Exercise Restores Aging Mice Gut Microbiome, Cuts Heart Risk
Late-in-life treadmill training mitigates gut microbiome imbalances and cardiovascular disease risk in mice "Here we demonstrate that a 12-wk treadmill running program in older mice rejuvenates the gut microbiome and attenuates markers of cardiovascular disease (CVD) risk. Notably, specific microbial taxa correlate with activity-induced improvements in overall myocardial performance and inflammation, highlighting the importance of gut health on CVD and illustrating the restorative benefits that can be attained from a low-cost lifestyle intervention." https://t.co/49qVozrW3A
Hinge Patterns Offer Untapped Potential, Not Just Accessories
There is a world of hinge pattern opportunities available to you. Yet it’s often treated like an accessory exercise. https://t.co/kqqVHYANTJ
Discuss NYC Chinatown's Past, Present, Future with Grace Young
Join us on Monday April 13th at 12 pm for a conversation with Grace Young about the present and future of the NYC Chinatown. The event is open to the public; please RSVP at https://t.co/p1jNrYfRoL https://t.co/WTzkW3w4bf
Scaling Fast Can Cost More Than Funding
New @ThePeelPod with @sophiaamoruso We talk bootstrapping her vintage Ebay store Nasty Gal to $28m revenue, raising $50m, turning down a $400m acquisition offer, and declaring bankruptcy a few years later. We talk about what it was like failing so publicly, what...
Focus Requires Goal, Discipline, Not Silence or Willpower
What you don't need to stay focused: - A silent office - Zero notifications - Monk-level willpower What you really need: - One clear goal - The discipline to start - A distraction-free hour a day No more excuses.
Real‑World Example Shows Mood Drives Leadership Style
Once again, the real-world provides the perfect real-time example. In this case for today's class on the unappreciated connection between social mood and leadership styles.
Artemis II Crew Witnesses Rare Earth Sunset From 44,000 Mi
On their first apogee, nearly 44,000 miles from Earth, the Artemis II crew is getting a look at home unseen in 53 years. Here's Christina Koch describing her view of sunset in India a few minutes ago. https://t.co/uBZmQjCoFt
Rye Bunny Reinvents Fine‑Casual with Counter‑First Dining
The format at the beloved Tail Up Goat in DC wasn’t sustainable. So the owners switched gears. The new Rye Bunny, from chef Jon Sybert and hospitality ace Jill Tyler, finds diners ordering food and drink from a counter, then...
New Ebook “World War Trade” Discussed on Podcast
Is there a podcast on my new ebook, World War Trade? Of course ⭐Tim Phillips of VoxTalks & I chat about the book for 20min https://t.co/cUYRcRu5gS
Choose to Let Challenges Energize, Not Destroy You
Life's challenges can slowly destroy you or energise the shit out of you. Your choice.
100 Recordings Reviewed: Proof of Listening, Proof of Life
Proof of listening, proof of life: I reviewed 100 recordings for THE FUTURE IS OURS TO MAKE Thank you for reading, for subscribing, for telling a friend https://open.substack.com/pub/thefutureisourstomake/p/who-are-you-going-down-in-history
Master the Hip Hinge: Restore Fundamentals, Prevent Injuries
We've lost the craft of fundamentals. Everyone chases "big numbers" and fancy variations, but the simple hip hinge? Most butcher it. They mess-up their RDLs, round their backs, or turn it into a stiff-legged mess that wrecks hamstrings and lower backs instead...
Walking to the Gym Adds Purposeful Cardio
I walked to and from the gym . 30 mins each way. Purposeful Cardio unlocked
Break Free: Reclaim Life From Screen‑Bound Work
Given that many of us can take our work with us wherever we go, it’s never been harder to set boundaries around our non-work lives. That’s what @GuyWinch's new book, "Mind over Grind: How to Break Free When Work Hijacks...
Coach for Joyful Curiosity, Not Fear‑Driven Ego
The longer I coach, the more I’m convinced that it’s mostly about putting people in a place where they can perform out of joy, curiosity, exploring their potential, and taking on a challenge. Too often we let fear, protecting our...
First Human Trial Shows Fasting Mimic Boosts Autophagy
As a medical school professor, I teach that autophagy -- the body's cellular recycling system -- is one of the most powerful defenses against aging and disease. Now the first-ever human clinical trial proves a fasting mimicking diet activates it. Cedars-Sinai and...
FOMO Drives High Price to Quit Social Media
How much would someone have to pay you to get off social media for a month? When psychologists ask college students this question, most of them want to receive a lot of money to live without social media for a month. Why?...
Health Is True Wealth: Prioritize Sleep, Exercise, Nutrition
True wealth isn’t found in your bank account it’s waking up with your health intact and needing nothing from a prescription bottle. You can always make more money, but you can’t buy back your health. Protect it like your life...
BeamTx's Risto‑cel Shows Promising Phase
1/@BeamTx announced the publication of clinical data from its Phase 1/2 BEACON clinical trial evaluating risto-cel - formerly known as $BEAM-101 for the treatment of sickle cell disease (SCD). The data was presented at #ASH25 🧵👇 & was published in...
Three Crews in Space, Artemis II Heads to Moon
In the unique moment in history, three crews are in space, including two on Earth-orbiting space stations and, for the first time, one simultaneously heading to the vicinity of the Moon. But things are not good on Earth, so only...
Effective Leadership Requires Purposeful Repetition to Change Behavior
I used to wonder why I kept hearing leadership repeat themselves as though they’d never said it before. Amnesia? Just… really passionate? Shouldn't we be moving on now? No. It's just what it takes to get groups of humans aligned. Repeat...
Artemis 2 Crew Cleared for Launch After Troubleshooting
From last night: after some troubleshooting, the Artemis 2 crew is go to, ah, go. https://t.co/ckl9ScopAj
Exploring Rocket Fuels Behind Artemis II’s Moon Launch
With Artemis II blasting off to the Moon, here's a look at the different fuels used to get rockets off of the ground in this edition of #PeriodicGraphics in C&EN: https://cen.acs.org/physical-chemistry/astrochemistry/Periodic-Graphics-Fuels-space-travel/100/i43
Ranbir Kapoor Leads Action-Packed Ramayana Epic Teaser
Vivid Teaser for 'Ramayana' Indian Action Epic Starring Ranbir Kapoor https://t.co/58OUNoPzu8 #Rama #NiteshTiwari #RanbirKapoor #Yash #Ramayana https://t.co/73yXMs53bC
Harlequin's AI Microdramas: Unwanted, Gimmicky, And
I wrote about the new AI partnership that Harlequin announced as if it was an exciting thing. https://lithub.com/dear-harlequin-nobody-asked-for-your-weird-new-ai-video-microdramas/
Envisioning Space's Future with AI, Autonomy, Quantum
Thanks CU Boulder for hosting the National Academy of Engineering last week. I had a great time and enjoyed sharing a vision of the future of Space with AI, Autonomy, and Quantum. (Nice shots Jesse Petersen, University of Colorado) https://t.co/2AyzXK4fn5
Artemis Crew to Witness Lunar Total Solar Eclipse
While on the far side of the Moon, the orbit of the Orion capsule will just happen to align with the Sun and the Moon, treating the Artemis astronauts to a total eclipse. The Sun's corona will be visible. Should...
New Book A Fabulous Debt Now Open for Pre‑Orders
Please prepare yourself for months of shameless self-promotion, mute me on socials, feel free to avoid me in public etc, because my next book — A Fabulous Debt: The Epic Story of How Bonds Built the Modern World — ...
Post Malone Announces Hong Kong Stadium Show – Presale Starts April
Post Malone to perform at Kai Tak Stadium September 16th. Ticket presale: • Artist presale April 24th • HSBC Mastercard & Trip.com April 27th • LiveNation April 29th General ticket sales from April 30th. https://www.livenation.hk/event/post-malone-presents-the-big-stadium-world-tour-hong-kong-tickets-edp1664523
Riverside Retreat: Unwinding at Langdale Hotel & Spa
A Riverside Sanctuary in the Fells: My Stay at The Langdale Hotel & Spa https://t.co/TmwfZ7NFp7
Patients Maintain Weight Loss After Discontinuing GLP‑1s, Epic Shows
Interesting data from Epic medical records - suggests that for many patients in the "real world", they are able to keep the weight off after stopping GLP1s... https://t.co/dHfYdG6rEX #EpicResearch
Artemis Rockets at 28,000 Km/H—Mind‑blowing Speed
Literally every stat of the Artemis mission is mind blowing, because WHAT DO YOU MEAN they travel speeds of 28,000km/h. That’s incredible and terrifying #artemis #nasa #moon
You’re Not Alone: Community Beats Solo Weight‑Loss Journey
Founder Diaries Day 2 - About feeling less alone. Community. Something I feel very strongly about while building MYRESET — treatment alone is not enough. Especially for weight loss. It can be quite scary… injections, side effects, all the unknowns. Yes, doctor support matters. But honestly,...
Fine Particulate Air Pollution Raises Alzheimer's Risk
As a medical school professor, I teach students that Alzheimer's has many risk factors. But this one is invisible -- and almost nobody talks about it. A massive study of 27.8 million Medicare beneficiaries just found that fine particle air pollution...
Intelligence Hinders Action: Overthinking Stalls Progress
The older I get, the more I realize intelligence is overrated. Intelligent people are more likely to overthink, overplan, and overanalyze. They hide behind motion that doesn't create progress. They fear the judgment of others if they're proven wrong.
Leaders Scale by Hiring Experts, Not Doing Everything
You are not supposed to be the best at everything in your business. You are supposed to have the vision, set direction, build the environment And hire people who can execute better than you. That’s how you scale.
Vulnerability Unfolds in Three Stages: Powerlessness, Cause‑Seeking, Blame
Just as there a stages to grief, there are stages to vulnerability. First come our intense feelings of powerlessness and uncertainty. Second comes our search for a cause. Third comes our assignment of blame.
ADHD Misunderstood: Overwhelm, Not Laziness, Drives Task Resistance
ADHD is not laziness. The resistance to starting or finishing a task is deeply rooted in overwhelm, lack of stimulation, or questioning a task's purpose.
SpaceX Accuses Amazon of Unsafe High‑orbit Satellite Deployment
.@SpaceX @Starlink tells @FCC it was forced to perform 30 collision-avoidance maneuvers after @Amazonleo's Feb 12 launch w/ @Arianespace because sats were released at 480 km, 50-90 km higher than authorized, and did not warn other operators beforehand.
Even Legends Doubt Themselves; Imposter Syndrome Is Universal
Neil Gaiman shares a brilliant story on imposter syndrome: “Some years ago, I was lucky enough invited to a gathering of great and good people: artists and scientists, writers and discoverers of things. And I felt that at any moment they...
Creatine Plus Probiotic Eases Depression via Gut‑brain Energy Boost
1/2) New placebo-controlled human randomized controlled trial finds creatine + a specific probiotic is effective in treating depression. The mechanism is fascinating, involving the probiotic increasing creatine transporters in the gut, leading to increased brain energy metabolism. If you're passionate about this...
Explore Hawkshead: 21 Must‑Do Activities in the Lake District
A Visitor’s Guide to Hawkshead: 21 Best Things to Do in the Lake District’s Prettiest Village https://t.co/Rh45Cz9rhb
Build a Solid Base Before a 16‑week Marathon Plan
Most online marathon plans are too short, and progress too quickly. If your marathon training block is truly only 16 weeks, I think you should be entering that plan with a solid base already. This generally means: - Being able to...
Just Start: Turn Dreams Into Action Today
People always ask me how they start on their dreams and I think the big secret is that you just start. Like on a random day you wake up and and just decide to do it
Artemis II Poised for Engine Burn, Mission on Track
All things considered the Artemis II mission seems to be going splendidly. Big moment for today comes this afternoon with the go/no go decision to burn Orion’s engines for the Moon.
Andersen's Unrequited Love Birthed The Nightingale
The nightingale and the loneliness of unrequited love – how Hans Christian Andersen, born 221 years ago today, turned his heartbreak into one of the most beloved fairy tales of all time https://t.co/U5Pt4y6tOm
Dual-Purpose Small Room: Office Today, Blackout Nursery Tomorrow
This is why a *separate* Nursery room (with blackout shades) is really helpful … but it can be small, so that before the baby comes it can be an office A Baby Maybe room https://t.co/g8vejcKI2a
OneWeb
1st of 440 @Eutelsat OneWeb sats built by @AirbusSpace launch this yr on @SpaceX; the balance 2027-31 on @MaiaSpaceOff , debuting 2027. @defis_eu #Iris2 LEO constellation's 264 sats, likely from Airbus & @aerospacelab_ , to be interleaved somehow w/...
Pro Secrets to Conquer the Cape Epic
Our latest podcast: How to win one of the world's toughest mountain bike races. We're joined by Dr @MikePosthumus, Head of Performance for Specialized Racing, who shares tactical, training & nutrition insights on a SA victory at the 2026 @CapeEpic...
Certainty and Control Shape What We Want and Do
I realize this is entirely self-serving but my book "The Confidence Map" gives you a framework for understanding how and why what we want and do change with changes in our feelings of certainty and control - which today is...