TTN's High Mutation Rate Reflects Size, Not Significance
TTN shows up as one of the most mutated genes in almost every cancer exome. New bioinformaticians see it and think they found something. They didn't. It's a 364-exon gene encoding the largest human protein. It collects mutations like a lint roller. https://t.co/icN6Zp856v
Early Run, Adjusted Pace, Trust Body Before Marathon
I woke up at 4:30 this morning to start my 23 mile run so that I could get it done before the temps started rising. My plan had me doing a 12-mile race pace block as a part of this...
Weight‑loss Drugs Curb Intake; Future Targets Calorie Burn
The current meds help people eat fewer calories. That’s how they work for weight loss (yes they have weight independent effects like CVD reduction). The next frontier is helping burn more calories.
Six Months at 75% MHR Boosts Fitness and Speed
Related to another post from yesterday... Most athletes could afford to spend at least 6 months of every year capped at 75% MHR. You won't do that, because you'll get bored and distracted (probably by something you read here) But you'd be a...
Stay Calm During 50% Market Drops or Underperform
"If you're not willing to react with equanimity to a market price decline of 50% two or three times a century, you're not fit to be a common shareholder - and you deserve the mediocre result you are going to...
Sleep Deprivation Triggers Hormone That Fuels Heart Disease
Sleep loss can causally drive heart disease. 1/2) Here's how it works: Sleep loss causes release of a brain hormone (hypocretin) --> goes to bone marrow to simulate the production of inflammatory cells --> these go to arteries and drive atherosclerosis But...
Oral GLP‑1 Battle Heats up Amid FDA Uncertainty
Oral GLP-1 wars, FDA drift, HIV franchise defense, and a few biotech landmines | Ep. 970 https://t.co/sx4kBXzgSL [ 02:30 ] oral GLP-1 battlefield heats up [ 03:08 ] convenience factor drives adoption [ 04:51 ] tolerability issues hit persistence [ 05:45 ] Novo writes $2.1...
Writing Daily Turned My Wall Street Job Into 8‑Figure Business
One simple daily habit helped me: • Quit my Wall Street job • Become an entrepreneur • And build an 8-figure digital business The habit? Writing online. But when I first started out, I was a horrible writer. So I spent 1,000+ hours studying how to write...
New Nutrient Score Ranks Top 10 Superfoods
The most nutritious foods for health and disease prevention 🥗 This new study introduces a new way to rank foods based on true nutritional value including factors such as… 👉 Micronutrient density 👉 Protein quality 👉 Bioavailability Establishing a new system called Nutritional Value Score...
Break Free From NPC Mode to Find Meaning
Crazy how most people are living like NPCs in someone else's video game. • Leveling up linearly • Following "the" script • Repeating the same dialogue • Hitting the same checkpoints Then they wonder why life feels meaningless.
Spend Money on Quality, Comfort, and Growth Essentials
A handful of things that are worth the money: - Eight Sleep - One $5000+ watch - Blackout curtains - Bamboo sheets - Uber Black - Home espresso machine - 1:1 skill tutoring - High-level masterminds - Standing desk - Herman Miller chair - Specced out MacBook Pro - Home sauna &...
Visual Summaries Reveal Greene's Power, Strategy, Mastery Lessons
Robert Greene is one of the most popular non-fiction authors of our time. His books on power, strategy, mastery, and human nature have been read by millions of people. Here are a few awesome visual summaries of his books:
Leaving Comfort Zone Sparked Unplanned Growth
10 years ago, I quit my job with no plan. But I had to do it: My personal growth had plateaued. And the only way I'd become the person I wanted to be was to work on something outside my comfort zone. Otherwise, I'd...
Mysticism Enriches Life
Mysticism is a way of exploring that which cannot be perceived by the five senses. What is the use of it? There is no use. But without it, you live a poor life. Mysticism is neither about utility nor is...
Define Your Coaching Core Philosophy in Four Points
Something I do with mentees is get them to generate a ‘Core Philosophy’ 4 points that underpin your coaching approach. Here’s mine; https://t.co/gBc0XZCLjQ
Science-Backed Training Week Explained: Methodology Revealed
Long post. What my training week looks like… and why it looks like this. Sometimes understanding the science and theory helps anchor the methodology. Link for there 👇 https://t.co/2Xzne078WC
LVMH Balances Cycles by Pairing Stable Spirits with Fashion
$LVMH laid out the strategy driving their acquisitions in 2002 Holding so many different luxury goods businesses would help to balance the cyclicality of each category. “Wines and spirits are stable businesses with long cycles” versus luxury fashion and ready-to-wear...
Discovered Tatsumi Atsukawa’s New Novel ‘Dead Man’s Chair’
Found and picked up “Dead Man’s Chair,” the latest novel by Tatsumi Atsukawa, at a bookstore. https://t.co/1ZkNJ8K7fw
Delta Turns Empty First-Class Seats Into Breakdance Contest
Delta Had Empty First Class Seats — So The Gate Agent Held A Break Dance Contest - View from the Wing https://t.co/ed9Hc5bPcW
Choosing Not to Match: A Bold Path to Wellbeing
The hardest decision a medical student can make is choosing not to match. We are conditioned to believe the medical training pipeline is a one way street. You sacrifice your twenties, survive the clerkship years, match into a residency program, and...
Lactate: Misunderstood Molecule, Actually Helps, Not Harms
"Lactate was at the scene of the crime but was not the criminal. It was actually trying to help" Lactate: The Most Misunderstood Molecule in Biology👇 https://t.co/3skDRDEuqw
15‑Minute Walks Cut Heart Risk for Sedentary Adults
Instead of only short bursts of movement, add walks that last 15+ minutes. Among people averaging <8,000 steps/day, those who got most of their daily steps from walks lasting 15+ minutes had the lowest cardiovascular risk and among the lowest mortality...
Prioritize Your Inner Voice Over Social Media Distractions
“Always remain alert to how much time and attention you spend on social media versus how much time and attention you spend listening to the song in your heart.” ➤ https://t.co/dVtefi5Sf9 #careeradvice #careergrowth #personaleffectiveness https://t.co/C5Vj6aaFXv
Consistent Sleep Schedule Beats Hours for Brain Health
Sleep timing regularity may be just as (if not more) important than total hours. Irregular sleep–wake times (even 1–2 hour shifts) are linked to: → Poorer cognitive performance → Higher inflammation & blood pressure → Increased risk of cardiovascular & neurodegenerative disease Your brain’s “master...
Enduring Anxiety over Youth Corruption Persists Across Ages
By @JMchangama and Jeff Kosseff: Gift link: The Timeless Fear of Corrupting the Youth https://t.co/glJdOSxxox
11‑Year‑Old Bruno Mars Delivered Legendary Aloha Stadium Performance
11 year old Bruno Mars was at this Aloha Stadium concert. It was legendary, unks speak of it in reverence to this day
Rest Fuels Momentum, Not Breaks It
Rest is part of the process, not a break from it. You are not losing momentum by resting, you're actually maintaining it.
Design Your Environment, Not Willpower, for Deep Work
How I get into deep work: 1. Journal before bed - write the 1-2 things for tomorrow 2. Go to bed early 3. Get up before distractions begin 4. Don't check the phone first thing 5. Change environments when stuck The key insight: deep work isn't...
Your 70‑year‑old Self Depends on Today's Activity
A patient asked me yesterday why so many orthopedic surgeons seem to be in good shape. I told her... Because we know what happens to the human body when we're not. We see it every day. The loss of muscle that...
You’re Probably Getting Enough Protein without Shakes
Do you not get enough protein or has social media confused you into **believing** you’re not getting enough of protein? Just because you don’t eat protein bars & drink protein shakes doesn’t automatically mean you’re not getting enough. Instead of falling...
AI Creates Six-Figure Art Live, Redefining Creation
An AI artist is now creating six-figure works live in front of an audience. At Art Basel Hong Kong, Botto is not just generating art, but performing the process in real time, turning creation into something people can watch unfold. It...
Thought Shapes Reality; We Live Under Suggestion
Two thoughts from Émile Coué "The power of thought, of idea, is incommensurable, is immeasurable. The world is dominated by thought." "From our birth to our death we are all the slaves of suggestion."
Adapt Your Training to Life’s Stress, Don’t Force Progress
Be flexible with the plan. Life stress = training stress. Missed sleep or travel = immediate pivot, never forced progression.
Aging Cells Self‑Destruct via ER‑phagy Early
As a medical school professor, I used to teach that aging is gradual wear and tear. But a Vanderbilt study in Nature Cell Biology reveals something far more disturbing. Your cells are actively dismantling themselves through a process called ER-phagy. Starting early...
AI‑Designed Enzymes Signal SynBio’s Sugar‑Reduction Promise
Can synbio solve sugar reduction? The @ArzedaCo + @ManeGroup partnership is a strong signal. AI-designed enzymes Cell-free manufacturing at scale Real products in market Excited to host Alexandre Zanghellini (@biopraxis) at #SynBioBeta2026. Visit the SynBioBeta website to read the full article: https://t.co/1S29MUqfWh
Europe Condemns UK's Self‑inflicted Collapse of Physics Research
A view from Europe on the self-inflicted damage to UK particle, astro and nuclear physics. What a mess this is.
Uzbek High Pull Resurfaces as Grappler Strength Tool
While I don't program full lifts often. I still program high pulls especially for grapplers. Neat to see a resurgence with what is being called Uzbek high pull, which is a hinge into a high pull. https://t.co/miW6fkMiS2
Commitment, Not Mistakes, Drives Success for Individuals and Companies
"Look at those who fail, and you will find that most people fail not because they make mistakes, but because they are not fully committed, and the same goes for companies." - John D. Rockefeller's Letter to His Son. https://t.co/tt0tT7nQNh
Munger's 10 Essential Wisdom Lessons for Smarter Thinking
Charlie Munger’s 10 “Remedial Worldly Wisdom” Lessons That Make You Smarter Than Most People https://t.co/PaGtKkwdfZ
Explore Bali’s Iconic Potato Head Beach Club in 4K
Watch my new YouTube video: Potato Head Bali | Most Famous Beach Club & Hotel in Bali (Full Tour in 4K) https://www.youtube.com/watch?v=YROuC8Z5Vig
Older Diner Pushes Back Against Intrusive Waiter Questions
I have a second piece in today’s @ftweekend in which I rant about waiters asking intrusive questions. Because I am old, and have lived too much life for this malarkey. https://t.co/bAPwIWdjXX https://t.co/FZ92RNSLJB
Breakthroughs Spark When Tech Meets Biology, Not Tools
I didn’t expect a piano to make music visible but this does. That caught my attention. Someone spent three years trying to turn sound into something you can see. No AI. No screens. Just experimentation. They tried lasers, smoke, different materials. Nothing worked. Until they found...
Liquid Molecule Stores Sunlight, Releases Heat On Demand
Scientists “Bottle the Sun” With Revolutionary Liquid Battery 🔋 ☀️ https://t.co/OwRj1KreUq 💬 Solar energy has one persistent weakness: it disappears at sunset. Finding a reliable way to store that energy for later use remains one of the biggest obstacles to expanding renewable...
Aces Food Craft: Must‑Visit Japanese‑Inspired London Eatery
For today’s @ftweekend I am at Aces Food Craft in London’s Fitzrovia, a terrific Japanese inspired restaurant which is very much worth your time (and, if you have it, money) https://t.co/en3A2z7fl5
Intense Training Costs My Heart, Fuels Scientific Insight
For nearly 40 years I've used my body to test ideas about training intensity, HIIT, monitoring, etc. I seem to be paying for those sins now with big atrial fibrillation challenges. This distracts me a bit, but hey,...
Traditional Periodization Remains Core to Modern Sports
Ever since I travelled to Moscow in 1986 as a 20y old student in search of secrets, "periodization models" have spun in my head. This review helped slow the spin. Revisiting Tradition: Why the Traditional Periodization Still Shapes Modern Sport...
Prioritization Starts with Your Values, Not Your Planner
We often think prioritisation is about managing time… but it’s really about managing ourselves. Because before the planner, before the to-do list, before the system— there’s you. Your values. Your direction. Your decision on what truly matters. When you get that right, everything else starts to fall...
Stop Fearing Failure; Act Now and Own Your Results
STOP PLAYING WITH YOUR LIFE • You know what to do • You just not doing it • You scared to fail • You scared to look dumb • You wasting time • You delaying results • That’s on you • Pay attention
Β‑Hydroxybutyrate's Dual Impact on Colorectal Cancer
β-Hydroxybutyrate, a primary metabolite of ketogenic diets and its dual role in modulating colorectal cancer: from molecular mechanisms to therapeutic insights https://t.co/pPCdm2AcFo https://t.co/mPtz1Xqiep
Pre‑pandemic Train Reads: Edinburgh‑Bought Journey Companion
Railway reading for a journey on the train …originally purchased in Edinburgh before the pandemic https://t.co/F3J480eTBg