Senkyunolides: A Promising Natural Compounds for the Treatment of Migraine Headaches
A Frontiers in Nutrition review published April 10, 2026 examines senkyunolides—phthalide‑type compounds from herbs such as Ligusticum chuanxiong—as a new class of natural anti‑migraine agents. The authors detail the compounds’ chemical diversity, modern extraction and purification methods, and multi‑target mechanisms that modulate neurovascular inflammation, oxidative stress, and blood‑brain barrier integrity. Pharmacokinetic data show small‑molecule structures enable rapid BBB penetration and lower hepato‑renal toxicity compared with existing triptans and CGRP antagonists. The paper stresses formulation stability as the primary hurdle before clinical translation can proceed.
Promoting Healthier Food Purchases via Social Media: The Role of Polls and Their Visual Features
The research investigated how descriptive social‑norm feedback presented through Instagram‑style polls influences purchase intentions for healthy versus unhealthy foods. In a sample of 227 participants, those who reported a healthy diet showed significantly higher intention to buy healthy products when...
Neural Mechanisms of Food Preference and Reward Processing: A Review of Multifaceted Influencing Factors and Intervention Strategies
The 2026 review by Gao et al. maps the brain network—midbrain dopamine, prefrontal cortex, amygdala, hypothalamus and cerebellum—that underlies food “wanting” and “liking.” It shows how genetics, stress, socioeconomic status and cultural norms modulate these circuits, and how ultra‑processed foods can...
Commentary: The Effects of Creatine Supplementation on Cognitive Function in Adults: A Systematic Review and Meta-Analysis
Tom Citherlet’s commentary challenges the recent meta‑analysis by Xu et al., arguing that it double‑counts multiple cognitive outcomes from the same participants, inflating sample size and statistical power. He cites similar methodological errors in earlier creatine‑memory reviews and notes the European...
The Role of Peripheral Blood HIF-1α in Pancreatic Β-Cell Dysfunction and Insulin Resistance Among Patients with Type 2 Diabetes: A...
A systematic review and meta‑analysis of 36 observational studies involving 5,979 patients with type 2 diabetes found that elevated peripheral HIF‑1α levels are significantly associated with worse glycemic control. Compared with low‑HIF‑1α groups, high‑HIF‑1α patients exhibited a mean increase of 1.13 mmol/L...
The Preoperative Albumin-to-Carcinoembryonic Antigen Ratio (ACR) Predicts Prognosis and Facilitates Risk Stratification in Gastric Cancer: A Retrospective Cohort Study
The retrospective cohort of 1,161 gastric‑cancer patients who underwent radical gastrectomy showed that a low pre‑operative albumin‑to‑CEA ratio (ACR) correlates with aggressive pathology and significantly shorter overall and disease‑free survival. Multivariate Cox analysis identified high ACR as an independent protective...
The Effect of Immunonutrition on Postoperative Ileus Following Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
A systematic review and meta‑analysis of 28 randomized trials involving 2,367 colorectal cancer patients found that peri‑operative immunonutrition significantly accelerates gastrointestinal recovery. Compared with standard diet, immunonutrition reduced time to first flatus by 0.56 days, time to first defecation by...
Emergence of Hypomania and Mania Following Initiation of a Ketogenic Diet: Case Series
A new case series of nine individuals who started a ketogenic diet reports that eight experienced hypomania and one developed mania within two months. Seven of the participants had no prior bipolar‑spectrum history, and symptoms emerged after an average weight...
Creatine Supplementation in Young Men Under Resistance versus Non-Resistance Training: A Systematic Review and Meta-Analysis of Strength, Performance, and Lean...
A systematic review and meta‑analysis of 39 randomized trials in healthy men aged 18‑30 examined creatine supplementation under resistance training (RT) versus non‑resistance training (non‑RT). Creatine combined with RT produced significant gains in fat‑free mass (+3.39 kg) and lean body mass...
Reducing Relapse in Children After Recovery From Severe Acute Malnutrition in Mali: Participatory Development of a Theory of Change for...
Researchers in Mali built a theory of change to curb the high relapse rate among children recovering from severe acute malnutrition. They pinpointed three direct drivers—insufficient initial treatment, poor post‑discharge diet, and frequent illness with low care‑seeking. The proposed solution...
Health Associations of Various Fruit Forms: Solid Fruits, Juices, and Smoothies
A cross‑sectional survey of 443 adults compared solid fruit, 100 % fruit juice, and fruit smoothies. Participants who primarily drank smoothies showed the most favorable health profile, including the lowest hypertension prevalence (18.6 %), lowest BMI (22.7 kg/m²) and highest energy ratings. Juice...
Perspective: Use of Beef in a Dietary Intervention as an Effective Strategy for Improving Cognition in Young Adult Females
A new perspective review highlights beef as a viable dietary strategy to boost cognition in young adult females, a group disproportionately affected by iron deficiency. The authors synthesize evidence linking heme iron and other beef‑derived nutrients—vitamin B12, zinc, choline, and creatine—to...
Comprehensive Evaluation of the Efficacy and Safety of Different Vitamin D Combination Regimens Based on Indirect Comparisons for Children with...
A Bayesian network meta‑analysis of ten randomized trials involving 867 children compared nine oral vitamin D‑based combination regimens with vitamin D₃ monotherapy for nutritional rickets. The combinations produced significantly higher serum 25‑hydroxyvitamin D, lower bone‑specific alkaline phosphatase, and increased calcium and phosphate levels,...
Effects of Sodium Bicarbonate, Cholecalciferol, and Protein Supplementation Interventions on Muscle Mass and Metabolic Disturbances in Patients with Chronic Kidney...
A systematic review and network meta‑analysis of 22 trials involving 2,879 chronic kidney disease (CKD) patients compared sodium bicarbonate, cholecalciferol (vitamin D3) and protein supplementation. The analysis found cholecalciferol significantly increased muscle mass, sodium bicarbonate most effectively raised serum albumin, and...
Bioactive Compounds and Exercise in Aging and Neurodegeneration: Mechanistic Insights From the Gut–Brain–Metabolic Axis
A new review in Frontiers in Nutrition proposes a neuro‑nutritional‑metabolic axis that links dietary bioactive compounds and physical exercise to hippocampal neurogenesis, synaptic plasticity, and cognitive resilience. It synthesizes pre‑clinical data showing convergent pathways—BDNF, AMPK, mitochondrial biogenesis, and anti‑inflammatory signaling—while...
Luteolin as a Dietary Flavonoid for Brain Health: Modulating Neuroinflammation and Cognitive Decline in Neurodegenerative Disorders
Luteolin, a flavone abundant in celery, parsley and other herbs, possesses antioxidant and anti‑inflammatory properties that enable it to cross the blood‑brain barrier and influence neurodegenerative pathways. Its oral bioavailability is modest, but nano‑delivery systems and phospholipid complexes significantly boost...
Identification of Nutritional Risk Factors and Construction of a Nomogram Prediction Model in AIDS Patients
A 2026 study of 110 AIDS patients identified low body mass index, low CD4⁺ T‑lymphocyte count, and low serum albumin as independent nutritional risk factors. Using these three routinely measured variables, the authors built a nomogram that achieved an area...
Association of Dietary Phytochemical Index with Sleep Quality, and Inflammatory Markers in Adults with Type 2 Diabetes: A Cross-Sectional Study
Researchers analyzed 675 adults with type 2 diabetes to assess how the dietary phytochemical index (DPI) relates to sleep quality and inflammation. Participants in the highest DPI quartile slept longer, had higher sleep efficiency, and reported better subjective sleep scores than...
Gut-Brain Health Effects of PREbiotics in Older Adults with Suspected COgnitive DEcline: Design of the PRECODE Randomised Placebo-Controlled Trial
The PRECODE trial is a four‑arm, double‑blind, placebo‑controlled study enrolling 164 adults aged 60‑79 with subjective cognitive decline (SCD+) and additional lifestyle risk factors. Over 26 weeks participants receive chicory inulin, resistant dextrin, seaweed polysaccharide, or maltodextrin placebo to test whether...
Selective Anticancer Activity of Vachellia Nilotica Fruit Extract: Integrated Phytochemistry with Antioxidant, Antimicrobial, and Cancer Cell Targeting
Researchers evaluated methanolic fruit extract of Vachellia nilotica, revealing high phenolic (419 mg GAE g⁻¹) and flavonoid (245 mg QE g⁻¹) contents that confer strong antioxidant activity (IC₅₀ ≈ 31.8 µg mL⁻¹). The extract inhibited a range of bacteria, producing up to 23 mm inhibition zones, and suppressed growth of several...
Fermented Cotton Stalks Preserve Colonic Epithelial Integrity in Hu Sheep via the Microbiota–Metabolite–NF-κB/MLCK Axis and Mitigate the Adverse Effects of...
A recent study compared three processing methods for cotton stalks—grinding, steam explosion, and microbial fermentation—when fed to Hu sheep at 40% of the diet. Fermented cotton stalks (FJ) delivered the highest average daily gain (322 g d⁻¹), reduced colonic free gossypol, ammonia...
Food-Derived Dihydromyricetin and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Preclinical Systematic Review and Meta-Analysis
A systematic review and meta‑analysis of 14 murine studies evaluated dihydromyricetin (DHM) as a nutraceutical for diet‑induced metabolic dysfunction‑associated steatotic liver disease (MASLD). Across the pooled data, DHM consistently reduced hepatic triglycerides, total cholesterol, and liver enzyme levels (ALT, AST,...
Development of Functional Foods with Stable Encapsulated Docosahexaenoic Acid
The review outlines recent biotechnological advances that stabilize docosahexaenoic acid (DHA) for functional foods through encapsulation techniques such as micro‑, nano‑, and emulsion systems. It highlights the shift toward microalgal and genetically engineered plant sources, providing vegan‑friendly, sustainable DHA supplies....
Ultrasound- and Circumference-Based Quadriceps Mass Is an Independent Predictor of 28-Day Mortality in Critically Ill Patients
A prospective study of 603 ICU patients found that bedside measurements of quadriceps muscle – both circumference and ultrasound thickness – independently predict 28‑day mortality. Higher quadriceps circumference (QC) and greater ultrasound‑derived thickness under minimal (QT‑min) and maximal (QT‑max) transducer...
Omega-3 PUFAs in Musculoskeletal Health and Sports Medicine: From Molecular Pathways to Precision Nutrition Strategies
A new narrative review links omega‑3 polyunsaturated fatty acids (PUFAs) to musculoskeletal health by tracing their anti‑inflammatory and tissue‑repair pathways from the cellular level to clinical outcomes. The authors detail how omega‑3s remodel cell membranes, shift lipid mediator profiles, and...
Association Between PNI and All-Cause Mortality in Ischemic Stroke Patients: A Large-Scale Retrospective Cohort Study
A retrospective cohort of 1,152 ischemic stroke patients in China found the prognostic nutritional index (PNI) to be a strong, independent predictor of all‑cause mortality. Over a median 14.2‑month follow‑up, 96 deaths occurred, and each one‑point rise in PNI lowered...
Regulation of Ascorbic Acid Metabolism in Postharvest Navel Orange Fruit During Storage by Exogenous Hydrogen Sulfide
Researchers applied a brief 30‑minute fumigation of 25 µL L⁻¹ hydrogen sulfide (H₂S) to postharvest navel oranges stored at 20 °C for 18 days. The treatment significantly slowed weight loss, preserved soluble solids and titratable acidity, and curtailed the typical decline in total and...
Association of Menarche Age with Macrosomia and Modified Effect From Dietary Pattern: Findings From the Chinese Pregnant Women
A prospective cohort of 2,554 Chinese pregnant women found that early menarche (before age 13) nearly doubles the odds of delivering a macrosomic infant (birth weight >4,000 g). The analysis identified three dietary patterns, showing that a diet rich in vegetables...
Unveiling the Relationship Between Dietary Patterns and Sleep Quality: Cross-Sectional Evidence From University Students in Jinan City
A cross‑sectional study of 1,497 Chinese university students identified three dietary patterns and found that the pattern rich in fresh fruits, vegetables, and dairy (PCA3) was linked to significantly lower odds of poor sleep quality (OR = 0.81 per standard‑deviation increase). A...
Targeting Muscle–Vasculature Crosstalk in Aging Through the Integrative Roles of L-Citrulline, Leucine, and Exercise: Focus on Muscle Metabolism, Vascular Function,...
Aging simultaneously erodes skeletal muscle mass and vascular function, creating a feedback loop that accelerates sarcopenia. L‑citrulline boosts nitric‑oxide production, enhancing endothelial health, while leucine stimulates the mTOR pathway to increase muscle protein synthesis. Recent studies show that combining these...
Omega-3 Fatty Acids in Mental Disorders: From Neurobiological and Metabolic Mechanisms to Therapeutic Potential
Recent research highlights omega-3 fatty acids as a modifiable risk factor across a spectrum of mental health conditions, from schizophrenia and depression to ADHD and Alzheimer’s disease. The review links dietary shortfalls and an elevated omega-6/omega-3 ratio to heightened neuroinflammation...
Nutrition in the Prevention and Treatment of Pelvic Inflammatory Disease: A Review
Pelvic inflammatory disease (PID) affects up to 1 million U.S. women annually, costing roughly $3,025 per case. While antibiotics remain the primary therapy, emerging evidence shows that specific nutrients—antioxidants, magnesium, phosphorus, copper, and choline—can modulate inflammation and support tissue repair. Large‑scale...
Protective Effects of Gypenosides on LDL-Induced Myocardial Injury Through the miR-223/NLRP3 Axis in Hyperlipidemia
A cross‑sectional analysis of 19,862 Chinese adults linked elevated LDL‑C to higher glucose, BMI, blood pressure, white‑blood‑cell count and triglycerides, especially among middle‑aged and older men. Parallel in‑vitro experiments showed native LDL directly impairs H9C2 cardiomyocyte viability, proliferation, migration and...
Legume Intake on Gut Microbiome and Glycemia in Type 2 Diabetes Management: Narrative Review
Legume consumption is highlighted for its fiber, protein, and bioactive compounds that can improve glycemic control in type 2 diabetes (T2D). A narrative review of 17 studies (three human, 14 animal) finds human trials associate legumes with better glucose tolerance but...
Association Between Prognostic Nutritional Index and Major Adverse Cardiovascular Events in Patients with Atrial Fibrillation Combined with Heart Failure with...
A retrospective cohort of 734 patients with atrial fibrillation and heart failure with preserved ejection fraction found that a higher prognostic nutritional index (PNI) was independently associated with lower rates of major adverse cardiovascular events (MACE) and all‑cause mortality over...
Long-Term Effects of Plant Vs. Animal Protein Supplementation on Body Composition, Muscle Strength, Physical Performance, and Cardiometabolic Risk Factors in...
A new systematic review and meta‑analysis of 18 randomized controlled trials involving 1,893 adults examined the long‑term (≥6 months) effects of plant‑based protein (primarily soy) versus animal‑based protein supplementation. The pooled data showed no statistically significant differences in lean body mass,...
Prevalence of Borderline Elevated and Elevated Cholesterol Among New Adult Patients From 23 Hospitals in 12 Cities of Jiangsu Province:...
A multicenter cross‑sectional study of 4,503 newly admitted adult patients across 23 hospitals in Jiangsu Province found that 24.9% had borderline‑elevated or elevated total cholesterol. Prevalence was higher in women (28.7%) than men (22.1%) and peaked at 31.6% among those...
High-Fat Diet, Triglyceride Glucose Index, and Gastrointestinal Cancer: Integrative Insights From Human and Animal Studies
A recent integrative study links high‑fat diet exposure to elevated triglyceride‑glucose (TyG) index and a higher risk of gastrointestinal (GI) cancers. Analysis of 11,340 NHANES participants showed a nonlinear association, with a risk inflection at TyG ≈ 9.66 and the highest TyG...
Duration-Dependent Effects of Water-Only Fasting on Blood Lipids: A Systematic Review, Meta-Analysis, and Threshold Meta-Regression
A systematic review of 32 human studies examined how water‑only fasting alters blood lipids across durations from one to 17 days. The analysis found HDL declines after about three days, while LDL and total cholesterol rise early and plateau around...
Daily Intake of Antioxidants Ameliorates PM2.5-induced Neuronal Injury in Mice
A recent Frontiers in Nutrition study shows that sub‑chronic exposure to low‑level PM2.5—below WHO limits—induces mitochondrial‑dependent oxidative stress and neurofilament loss in mouse cortex, hippocampus, and thalamus. Daily supplementation with vitamin C (10 mM) or N‑acetylcysteine (40 mM) via drinking water markedly reduced...
Association Between Pre-Operative Computed Tomography-Based Adipose Tissue Quantification and Post-Transplant Dyslipidemia in Renal Transplantation Recipients
A 2026 Frontiers in Nutrition study of 250 kidney‑transplant recipients found that pre‑operative visceral adipose tissue (VAT) measured by CT strongly predicts post‑transplant dyslipidemia. While BMI and other fat depots correlated with lipid abnormalities in univariate tests, multivariate models identified...
Integrated Transcriptomics–Metabolomics Analysis Reveals Biomarkers and Metabolic Dysregulation Characteristics of Parenteral Nutrition–Associated Liver Disease
A mouse model of parenteral nutrition‑associated liver disease (PNALD) was analyzed using combined RNA‑sequencing and untargeted metabolomics. Integrated machine‑learning pipelines (LASSO and SVM‑RFE) pinpointed five gene biomarkers (Itgam, Clec4d, Orm2, Lcn2, Cd14) and three metabolites (6‑n‑octylaminouracil, 6β‑hydroxy‑hydromorphone, α‑teresantalic acid). These...
Effect of High-Intensity Interval Training on Aerobic Capacity, Physical Fitness, and Body Composition in Martial Arts Athletes: A Systematic Review...
A systematic review and meta‑analysis of 14 randomized trials involving 348 martial‑arts athletes found that high‑intensity interval training (HIIT) significantly enhances aerobic capacity, athletic performance, and body‑fat reduction. VO₂max improved with a large effect size (SMD = 1.04), while lower‑limb power, agility,...
Low Vitamin D Status and 10-Year Dementia Risk in Sensory-Impaired Adults: A Propensity Score-Matched Cohort Study
Researchers analyzed over 158,000 adults aged 50+ with vision or hearing impairment using the TriNetX database. After propensity‑score matching, those with vitamin D deficiency (<20 ng/mL) faced a 55 % higher hazard of developing dementia over ten years compared with individuals with...
Application of an ACE Star Model–Based Evidence-Based Enteral Nutrition Management Protocol in Neurocritical Care Patients
Researchers applied the ACE Star evidence‑based model to create a standardized enteral nutrition protocol for neurocritical care patients in a Chinese tertiary ICU. Compared with a historical control, the protocol lowered feeding intolerance incidence from 70% to 31% and boosted...
Unlocking the Potential of Polygonatum Odoratum Protein Hydrolysate: Identification, Characterization, and Antidiabetic Activity in HFD/STZ-Induced Type 2 Diabetic Mice
Researchers identified a low‑molecular‑weight protein hydrolysate from Polygonatum odoratum (POP) composed mainly of <1.5 kDa leucine‑ and valine‑rich oligopeptides. In a high‑fat diet/streptozotocin mouse model of type 2 diabetes, oral POP markedly reduced fasting and random glucose, HbA1c, and insulin resistance while...
L–Carnitine in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms and Therapeutic Potential
A new review in *Metabolism* outlines how L‑carnitine may counteract metabolic dysfunction‑associated steatotic liver disease (MASLD), which now afflicts roughly one‑third of the global population. The authors detail L‑carnitine’s role in boosting mitochondrial fatty‑acid oxidation, improving insulin sensitivity, and dampening...
Finger Millet and Soybean as Functional Ingredients in Next-Generation Fermented Foods: A Review of Nutritional, Technological, and Health-Promoting Perspectives
A recent review highlights finger millet and soybean as complementary, under‑utilized crops whose combined fermentation can dramatically improve nutrient density and functional properties. Fermentation reduces antinutrients, boosts mineral bioavailability, and enhances protein digestibility, while also improving flavor and shelf stability....
Editorial: Investigating the Roles of Nutritional Determinants, Genetic Predispositions, and Environmental Risk Factors in the Development of Obesity and Associated...
A new Frontiers in Nutrition Research Topic compiles ten studies that deepen understanding of obesity’s nutritional, genetic, and environmental drivers. The work highlights ethnicity‑specific adiposity indices, such as the Chinese Visceral Adiposity Index, that outperform traditional BMI in predicting metabolic...
Nutritional Considerations for Athletes with Diabetes: Optimizing Performance and Glycemic Control
The review consolidates recent evidence on nutrition strategies that enable athletes with Type 1 and Type 2 diabetes to balance peak performance with tight glycemic control. It grades recommendations from strong (meta‑analyses) to expert consensus, emphasizing carbohydrate timing, protein intake, and targeted...