Business Podcasts

The First $100,000,000 ARR at Datadog: How Founder CEO Olivier Pomel Built a Customer-Centric Observability Giant
PodcastNov 17, 20250 min

The First $100,000,000 ARR at Datadog: How Founder CEO Olivier Pomel Built a Customer-Centric Observability Giant

In this episode, Datadog founder‑CEO Olivier Pomel recounts how the company reached its first $100 million ARR by obsessively prioritizing genuine customer insight over sales or engineering shortcuts. He explains why closed alphas and annual contracts stifle learning, why enterprise SaaS...

By Jason Lemkin
Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering
PodcastNov 17, 20251h 10m

Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering

In this episode, Emmett Shear—founder of Twitch and former OpenAI interim CEO— challenges the prevailing "control and steering" approach to AI alignment, arguing it’s fundamentally flawed and proposing an "organic alignment" model where AI genuinely cares about humans. He explains...

By a16z Podcast
Synthetic Data and the Future of AI | Cohere CEO Aidan Gomez
PodcastNov 17, 20251h 11m

Synthetic Data and the Future of AI | Cohere CEO Aidan Gomez

In this episode, Cohere CEO Aidan Gomez discusses how synthetic data has become essential for training AI models, enabling enterprises like Salesforce and Dell to scale intelligence securely across cloud environments. He explains Cohere's approach to building flexible, deployable AI...

By Grit (Kleiner Perkins)
20VC: Andrew NG on The Biggest Bottlenecks in AI | How LLMs Can Be Used as a Geopolitical Weapon |...
PodcastNov 17, 20251h 2m

20VC: Andrew NG on The Biggest Bottlenecks in AI | How LLMs Can Be Used as a Geopolitical Weapon |...

In this episode, Andrew Ng identifies the biggest bottlenecks slowing AI progress—data quality, compute costs, and talent scarcity—while arguing that large language models can become geopolitical tools for influence and misinformation. He debates whether traditional profit margins still matter and...

By The Twenty Minute VC (20VC)
The Brutal Truth About Biotech: Why $2B Per Drug Is Killing Innovation
PodcastNov 14, 20251h 2m

The Brutal Truth About Biotech: Why $2B Per Drug Is Killing Innovation

In this episode, venture capitalists Elliot Hershberg and Lada Nuzhna examine how soaring drug development costs—now around $2.5 billion per approval—are stifling biotech innovation, identifying three key forces they call the "three horsemen" that drive expense. They contrast the U.S. model...

By a16z Podcast
The Frontier of Spatial Intelligence with Fei-Fei Li
PodcastNov 13, 202544 min

The Frontier of Spatial Intelligence with Fei-Fei Li

In this episode, a16z partner Martin Casado chats with AI pioneers Fei‑Fei Li and Justin Johnson about the evolution from early AI winters to deep learning breakthroughs like ImageNet, and how those advances paved the way for spatial intelligence and Large...

By a16z Podcast
VC10X Micro - The Big Short 2.0
PodcastNov 13, 20256 min

VC10X Micro - The Big Short 2.0

The episode dissects Michael Burry’s newly revealed 13F bet shorting Nvidia and Palantir, arguing it could signal an AI bubble as smart money like SoftBank pulls back, valuations soar, and spending outpaces profits. It outlines three warning signs Burry cites,...

By VC10X
The Future of Crypto, with Coinbase’s Emilie Choi
PodcastNov 13, 202522 min

The Future of Crypto, with Coinbase’s Emilie Choi

In this Masters of Scale episode, Coinbase President and COO Emilie Choi discusses how the company navigated the crypto winter and the operating principles that enable hyper‑scaling in a volatile industry. She shares insights on the future of money, the...

By Masters of Scale
E650 | Patrick Odier (Lombard Odier & Building Bridges) & Enrique, Chi Impact Capital: Three Systemic Plays to Underwrite Now
PodcastNov 13, 202547 min

E650 | Patrick Odier (Lombard Odier & Building Bridges) & Enrique, Chi Impact Capital: Three Systemic Plays to Underwrite Now

In this episode, Patrick Odier, chairman of Lombard Odier and Building Bridges, outlines a pragmatic shift from risk‑avoidance to opportunity‑driven system redesign, highlighting circularity, energy electrification, nature‑based solutions, and materials as the core arenas for transition investing. He argues that private‑asset classes—especially...

By The European VC (EUVC)
20VC: Sequoia's Leadership Transition | Michael Burry Shorts NVIDIA and Palantir | Gamma Raises $100M at $2BN | Has Defensibility...
PodcastNov 13, 20251h 15m

20VC: Sequoia's Leadership Transition | Michael Burry Shorts NVIDIA and Palantir | Gamma Raises $100M at $2BN | Has Defensibility...

The episode walks through Sequoia’s leadership transition and its strategic implications, then examines Michael Burry’s contrarian short on Nvidia and Palantir, highlighting his view that AI‑related valuations are overheated. It covers Gamma’s $100 million raise at a $2 billion valuation as a...

By The Twenty Minute VC (20VC)
Inside India’s $1 Trillion Venture Revolution W/ Kalaari Capital, General Catalyst, DM Gupta & Lightspeed India
PodcastNov 13, 202532 min

Inside India’s $1 Trillion Venture Revolution W/ Kalaari Capital, General Catalyst, DM Gupta & Lightspeed India

The episode examines India’s rapidly evolving venture ecosystem, highlighting how women investors and family offices are driving a shift toward a $1 trillion wealth era and reshaping where capital flows. Panelists Vani Kola, Priya Mohan, Aarti Gupta, and Shruvi Shrivastava discuss...

By Billion Dollar Moves
Rocket Mortgage CEO: Here’s How to Fix the Housing Crisis
PodcastNov 12, 202555 min

Rocket Mortgage CEO: Here’s How to Fix the Housing Crisis

In this episode, Alex Rampell and Rocket Mortgage CEO Varun Krishna dissect how asset inflation has turned homeownership into a wealth‑transfer mechanism, pushing the median first‑time buyer’s age from 30 to 38. They explain Rocket’s strategy of owning the entire...

By a16z Podcast
#174 Investrio: QuickBooks for the People
PodcastNov 12, 202540 min

#174 Investrio: QuickBooks for the People

In this episode, founders Joyce and Laura pitch Investrio, an AI‑driven bookkeeping platform designed to replace clunky finance tools like QuickBooks for solopreneurs. They explain how the product automates expense tracking, tax prep, and cash‑flow insights, and discuss early traction...

By The Pitch
Lee Edwards of Root VC: "Let's Get Technical!" -- An Engineer Becomes a VC
PodcastNov 11, 20251h

Lee Edwards of Root VC: "Let's Get Technical!" -- An Engineer Becomes a VC

In this episode, Lee Edwards, a former CTO and mechanical/software engineer turned General Partner at Root VC, shares how his hands‑on engineering background informs his seed‑stage investing in deep‑tech, AI, and devtools. He dives into the value of pair programming,...

By Something Ventured
Founder10x - From $500M Exit to Reinventing Software - Shay Levi, Co-Founder & CEO, Unframe
PodcastNov 11, 202541 min

Founder10x - From $500M Exit to Reinventing Software - Shay Levi, Co-Founder & CEO, Unframe

In this episode, Shay Levi recounts his journey from co‑founding Noname Security, which sold to Akamai for $500 million, to launching Unframe—a venture that promises to build custom software for free and charge only when it delivers measurable impact, leveraging AI...

By VC10X
How to Get Funded Now: VCs Reid Hoffman, Aileen Lee, and Stacy Brown-Philpot, with Van Jones
PodcastNov 11, 202527 min

How to Get Funded Now: VCs Reid Hoffman, Aileen Lee, and Stacy Brown-Philpot, with Van Jones

In this Masters of Scale session, Reid Hoffman, Aileen Lee, and Stacy Brown-Philpot discuss how venture capital strategies have shifted in 2025, emphasizing a more selective, founder‑centric approach amid rapid AI growth. They outline the key green‑lights—clear product‑market fit, defensible...

By Masters of Scale
E649 | Mariette Roesink, Curie Capital: Backing Life Sciences, Unicorns & Zero Bankruptcies
PodcastNov 11, 202526 min

E649 | Mariette Roesink, Curie Capital: Backing Life Sciences, Unicorns & Zero Bankruptcies

Mariette Roesink, co‑founder of Curie Capital, explains the firm’s biotech‑focused VC model that seeks both outsized financial returns and meaningful patient outcomes. She showcases a track record of two unicorn exits, €200 M raised in a single year, and zero bankruptcies...

By The European VC (EUVC)
From Yext to Roam: Howard Lerman’s Second Act
PodcastNov 10, 20251h 25m

From Yext to Roam: Howard Lerman’s Second Act

In this episode, Howard Lerman reflects on the challenges of launching a second venture after Yext’s success, describing how he founded Roam as an AI‑augmented "Office of the Future" that lets people work from anywhere. He discusses the solitude that...

By Grit (Kleiner Perkins)
20VC: Benchmark's Newest General Partner Ev Randle on Why Margins Matter Less in AI | Why Mega Funds Will Not...
PodcastNov 10, 20251h 25m

20VC: Benchmark's Newest General Partner Ev Randle on Why Margins Matter Less in AI | Why Mega Funds Will Not...

In this episode, Benchmark GP Ev Randle argues that traditional profit margins matter less for AI startups, emphasizing growth, data advantage, and network effects over short‑term profitability. He warns that mega‑funds will struggle to deliver strong returns because capital scarcity...

By The Twenty Minute VC (20VC)
20Sales: Why You Need a CRO Pre-Product | Why Remote Sales Teams Do Not Work | How Snowflake Built a...
PodcastNov 7, 20251h 9m

20Sales: Why You Need a CRO Pre-Product | Why Remote Sales Teams Do Not Work | How Snowflake Built a...

In this episode, host Harry Stebbings and sales veteran Chad Peets explore why SaaS startups should appoint a Chief Revenue Officer before product launch, argue that fully remote sales teams often fail without strong structure, and dissect how Snowflake engineered...

By The Twenty Minute VC (20VC)
Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease
PodcastNov 6, 202545 min

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

Mark Zuckerberg and Priscilla Chan explain how the Chan Zuckerberg Initiative is creating AI‑driven computational tools—like the open‑source Cell Atlas and virtual cell models—to accelerate discovery, test high‑risk hypotheses in silico, and ultimately cure, prevent, and manage all disease by...

By a16z Podcast
VC10X Micro - The Reason Behind 100,000 Layoffs in 2025 - VC10X Micro
PodcastNov 6, 20256 min

VC10X Micro - The Reason Behind 100,000 Layoffs in 2025 - VC10X Micro

In this micro‑episode, Prashant Choubey explains why even profit‑rich giants like Meta and Amazon are cutting thousands of jobs in 2025, attributing the wave to three forces: the "Great AI Re‑allocation" that shifts talent to automation, a newly permanent "Year...

By VC10X
From Billion-Dollar Brand to Blank Slate: Bobbi Brown’s Comeback
PodcastNov 6, 202535 min

From Billion-Dollar Brand to Blank Slate: Bobbi Brown’s Comeback

In this episode, Bobbi Brown recounts how she grew Bobbi Brown Cosmetics into a billion‑dollar powerhouse and the fraught split with Estée Lauder that forced her to choose between retirement and reinvention. She shares hard‑won lessons on scaling a brand, navigating...

By Masters of Scale
Seeing The Future From AI Companions to Personal Software
PodcastNov 5, 202550 min

Seeing The Future From AI Companions to Personal Software

In this episode, Eugenia Kuyda, the founder of Replika and CEO of Wabi, discusses how AI‑driven personal software will shift from a developer‑only tool to a creative medium accessible to anyone, likening command‑line AI interfaces to the early days of...

By a16z Podcast
#173 STAG: The Tesla of Construction Equipment?!
PodcastNov 5, 202543 min

#173 STAG: The Tesla of Construction Equipment?!

In this episode, founders Adam and Patrik pitch STAG, an electric mini skid‑steer they describe as the "Tesla of construction equipment," highlighting its multi‑function design, Made‑in‑USA manufacturing, and early traction with major dealers like Bobcat. They explain the market opportunity...

By The Pitch
E646 | Alper, Agave Games & Enis Hulli, E2vc: Pivoting Models & Building Global Gaming Success From Turkey
PodcastNov 5, 202549 min

E646 | Alper, Agave Games & Enis Hulli, E2vc: Pivoting Models & Building Global Gaming Success From Turkey

In this episode Alper Oner, co‑founder of Agave Games, and VC Enis Hulli discuss Agave’s evolution from a publisher to an in‑house studio that struck global success with the hidden‑object hit “Find the Cat” and is now scaling its next...

By The European VC (EUVC)
ElevenLabs CEO: Why Voice Is the Next AI Interface
PodcastNov 5, 202531 min

ElevenLabs CEO: Why Voice Is the Next AI Interface

In this episode, ElevenLabs CEO Mati Staniszewski explains how his small, autonomous, globally‑hired team ships research‑grade AI—text‑to‑speech, licensed AI music, and real‑time voice agents—at lightning speed, arguing that voice will become the primary human‑computer interface. He details the Voice Marketplace’s creator‑centric...

By a16z Podcast
The Startup Building Edible Insulation to Tackle a 1.4 Gigaton CO2 Problem
PodcastNov 4, 202527 min

The Startup Building Edible Insulation to Tackle a 1.4 Gigaton CO2 Problem

In this episode, host Tom Britton talks with Theresa Hoffmann, founder of Nanoplume, about their bio‑aerogel insulation that is three times more effective and 60% thinner than conventional materials, a non‑toxic product so safe she even eats it during demos....

By Angel Invest Boston
VC10X - What Is A Continuum Fund? - Michelle Urben, Managing & General Partner, Synergos Fund
PodcastNov 4, 202535 min

VC10X - What Is A Continuum Fund? - Michelle Urben, Managing & General Partner, Synergos Fund

In this episode, Michelle Urben explains Synergos Fund’s "continuum fund" model, which provides patient, evergreen capital to companies from seed through commercialization, rejecting the traditional exit‑focused VC mindset. She highlights how the fund aligns with conscious capitalism, offering flexible, transparent...

By VC10X
David Sacks: AI, Crypto, China, Dems, and SF
PodcastNov 3, 20251h 16m

David Sacks: AI, Crypto, China, Dems, and SF

In this episode, White House AI and Crypto Czar David Sacks joins Marc, Ben, and Erik to dissect the Trump administration’s approach to AI and crypto, highlighting a regulatory capture strategy by major AI firms. He argues that open‑source technology...

By a16z Podcast
Rebuilding Front for the AI Era | CEO Dan O’Connell
PodcastNov 3, 202559 min

Rebuilding Front for the AI Era | CEO Dan O’Connell

In this episode, Dan O’Connell, the new CEO of Front, discusses how the company is navigating the AI revolution by balancing legacy systems with innovative technology, emphasizing that the toughest part of transformation is deciding what to let go of....

By Grit (Kleiner Perkins)
Why Speed, Not Size, Will Define the Next War
PodcastNov 1, 202539 min

Why Speed, Not Size, Will Define the Next War

In this episode, Horacio Rozanski of Booz Allen Hamilton and Gary Shield of Shield AI explain how speed, software agility, and public‑private partnerships are reshaping U.S. defense amid rising global tensions. They draw lessons from the Ukraine and Taiwan conflicts,...

By a16z Podcast
Beyond Chatbots: Marc Andreessen and Ben Horowitz on AI's Future
PodcastOct 31, 202538 min

Beyond Chatbots: Marc Andreessen and Ben Horowitz on AI's Future

In the closing keynote of a16z’s Runtime conference, host Erik Torenberg chats with co‑founders Marc Andreessen and Ben Horowitz about the event’s highlights, the current capabilities of large language models, and why massive AI capital expenditures don’t signal a bubble....

By a16z Podcast
20VC: Tim Ferriss: Why I Walked Away From Angel Investing After Uber | How I Accidentally Lost $150 Million |...
PodcastOct 31, 20251h 31m

20VC: Tim Ferriss: Why I Walked Away From Angel Investing After Uber | How I Accidentally Lost $150 Million |...

In this episode, Tim Ferriss reflects on why he stepped away from angel investing after his early involvement with Uber, recounting a costly $150 million mistake and how money both solved and later complicated his personal challenges. He shares insights on...

By The Twenty Minute VC (20VC)
VC10X Micro - Intel's Epic Turnaround: Up 100% in 6 Months📈🤯
PodcastOct 30, 20259 min

VC10X Micro - Intel's Epic Turnaround: Up 100% in 6 Months📈🤯

The episode dissects Intel’s dramatic reversal from an $18.8 billion loss to a $4.1 billion profit in six months under new CEO Lip‑Bu Tan, highlighting his outsider‑driven turnaround playbook that emphasized strategic capital, ruthless focus, and rapid execution, even attracting a $5 billion investment...

By VC10X
"Is There an AI Bubble?” Gavin Baker and David George
PodcastOct 30, 202531 min

"Is There an AI Bubble?” Gavin Baker and David George

In this a16z Runtime conversation, Managing Partner Gavin Baker and GP David George examine the macro forces driving the AI surge, including the trillion‑dollar data‑center expansion and shifting economics of GPU pricing. They assess whether the rapid growth signals a...

By a16z Podcast
E643 | Sebastian Peck, KOMPAS VC: Europe’s Industrial Tech Moment: Decarbonisation, AI & the Risk Appetite Gap
PodcastOct 30, 202549 min

E643 | Sebastian Peck, KOMPAS VC: Europe’s Industrial Tech Moment: Decarbonisation, AI & the Risk Appetite Gap

In this episode, Andreas Munk Holm talks with Sebastian Peck, a partner at KOMPAS VC, about why industrial tech—focused on decarbonisation, productivity and resilience—is finally gaining traction in European venture capital. Peck highlights the divergent energy strategies across regions, the...

By The European VC (EUVC)
20VC: A16z Raises $10BN in New Funds | Mercor Raises $350M at a $10BN Valuation | OpenAI Restructuring: Who Wins...
PodcastOct 30, 20251h 24m

20VC: A16z Raises $10BN in New Funds | Mercor Raises $350M at a $10BN Valuation | OpenAI Restructuring: Who Wins...

The episode breaks down four major topics: OpenAI's restructuring and its impact on stakeholders; Andreessen Horowitz's $10 billion fundraise; Mercor's $350 million raise at a $10 billion valuation; and a critique of IRR as a VC metric, followed by three actionable strategies to...

By The Twenty Minute VC (20VC)
Building the Real-World Infrastructure for AI, with Google, Cisco & A16z
PodcastOct 29, 202532 min

Building the Real-World Infrastructure for AI, with Google, Cisco & A16z

In this episode, a16z’s Raghu Raghuram talks with Google’s Amin Vahdat and Cisco’s Jeetu Patel about the massive physical build‑out required for AI, covering everything from custom chips and power grids to global data‑center networks. They frame this as an...

By a16z Podcast
#172 My Town AI: ChatGPT Meets SimCity
PodcastOct 29, 202543 min

#172 My Town AI: ChatGPT Meets SimCity

In this episode, founder and mayor‑pro‑tem Nichole Sterling pitches My Town AI, an AI‑driven civic‑intelligence platform that gives small towns access to data, workflow automation and low‑cost digital twins to solve grant‑writing bottlenecks and operational blind spots. She illustrates how...

By The Pitch
How Anastasia Soare Built a Beauty Brand Worth Billions
PodcastOct 29, 202531 min

How Anastasia Soare Built a Beauty Brand Worth Billions

In this episode, Anastasia Soare recounts her journey from a Romanian immigrant running a one‑room Beverly Hills salon to creating a global beauty empire valued at roughly $3 billion, highlighting the power of relentless focus on a niche—eyebrows. She shares key...

By Masters of Scale
Founder10x - Can AI Beat The Top Investors? - Jan Szilagyi, Co-Founder, Reflexivity
PodcastOct 28, 202534 min

Founder10x - Can AI Beat The Top Investors? - Jan Szilagyi, Co-Founder, Reflexivity

In this episode, Jan Szilagyi, co‑founder of Reflexivity, explains how his AI‑driven market research platform transforms raw market data into an analytical partner for top hedge funds, embedding principles from legends like Stanley Druckenmiller. He details the platform’s differentiation, its...

By VC10X
Chobani & Patagonia CEOs Break Down Where Values Meet Profit
PodcastOct 28, 202527 min

Chobani & Patagonia CEOs Break Down Where Values Meet Profit

In the episode, Patagonia CEO Ryan Gellert and Chobani founder Hamdi Ulukaya discuss how they align values with profit, navigating activist government pressure and anticipatory compliance while scaling their businesses. They share strategies for integrating environmental stewardship and immigration support...

By Masters of Scale
Raghu Raghuram: AI, Robotics, and the Rebirth of Infrastructure
PodcastOct 27, 202530 min

Raghu Raghuram: AI, Robotics, and the Rebirth of Infrastructure

Raghu Raghuram reflects on his front‑row experience of the early internet wars, the Netscape‑Microsoft browser battles, and the landmark VMware acquisition of Nicira that reshaped networking. He and the a16z hosts discuss how VMware grew from a modest startup to...

By a16z Podcast
ElevenLabs’ Vision for Voice Interfaces | CEO Mati Staniszewski
PodcastOct 27, 20251h 4m

ElevenLabs’ Vision for Voice Interfaces | CEO Mati Staniszewski

In this episode, ElevenLabs co‑founder and CEO Mati Staniszewski discusses how the company’s emotion‑driven voice AI is reshaping sectors such as personalized healthcare and film production. He explains the technology’s ability to generate nuanced, expressive speech that can adapt to...

By Grit (Kleiner Perkins)
20VC: Sequoia's David Cahn on The Winners and Losers in AI | The $0-$100M Revenue Club: Is Triple, Triple, Double,...
PodcastOct 27, 20251h 14m

20VC: Sequoia's David Cahn on The Winners and Losers in AI | The $0-$100M Revenue Club: Is Triple, Triple, Double,...

In this episode, Sequoia partner David Cahn argues we’re in an AI bubble but sees lasting moats in physical data‑center infrastructure, while mapping out which companies will thrive or falter as AI reshapes markets. He discusses the impact of big‑tech...

By The Twenty Minute VC (20VC)
20Growth: How to Build a Paid Marketing Machine: ROAS (Return on Ad Spend) 101 | The Rise of User Generated...
PodcastOct 24, 20251h 16m

20Growth: How to Build a Paid Marketing Machine: ROAS (Return on Ad Spend) 101 | The Rise of User Generated...

In this episode, growth veteran Sandy Diao shares the biggest lessons she learned scaling products at Pinterest, Meta, and Descript, emphasizing how to craft strong growth hypotheses and avoid common strategic pitfalls. She breaks down the fundamentals of Return on...

By The Twenty Minute VC (20VC)
20VC: Why VC Today Is Worse Than 2021 | Why Vertical SaaS Is a Bad Investment Today | Why We...
PodcastOct 23, 20251h 28m

20VC: Why VC Today Is Worse Than 2021 | Why Vertical SaaS Is a Bad Investment Today | Why We...

The episode critiques the current venture‑capital climate, arguing it’s as over‑hyped as the 2021 COVID boom and warning that vertical SaaS and legal‑SaaS investments are now unattractive. Host Harry Stebbings and guests discuss Revolut’s $3 bn raise at a $75 bn valuation...

By The Twenty Minute VC (20VC)
Marc Andreessen and Amjad Masad: English As the New Programming Language
PodcastOct 23, 20251h 11m

Marc Andreessen and Amjad Masad: English As the New Programming Language

In this episode Marc Andreessen, Erik Torenberg, and Replit CEO Amjad Masad explore how AI agents are reshaping programming, arguing that English‑based prompts are becoming the new coding language. Masad explains how reinforcement learning unlocked reasoning in large models, how...

By a16z Podcast