Artificial Intelligence-Based Modeling of the Dynamics and Regulation of Intracellular Signaling Pathways
Researchers introduced a hybrid artificial‑intelligence framework that merges physics‑informed neural networks, temporal convolutional networks, and graph neural networks to model intracellular signaling dynamics. The system was trained on 23,456 multi‑omics samples spanning key pathways such as MAPK/ERK and PI3K. Results show markedly improved predictive accuracy over conventional ordinary‑differential‑equation models. The approach promises faster simulation of pathway perturbations, aiding drug target discovery and personalized therapeutic strategies.
Neonatal Septicemia Caused by Edwardsiella Tarda: A Case Report and Literature Review
A five‑day‑old infant presented with jaundice, reduced feeding and irritability; blood cultures identified the rare pathogen Edwardsiella tarda. The neonate was successfully treated with meropenem and intravenous gamma globulin and discharged without complications. Follow‑up showed no residual issues. This case...
Graph-Based Pan-Genome Reveals Structural and Functional Diversity Across Oil Palm Domestication Gradients
Researchers assembled a graph‑based pan‑genome from 30 oil palm genomes representing wild, semi‑domesticated, and commercial accessions. The analysis revealed a conserved core genome plus a variable shell enriched for regulatory, stress‑responsive, and defense functions. Semi‑domesticated lines showed the greatest structural...
Algorithmic Optimization of Passive Phase-Shifts in RIS-Assisted mmWave Networks
Researchers unveiled a hardware‑in‑the‑loop (HIL) platform that optimizes passive reconfigurable intelligent surfaces (RIS) for 28 GHz millimeter‑wave links. The system uses an 8×8 element RIS with 2‑bit phase shifters and a microcontroller‑driven coordinate‑descent algorithm that adapts to real‑world pin‑diode losses via...
China’s Oldest Rocks Reveal 3.95 Ga Subduction and Hadean Mantle Depletion
A newly identified 3.95 billion‑year‑old trondhjemitic gneiss from eastern Hebei, North China Craton provides the oldest known rocks in Asia and rivals the Canadian Acasta Gneiss as a window into Earth’s Hadean era. Zircon analyses reveal elevated δ¹⁸O values (+6.77 ‰) and...
Safety and Feasibility of Electrotherapeutic Modalities Over Titanium Spinal Fixation Implants in Patients With Spinal Cord Injury: A Quasi Experimental...
A quasi‑experimental study evaluated neuromuscular electrical stimulation (NMES) and low‑level laser therapy (LLLT) in 50 spinal cord injury patients with titanium spinal fixation. Over a six‑week program, participants experienced a marked decline in pain, with Visual Analogue Scale scores dropping...
Association of HBB Gene Polymorphisms Rs10768683, Rs1609812 and Rs334 with Transfusion-Dependent Beta-Thalassemia (TDT): A Case-Control Study
A case‑control study in southeastern Iran examined three HBB gene polymorphisms in 400 transfusion‑dependent beta‑thalassemia (TDT) patients and 400 healthy controls. The rs1609812 GG genotype was linked to a nearly threefold increase in TDT risk, while rs10768683 GC heterozygosity showed...
SNP-Based Genomic Variation in Candidate Disease Resistance Genes of Theobroma Cacao
Researchers used bioinformatics to map single‑nucleotide polymorphisms in Theobroma cacao and identified 4,523 candidate disease‑resistance genes. The study uncovered 17,576 SNPs in coding regions, including 9,014 missense and 156 high‑impact variants, and highlighted 196 uncharacterized genes with defense‑related domains. Enrichment...
Synthesis and Characterization of Size-Controllable Titanium Dioxide Nanocolloids via Pulsed Laser Ablation in Distilled Water
Researchers used pulsed laser ablation in liquid (PLAL) to synthesize titanium dioxide nanocolloids by ablating a titanium target in distilled water with a 532 nm Nd:YAG laser. By varying laser fluence between 1.3 and 3.25 J cm⁻² and irradiation times from five to...
Multi-Year Pathogenicity and Fungicide Sensitivity Assessment of Colletotrichum Coccodes and Emerging C. Nigrum, Both Causing Black Dot in Manitoba Potatoes
A multi‑year survey (2023‑2025) across Manitoba identified 189 Colletotrichum isolates from potato fields, confirming that C. coccodes remains the dominant cause of black dot. Phylogenetic analysis also detected C. nigrum, the first report of this species on Canadian potatoes. Pathogenicity...
Selective Deoxygenation of Palm Oil Into Green Diesel over NiO, Ru₂O₃, and NiRu2O4/Al2O3@Date Seed Catalysts
A recent study evaluated NiO, Ru₂O₃ and NiRu₂O₄ catalysts supported on Al₂O₃‑modified date seed for palm‑oil deoxygenation. The NiRu₂O₄/Al₂O₃@DS catalyst delivered the highest hydrocarbon yield of 97.18% under optimal conditions (350 °C, 3 h, 5 wt% loading). Characterization showed strong Ni‑Ru synergy and...
Entrepreneurial Opportunity Evaluation for Financial Technology Decision
Researchers surveyed CFOs at Thai listed financial firms and found that entrepreneurial opportunity evaluation strongly predicts FinTech adoption decisions. Mediation analysis identified three pathways—risk re‑categorization, financing‑constraint alleviation, and reduction of information asymmetry—that explain the link. These mechanisms enable more inclusive...
Larval Competition Between the Invasive Anopheles Stephensi and African Native Mosquitoes
Laboratory experiments examined larval competition between invasive Anopheles stephensi and native African mosquitoes under varying food and density conditions. When reared alone, high food did not boost emergence, but crowding delayed development. Co‑rearing with An. arabiensis or An. gambiae reduced...
Relationships Between GPS-Derived Outdoor Activity Space Ambient Heat Exposure, Mental Health, and Salivary Cortisol in a Longitudinal, Repeated Measures Sample...
Researchers tracked Detroit residents with GPS and accelerometers over four years to quantify everyday heat exposure in their outdoor activity spaces. Using high‑resolution satellite‑derived land surface temperature data, they linked heat exposure to mental health outcomes and salivary cortisol, a...
Structural Resonance and Kinematic Tuning in the Pure-Tone Song of the Bell Cricket Meloimorpha Japonicus
Researchers combined high‑speed video, 3D microscopy, and laser Doppler vibrometry to dissect the song mechanism of the Japanese bell cricket (*Meloimorpha japonicus*). They discovered two novel file features—a directional asymmetry in tooth angle and a progressive reduction in tooth spacing—that...
Single-Contig Bacterial Genomes Recovered From Cattle Fecal Metagenomes at Farms with Variable Antibiotic Use
Researchers have generated 84 single‑contig, medium‑to‑high‑quality metagenome‑assembled genomes (MAGs) from cattle fecal samples enriched in acetate‑supplemented minimal medium. The MAGs span five phyla—Actinomycetota, Bacillota, Bacteroidota, Patescibacteriota, and Pseudomonadota—and 41 represent potentially novel taxa at the species‑to‑family level. Nineteen of the...
Quantum Modelling of Hydroxyl Topology Control of the Stokes-Induced Stark Effect in Hybrid Flavonoid–Semiconductor Interfaces
Researchers have introduced a quantum‑mechanical model that links the hydroxyl‑topology of flavonoid chromophores to the Stokes‑Induced Stark Effect (SISE) at hybrid molecular‑semiconductor interfaces. The model defines a descriptor Ω_OH, capturing dipole change, orientation and separation, and applies it to five...
Research on Potatoes Defect Classification Based on Hyperspectral Imaging and Convolutional Neural Networks
Researchers developed a lightweight convolutional neural network, WavebandCNN, integrated with hyperspectral imaging to classify potatoes into healthy, greening, skin damage, and dry rot categories. The study collected hyperspectral data from 400 samples and evaluated the model against raw and pre‑processed...
Short-Term HPV Detection Dynamics Across Hormonal Contraceptive Methods in Adolescent Girls and Young Women: A Secondary Analysis of a Randomized...
A randomized secondary analysis in South Africa examined 98 adolescent girls and young women (15‑19) assigned to norethisterone enanthate, combined oral contraceptive pills, or a combined contraceptive vaginal ring. Baseline HPV prevalence was 94.9% and remained high at 89.5% after...
Machine Learning-Guided Dual Optimization of the Substrate Specificity and Thermostability of Yeast Alcohol Dehydrogenase
Researchers used a machine‑learning workflow to simultaneously redesign the substrate specificity and thermostability of yeast alcohol dehydrogenase I (YADH). By coupling docking‑driven mutagenesis with a predictive model, they generated variants that preferentially reduced the non‑native aldehyde trans‑2‑nonenal. The top variant...
Differential Effects of PD-1 and PD-L1 Immune Checkpoint Inhibition on Cognition and Anxiety-Like Behavior Through ΓδT Cells and Tumor–Dependent Neuroinflammation
A new preprint examines how anti‑PD‑1 and anti‑PD‑L1 checkpoint inhibitors affect cognition and anxiety in mice bearing different tumor immune phenotypes. Immuno‑excluded and immuno‑inflamed cancers impair short‑term memory and provoke anxiety‑like behavior, with the latter showing heightened IL‑6/IL‑17 inflammation and...
Macroscopic Porosity Optimization Using Thermodynamic Topology Optimization
The authors present a macroscopic, single‑scale method that jointly optimizes topology and local porosity using thermodynamic principles. By treating topology and porosity as independent variables, the approach translates theoretically optimal “gray” material concepts into designs that additive manufacturing can actually...
Multiple Linear Regression–Artificial Neural Network (MLR-ANN) Model for Assessing Customer Satisfaction Using SERVQUAL Scale in Online Food Delivery Services
A recent study examined customer satisfaction in online food‑delivery platforms using the SERVQUAL framework and a hybrid Multiple Linear Regression–Artificial Neural Network (MLR‑ANN) model. Data from 216 users revealed that efficiency, fulfillment and compensation positively influence satisfaction, while system availability,...
Assessing the Generalizability of Machine Learning Models for Chronic Kidney Disease Prediction Using Cross-Dataset Validation
A recent study evaluated Logistic Regression, Decision Tree and Random Forest models for chronic kidney disease (CKD) prediction using two independent clinical datasets. When trained on Dataset A and tested on Dataset B, Logistic Regression and Decision Tree each reached 98% accuracy,...
Applications of Artificial Intelligence in Antimicrobial Resistance Surveillance, Prediction, and Control in Low- and Middle-Income Countries: A Scoping Review
A new scoping review catalogued 128 studies from 2013‑2026 that applied artificial intelligence and machine learning to antimicrobial resistance (AMR) challenges in low‑ and middle‑income countries (LMICs). The research identified AI use across surveillance, resistance prediction, rapid diagnostics, stewardship, outbreak...
La Cuna: Community-Led Spanish Perinatal Education and Social Needs Navigation for Hispanic Immigrant Families
La Cuna is a community‑led, Spanish‑language perinatal education and social needs navigation program launched in Arkansas for Hispanic immigrant families. From 2021‑2025 it served 498 participants, screening high rates of food insecurity (42‑45%), financial strain (43‑60%) and unemployment (38‑81%). The...
Gap CO2 in Septic Patients to Predict Septic Cardiomyopathy
A recent observational study of 98 sepsis patients at Mohammed VI University Hospital identified septic cardiomyopathy as a major driver of mortality. Patients with left‑ventricular ejection fraction below 40 % showed a median cardiac output of 3.3 L/min versus 6 L/min in those without...
Effectiveness of a Multisectoral Community-Based Intervention for Psychosis in West and Southeast Africa: Protocol of the SUCCEED Africa Randomised Controlled...
The SUCCEED Africa project is conducting two parallel, open‑label randomized controlled trials in Nigeria and Zimbabwe to test a multisectoral, community‑based intervention for adults living with psychosis. Over a 12‑month period, participants receive formal peer support, case management that mobilises...
A Spatter-Aware, Data-Driven Closed-Loop Framework for Real-Time Monitoring and Adaptive Control in Wire Arc Additive Manufacturing
The study introduces a low‑cost, real‑time closed‑loop framework for Wire Arc Additive Manufacturing that combines spatter detection, parameter control, and quality prediction. Using a modified YOLOv11 model with CBAM attention and CIoU localization, the system detects tiny spatter particles with...
Preventive Nutrition Interventions in Protracted Humanitarian Crises: A SystematicReview and Meta-Analysis
A new systematic review and meta‑analysis of 71 studies—56 with quantitative data—examines preventive nutrition interventions in protracted humanitarian crises. The analysis finds statistically significant benefits across all six intervention categories, including a 28% reduction in wasting odds and a 48%...
RADAR CARE Study: A Multicenter Deep Learning Model for Real-Time Prediction of Recurrence in Early-Stage Non–Small Cell Lung Cancer Using...
A multicenter study updated a transformer‑based deep learning model that integrates clinical, pathological, laboratory, and radiologic data to predict early‑stage non‑small cell lung cancer (NSCLC) recurrence within one year. Using data from 15,439 patients across three Korean hospitals, the model...
Dynamic Machining Force Signal-Based Surface Quality Prediction in MAF Using XGBoost
Researchers have built a surface‑roughness prediction model that leverages real‑time dynamic machining force signals processed with continuous wavelet transform and fed into an extreme gradient boosting (XGBoost) algorithm. The study used a full factorial design of three process parameters—current, gap,...
Dietary Intake and Nutritional Adequacy in Saudi Children and Adolescents with Autism Spectrum Disorder: A Case-Control Exploratory Study
A case‑control study in Jeddah compared dietary intake of 36 Saudi children with autism spectrum disorder (ASD) to 36 age‑matched peers. The ASD group consumed a significantly lower proportion of polyunsaturated fatty acids and a higher share of high‑risk FODMAP...
System-Level Safety Engineering of Unmanned Aircraft Operations: Incident-Derived Requirements for Control, Feedback, and Recovery
The paper presents a system‑level safety engineering analysis of unmanned aircraft systems (UAS) based on 147 incident reports, combining 97 official cases with 50 voluntary submissions. It codes each event for control structure, unsafe actions, feedback degradation, and assurance gaps,...
Real-World Predictors of Survival and Response in Advanced Melanoma
Immunotherapy has transformed advanced melanoma care, yet many patients fail first‑line treatment. Researchers applied machine‑learning to a large, real‑world electronic health record database to build interpretable models for overall survival, progression‑free survival, and response. ECOG performance status, PD‑L1‑based first‑line therapy,...
Enhanced Diagnostic Value of Deep-Inspiration Breath-Hold Total-Body PET/CT Imaging for Upper Abdominal Lesions Compared to Free-Breathing
Researchers evaluated a 30‑second deep‑inspiration breath‑hold (DIBH) protocol on a total‑body PET (TB‑PET) scanner against standard free‑breathing (FB) PET/CT for upper‑abdominal lesions. In 116 participants, DIBH‑30s scans reduced PET/CT misregistration and achieved a 98.2% detection sensitivity, surpassing the 91.8% of...
Antimicrobial Resistance Patterns of Bacterial Isolates From Urine Samples in Selected Tertiary Hospitals in Addis Ababa, Ethiopia
A retrospective study of 586 urine cultures from three tertiary hospitals in Addis Ababa found that 32.3% yielded bacterial growth, dominated by Escherichia coli (35.4%) and Klebsiella spp. (20.1%). Resistance was alarmingly high to amoxicillin (83.5%), tetracycline (70.4%), ceftriaxone (72.1%)...
Determinants of Farmer Satisfaction with the First Open Pollinated Tomato Varieties Developed in Ghana
The Korea Partnership for Innovation of Agriculture (KOPIA) and Ghana’s CSIR‑Crops Research Institute released the country’s first locally bred open‑pollinated tomato varieties. A cross‑sectional survey of 120 smallholder farmers identified four perception dimensions and linked them to satisfaction via ordered...
Opposing Carbon Dioxide Removals and Emissions Reductions Confuses Mitigation Policies
Researchers argue that separating carbon dioxide removals (CDR) from emissions reductions (ER) hampers climate mitigation. They identify three flaws: economic criteria for CDR are under‑defined, carbon‑market methodologies are inconsistent, and the focus on distant net‑zero goals neglects immediate ER potential....
Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers in Primary Open-Angle Glaucoma: Differential Expression in Aqueous Humor and...
Researchers measured neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in the aqueous humor and plasma of 38 primary open‑angle glaucoma (POAG) patients versus 62 cataract controls using ultra‑sensitive SIMOA assays. NfL concentrations were significantly higher in both...
Operationalising Infection Prevention for Caesarean Section in Two Ghanaian Hospitals: A Qualitative Study of Healthcare Provider Perspectives
A qualitative study of 18 providers in two Ghanaian hospitals examined how infection‑prevention guidelines are applied during caesarean sections. Researchers identified five practice themes spanning pre‑operative preparation to post‑operative wound education. Core theatre behaviours—hand hygiene, barrier precautions, skin antisepsis, and...
3U Transat Constellation: Performances and Operations Preparation
The IRAP‑CNES 3U Transat project proposes a constellation of 25 3‑U nanosatellites in five heliosynchronous low‑Earth orbits to deliver near‑continuous, all‑sky monitoring for short gamma‑ray bursts. Mission simulations indicate the fleet can detect GRB 170817A‑type events with sensitivity comparable to existing...
LLM-Gated FinRL: Point-in-Time Risk Auditing for Reinforcement Learning in High-Beta Portfolio Trading
Researchers introduce an LLM‑gated reinforcement learning framework that audits PPO portfolio allocations in real time. The gate activates on high‑risk signals such as extreme RSI, volatility, drawdowns, and momentum reversals, providing deterministic risk control. Tested on the Magnificent Seven tech...
The Game of Peers: Toward a Credential Algebra for Human-AI Actor Networks
The paper introduces a credential algebra that positions human and AI actors as structural peers, replacing the traditional top‑down delegation model. It defines four set‑based operators—intersection, union, left join and right join—applied to edges in a directed actor graph. A...
LLM4KT: Enhancing Knowledge Tracing via Large Language Models
Knowledge tracing (KT) models students' mastery over time, but existing large‑language‑model (LLM) approaches have struggled with long, text‑heavy interaction logs. Researchers propose LLM4KT, a two‑stage framework that first compresses each interaction via an Inter LLM using a novel token‑reweighting scheme,...
Development of a Clinical Prediction Model for Parenteral Nutrition-Associated Cholestasis in Preterm Infants: A Retrospective Cohort Study
A retrospective cohort of 329 preterm infants identified three independent predictors of parenteral nutrition‑associated cholestasis (PNAC): birth weight ≤1,375 g, hemodynamically significant patent ductus arteriosus, and maximum daily parenteral amino‑acid intake ≥4.01 g/kg/day. The multivariable model achieved an area under the ROC...
Faultformer: A CNN–Transformer Multi-Domain Feature Fusion Network for Intelligent Bearing Fault Diagnosis
FaultFormer, a hybrid CNN‑Transformer network, fuses statistical, frequency‑domain and deep features to diagnose rolling‑bearing faults from vibration data. Tested on the CWRU bearing dataset across ten fault types and load conditions, it achieved a mean classification accuracy of 99.98 % over...
Exploring Length of Stay in Native and Periprosthetic Hip Fractures in a Newly Established Ortho-Geriatric Co-Management Service: Male Sex and...
A new orthogeriatric co‑management program at a Northeastern academic hospital evaluated length of stay (LOS) for 328 admissions involving native and periprosthetic hip fractures. The analysis found no statistically significant LOS difference between fracture types, with median stays of six...
Multimodal Emotion Recognition From Images and Text Using Deep Learning and Explainable AI
Researchers introduced ITMER, a unified framework that combines textual and visual data for emotion classification. The system evaluates three configurations: text‑only transformers, image‑only CNNs, and a fused image‑text model. In benchmark tests, the multimodal approach achieved up to 92 % accuracy...
Multireference Investigations of Ethylene Hydrogenation over Bimetallic Catalysts
Researchers used GPU‑accelerated multireference quantum chemistry to study ethylene hydrogenation on unsupported and silica‑supported Ni‑Fe bimetallic hydride catalysts. Conventional DFT gave conflicting spin‑state orders, barrier heights, and even different rate‑determining steps, while multireference methods delivered a consistent energetic profile. The...