Single‑cell Methylation Reveals Age
Epigenetic aging happens at different rates in individual cells within the same tissue. Using single-cell DNA methylation analysis, Hagit Masika, Tommy Kaplan, Howard Cedar, and colleagues show polycomb CpG island methylation creates 'young' vs 'old' cell subpopulations even at fixed chronological age. Fascinating finding: white vs black hairs from the same 53-year-old person show dramatically different epigenetic ages. This single-cell view of aging could explain why age-related diseases often start from individual cells (like cancer). Title: Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging. Link: https://t.co/DXXhRhYAXd
Seed Oils Aren’t Uniquely Toxic Compared to Other Fats
#380 ‒ The seed oil debate: are they uniquely harmful relative to other dietary fats? | Layne Norton, Ph.D. https://t.co/tezM4gAKI9
Diversity Still Missing: No Black, Latina, Indigenous Nominees
I appreciate everyone's optimism that Coogler will be back but... He's only the seventh in 98 years, and none of them have been back. We still haven't seen a Black woman, or Latina woman or an Indigenous person nominated. We are still banging...
Sierra Foothills Feel Like an Alien, Signal‑free Planet
Driving up the eastern foothills of the Sierra Nevadas is the closest I've ever felt to being on another planet. Extremely isolated, extremely visually striking, no signal.
500‑book Home Library Adds 3.2 Years of Schooling
"A home library of 500 books propels a child an average of 3.2 years further in education"
AI Arm Extends Brush, Merges Ink Tradition with Tech
A Hong Kong artist is doing something fascinating with AI. Victor Wong uses an AI-powered robotic arm to create landscapes inspired by traditional Chinese ink painting. It’s not replacing the artist, it’s extending the brush. When technology starts collaborating with centuries-old art forms,...
Understanding Fuels Progress More than Effort
Monday reminder: Knowledge changes how you see the world. The more you learn, the more patterns you recognize, the more opportunities you notice, and the better decisions you can make. Often the difference between struggle and progress isn’t effort. It’s understanding. Start the week curious. Small...
Kamal Ravikant's Raw Memoir Reveals Hidden Struggle
Everyone knows @naval. Not enough people know his brother @kamalravikant. That asymmetry is strange. Because Kamal went somewhere Naval never publicly went. He broke completely. And then wrote the most honest book about it he almost did not publish. Here is what I found when I...
Live with Minimal Wants, Become Untouchable
No attachments or aversions When you’re able to go through life with very little needs, desires and or fears, life cannot touch you.
Trust and Safety Precede Discipline in Child Development
A child needs trust and safety first to form a strong bond and connection before a parent can expect them to be regulated, behave and cooperate to requests, and respect them.
Kamal Ravikant Teaches Inner War, Truth, and Rebuilding
Everyone quotes Naval. Not enough people talk about @kamalravikant. Which is strange. Because Kamal teaches a kind of strength most people completely miss. Not performance. Not status. Not hype. Inner war. Then truth. Then rebuilding. Here is why he matters:
Award Season Ends, Next Contender Opens in Five Days
Kind of crazy this award season comes to an ends to only have next years first contender open five days later https://t.co/l5dNi2Khfw
Finding and Carrying Your Inner Light
I Touched the Sun – a tender illustrated fable about how to find and bear your inner light https://t.co/I6uFCzCfZO
Red Meat in Plant-Forward Diet Impacts Aging Biomarkers
Effects of Minimally Processed Red Meat within a Plant-Forward Diet on Biomarkers of Physical and Cognitive Aging: A Randomized Controlled Crossover Feeding Trial https://t.co/hpjHcUsbtP https://t.co/Kf2yZhbmVe
Aging Driven by DNA Instability and Mitochondrial Decline
So great to see the OG work that helped spark the longevity revolution taken to the next level: New paper confirms two main causes of aging: 1. DNA instability -> epigenetic noise 2. Mitochondrial decline ...independently causing failure of the cell Is this relevant to...
Science Advances, yet Humanity Loses Its Natural Symbolism
This paragraph by Carl Jung, written in 1964, still hits hard: As scientific understanding has grown, so our world has become dehumanized. Man feels himself isolated in the cosmos, because he is no longer involved in nature and has lost his emotional...
Judith Curry Led Trump‑appointed Group to Undermine EPA Science
#JudithCurry was a key member of the "unlawful" working group tasked by the Trump administration with discrediting the science underlying the EPA endangerment finding (the legal basis for regulating carbon emissions).
Swapped $13k for Rare 1940s Pink Gold Rolex
I give a guy $13,000, he gives me this 1940s pink gold Rolex bubble back. Who says no? https://t.co/UoMrhnodCA
Oscars 2026 Sparks Menswear Renaissance with Bold Accessories
Menswear drip at the 2026 Oscars was insane. Brooches clearly aren’t going anywhere. Jacob Elordi in Bottega was breathtaking. Sprezzatura. Rings, chains, watches. All those quiet flex details saying je sais exactement ce que je fais. Menswear is in a full renaissance...
Porsche’s Ads Consistently Hit the Mark
Porsche ads Always hit the mark h/t Porsche
Timothée Chalamet Targets Oscar‑Bait Roles, From Biopics
timothee is going to go oscar bait apeshit, biopics and wwii movies and makeup-heavy physical transformations, it's all on the table
Commit Fully Today to What Truly Matters
Do not waste your time and Life on things that do not matter. What truly matters to you, commit to it one hundred percent – today, not tomorrow. #SadhguruQuotes https://t.co/60ZgSbLC7t
Disappointed with ONAA, Except for Its Car Chase
fine ill say it i really did not like ONAA as much as everyone else apparently (beside that insane car chase scene.)
Oscars Postgame Show Streams Live on MMT
The official #Oscars postgame show gets underway immediately following on #MMT🌕 Both here & YouTube https://t.co/xBbS7oam4C
Father‑Son
Priceless experience playing in the pit with my son for pretty much the highest quality community theater you could ask for.
Michael B. Jordan Clinches First Oscar, Celebrated by Coogler
First ever Oscar win for Michael B. Jordan. Standing ovation, monster hug from Coogler. Let’s go! #Oscars https://t.co/JPwRN0qABc
Fans Fear Chalamet's Next Film with Iñárritu
suddenly terrified that Chalamet might be about to make a movie with Alejandro González Iñárritu
Tech Noir Tracks Echo Post‑Apocalyptic Hope
Gunship Tech Noir and Tech Noir 2 hits hard. Heavily recommend these two songs in your rotation. Post apocalyptic no hope, everything is lost - to hope, life will move on and rebuild stronger. Dire strait to life finds a way. Deep....
Surprised PTA Still Lacks a Masters Title
I still can’t believe PTA didn’t already win one of these for THE MASTER https://t.co/GGbZCRCN8K
SentimentalValue Clinches Oscar, Sparking Secret Agent Nostalgia
In one of the most disputed editions of the category ever, #SentimentalValue wins the #Oscar for BEST International Film, overcoming #TheSecretAgent aka #OAgenteSecreto at #Oscars 202 I loved both films and both extremely deserved the win, although I truly wished #TheSecretAgent...
SentimentalValue Secures Sole International Oscar Win
#SentimentalValue wins Best International Feature Not a big night for international wins this year… #Oscars https://t.co/ClQfdWuc5T
Chalamet's Oscars Outfit Sparks Jaw‑Dropping First Impressions
My first thought when I saw the fit chalamet wore to pull up to the Oscars https://t.co/XBJEJJheVJ
First Woman of Color Wins Best Cinematography
Autumn Durald Arkapaw is the first woman (and woman of color) to win Best Cinematography 🙏🏽
Nicotinamide Study on Amyloid Beta Retracted Over Editing Concerns
FYI - Retracted paper in the NAD field: Nicotinamide Ameliorates Amyloid Beta-Induced Neurodegeneration in Adult Mouse Brain. The editors lost confidence in the findings after "indications" of inappropriate editing & partial duplication https://t.co/WVJBCeKjQ4 https://t.co/lmUObhFxcK
Support Adult Children: Money Should Ease Life Choices
This is similar to how my wife and I have come to feel … except that for each of their careers it may/not make sense for them to live with us But regardless, we are going to try and knock down...
Frankenstein Wins Best Production Design, Sinners Fall Short
Whelp, that’s it - #Sinners can’t match the record for 11 wins Best Production Design #Frankenstein #Oscars https://t.co/Qbu0qX8wEO
Low‑dose EGCG + L‑theanine Reverses Fatty
Low-dose epigallocatechin gallate combined with L-theanine effectively alleviate obesity and metabolic dysfunction-associated steatotic liver disease by remodeling gut homeostasis and avoiding its hepatotoxicity https://t.co/rRnmHMr0An https://t.co/8DyZbmkAwg
ANORA: The Worst BP Winner Ever,
Nothing and I mean N-O-T-H-I-N-G will be worse than the single most atrocious BP winner of all time: ANORA
Fans Want Surprise Avengers Trailer at Oscars
Man, they got all these trailers for Hulu and FX shows, they should’ve went from Downey Jr. and Evans into a surprise trailer drop for #AvengersDoomsday during the commercials. #Oscars https://t.co/pauRuMliUy
RDJ and Evans Tease Avengers Doomsday’s Witty Banter
that RDJ / Chris Evans banter was a preview of the scintillating humor we can all expect from Avengers Doomsday
Free Substack: St. Patrick's Day Barbacoa Shepherd's Pie
Look for my free Substack on Monday, including, for St. Patrick's Day, this version of shepherd's pie filled with Mexican barbacoa instead of ground lamb. https://t.co/3xBf0pkbsj
Sinners' Loss Prevents Tying Historic Oscars Record
If #Sinners loses one more category it won’t tie for the most wins ever with #Titanic #RetunOfTheKing and #BenHur… #Oscars
Both Supporting Oscars Go to Villains—First Time?
Both Best Supporting Actor and Actress #Oscars went to actors playing villains in their respective films. I don’t think that has ever happened before in the same year. Has it? https://t.co/1LC720QqKt
Sean Penn's Oscar‑Worthy Range Shines in Two Roles
With respect, there was no performance more worthy of an Oscar this year in any category than Sean Penn. Winning for Harvey Milk and for Lockjaw is one of the great shows of range imaginable.
Sean Penn Wins Expected Supporting Actor Oscar, Benicio Missed
Best Supporting Actor - Sean Penn from One Battle After Another. Expected though I still would've liked to see Benicio win this one. #Oscars
Live Deep Groovy Electronic Mix Brightens the Day
Twitter is tough to take these days, with all the negativity. Here's something positive. If you like electronic music, you'll love this deep, groovy mix of mine, recorded live in my studio in Pawleys Island, SC. https://t.co/drQnSOTLvK
Oscars Audience Crowns ‘
Everyone watching the Oscars just realized ONE BATTLE AFTER ANOTHER is definitely winning Best Picture.
Casting Finally Gets Its Own Oscar—Essential for Film Success
i am so so so glad there's an oscar for casting now, so many movies live and die by the casting
Ask Open-Ended Prompts, Not Single-Answer Questions
The single best “conversational” tip I’ve learned in the last few years: Stop asking “finite” questions that require someone to filter the ideas that come to mind. For example, don’t ask for “the BIGGEST mistake” someone’s made. Ask for “SOME of the biggest...
Three Distinct Luxury Icons: Patek, AP, Vintage Rolex
3 very cool and very different watches I saw today Medium size (37mm) Patek Philippe Nautilus in white gold AP Offshore with a kind of ridiculous but also kind of fire red dial Pristine condition 1940s pink gold Rolex bubble...