Metabolic and Bariatric Surgery and Male Endocrine and Reproductive Health: A GRADE-Assessed Meta-Analysis
A GRADE‑assessed meta‑analysis of 59 studies (2,401 men) shows metabolic and bariatric surgery markedly improves male endocrine function. Total testosterone rises 5‑8 nmol/L across all follow‑up intervals, while free testosterone shows significant gains after six months. Estradiol declines and SHBG increases, together with a 9‑point boost in IIEF scores, indicating better sexual function. Prolactin levels also fall, reinforcing the hormonal benefits of weight‑loss surgery for obese men.
Case Report: Optimizing Wound Care: Tailored Nutritional Strategies with Immune- Modulating Enteral Nutrients
A dietitian‑led case series of four critically ill patients with advanced pressure ulcers implemented personalized enteral nutrition, targeting progressive energy and protein goals, glycemic control, and selective immunonutrient supplementation (arginine, glutamine, HMB). Over several weeks to months, each patient showed...
The Milpa Diet: A Functional, Sustainable Pattern for Human and Planetary Health
The Milpa diet revives a Mesoamerican polyculture of maize, beans, squash and chili, combined with traditional processing like nixtamalization, to create a nutrient‑dense, bioactive‑rich food system. Agroecologically, the intercropping maximizes land equivalent ratio, cuts water use and curtails deforestation, while...
Gut Microbiota Mediates the Anti-Obesity Effects of Gnaphalium Affine Methanol Extract in HFD-Induced Obesity
A methanol extract of the traditional plant *Gnaphalium affine* (GAE) markedly reduced weight gain, visceral fat, and metabolic dysfunction in high‑fat diet mice. The treatment restored antioxidant defenses, improved glucose tolerance, and reinforced intestinal tight‑junction proteins. Multi‑omics revealed GAE reshaped...
Immunomodulatory Effects of Short-Chain Fatty Acids and Immune-Supporting Nutrients on Slice Cultures of Head and Neck Tumors
Researchers used patient‑derived organotypic slice cultures from nine head and neck squamous cell carcinoma (HNSCC) tumors to test short‑chain fatty acids (SCFAs) and an immunonutrition (IN) blend containing glutamine, alanine and omega‑3 fatty acids. IN alone or combined with SCFAs...
One-Month Early Time-Restricted Eating Enhances Cognition via White Matter–Cortical Pathways in Males with Metabolic Syndrome: Evidence From TBSS and SBM...
A one‑month early time‑restricted eating (eTRE) regimen in 21 male patients with metabolic syndrome led to significant reductions in weight, BMI, fasting glucose, insulin and HOMA‑IR. Neuroimaging revealed increased fractional anisotropy in the left anterior thalamic radiation and cortical thinning...
Development and External Validation of a Machine Learning Model Based on Preoperative Nutritional Status for Predicting Acute Kidney Injury After...
A retrospective study of 811 coronary artery bypass grafting (CABG) patients identified pre‑operative nutritional status, especially the Prognostic Nutritional Index (PNI), as an independent predictor of postoperative acute kidney injury (AKI). Six machine‑learning algorithms were trained on clinical and nutritional...
Association Between Triglyceride-Glucose Index-A Body Shape Index and Atherosclerotic Cardiovascular Disease, and the Modification Effect of Dietary Patterns
A retrospective cross‑sectional study of 13,638 Chinese adults found that the combined triglyceride‑glucose and body shape index (TyG‑ABSI) is linearly associated with atherosclerotic cardiovascular disease (ASCVD). Each unit increase in TyG‑ABSI raised the odds of ASCVD by 152 % (OR 2.52). TyG‑ABSI...
Effect of Doum (Hyphaene Thebaica) Mesocarp and Endosperm Extracts on Triton X-100 Induced Hyperlipidemic Rat: Mitigative Cardiovascular and Renal Dysfunction...
Researchers evaluated aqueous extracts of Doum palm mesocarp (DM) and endosperm (DE) in Triton X‑100‑induced hyperlipidemic rats. High‑dose DM (1,000 mg/kg) markedly lowered triglycerides, total cholesterol, LDL‑C and improved cardiovascular risk indices and renal function, while low‑dose DE (500 mg/kg) produced a...
Prognostic Value of the AIP Index in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
Researchers evaluated the atherogenic index of plasma (AIP) as a prognostic marker in 314 patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Over a median 29‑month follow‑up, each 1‑unit increase in pre‑operative AIP was linked to a...
Association and Predictive Value of Sarcopenic Obesity for the Prognosis of Lung Cancer Patients Receiving Immune Checkpoint Inhibitors
A retrospective cohort of 119 lung‑cancer patients treated with immune checkpoint inhibitors identified sarcopenic obesity (SO) in 15% of cases. Patients with SO experienced the shortest median overall survival (22.6 months) and a three‑year hazard ratio of 3.48 for mortality,...
Optimal Dosage of Exercise Combined with Intermittent Fasting for Body Composition and Cardiometabolic Health in Adults: A Systematic Review and...
A three‑level meta‑analysis of 65 randomized trials (3,293 adults) examined exercise combined with intermittent fasting (EX + IF). Compared with exercise alone, fasting alone, or no intervention, EX + IF produced modest but significant reductions in body mass, BMI, body‑fat percentage, waist circumference and...
Stage-Specific Variations in Urinary and Salt Iodine Among Pregnant Women in Beijing
A longitudinal study of 400 Beijing pregnant women from 2021‑2024 found urinary iodine concentrations (UIC) declined sharply, with median levels dropping from 151.3 µg/L in 2022 to 122.9 µg/L in 2024, falling below the WHO adequacy threshold of 150 µg/L. Mixed‑effects modeling showed...
A Nutritional Blend of Taurine, Vitamins B6, B9, and B12 Improves Motivated Behaviors in Healthy Adults—A Double-Blinded Randomized Clinical Trial
A double‑blind, crossover trial involving 44 healthy adults tested a four‑week supplement containing taurine, vitamin B6, B9, and B12. The blend raised blood taurine and B‑vitamin levels and produced a roughly 12% increase in motivated performance on a monetary incentive force...
Effects of Low-Dose Medium-Chain Triglycerides on Bowel Habit Outcomes in Japanese Adults Prone to Constipation: A Randomized, Double-Blind, LCT-Controlled Crossover...
A randomized, double‑blind crossover trial in 82 Japanese adults prone to constipation found that consuming 2 g of medium‑chain triglycerides (MCT) daily for two weeks significantly increased the number of days with bowel movements, overall frequency, and stool volume compared with...
Regulatory Effects of Hawthorn on Lipid Metabolic Homeostasis: Mechanisms, Evidences, and Perspectives
A recent review highlights hawthorn (Crataegus spp.) as a promising natural agent for restoring lipid metabolic homeostasis. The plant’s rich flavonoids, phenylpropanoids, and terpenoids suppress hepatic lipogenesis, boost fatty‑acid β‑oxidation, and improve insulin signaling. Additional benefits arise from gut‑microbiota remodeling...
A Clinical Assessment of the Therapeutic Effects of Ashwagandha Root Extract on Cognitive Performance, Sleep, and Fatigue in Children Aged...
A randomized, double‑blind, placebo‑controlled trial evaluated standardized Ashwagandha root extract gummies (150 mg twice daily) over eight weeks in 85 healthy children aged 6–12 with parent‑reported attention or memory concerns. Seventy‑three participants completed the study, and the Ashwagandha group showed significant...
Effectiveness of Whole Grain to Body Weight and Cardiometabolic Risk in Adults with Obesity: A Parallel Randomised Controlled Trial
A 12‑week parallel randomised controlled trial involving 115 obese adults examined the impact of daily whole‑grain consumption at 50 g and 100 g doses. Both intervention groups lost approximately 2 kg more weight than the control, with corresponding reductions in BMI, body‑fat mass,...
Preoperative Carbohydrate Loading: Evolution, Trends, and Future Directions
A new bibliometric study maps the evolution of preoperative carbohydrate loading (PCL) research, analyzing 269 publications from 38 countries up to March 2025. China produced the most papers, while England occupied the most central position in international collaboration networks. The...
3-Month Oral Nutritional Supplementation Adherence Impacts Positively on Survival in Malnourished Older Patients Following Hip Fracture: A Real-Life Study
A prospective cohort of 300 patients aged 65+ with fragility hip fractures examined how adherence to oral nutritional supplements (ONS) affected mortality. Patients who consistently retrieved ONS for at least three months showed a markedly lower 12‑month death rate (15.2%)...