introgression Shape the Genomic Landscape of the Red Alga Amansia Glomerata in the Hawaiian Archipelago
Researchers examined two lineages of the red alga Amansia glomerata around Oʻahu using ddRAD sequencing, spatial transects, and demographic modeling. The study found strong genomic differentiation between lineages even in extensive sympatric zones, supporting allopatric divergence followed by secondary contact...
Trade-Offs and Synergies of Conservation Agriculture: Soil Properties and Crop Performance After Five Years of Minimum Tillage and Residue Retention
Researchers evaluated five years of minimum tillage combined with crop residue retention across multiple sites. The study found notable improvements in soil organic carbon, bulk density, and water infiltration, while crop yields increased modestly. Economic modeling indicated profitability after the...
In Vitro Generation of Highly Infectious Recombinant Prions Adopting Structural Architectures of Bona Fide Prions
Researchers have developed a protein misfolding cyclic amplification (PMCA) assay that reliably produces recombinant prion fibrils with infectivity comparable to the RML brain‑derived strain. Cryo‑EM analysis shows these fibrils adopt the characteristic V‑shaped, parallel in‑register β‑sheet architecture, though the C‑terminal...
Post-Earthquake Health-Related Quality of Life in Afghanistan: A Cross- Sectional Study
The cross‑sectional study of 902 adult survivors of the 2023 Herat earthquake found substantial deficits in health‑related quality of life (HRQoL). Approximately 38% reported low physical HRQoL and 37% low psychological HRQoL, with women, widowed/divorced persons, large households, low‑income and...
Complications After Corneal Allografts Intrastromal Rings Segments (CAIRS) In Keratoconus And Post LASIK Ectasia A Case Series
Corneal Allogenic Intracorneal Ring Segments (CAIRS) have been used to improve vision in keratoconus and post‑LASIK ectasia, but a multicenter case series of nine eyes reveals notable complications. Patients experienced progressive corneal neovascularization, lipoid keratopathy, and segment extrusion, linked to...
Determinants of Neonatal Mortality Among Neonates Admitted to Neonatal Care Unit at St. Paul Hospital Millennium Medical College, Addis Ababa,...
A retrospective case‑control study at St. Paul Hospital Millennium Medical College identified six key determinants of neonatal mortality among 324 NICU admissions from 2020‑2022. Lack of antenatal care (ANC) visits, home delivery, pregnancy‑induced hypertension, low birth weight, prematurity, and fetal...
Unified Real-Time Anomaly Detection Across Retail Fraud and Network Intrusion Streams Using Dependency-Aware Feature Extraction
A unified, domain‑aware anomaly detection pipeline maps retail transaction and network traffic streams to a common event schema, enabling real‑time monitoring of rare, high‑impact events. The approach extracts temporal features (e.g., time‑since‑last‑event) and contextual typicality without data leakage, then trains...
Fatigue Life Prediction of Ceramic Matrix Composite Materials Based on Physical Constraint Multi-Scale Attention Network
Researchers introduced a physically constrained multi‑scale attention network (PC‑MSANet) to predict fatigue life of ceramic matrix composites under high‑temperature, high‑stress conditions. Experiments on Cf/SiC specimens generated macroscopic stress, time‑domain, and frequency‑domain features for model training. PC‑MSANet achieved an RMSE of...
Exploring Spatial Inequities and Livability: A Mixed-Methods Study Using Artificial Intelligence and Community Insights
A mixed‑methods study in St. Louis combined a vision‑language model with community interviews to map micro‑scale built‑environment features across 7,848 Google Street View segments. AI detected high prevalence of basic infrastructure—street lighting (85%) and continuous pavement (77%)—but uncovered severe shortages...
Galaxy Rotation Curves and Baryonic Scaling Relations in Time-Field General Relativity: A Systematic Analysis of the SPARC Sample
Researchers applied Time-Field General Relativity (TFGR) to 165 late‑type galaxies from the SPARC catalog, fitting a three‑parameter velocity profile that includes a saturation speed, transition radius, and sharpness. The TFGR model outperformed baryonic‑only predictions in 157 cases, reducing the median...
Network Analysis of the Association Between Frailty and Depression in Patients with Gastrointestinal Cancer: A Cross-Sectional Study
A cross‑sectional study of 238 gastrointestinal cancer patients used symptom‑level network analysis to map the frailty‑depression relationship. The strongest links were found between slowed gait and low physical activity, and between bradykinesia/agitation with suicidal ideation and guilt. PHQ‑4 (lack of...
Association of D-Dimer and Fibrinogen Levels with Stroke Severity in Acute Ischemic Stroke Patients: A Cross-Sectional Study at a Tertiary...
Researchers at Haji Adam Malik General Hospital examined 69 acute ischemic stroke patients to determine whether admission D‑dimer and fibrinogen levels reflect stroke severity. Patients with severe strokes had median D‑dimer levels of 2060 ng/mL versus 620 ng/mL in moderate cases, and...
A Comparative Study of Elderly and Young Adults’ Needs of Smart Home Security Systems: Evidence From an Extended Technology Acceptance...
The study compares senior citizens’ and young adults’ acceptance of smart home security systems using surveys of 220 seniors and 215 younger participants. Findings reveal seniors value simple, one‑click and voice‑controlled interfaces, while younger users focus on ecosystem integration. Researchers...
Experimental Study on the Construction of a Rabbit Biliary Stent Model via Transduodenal Puncture and the Placement of an Modified...
Researchers have created a New Zealand rabbit model that mimics biliary stenting by using a transduodenal wall puncture and a modified intravenous catheter. The experimental group achieved an 86.7% technical success rate, with most complications being mild and transient. Serum liver...
Headteachers’ Leadership in Implementing Differentiated Instruction to Address Diverse Learning Needs in Public Primary Schools
A mixed‑methods study in Rwanda’s Gasabo District examined how headteachers lead the implementation of differentiated instruction in public primary schools. Survey data from 99 teachers, 37 Directors of Studies and 37 headteachers, plus interviews with 15 headteachers, showed moderate adoption...
Tigecycline-Induced Hypoglycemia in Critically Ill Patients with Severe Infections: A Retrospective Cohort Study
A retrospective cohort of 169 critically ill patients receiving tigecycline showed significant reductions in blood glucose at three daily time points. Hypoglycemia occurred in 11.2% of patients and was linked to a nearly four‑fold increase in 28‑day mortality (OR 3.83). Larger...
Investigation of Differential Expression in Phospholipid Metabolism-Related Genes in Bronchial Epithelial Cells of Asthma Patients
The study examined phospholipid metabolism‑related gene expression in bronchial epithelial cells from asthma patients versus healthy controls. Six differentially expressed genes were identified, and a logistic‑regression model built on these markers achieved an AUC of 0.76 in training and 0.83...
Infantile Acid Sphingomyelinase Deficiency Presenting With Severe Gastrointestinal and Recurrent Respiratory Symptoms: A Diagnostic Challenge Case Report in Palestine
An 8‑month‑old infant in Palestine was diagnosed with infantile acid sphingomyelinase deficiency (Niemann‑Pick disease type A) after presenting with severe gastrointestinal distress, feeding intolerance, failure to thrive, hepatosplenomegaly, and recurrent pneumonia. Initial treatments targeted common pediatric conditions but failed, prompting clinicians...
Factors Affecting Operative Time in Ureteroscopic Stone Removal: A Cross-Sectional Study for Prediction Model Construction
A cross‑sectional study of 495 ureteroscopic lithotripsy cases identified stone length and maximum stone density as independent risk factors that extend operative time, while simple ureteral stones reduce it. Using LASSO selection, researchers built a Gamma regression model and a...
Chronic Non-Bacterial Osteomyelitis Presenting as Fever of Unknown Origin in a Child: A Diagnostic Pitfall
A 12‑year‑old girl presented with recurrent fever of unknown origin, later developing intermittent joint pain. Extensive infectious, rheumatologic and oncologic testing, including cultures, metagenomic sequencing and bone‑marrow analysis, were negative. MRI and PET‑CT revealed multifocal hypermetabolic bone lesions, prompting concern...