Re: Alzheimer’s Drugs Targeting Amyloid Do Not Produce Clinically Meaningful Effects, Concludes Cochrane Review
A recent Cochrane review concluded that amyloid‑targeting drugs for Alzheimer’s disease do not deliver clinically meaningful benefits, prompting disappointment among researchers, investors, and caregivers. In a BMJ rapid response, emeritus professors Elaine and Robert Perry argue that cholinergic therapy—available for three decades—remains a viable option, citing improvements in cognition, behavior, and disease‑specific response patterns. They highlight advances such as drug‑specific efficacy differences, combination regimens with memantine, novel delivery routes, and natural‑product cholinesterase inhibitors. The letter also notes emerging strategies like muscarinic M1 agonists and deep‑brain stimulation of basal forebrain nuclei as future avenues.
Teen Suicide Comes Out of Hiding
Teen Suicide’s new album _Nude descending staircase headless_ marks the band’s first full‑studio effort, produced by Mike Sapone, and delivers a cleaner, heavier sound than their lo‑fi catalog. After a dozen years with Run for Cover Records, Sam and Kitty Ray...
Andrew Cranston’s Paintings of Dreamlike Domesticity
British painter Andrew Cranston reveals how a round of golf sparked a fresh take on landscape, echoing the depth of Bruegel while grounding his work in contemporary domesticity. His latest series, titled “I’m Going in a Field,” showcases six dreamlike...
Can Bicycling Help You Become a SuperAger?
A 2024 Journal of Neuroscience study links superior white‑matter microstructure to the remarkable memory of SuperAgers—people 80+ whose cognition rivals that of those in their 50s. Researchers interviewed cyclists aged 80‑90 who exemplify this group, noting their mobility, social connections,...
How to Handle a Velcro Kid
The article defines a “Velcro kid” as a child who clings to parents for safety, often triggered by moves, trauma, or developmental changes. It outlines the downsides of prolonged dependence, including parental burnout, weakened coping skills, and marital stress. Practical...
What Should My Macros Be? Your Nutrition Questions Answered
The article breaks down how to calculate personal macronutrient ratios, citing USDA guidelines of 45‑65% carbs, 10‑35% protein, and 10‑35% fat. It illustrates a sample 1,600‑calorie plan that translates to 160 g carbs, 120 g protein, and 53 g fat, and explains how...
Is Art Good for Your Health?
Daisy Fancourt’s new book *Art Cure* argues that regular arts experiences can improve mental health, boost neuroplasticity, and even increase the likelihood of meeting dietary guidelines, citing a range of epidemiological studies. The author claims that creative engagement halves the...
5 Essential Habits I’ve Embraced as I Approach 50 to Keep Running Strong
Colin McSherry, a senior art director at Runner’s World, shares five habits he’s adopted as he nears 50 to keep running sustainably. He emphasizes a proper warm‑up, building a solid base before speed work, smart recovery using foam rollers and TENS devices,...
The 10 Best Electrolyte Powders (We Tested Nearly 20)
Wired’s product team tasted and evaluated nearly 20 electrolyte powders, tablets, drops and chews, publishing a ranked list of the best options for athletes, hangover relief, and everyday hydration. Liquid I.V. Hydration Multiplier emerged as the overall winner, praised for its...
Sun Pharma’s ‘Heart Ke Liye 8’ Campaign Crosses 24.1 Million Views
Sun Pharmaceutical Industries’ "Heart ke Liye 8 – Making India Heart Strong" campaign has amassed 24.1 million views since its February launch, leveraging YouTube, Meta, connected TV and health‑tech platforms to promote eight daily habits for cardiovascular wellness. The initiative dovetails...
Merck, Eisai’s Keytruda Triplet Fails to Improve Survival in Kidney Cancer
Merck and Eisai announced that their Phase 3 LITESPARK‑012 trial of a three‑drug regimen—Keytruda, Welireg and Lenvima—failed to improve overall survival or progression‑free survival in first‑line renal cell carcinoma. The control arm received the approved Keytruda‑Lenvima doublet, which also did not...
One Great Poem to Read Today: Allen Ginsberg’s “A Supermarket in California”
Literary Hub’s daily‑poem series for National Poetry Month recommends Allen Ginsberg’s “A Supermarket in California.” The piece imagines Walt Whitman wandering a modern supermarket, blending high‑brow philosophy with everyday grocery imagery. The article highlights the poem’s catchy lines and its...
Waterfront Condo Sets New Hoboken Record with $4.8M Sale
A waterfront condo at 1500 Hudson Street in Hoboken sold for $4.75 million, setting a new city record. The 3,000‑square‑foot unit, featuring four bedrooms, four baths and central air, fetched roughly $1,500 per square foot. Hoboken’s median home price climbed 23%...
Delta Announces Next Generation Of Delta One Suites – ‘Incomparable Sleep At 30,000 Feet’
Delta Air Lines announced that its next‑generation Delta One suites will debut on new Airbus A350‑1000 aircraft in 2027, with parallel upgrades slated for its A330‑200 and A330‑300 fleet. The redesigned cabins feature longer lie‑flat seats, memory‑foam cushions, Missoni bedding,...
WWG26 Armchair Picks: Robin’s Top 3 From New Releases
Watches & Wonders Geneva 2026 showcased a mix of bold and safe releases, with three standout pieces selected by the author. Rolex unveiled the Oyster Perpetual 36 featuring a colorful “Jubilee” dial, while Cartier introduced the Privé Crash Skeleton in...
This Buzzy Seattle Coffee Shop Is Blending Hawaiian And Korean Flavors In A New Way
Orange Goose Coffee, a Hawaiian‑Korean‑inspired concept that began as a pop‑up in 2024, opened a permanent brick‑and‑mortar location in Seattle's Queen Anne neighborhood in March 2026. Founder Polu Arsiga hand‑built the interior and curates a menu of espresso drinks featuring in‑house...
Refining Tradition
The Austin, Texas remodel by Davey McEathron Architecture + Interiors and builder Render ATX transforms a 1970s postmodern shell into a “new‑old” residence that blends New Orleans‑inspired ornamentation with a restrained modern palette. Traditional elements such as dentil cornices, Corinthian posts,...
A Bizarre New State of Matter May Be Hiding Inside Uranus and Neptune
Carnegie researchers Cong Liu and Ronald Cohen used quantum simulations to predict a previously unknown quasi‑one‑dimensional superionic phase of carbon‑hydride deep inside Uranus and Neptune. The phase features a hexagonal carbon framework with hydrogen atoms spiraling through it, emerging under...
Rediscovering Midcentury Modern
A Greenville, South Carolina ranch was meticulously restored to its original midcentury‑modern roots, emphasizing clean lines, integrated materials, and a seamless indoor‑outdoor flow. Designed by Ario Studio and built by Tekton Builds, the renovation highlights double‑stacked windows, wooden ceilings, and...
Bowling For Soup Unveil Cover Of Sum 41’s ‘In Too Deep’
American pop‑punk outfit Bowling For Soup has dropped an animated cover of Sum 41’s 2001 single “In Too Deep.” The video recreates the original’s nostalgic vibe and follows the band’s recent Simple Plan cover. Frontman Jaret Reddick highlighted a 25‑year friendship...
Michael Bingham of Spiritual Cramp to Join Joel Madden on Ep. 162 of Artist Friendly
Alternative Press announced that Michael Bingham, frontman of punk band Spiritual Cramp, will appear on episode 162 of the Artist Friendly podcast hosted by Joel Madden. The episode follows recent conversations with Marc Roberge, Slayyyter, and Ziggy Marley and will...
"Discharge Meets GBH and Motörhead at an Anti-Nazi Demonstration After Drinking Cider All Afternoon in a Hackney Squat." Ten Obscure...
The article spotlights ten overlooked UK punk albums, ranging from the chaotic anti‑Nazi fury of Defcon Zero’s *Music For Gluesniffers* to the experimental edge of The Damned’s *Music For Pleasure*. It highlights how many of these records were dismissed at...
El Nino May Emerge Between May and July
Major climate models, including those from Australia’s Bureau of Meteorology, indicate a warming tropical Pacific that could trigger El Nino between May and July 2026. The Nino3.4 index has risen to –0.27 °C, moving out of the neutral range, while subsurface heat...
Larry McMurtry in Hollywood. His Novels Became Source Material for Movies that Reinscribed the Very Myths of the West that...
Larry McMurtry spent a career dismantling the romanticized myths of the American West, writing novels that portrayed cowboys and Texas life with stark realism. His work attracted Hollywood, which turned titles like *Horseman, Pass By* into films such as *Hud*...
Aaron MF Olson Announces “Songs Album II” And Shares “Nobody Can Tell”
Aaron MF Olson announced his sophomore solo effort, Songs Album II, slated for release on June 26 through Country Thyme Records. The LA‑based musician unveiled the lead single “Nobody Can Tell,” accompanied by a quirky desert‑hike video directed by Matt Hewitt. The track blends...
Shortlist Announced for the $150,000 Carol Shields Prize for Fiction
The Carol Shields Prize for Fiction, the largest English‑language literary award for women and non‑binary writers in the United States and Canada, has released its fourth‑annual shortlist of five titles spanning novels, a graphic novel, and a short‑story collection. The...
Beck Follows Surprise Single with News of 2026 ‘Ride Lonesome’ Tour
Beck has dropped a new acoustic‑driven single, “Ride Lonesome,” and announced a 25‑date North American tour slated to begin in September 2026. The tour will hit high‑profile venues such as the Greek Theatre in Los Angeles, Red Rocks Amphitheatre, and...
Modest Mouse Announce New Album ‘An Eraser And A Maze’
Modest Mouse announced their eighth studio album, “An Eraser And A Maze,” slated for release on June 5, 2026 via Isaac Brock’s Glacial Pace Recordings, ending a two‑decade partnership with Epic Records. The record follows 2021’s The Golden Casket and...
Psychology Says the Most Powerful Words You Can Learn Aren’t ‘I’m Sorry’ or ‘I Love You’, They’re ‘that Doesn’t Work...
The article argues that the five‑word phrase “That doesn’t work for me” is a powerful boundary‑setting tool, offering clarity without apology or over‑justification. Psychological research links assertiveness and the ability to say no with better mental‑health outcomes. Over‑explaining or apologizing...
Dane Bahr on Craft and Why Crime Fiction Is the Punk Complement to Literary Fiction
Dane Bahr uses a punk‑rock metaphor to argue that crime, horror and western novels are the rebellious counterpart to literary fiction. He stresses that plot, not lofty prose, is the engine that keeps a manuscript alive, and shares how techniques...
Newme Expands to Northeast as Brands Eye Region’s Consumption Boom
Fast‑fashion label Newme has entered Northeast India with stores in Shillong and Guwahati, bringing its footprint to 24 locations. The move follows a revenue surge to Rs 183.5 crore ($19.65 million) in FY ’25, up from Rs 49.7 crore ($5.32 million) a year earlier. The expansion taps...
Philosophy Hiding in Plain Sight: A Profile of Scholar and Author Frank Griffel
Frank Griffel’s monograph “The Formation of Post‑Classical Philosophy in Islam” won the 2024 Sheikh Zayed Book Award for Arab Culture in Other Languages. The book argues that Islamic philosophy did not end with al‑Ghazali’s critique but continued under the term...
Salim Nourallah Connects Manila to the Stars
Texan singer‑songwriter Salim Nourallah is releasing an unprecedented slate of five records in 2024, ranging from his surprise self‑titled solo album dropped on New Year’s Day to the collaborative Nourallah Brothers project "Calling Manila" and a new Disappearing Act album....
In a New Biopic, Michael Jackson Is an Eccentric Saint. Yuck
Lionsgate has released a new biopic that portrays Michael Jackson as an eccentric, almost saint‑like figure, emphasizing his whimsical traits while downplaying his controversial past. The film leans heavily on stylized visuals and a mythic narrative, casting Jackson as a...
Fable Brings Its Whole-Food Shiitake Mushroom Range to Waitrose Nationwide
London‑based Fable, a mushroom brand serving over 1,500 restaurants across the UK, Europe, Australia and North America, is launching its Tender Pulled Shiitake range in Waitrose stores nationwide on 6 May. The product is priced at £3.99 (about $5.10) and...
The People Who Say ‘I’m Fine’ the Fastest Are Usually the Ones Who Learned, Very Young, that Nobody Had the...
The article explains how children who experience emotional neglect learn to answer “I’m fine” instantly, treating the phrase as a protective shortcut rather than a truthful statement. This rapid response stems from an early need to conserve emotional bandwidth in...
Friko Bring the Noise on ‘Something Worth Waiting For’
Friko released its sophomore album *Something Worth Waiting For* on April 24, 2026, produced by Grammy‑winner John Congleton. The record leans heavily on early‑1990s English rock, echoing the sounds of Arcade Fire, Radiohead and Suede while delivering modern pop hooks....
Does Deleting Social Media Make You Happier or Lonelier? Short Answer: It Depends.
Recent research shows that taking a break from social media can improve mood for some users but may increase loneliness for others, depending on usage patterns and social ties. A 2020 Stanford study of 35,000 participants found modest emotional gains,...
Lacoste ‘Returns to Its Roots’ with New Visual Identity
Lacoste unveiled a refreshed visual identity that reintroduces a serif‑based logo and highlights the original Robert George crocodile illustration. The redesign sharpens the brand’s proportions, restores its historic green hue and adds clay and farine tones, while the iconic crocodile and...
Street Style Look of the Week: Airy Beachy Clothes
The Times’ visual columnist Simbarashe Cha spotlights a Manhattan couple whose airy, beach‑inspired outfits blend oversized blue and neutral tones. Kendra Austin, after shedding 100 pounds, credits the transformation for a renewed relationship with clothing, while her partner Sakief Baron infuses hip‑hop, basketball and...
Neolaia Synthesizes New CD38 Inhibitors
Biohaven disclosed detailed preclinical data on BHV‑2100, a TRPM3 calcium‑channel modulator aimed at neuropathic pain. A new meta‑analysis concluded that anti‑amyloid therapies for Alzheimer’s have not demonstrated clinically meaningful benefits, intensifying debate over the approach. Jiangsu and Shanghai Hengrui patented...
Twombly Foundation to Exhibit Rare Rauschenberg Works at Gagosian
The Cy Twombly Foundation is loaning six early Robert Rauschenberg works to Gagosian’s new 980 Madison Avenue gallery, opening on April 25. The group includes a 1950 twig-and‑glass assemblage, a cyanotype made with his then‑wife Susan Weil, a Black Painting from 1952, and a...
This Country Eats Even More Kraft Mac And Cheese Than The US
Canadians eat more Kraft Dinner than Americans, consuming over 50% more per capita. About 90 million boxes are sold annually in Canada, representing roughly a quarter of global Kraft mac‑and‑cheese sales despite the country's tiny share of world population. Over 80%...
April 21, 1994: The Discovery of Exoplanets
On April 21, 1994 astronomers Aleksander Wolszczan and Dale Frail announced the first unambiguous detection of planets beyond the Solar System. The objects, orbiting the pulsar PSR B1257+12, were roughly three and four Earth masses and completed orbits every 67 and 98 days....
What New Atopic Dermatitis Treatments Are in the Pipeline in 2026?
The atopic dermatitis pipeline in 2026 is dominated by next‑generation biologics and selective small molecules that aim to improve efficacy while reducing side‑effects. Connect Biopharma’s rademikibart achieved near‑complete skin clearance in a phase 3 trial, and Apogee’s extended‑half‑life zumilokibart showed durable...
Amazon Music Reveals ‘Just Walk Out’ Merch Plans for BTS Concerts
Amazon Music has secured exclusive rights to sell merchandise for BTS’s North American comeback tour, covering the United States, Canada and Mexico. The partnership includes pre‑sale events, on‑site booths and a full line of apparel, physical music and signature light...
Teyana Taylor Just Cosigned the $12 Viral Lipstick That Makes You Look Like a ‘90s Icon
Teyana Taylor has been named the new face of Revlon’s Super Lustrous Lipstick, joining the brand’s “Be Unforgettable” campaign that champions bold colour as self‑expression. The $12 drugstore product offers 72 shades, 80% conditioning ingredients, and a micro‑fine pigment formula....
Incyte Discloses New TYK2 And/Or JAK1 Inhibitors
Incyte announced the discovery of a new series of small‑molecule inhibitors that selectively target TYK2 and JAK1, two kinases central to cytokine signaling in autoimmune disorders. The compounds demonstrated sub‑nanomolar potency in cell‑based assays and favorable safety margins in early...
Mr Eazi and King Promise Document a Long Kinship
Mr Eazi and King Promise release their joint nine‑track album *See What We’ve Done*, marking a reunion after 13 years of parallel solo success. The record blends Afropop, highlife, Afro‑Amapiano and even acoustic‑punk elements, highlighted by the Backstreet Boys‑inspired single “That Way.”...
Dario Russo’s The Fox Turns Talking Animals Into a Dark Relationship Fable
Australian filmmaker Dario Russo’s debut feature, The Fox, premiered at SXSW 2026 after debuting at the Adelaide Film Festival in October 2025. The dark magical‑realism comedy follows a cheating fiancé who enlists a talking fox, voiced by Olivia Colman, to transform his...