Network Architecture Determines Delay Robustness in the Spindle Assembly Checkpoint
The preprint introduces a distributed‑delay framework to study how timing lags affect the spindle assembly checkpoint (SAC). By embedding experimentally realistic delays into several mechanistic SAC models, the authors discover two distinct architecture classes: delay‑robust designs that sustain strong APC/C inhibition, and delay‑sensitive designs that collapse under delay. They propose a bistable template that merges Mad2 templating with an autocatalytic feedback loop, preserving bistability across a wide range of physiological delays. The work highlights network architecture as the primary determinant of delay robustness in mitotic control.
Balancing Ecosystem Carbon Storage and Economic Development: An Environmental Disparity Perspective in China
A new study quantifies the spatial mismatch between ecosystem carbon storage and economic output across China. Western regions hold 74.6% of the nation’s carbon stocks but generate less than 5% of carbon‑adjusted GDP, while the east dominates carbon‑adjusted GDP with...
Effects of Standardized Near Activities on Retinal and Choroidal Structure, Microcirculation, and Visual Outcomes in Children with Anisometropic Amblyopia: Study...
A prospective, single‑center randomized trial will enroll 80 children with hyperopic anisometropic amblyopia to evaluate whether a standardized 15‑minute near‑activity task, added to conventional patching, produces measurable changes in retinal and choroidal structure and microcirculation. Optical coherence tomography and OCT‑angiography...
Multi-Scale Thermal Homeostasis: Plants Achieve Temperature Control Through Hierarchical Regulation
Researchers combined custom nanothermometric probes with time‑gated imaging to map internal temperatures of living plants. In Nicotiana benthamiana leaves, a 21 °C external swing (24 °C → 45 °C) produced only a 10 °C rise near the cell wall, less than 7 °C in the cytoplasm, and...
Impact of Maternal Thyroid Dysfunction on Neonatal Thyroid Profile and Blood Glucose Levels: A Comparative Study
A prospective study of 100 newborns compared infants of mothers with hypothyroidism to those of euthyroid mothers. Neonates of hypothyroid mothers exhibited significantly higher TSH (8.42 mIU/L vs 5.61 mIU/L) and lower FT4 (1.21 ng/dL vs 1.48 ng/dL). Their blood glucose at two hours...
Knowledge, Attitude, and Practice Regarding Multi-Parameter Monitor Alarms Among ICU Nurses: A Multi-Center Cross-Sectional Study
A multi‑center cross‑sectional study of 813 ICU nurses in nine Chinese tertiary hospitals measured knowledge, attitudes, and practices (KAP) toward multi‑parameter monitor alarms. The average KAP score was 66.22 ± 6.70, translating to an 80.76% score rate, indicating a moderate competency level....
Internet of Things and Artificial Intelligence for Carbon Emissions Monitoring and ForecastingA Systematic Review of Smart Environmental Accounting Systems
A systematic review of 100 peer‑reviewed studies finds that Internet of Things (IoT) sensor networks enable real‑time carbon emissions monitoring, while artificial intelligence (AI) models can reliably forecast emission trends. The analysis highlights strong performance in data collection and prediction...
Soil-Transmitted Helminth Contamination Around Sanitation Facilities in Ile-Ife, Nigeria: The Role of Latrine Type, Soil Characteristic, and Community Knowledge
A cross‑sectional study of 200 households in Ile‑Ife, Nigeria, found 78.5% of soil samples within 100 m of latrines contaminated with soil‑transmitted helminth eggs, chiefly Ascaris lumbricoides and hookworm. Pit latrines showed the highest mean egg count, while pour‑flush latrines had...
MDT-Based Comprehensive Management of Type 3 Von Willebrand Disease in Pregnancy: From Preimplantation Genetic Testing to Antenatal Care, Delivery and...
Researchers reported the first use of recombinant von Willebrand factor (rVWF) in China to manage a pregnancy complicated by type 3 von Willebrand disease. A 36‑year‑old patient conceived via IVF and received target‑guided rVWF dosing before amniocentesis and elective caesarean, achieving activity...
Patient Perspectives on Gene Therapies and Gene Editing for Familial Cardiomyopathies
Early‑phase trials are testing gene replacement and editing for hypertrophic and dilated cardiomyopathies, yet patient viewpoints remain understudied. Interviews with 21 adults (average age 57, 57% female) revealed four decision drivers: perceived disease severity, quality‑of‑life impact, treatment safety and delivery,...
Favorable Long-Term Functional Outcome Following Left-Sided Compartmental Epaxial Muscle Resection (T13-L7) for a Longissimus Lumborum Liposarcoma in a Dog: A...
A 10‑year‑old Border Collie was diagnosed with a well‑differentiated liposarcoma spanning the left longissimus lumborum from L1 to L6. Surgeons performed a unilateral compartmental excision of the multifidus, longissimus and iliocostalis muscles, managing intra‑operative hemorrhage with a blood transfusion. Post‑operative...
Male Survivors of Childhood Sexual Abuse: Perceived Social Support as a Correlate of Imposter Phenomenon — An Exploratory Study
A new exploratory study of 85 male childhood sexual abuse survivors in Delhi NCR found a strong inverse relationship between perceived social support and imposter phenomenon, with a correlation of r = –.567. Support from significant others showed the greatest protective effect...
Investigating Working Memory and Brain Activation in Major Depressive Disorder with and without Insomnia: Insights From Functional Near-Infrared Spectroscopy (fNIRS)
Researchers used functional near‑infrared spectroscopy to compare cortical activation during working‑memory tasks in 55 major depressive disorder (MDD) patients with insomnia and 67 without. Insomnia‑comorbid patients showed lower RBANS scores, poorer accuracy on medium‑load tasks, and diminished oxygenated hemoglobin responses...
Educational Innovation and Students’ School Well-Being: Insights From a Multi-Informant Study
A multi‑informant study of 589 Italian students, their parents and 167 teachers found that perceived educational innovation is positively associated with student well‑being. Students who view their schools as innovative report higher satisfaction, stronger teacher and peer relationships, greater emotional...
Aspirin Enhances Chemosensitivity of Colorectal Cancer Cells by Downregulating FOXP3 to Inhibit ABCB1 Expression
Aspirin use was linked to lower colorectal‑cancer‑specific mortality in a large NHANES cohort. Laboratory studies showed that aspirin combined with doxorubicin synergistically inhibited tumor growth and increased apoptosis. The drug acts by suppressing the transcription factor FOXP3, which in turn...
Experimental Study of Sand Agglomeration Chemical Performance Under Varying Sand Characteristics Based on Field T
A field‑scale experimental study evaluated a polymer sand‑agglomeration chemical (SAC) in Field T’s unconsolidated reservoirs. Tests on ultra‑fine (85 µm D₅₀) and fine (171 µm D₅₀) sands showed D₅₀ growth of 1,479 % and 1,163 % and cut sand production by more than 53 %. Permeability...
Bimanual versus Unimanual Capacity and Visuospatial Monitoring in Children with and without Unilateral Cerebral Palsy
Researchers compared upper‑limb motor capacity and visual monitoring during bimanual and unimanual tasks in children with unilateral cerebral palsy (uCP) and typically developing peers. Using a robotic exoskeleton with eye‑tracking, they found that bimanual tasks amplified arm asymmetry in the...
Planning and Evaluation Methods in LLM-Based Autonomous Workflow Systems: A Comprehensive Review
The paper delivers a systematic review of planning and evaluation techniques for large‑language‑model (LLM) driven autonomous workflow systems. It introduces a five‑category planning taxonomy and a five‑axis evaluation framework that measures utility, efficiency, quality, robustness, and safety. The analysis uncovers...
Serogroup Diversity, Virulence Gene Distribution, and Antimicrobial Resistance Profiles of Intestinal Escherichia Coli in Broilers
Researchers in Changchun, China analyzed 690 broiler‑farm samples and isolated 70 avian pathogenic Escherichia coli (APEC) strains, revealing a 10.14% isolation rate. The dominant serogroups were O78 (34.3%), O1 (12.9%) and O18 (4.3%), while nearly half of the isolates were...
Antiglycation Potential of Launaea Taraxacifolia on Pentosidine- and Vesperlysine-Like Advanced Glycation End Products (AGEs)
Researchers evaluated a 70 % ethanol leaf extract of Launaea taraxacifolia for its ability to counteract advanced glycation end‑products (AGEs) linked to diabetic complications. Phytochemical analysis revealed notable levels of phenolics (7.27 mg GAE/100 mg) and flavonoids (11.03 mg QE/100 mg), and the extract showed...
Predictive Value of Combined Lipoprotein(a) and Hs-CRP for Contrast-Induced Acute Kidney Injury After PCI in Elderly Patients With Acute Coronary...
A retrospective analysis of 1,321 patients aged 60 and older with acute coronary syndrome undergoing percutaneous coronary intervention evaluated whether pre‑procedural high‑sensitivity C‑reactive protein (hs‑CRP) and lipoprotein(a) (Lp(a)) together improve prediction of contrast‑induced acute kidney injury (CI‑AKI). The combined biomarker...
Genetic Parameters and Breeding Values for Racing Performance in Egyptian Arabian Horses
The study evaluated 52 Egyptian Arabian horses to link morphometric body measurements with racing speed, using mixed linear models and BLUP/REML analysis. Racing speed showed very low heritability (h² ≈ 0.04), indicating strong environmental influence, while morphometric traits displayed high phenotypic and...
Effects of Dietary Energy and Protein Levels on Growth Performance and Immune Competence of CARI-Nirbheek Chickens in Tropical Environments
The study examined how varying metabolizable energy (ME) and crude protein (CP) levels affect growth, serum biochemistry, and immunity in CARI‑Nirbheek chickens raised in tropical conditions. Nine diets (ME 2,900, 2,700, 2,500 kcal/kg; CP 20, 18, 16 %) were tested on 288...
Hydrogeochemical Evolution and Circulation Mechanisms of Deep Groundwater in a Complex Coal-Bearing Basin: A Case Study of the Soma–Eynez Basin,...
The study investigates groundwater chemistry in the Soma‑Eynez coal basin of western Turkey, revealing a transition from Ca‑HCO₃‑type water in the shallow volcanic aquifer to Na‑Ca‑Mg‑SO₄‑rich water in the deep confined limestone aquifer. Isotopic data show longer residence times in...
Body Fatness, Physical Activity and the Risk of Cervical Cancer: Results From the Epic Cohort
The EPIC cohort analyzed 293,523 European women over a median 15‑year follow‑up to assess links between body fatness, physical activity and invasive cervical cancer (ICC). Women with a BMI above 30 kg/m² showed a non‑significant 19% higher ICC risk, while those...
Urban Temperature Dynamics in Sri Lanka: A Comparative Machine Learning and Time-Series Analysis Across Wet, Intermediate, and Dry Climate Zones
Researchers analyzed 13 years of daily temperature data from three Sri Lankan urban stations representing wet, intermediate and dry climate zones. They compared traditional ARIMA‑Fourier time‑series models with several machine‑learning techniques, including multiple linear regression, polynomial regression, random forest and...
Application of Dynamic Adjustment Strategy of Map Service Resources Combined with Reinforcement Learning in Power Supply Network Visualization
The paper introduces a dynamic map‑service resource adjustment framework that blends transformer‑based forecasting with reinforcement learning to manage modern power grids. By integrating the FEDformer model for demand prediction and an RL agent for real‑time resource allocation, the system can...
Development and Validation of a Multimodal Interpretable Machine Learning Model with SHAP for Malignancy Risk Prediction in Bethesda III Thyroid...
Researchers created a multimodal, interpretable machine‑learning model that combines clinical data, ultrasound features, and BRAF V600E mutation status to predict malignancy in Bethesda III thyroid nodules. In a dual‑center study of 490 patients, the fusion model achieved an AUC of 0.959 in...
Resource Allocation Challenges in Critical Care Nursing: A Cross-Sectional Study of Public Hospitals
A cross‑sectional survey of 200 critical‑care nurses in two Ahmedabad public hospitals identified resource shortages as the dominant operational challenge. Deficiencies in human and material resources represented roughly 27% of the overall challenge burden, while ICU‑related stressors accounted for about...
Mixed-Methods Evaluation of a Multi-Level, Multi-Component Implementation Theory: Results From Scaling Up Obstetric Triage in Six Referral Hospitals in Ghana
A midwife‑led obstetric triage system (OTIP) was scaled across six Ghanaian referral hospitals. Within 12 months, women assessed within 10 minutes rose from 5% to 85%, with 96% adoption of color‑coded wristbands and 83% accurate risk classification. Implementation outcomes showed...
Effect of Subscapularis Integrity on Functional Recovery After Posterior Latissimus Dorsi Tendon Transfer for Posterior–Superior Irreparable Rotator Cuff Tears
Posterior latissimus dorsi (LD) tendon transfer significantly reduces pain and improves function in patients with posterior‑superior irreparable rotator cuff tears (PSIRCTs). In a retrospective series of 53 patients, those with an intact subscapularis tendon achieved higher Constant (70.7 vs 62.3)...
Electrospinning of Hydroxypropyl Chitosan Nanofibers for Bone Regeneration Application
Researchers electrospun nanofiber mats using hydroxypropyl chitosan (HPCH) and poly(vinyl alcohol) (PVA) in varying ratios to assess osteoconductive potential in MC3T3 pre‑osteoblast cells. Characterization by SEM, FT‑IR and mechanical testing confirmed uniform fiber formation. Biological assays showed that a 50/50...
Multimodal Remote Digital Phenotyping for Detecting and Tracking Early Parkinsonian Change in LRRK2 Carriers
Researchers introduced a remote, multimodal video platform to phenotype Parkinson’s disease risk in LRRK2 gene carriers. The study analyzed 829 participants, including 158 carriers, and achieved 92.9% accuracy (AUROC 0.92, AUPRC 0.82) in distinguishing non‑manifest carriers from controls. A continuous “PD Weigh‑In” score...
How Farmers Recognise Breeds: Evidence From Nili-Ravi Buffalo Rearers in India
A new study of Punjab’s Nili‑Ravi buffalo shows farmer perception drives breed identification. Using stratified sampling of 240 households and fuzzy‑set Qualitative Comparative Analysis, researchers found pure Nili‑Ravi rearers rely on pink tongue, short forelimbs and walled eyes, while mixed...
Exposure Duration Determines ARDS in Nitrobenzene Poisoning
A recent case report compared two chemical workers exposed to high‑concentration nitrobenzene. The worker who received complete decontamination within three minutes recovered without acute respiratory distress syndrome (ARDS) or renal injury, while the worker who remained in contaminated clothing for...
Early Postoperative Inflammatory Markers Predict Major Complications After Rectal Cancer Surgery
A prospective cohort of 98 rectal cancer patients measured CRP and NLR at 24 and 48 hours after surgery. Elevated CRP at 48 hours strongly predicted major complications, while NLR showed no significant predictive value. Open surgery was linked to...
Frontline Experiences in Responding to Health Misinformation: Perspectives of Health Educators in Lagos State, Nigeria
A qualitative study of 56 primary health‑care educators in Lagos State reveals that frontline workers constantly confront health misinformation about vaccines, disease causes, and treatments. Social media—especially WhatsApp—alongside interpersonal and religious networks serve as the primary rumor mills. Educators combat...
Corporate Social Responsibility (CSR) Communication and Investor Loyalty: Evidence From South African Non-Profit Organisations (NPOs)
A quantitative study of 250 employees in Gauteng‑based South African non‑profits examined how CSR communication channels affect investor loyalty. The analysis found that workshops, public relations and traditional media each have a significant positive impact on donor commitment. In contrast,...
A Standardized Postoperative Recovery Atlas Reduces Early Anxiety After Female Genital Cosmetic Surgery: A Prospective Study
A prospective study of 132 women undergoing labiaplasty evaluated a standardized postoperative recovery atlas. Patients receiving the atlas alongside routine education reported significantly lower anxiety at one week and higher recovery experience scores at one month compared with controls. Both...
Quality of Life and Associated Factors Among Cancer Patients Receiving Palliative Care in Western Uganda: A Cross-Sectional Study
The cross‑sectional study of 204 cancer patients in Western Uganda receiving palliative care found overall low quality of life, with a mean global MVQOLI‑15R score of 3.47 out of 5. Symptom burden was the poorest domain, followed by interpersonal and...
Digital Transformation in Healthcare: The Critical Role of Clinical Staff Interactions
A study of 96 NHS hospital trusts and over 50,000 clinical staff finds that digital team capabilities boost team efficacy, which lowers mortality rates. Organizational digital readiness moderates this link, strengthening the impact where readiness is high. The research suggests...
Performance Comparison of QAOA Mixers for Ternary Portfolio Optimization
The study applies the Quantum Approximate Optimization Algorithm (QAOA) to a ternary portfolio optimization problem that includes holding, not holding, and short‑selling states. Researchers compare the standard QAOA mixer with several XY‑based mixers—XY Ring, XY Parity Ring, XY Full, and...
Maternal Distress — Guilt, Depression, and Anxiety Among Mothers of Children with and without Congenital Heart Disease
A cross‑sectional study of 246 mothers—123 with children diagnosed with congenital heart disease (CHD) and 123 with healthy children—found that guilt was reported by 78% of participants. Mothers of children with CHD experienced lower guilt but higher anxiety, while depressive...
Neural Spectroscopy Reveals Structure From a Learned Vacuum
Researchers have shown that a gauge‑equivariant neural‑network wavefunction, trained solely on the ground state of a two‑dimensional compact U(1) gauge theory, can be repurposed to generate detailed excited‑state spectra. By coupling the learned vacuum with correlation‑matrix variational analysis, the approach...
Impact of the Gate Oxide Material Composition on the Self-Heating and Short Channel Effects in Nanosheet Field Effect Transistor
The paper simulates a nanosheet field‑effect transistor that uses a dual‑layer gate oxide composed of SiO₂ and HfO₂ while keeping the equivalent oxide thickness constant. Varying the thickness ratio (R) from 1.286 to 10.154 leads to a 34% increase in...
Power, Policy, and Public Health in South Asia: A Narrative Review with Emphasis on Pakistan
The paper reviews how political factors shape health outcomes in South Asia, focusing on Pakistan. It highlights that governance weaknesses, corruption, and the post‑18th Constitutional Amendment fragmentation impede health‑system performance. Despite successes from the Sehat Sahulat insurance scheme and the...
Assessing Agricultural Yield Loss From Compound Extreme Events Using Three-Dimensional Vine Copulas: Evidence From Jiangsu Province
Researchers introduced a three‑dimensional vine copula framework that jointly models the Standardized Precipitation‑Evapotranspiration Index (SPEI) and Standardized Temperature Index (STI) to assess compound climate risks to rice yields in Jiangsu Province. Analyzing 27 years of county‑level data, they identified four...
Kick Bimodality of Neutron Stars and Mode Dependence of Their Parameters
A recent analysis of isolated radio pulsars reveals that neutron‑star natal velocity kicks are bimodal, with roughly 45 % of the sample occupying a low‑velocity mode and the remainder a high‑velocity mode. The two groups show divergent characteristic ages, distances and...
Enhanced Particle Swarm Optimization for Packaging Production Process Scheduling: A Novel Hybrid Approach
The study introduces a multi‑objective scheduling model for packaging production, targeting reductions in cycle time, order delay, and overall cost. An enhanced particle swarm optimization (IPSO) algorithm with dynamic inertia weights and adaptive learning solves the model. Simulations on a...
Hardware-Software Concealing of Secret Key and Enhancement of Pipelined Advanced Encryption Standard Cryptographic Core via Reconfigurable Devices for Hybrid Fast...
Researchers designed a pipelined two‑cycle AES‑256 cryptographic core on a Cyclone V SX SoC FPGA that delivers 12.8 Gb/s encryption throughput while occupying only 9 % of the device’s logic. Compared with recent FPGA implementations running at 96‑100 MHz, the new core achieves a seven‑fold...