Mapping the Evolution Stages of Major EHR Systems
Given the data program visualizations for @Cognizant and @PointClickCare in the May Monthly Review last week, I got a few questions on how far along other EHRs are in their evolution. So I thought it’d be fun to explain where some of the big EHRs (and other systems of record) are in that journey, starting with @HeyEpic.
Investment Banking Advises, Private Equity Owns and Grows
Difference Between Investment Banking and Private Equity 👇 Investment Banking - • Advises companies on M&A deals, IPOs, and fundraising activities. • Earns fees by helping clients execute transactions. • Focuses on deal execution and financial advisory services. Private Equity - • Invests directly in companies...
Personalized Emails at Scale with AI-Powered Blocks
Every once in a while, I see something in email and go… huh, why isn't this already how it works. This is one of those. It's called Allan. Your designer stops building emails, they build blocks (heros, body copy, CTAs, product modules)....
Myostatin Inhibitor Preserves 55% Lean Mass with Tirzepatide
Preserving lean mass during tirzepatide (Zepbound) treatment. A randomized trial of a myostatin inhibitor for muscle mass building shows proof-of-concept. A 55% retention of lean mass compared with placebo https://t.co/urw9Gvy11L just published @NatureMedicine https://t.co/ukUhLbAXFL
Biopharma CEOs Median Pay Jumps 13% to $5.35M
NEW: Here are biopharma's top-paid CEOs of 2025, taking in pay packages worth over $25M Median biopharma CEO pay for 2025 came in at $5.35M, up 13% from last year. The best-paid made far more & we have the receipts https://t.co/CBHCjCien5
Daraxon
Follow up on the $TNGX data from this morning. Cross-trial comparison caveats.... Daraxonrasib ORR results from the RASolute302 study: https://t.co/MJsD6KWPIi
House Rejects BOOTS Act, US Shoe Industry Remains Vulnerable
House lawmakers fail to pass BOOTS Act to strengthen US footwear production https://t.co/mVjuwQSA0o via @wwd
KZIA's Multi‑Asset Pipeline and Strong Balance Sheet Defy Market Sell‑off
$KZIA looks interesting after Friday's sell-off. The move felt more like sympathy pressure from the broader oncology tape following the $CELC ASCO reaction than anything company-specific. A few things stand out: > Paxalisib continues advancing in Phase 1b TNBC, with early signals suggesting...
IMMX's NXC-201 Shows 95
We have been fans of $IMMX for some time, and the recent selloff is creating what looks like an interesting opportunity in what may be one of the more disruptive cell therapy platforms in development. • NXC-201 has reported a...
Chinese Doctors Embrace AI Prescribing, Keep Final Say
In a study, authors asked 2708 physicians throughout China to interrogate their opinions on drug-prescribing AI. There seems to be a wide acceptance of conditional autonomous drug-prescribing AI. But only in a way that the physician remains the gatekeeper in the...
Fox Secures NFL Broadcast Rights for Mexico
Peace in our time? After speculation Fox was ticked off by clear signals that the NFL will seek to increase its rights fees, the two strike a deal that lets Fox show many games, including Thursday Night Football and the...
Tesla Wins FCC Nod for Ultra‑wideband Wireless EV Charging
Tesla Secures FCC Approval for Ultra-Wideband #Wireless #EV Charging by @IntEngineering #Innovation #EmergingTech #Tech #Technology https://t.co/ULCTNGJH72
Combo Achieves 92% ORR, 90% 6‑Month PFS
Some context for that 92% ORR / 90% 6mth landmark PFS in pancreatic cancer for the $TNGX vopimetostat + daraxonrasib combo: vopimetostat monorx 25% ORR, ~90% 6mth PFS $RVMD daraxonrasib monorx 32%, 6mth PFS 56% https://t.co/V7RjXlLrZK
Middle East Export Collapse Drives Record Crude Export Plunge
Pandemic-like declines, minus the Pandemic... Global seaborne crude and petroleum product exports averaged 11.8 mb/d lower in May than a year ago, driven by a 14.8 mb/d collapse in Middle East exports, only partly offset by a 3.5 mb/d increase from...
China’s Space Computing Hub Signals Off‑Planet Tech Race
China launches space computing hub as SpaceX gears up for historic IPO New institute highlights Beijing’s bid to leapfrog energy bottlenecks and underscores how tech race with US is moving off-planet https://t.co/gH7wZu4Fkw via @scmpnews
AI Roll‑Up Dwelly Secures $200M After 9 Acquisitions
Want to see true product-market fit? Look at Dwelly. After 9 acquisitions in 24 months, Dan's AI-enabled roll-up is in talks to raise an additional $200m from General Catalyst and other investors. It's great news, as earlier this year they raised $93 million...
Former NASA Chief Leads Quantum Space SPAC IPO
Quantum Space, a company developing highly maneuverable spacecraft whose CEO is former NASA Administrator Jim Bridenstine, is going public through a SPAC merger: https://t.co/gSoUO8S5wV
Legal Energy Shots Containing Kratom Trigger Opioid Dependence
These are sold at gas stations and vape shops. They are labeled as energy and focus aids. And many of them contain compounds that act on the same receptors as opioids. That is legal, by the way. The FDA chose...
ADNOC’s New Tender Signals Surge of Dark Shipments
UAE state owned oil company ADNOC has awarded a tender for ~14 million barrels of crude, and it’s planning a 2nd tender. The sales are a further indication that significant volumes of crude are exiting the Strait of Hormuz in...
Five Indicators Your Threads Content Earns Algorithmic Trust
5 signs your Threads account is gaining algorithmic trust. And if the first two are missing, you're stuck in low-distribution. • Replies coming from non-followers • Follows generated directly from a post • Reshares from people you don't know • Time-on-post increasing week over week •...
PepsiCo Deploys Autonomous Trucks for Regional Grocery Deliveries
PepsiCo is using autonomous trucks to distribute beverages and chips to multiple grocery stores in Texas, Arizona and Arkansas https://t.co/JIu33ZHKyj via @WSJ
2020s Shocks Could Spark New Oil Exploration Wave
The 1970s oil crises forced Western countries to seek new oil reserves outside of the Middle East. It took a while, but vast fields opened up in the North Sea, Alaska, Mexico, Brazil and Siberia. Who dares invest in new...
Healthcare AI Will Augment, Not Replace, Clinicians
If you had to make 10 near-term predictions about the future of healthcare AI, what would those be? Here is my attempt to separate the signal from the noise. Briefly, here are mine: 1) The future of large language models (LLMs) is multimodal 2)...
FDA Grants Breakthrough Status to Preterm Skin‑to‑Skin Wearable
A few months ago, the CEO of the company, Alon Metrikin-Gold, just shared that the FDA has granted "Skincubator" a so-called Breakthrough Device Designation (BDD)! They have developed a wearable device designed to enable immediate, prolonged, skin-to-skin care for the tiniest...
NRIX Secures $700M Upfront, Expands Bexo Into Immunology, Neurology,
$NRIX just got $700m up front for bexo from $RHHBY. Deal includes expansion into immunology, neurology & MS
Asian Coal Prices Surge to Two-Year High Amid Supply Tightening
Asian coal prices rise to the highest level in almost two years 🪨📈 What's going on? 🇮🇩 New Indonesia export rules are delaying shipments, tightening the market 🚢 Japan/Korea depending more on coal as Hormuz closure chokes LNG 🇨🇳 Summer heat is coming (higher...
JetBlue Delays 3.5 Hours over Weight‑balance Check
Holy cow @JetBlue, you have been trying to get the "weight and balance" right for flight 1733 for the better part of 90 mins. Flight is now 3.5 hours delayed
Gulfstream G200 Crashes on Emergency Landing, Two Pilots Killed
La Romana Airport yesterday... Gulfstream G200 from Puerto Rico veers off runway after emergency landing, explodes in flames. Two pilots killed, no pax. Engine issue shortly after takeoff. RIP crew
Loombotic Delivers Instant Quotes, Fast Wire Harness Automation
Loombotic Automates Wire Harness Production With Instant Quotes and Rapid Turnaround by @loombotic #Robotics #Engineering #ArtificialIntelligence #Innovation #Technology https://t.co/B0RiK7t7kK
Nanoplatform Revives Aged Stem Cells for Bone Healing
A sustained NAD+ supplementation-biosynthesis nanoplatform for metabolic restoration in aged bone regeneration "...These findings demonstrate that this nanoplatform can effectively restore the functions of senescent BMSCs, providing a promising therapeutic strategy for aging-related bone regeneration." https://t.co/V6anCVfDPU
NASA Reveals Artemis III Crew for Historic Moon Return
Pick of the week is NASA's announcement of the Artemis III crew on Tuesday. What’s Happening in Space Policy June 7-13, 2026 https://t.co/rXZdH6m2P7
Persona 5 Skyrocketed From Modest 6 Million Pre‑release Sales
Worth remembering that the Persona franchise had only sold around 6 million units prior to the release of Persona 5.
Iran Launches Ballistic Missiles at Northern Israel, Warns.
Iran fired ballistic missiles at northern Israel on Sunday after Israel carried out a strike in Beirut earlier on the day. Tehran described the attack as a warning.
Buried SSRI Failures Double Reported Efficacy Rates.
This was crazy. Burying failed SSRI trials. Published findings positive in ~100% vs 50% if they included the buried ones. Imagine reaction to bias like this psychedelic trials?! Tmk, no buried trials in psychedelic medicine. https://t.co/oRzHnk7mKu
Survodutide Delivers ~16% Weight Loss in Trials
The tide is coming in. High tide of the X-tides, that is in the new GLP-1 family of peptide drugs. Today @NEJM survodutide, a GLP-1 and glucagon dual receptor agonist (no GIP, like tirzepatide) drug that achieved ~16% body weight...
OPEC+ Raises Oil Output Quota for Fourth Month
OPEC+ approves fourth oil output quota hike in as many months No changes in group-wide output policy https://t.co/ie0Z7cJ19q
Xbox Reaffirms No Timed Exclusives, Supports Multi‑Platform Releases
"These are not timed exclusives. Games already announced for multiplatform releases will stick to that plan – we’re committed to investing in and growing XBOX both on console and beyond." https://t.co/YrgqaVqttv
Build Real Data Centers, Learn Internet Infrastructure
Most people use the internet every day but never see what powers it. 🎮 Data Center is a Steam game where you build a real data center from scratch. Buy racks, install servers, connect every cable manually, and manage customer traffic. It's one...
Senua Arrives 2027 Across Xbox, PC, PS5
Senua is set in the Hellblade universe, coming in 2027 to Xbox Series S / X, PC, and PS5 https://t.co/27YsGRnYEo
Prolonged Hormuz Closure Spurs Alternatives, Diminishes Regional Power
🔥Bottom Line on the Hormuz Crisis: 🚨Neither Iran nor the Trump administration is rushing to reopen the Strait of Hormuz, while the economies of the Arab countries are shattered and other countries suffer. 🚨The longer it stays shut, the faster alternatives on...
Freight Data Proves Economy’s Strength Amid Bearish Sentiment
There is a lot of bearish sentiment out there, but the freight data and channel checks are incredibly bullish. Freight data is an advanced indicator of the broader economy because materials and goods move through the supply chain well before people...
Mandal
Meanwhile, MANDALORIAN & GROGU will make $10M this weekend and has a worldwide gross of $293.6M... It's going to cross $300M but it's been a struggle. (2018's SOLO, the previous Star Wars low point and widely used as an example...
NIH Must Fund Human Trials for Untested Peptide Therapies
Why isn't the NIH funding human trials on the popular peptides lacking replicable or significant clinical data? BPC-157, TB-500, AOD-9604, MOTS-c, Semax, Selank - today just anecdotes, forum postings plus mostly animal studies are the evidence base. No pharma sponsor...
Mortal Kombat 2 Projected as WB’s Major Loss
At just $128M globally #MortalKombat2 will be a big cash loser for WB with its $80M budget Franchise finished https://t.co/ZrXctaYdKt
Canadians Demand Affordable Energy, Back Government Subsidies
Affordability Takes Centre Stage in Canadian Energy Conversation Canadians, increasingly squeezed by higher prices, want governments to support affordable and reliable energy policies. IMO, that includes public subsidies for pipelines, LNG, etc. https://markhamhislop.substack.com/p/affordability-takes-centre-stage
Lymphatic‑Targeted Prodrugs Boost Neuropsychiatric Oral Absorption
Loved getting these pictures. Full house w/ hundreds attending our oral presentation “Unlocking Medicines for Neuropsychiatry by Enhancing Oral Absorption Using a Lymphatic-targeting Prodrug Technology” at the American Society of Clinical Psychopharmacology annual meeting https://t.co/hylVMd1IWW
Even Older Block IV SSNs Remain World’s Most Capable Submarines
In case anyone needs to hear this, even a used Block IV VA-Class SSN is the most capable submarine on the planet. Also, the electronics (sonar, fire control, etc.) get regularly refreshed via the ARCI Program, so in many cases older...
U.S. Shipping Service Jumps $2,600
Peak indicator: $2,600 increase on one U.S. shipping service Demand spurs flurry of rate hikes, surcharges https://t.co/0hbqeuaz9k
Ukraine's Spiderweb Sh
"Operation Spiderweb: One Year Later," great review of the historic operation. https://t.co/GmuMowGckx On June 1, 2025, Ukraine’s Security Service (SBU) conducted the unique Operation Spiderweb, reportedly targeting 34% of Russia’s long-range aviation, including Tu-95MS and Tu-22M3 cruise missile carriers, A-50 airborne...
Unified AI Can Run 5M‑Customer Bank With Few Staff
Can AI Run A 5-Million Customer Bank With Only 50 People? 🏦🤖 | Banking | Fintech Can an entire bank with 5 million customers be run by just 50 to 500 people? 🤯 Backbase Founder & CEO Jouk Pleiter drops...