Pharma AI Shifts From Cloud to On‑Device
Most AI companies believe the future is cloud-first. Pharma is different. In this industry, data is the kingdom. Experimental data. Molecular designs. Clinical insights. Some of the most valuable intellectual property on Earth. And in many cases, it cannot leave the lab. This is where the typical cloud-first AI model becomes a strategic vulnerability. While building MMAI Gym and collaborating with Liquid AI, we had a realization: The next phase of scientific AI will be local. Smaller, highly specialized models deployed directly on-device can: • protect pharmaceutical IP • guarantee data privacy • accelerate experimentation • enable real-time discovery The AI industry is obsessed with bigger models. But in drug discovery, the advantage may come from deploying intelligence exactly where the data lives. At Insilico Medicine we’ve evolved: From building individual AI fighters to becoming the MMA coach for scientific foundation models. The future of pharma AI will not just be bigger models. It will be secure intelligence embedded inside the lab. #AI #DrugDiscovery #EdgeAI #Biotech
Mortgage Applications Up YoY, Weekly Demand Drops
#Mortgage purchase application data remains positive year over year, but weekly demand declined last week. @housingwire @sarahteresa6 #realestate #economics #mortgagerstes #chartdaddy
Questioning FDIC Expansion; Call for Data-Indexed System
With the floodgates open for industrial bank charters & private equity & crypto owned banks, I’m extremely suspect on why there’s such a drive to dramatically increase FDIC insurance in zero interest yield deposits. A data driven, indexed system is...
Separate Land and Home Sales Simplify Taxation, Japan Shows
The way you do this is by allowing land and houses to be sold separately, like Japan does. Incidentally, this also makes it easy to do a land tax.
Live on Bloomberg: Oil Markets and Iran War Outlook
Heads up that I'll be LIVE on @BNNBloomberg to talk oil markets and the [??end of??] the Iran War this morning at 11:15am ET. https://t.co/bqG3IGwkQS
Engineered Immune Cells Target Refractory Myeloma, Broader Cancer Potential
Steady progress towards engineering immune cells in the body now for refractory myeloma , with major implications for many autoimmune diseases and cancers https://t.co/K3IksrCFlg https://t.co/1AQ5rLuH1g
AI in Healthcare Must Address Algorithmic Bias
The #Algorithmic Divide: Why #Healthcare #AI Shouldn’t Treat Everyone The Same by Brad Porter @Forbes Learn more: https://t.co/Jw7zyu0LFo #MedTech #HealthTech #Tech #TechForGood https://t.co/Fo3KyOyzqZ
ACA's Bans and Tax Rules Kill Portable Individual Plans
And, the ACA banned individual guaranteed renewable plans which existed, and protected against the emergence of preexisting conditions. The tax deduction for employer based group plans, but not for contributions to portable individual plans nails the coffin. Great essay.
Tesla FSD Cautiously Monitors Pedestrians, Causing Ambiguous Hesitation
I appreciate that Tesla's FSD actively watches out for pedestrians. Even if they are not sure of what I am going to do. It's hard to tell if the system's hesitation is because of the pedestrians not sure if I am...
Mortgage Help Searches Hit 2008 Highs, Defaults Stay Low
Like rubbing a magic lamp, folks flock to #Google for help w/their #mortgage. Searches 'help w/mortgage' surge past 08 #GFC high. Though delinquency+#foreclosure activity remain low. #realestate #CRE #interestrates #tax #insurance https://t.co/AhoET2F9v7 https://t.co/vu2NMxs7ev
IRA 2.0 Aims to Reclaim U.S. Energy Leadership
Envisioning IRA 2.0: Restoring U.S. energy leadership #energysky -- via pv magazine usa: https://t.co/B6WHdajskP https://t.co/O9yPqcH9HM
Governments Sign Free‑trade Deals, Sparing Consumers New Tariffs
Yes, and the kicker is that these governments keep signing real, durable, comprehensive FREE TRADE deals without imposing costly new taxes (tariffs) on their consumers. Almost as if....
Exercise Raises Plaque Yet Cuts Heart Risk
Regular exercise reduces the likelihood of plaque accumulation in the arteries However, many long-term exercisers appear to have coronary artery calcification, indicating atherosclerosis progression The fascinating thing is that despite the higher plaque, those people still have lower rates of cardiovascular disease...
Dallas Fed Energy Survey: Tiny Executive Sample Reveals Key Insight
Dallas Fed Energy Survey for Q1 2026 is out. 2 Notes on this chart: - Only 34 executives responded - That second sentence in the description does all the work https://t.co/gAebgKUX4O
Oil Futures Curve Tracks Middle East News Shifts
I find the oil futures curve to be a useful way of keeping track of news out of the Middle East, as it provides a useful metric for assessing what's changing, and how much. https://t.co/Hl3XzfUEfP
Housing Bubble Persists Since 2012, Now Worse than 2008
Since 2012 housing has always been in a bubble and it's housing 2008 or worse ☺️😏😁🫡 https://t.co/l2fykhXDfn
Proposed $805 Teen Fine Dwarfs $
It's also just New Mexico. If it's the average then scaled to US pop it approaches $60 BILLION (italics=estimated). So a fine of approximately $805 per minor. Seems reasonable. Senator Blackburn shared Meta's internal analysis that their estimated...
Purchase Applications Dip 5% Weekly, YoY Growth Slows
Purchase application data, although still positive year over year, showed a week-to-week decline of 5% and the YoY growth slowed down. https://t.co/1ZaOtoeLuN
EU NIS2 Overhauls Cybersecurity for PV Plant Operators
How EU NIS2 is reshaping cybersecurity for PV plant operators #energysky -- via pv magazine global: https://t.co/eSJkuEt6jK
Amex's $295 Cash‑Back Card Beats Free Alternatives
Amex Launches A 2% Cash Back Business Card — Charging $295 For What You Can Get Free - View from the Wing https://t.co/QPkU0Fb3qH
Gulf Shut‑ins Cut Iraq, Iran Output by ~13 MMbpd
GULF SHUT-IN UPDATE: Brings Iraq's confirmed shut-ins to ~3.5 MMbpd as of yesterday, lifts overall confirmed *crude* Iran War output shut-ins to ~9.5 MMbpd. Gas condensate/NGL output losses are on top of that. ~200 million barrels of expected crude won't be...
Buyout Likely as Activists Target Governance, Shares Plunge
Market is ignoring the looming governance catalyst. Super-voting shares are being phased out as two activists build meaningful stakes, one owning a highly complementary peer. With shares at multi-year lows and the biz stabilizing, the path to a buyout is increasingly likely....
Mass General Purge Signals Years of Rebuilding Ahead
They just purged all their top generals. They're going to be rebuilding for a couple of years.
HST Cut Won’t Revive Ontario Construction, Despite Tax Relief
Will Removing The HST From All New Construction Homes In Ontario Kick Start The Residential Construction Industry: ABSOLUTELY NOT Since politicians mainly know nothing about the Industries for which they invent policies this should be expected BTW every Tax Removed is GOOD I...
Quitting a Disbanded Advisory Panel: Does It Matter?
Does it count if you quit a voluntary advisory panel that was already disbanded by a federal judge? The newly drama-averse Robert Malone tests this hypothesis. https://t.co/wEryoJvz99
Iran Rejects US Plan, Offers Five‑Point War‑End Conditions
Iran rejects US 15-point peace plan. Sets five-point conditional plan to end the war, via PressTV 1. A complete halt to "aggression and assassinations" by the enemy. 2. The establishment of concrete mechanisms to ensure that the war is not reimposed...
Gas Prices Surge Above $4, Highest Since 2022
National retail gas prices have crossed the $4.00 per gallon threshold. Highest prices since August 2022. Just a month ago, the President was saying they were under $2 https://t.co/o1wA1BwG3C
Spot Dubai Crude Holds Premium Amid Hormuz Uncertainty
Balance of the month cash Dubai crude barrels (white line) still trading higher than the prompt Oman futures (blue) I'm seeing quoted this morning, which are down more sharply, but spot Middle East barrels certainly feeling less pressure and all...
TikTok Hit “Chest Pain” Goes Platinum, Hits Mainstream
Malcolm Todd's "Chest Pain (I Love)" has been certified Platinum in the United States for selling 1 million copies, proving that his viral TikTok hit has officially crossed over into mainstream success. https://t.co/IEu7xmdYq6
Stripe, Affirm Merge BNPL with Agentic AI, Klarna Joins
Affirm and Stripe Team to Combine BNPL and Agentic AI SPTs let ANY merchant offering Affirm accept transactions in agentic flows (even without direct Stripe integration). Stripe direct merchants get capability now, non-Stripe merchants later 2026. Stripe also announced parallel Klarna...
Delta Ends VIP Airport Service For
Delta Suspends VIP Airport Help For Congress — But Lawmakers Still Don't Have To Fly Like You - View from the Wing https://t.co/qkUTxmKrpX
Factory Construction Falls 15% Despite Trump's $18T Promise
Factory construction was down 15% over the last year, even before adjusting for inflation https://t.co/YNFjjiLWfV Reality hasn't heard about Trump's $18 trillion in investment coming into the country. Trump always says, "no one has seen anything like it," which is...
US‑Iran Standoff: Unclear Resolution Timeline, Strait at Risk
US demands. Iran demands. Will there be resolution? If so, how long to achieve? And if not? In the meantime, what about maritime and the Strait? https://t.co/H96YCgv7lV
Iran Vows to End War on Its Own Terms
Iran state-owned TV says that Tehran will end the war at a time of its own choosing. Islamic Republic won’t allow Trump to dictate end of conflict, it says
Top Nations Relying on Hormuz for Fertilizer Imports
Which countries are most dependent on fertilizer through the Straits of Hormuz. More on this in the Chartbook Top Links today. https://t.co/r2Cnz3sGtS
Brent Stays >$100, WTI Under $100 Amid Strait Closure
While WTI has remained just under $100barrel, Brent has remained well above $100 as it is more dependent on the Strait. Per the bottom panel below, the backwardation of the forward curve has continued to sit around $20/barrel as the...
Creator Economy Booms While Mental Health Crises Double
1 in 10 content creators report serious mental health struggles tied to their work. That’s double the national average. At the same time, the creator economy is worth hundreds of billions and growing fast. So what’s broken? In this episode of TEQ, I...
Musk Halts X Creator Revenue Change Targeting Regional Impressions
Elon Musk paused X's creator revenue rule change that aimed to focus on regional impressions hours after the company announced it https://t.co/d2YT9fm7Jq
Brookfield Leads $9B Deal as M&A Spree Continues
Today's M&A notes $BLX.to to be acquired by Brookfield / La Caisse for $37.25 cash per share, 31.8% premium, $9.0 billion $TERN to be acquired by MRK for $53.00 cash per share, 6.0% premium, $5.7 billion $JHG / Trian bumped bid by 6.1%...
Higher Phenotypic Age Accelerates Cancer Survivors' Mortality Risk
The association between phenotypic age acceleration and the risk of all-cause and cancer mortality among cancer survivors: NHANES 1999–2018 "Our findings reveal a significant linear correlation between PhenoAgeAccel and both all-cause and cancer-specific mortality in cancer survivors." https://t.co/Rt7v8ECOB6
Remote Solar Inspections Cut Time and Boost Safety
Remote inspection of new residential solar saves time and can improve safety #energysky -- via pv magazine usa: https://t.co/ZX9BmJQz4P
Stray Ukrainian Drones Fly over Baltics, One Hits Power Station
VILNIUS/RIGA, March 25 (Reuters) - Two stray Ukrainian military drones entered the airspace of Estonia and Latvia on Wednesday morning via Russia, one of which slammed into a chimney at a local power station while the other crash landed, the...
Taiwan's Political Choices Ripple Through Global Supply Chains
Taiwan politics isn’t just a local issue. When a party like the KMT shapes how closely the country engages with China and the US, it influences a supply chain the entire world depends on. That’s why it matters far beyond Taiwan. https://t.co/2eGMOnyZKp
President's Anti‑wind Rant Sounds Like Grandpa Simpson
"The president's case against wind are literally the rantings of an old man. I've seen grandpa Simpson make more sense." https://t.co/3rAbLKpVqe
Europe Deploys Grid-Forming LDES‑Solar Hybrid Systems
VIDEO: Grid-forming, LDES and solar hybrids in Europe, with Envision Energy’s Michael Koller #energysky -- via Energy Storage News: https://t.co/lI5Hanqa0Y
CEO Amy Burroughs Discusses M&A Post‑ASH25 Data
I asked $TERN CEO Amy Burroughs right after the #ASH25 data was out how she felt about M&A. Congrats to her and her team. https://t.co/2HemPoiqWO
BCA Research Hormuz Crisis Dashboard Now Open to Public
Just a reminder that everyone should check out the BCA Research Hormuz Crisis dashboard, which we have now made available to non-cients. https://t.co/2w3YrSrMuA https://t.co/PRmuyuEG4a
Dominic McLaughlin Debuts as Harry Potter, Fans Thrilled
HBO just dropped the first photo of Dominic McLaughlin as Harry Potter and the Wizarding World looks exactly like it should. The 2027 premiere cannot come soon enough. https://t.co/vDP8I04omc
Margin Call Crushed Hunt Brothers' Silver Corner
On this day, March 25, 1980 the Hunt brothers received a massive margin call that helped trigger one of the biggest commodity crashes in history. Texas billionaires Nelson Bunker Hunt and William Herbert Hunt had cornered nearly one third of the...
Hormuz Optimism Overshadowed by Grim Long‑term Risks
COB Tuesday is the best weekly energy podcast. Period. Excited to join them yesterday to discuss the Persian Gulf. tl;dr There are reasons to be optimistic about Hormuz. But the worst case scenario & long term consequences are worse than anyone has...