Approve Longevity Drugs for Disease First, Then Expand to Aging
The only sustainable path to development of longevity therapeutics is to get the potential longevity drug approved for a disease, then go for indication expansion and study it in the context of aging at different doses and regimens. To be approved for the indication it should be better than the standard of care, so choosing the right indication and focusing on safety is critical. It is surprising that experts in aging research don't get it and blame the regulators. I used to be one of these "we need to classify aging as a disease for science to advance into the clinic" activists myself - not anymore. Only credible data from proper clinical trials counts.
Longevity Comes From Early, Consistent, Purposeful Hard Work
Longevity isn't about avoiding hard work, it's about doing the right hard work early and often.
Thank Anxiety, Then Choose Not to Follow It
Your child needs to hear, "Anxiety is your brain trying to protect you. You can thank it and still not listen to it."
The Borrowed Mind Tops Kindle Cognitive Psychology Rankings
A nice early moment for The Borrowed Mind. 👉The book is currently #1 New Release in Cognitive Psychology on Kindle and climbing in Epistemology. 🙏Thank you to everyone helping this conversation about AI and human thought get started. https://t.co/D7TcstgnY1
Accountability Today Transforms Your Life Tomorrow
Remember these 2 things this Sunday morning ☀️ and your life will change …we are 74 days into 2026 and May of you haven’t made the changes you promised yourself you would on Jan 1 … a lot of that...
Join Live Zoom Sessions for Daily Mindfulness Guidance
Join me live on Zoom each Monday, Tuesday, and Wednesday, starting at 9:00 a.m. Pacific Time. xoxo bk Register: athomewithbyronkatie.com theworkofbyronkatie #byronkatie #innerwisdom #selfhelp #selfinquiry #healingjourney #selflovejourney #dailylesson #mindfulness #TheWork
Psilocybin Aids Smoking Cessation; New African Psychedelic Mushroom Found
Psilocybin seems to help tobacco smokers quit; Scientists discover a new species of psychedelic mushroom in Africa https://t.co/E5d2aUHoUQ
Sweetbreads Reimagine Buffalo Wings at Baby Bistro
My favorite dish at the cozy Baby Bistro: Gently crisp sweetbreads and soft-cooked carrots on a puddle of celery root puree sharpened with blue cheese — a convincing twist on Buffalo chicken wings. (Calabrian chile oil helped.)
Deconstructing Psychedelics to Engineer Non‑Hallucinogenic Therapies
How do you break psychedelic molecules into parts, like cars in a chop shop, and build new ones? A look into non-psychedelic psychedelic medicine by Clayton Dalton, an ER doc and Ferriss-UC Berkeley Psychedelic Journalism Fellow @ucbsoj & @SciPsychedelics https://t.co/b7R4aTNdyf
AA Pays $4K to Relinquish Seat, Still Div
American Airlines Offered $4,000 To Give Up A Seat To Aspen — The Flight Diverted Anyway - View from the Wing https://t.co/brOlQ1bdWb
A24's Undertone Delivers Record ROI on Opening Weekend
#A24’s over-performs at US #BoxOffice with their new R-rated #Undertone, after grossing SPECTACULAR 9.3M over just 2.570 theatres on #5 BIGGEST 3-day Opening weekend in #A24’s history, and almost on par with 2023 #TalkToMe’s 10.4M debut, with a solid $3.6k...
Low‑budget Horror Nets $9.3M Opening, Hits #3 Nationwide
Solid $9.3M opening wknd #boxoffice for paranormal fright flick #undertone. Produced for only $500k, A24 release takes #3 spot nationwide and is already a moneymaking horror hit.
Wealth Grows When You Embrace Discomfort, Not Avoid It
The difference between rich people and everyone else isn't intelligence It's their relationship with discomfort. Poor people avoid discomfort at all costs Rich people run toward it Because they know: Comfort is expensive And discomfort is profitable...
Polished Success Masks Hidden Burnout and Silent Strain
When I was burnt out, I didn’t look fragile. I looked polished. Capable. Composed in every meeting. But my jaw never unclenched. My chest buzzed at night. I couldn’t sleep. I never stopped planning, worrying, doing. Success hid the fault lines that lay underneath.
Why Self‑Compassion Fails: Misconceptions, Evolution, and Inner Critic
Why Some People Struggle With Self-Comapssion: 1. Misconception Of Motivation. 2. Evolutionary Wiring. 3. Internalized Critic. 4. Fear Of Weakness. 5. Misunderstanding Self-Worth.
Picked Up Soji Shimada's Revised Complete Edition
I saw the revised complete edition of “Kisou, Ten wo Ugokasu” by Soji Shimada in the new releases section at the bookstore, so I bought it. https://t.co/hz4z2q6huB
True Change Comes From Jesus, Not Legislation
Pastor Hal’s message today centered on meeting Jesus. His point was we are living in a broken world. Things are not good right now. But changing laws and changing rules will not make things better. Things will only improve when...
Never Trust Bulk RNA‑seq without These 7 QC Checks
1/9 Every bulk RNA-seq experiment I run goes through the same 7 checks before I trust the results. I've been burned enough times to know: if you skip QC, you will find out the hard way. Usually during a meeting with...
Structure Emerges When You Prioritize What Matters
I’ve seen chaotic lives become organized in a month. I’ve seen forgetful people build reminders that never fail. I’ve seen messy desks turn into clean workflows. People build structure for what they care about.
Glyphosate Linked to Lower Bone Density and Fractures
Glyphosate exposure, bone mineral density, osteoporosis, and fractures in the United States population 👉"Results are internally consistent and align with existing literature concerning toxicity of glyphosate on bone and extend it to include adverse impact on osteoporosis and fractures." https://t.co/5kJOV4KD1X
No‑heat Premium Fare Lets Airport Bars Occupy Unused Space
The reason for the champagne and seafood bar is interesting. It is premium food which requires no heating and hence no ventillation, so can occupy airport real estate which other food vendors can't.
Redeem Reward Coffees at Airports for Free Drinks
@SoVeryBritish (Good arbitrage tip - save up your reward coffees for airport use, btw). I once asked someone at Toblerone what the weird airport thing is. It just happened really early and mushroomed from there. https://t.co/GRz6Kp8p8x
Neuromorphic Chips Simulate Physics with 1,000× Less Energy
Recent neuromorphic computer breakthroughs mean we can now simulate complex physics on brain-inspired chips using 1,000x less energy than supercomputers. We're literally making silicon think like neurons to solve equations that used to require entire data centers. The Cambrian explosion...
March Hits 113°F, Shattering Record by 10°
Monthly heat records being shattered by an unheard of 10 degrees beyond previous record —> 113F. In March.
Everyone's Busy with Themselves; Focus on Your Goals
The truth: No one is thinking about you nearly as much as you think. They’re busy thinking about themselves. So stop comparing, stop worrying about their opinions, and focus on your goals. https://t.co/zANCRSir4l
Turn Chaotic Calendar Into Clear Schedule in 5 Steps
What if your calendar felt like clarity instead of chaos? That’s 5 steps away. https://t.co/NSN09jpDaQ
Systems Aren’t Limits—They Unlock Freedom, Rest, Joy
I've been QUIET on here, I know. I'll share what I've been up to over the past few weeks, but for now, what I'll share is this: Most people perceive systems as restrictive or constraining...but for me? Systems are the...
Pete Wells Discusses New “Raisin D’etre” With Mikie Barb
.@pete_wells has a new raisin d’etre. A fun and meaningful conversation between the former food critic and @mikiebarb https://t.co/qrGi7STP3n
Redirect Misbehavior Calmly: A Psychologist’s No‑Power‑Struggle Trick
A child psychologist trick: how to correct behavior without turning it into a power struggle
Art at Sainsbury Centre Confronts Atrocities, Seeds Hope
Art confronting atrocities – there are Seeds of Hate and Hope at the Sainsbury Centre, Norwich. Read my full review of the show for @worldofFAD and plan your visit now >> https://t.co/42EKWqXivh #LondonArtCritic https://t.co/SbRSWU7ceI
Discipline Is Self‑respect: Choose Future over Now
Your entire life will change the day you realize discipline is the highest form of self-respect. It’s choosing what you want most over what you want now. It’s keeping your word. It’s an act of service to your future self.
Single Rapamycin Dose Boosts Brain Glucose, Cuts Synaptic Density
Single-dose rapamycin increases brain glucose metabolism but reduces synaptic density in Long-Evans rats [One week after intraperitoneal administration of rapamycin (8 mg/kg) 👨⚕️] https://t.co/6JhcZYS01h https://t.co/wruacgIvFM
No Agenda, Pure Value: The Secret to Viral Growth
This account happened by accident. I was bored on an airplane in 2021, randomly decided to start posting, and it has completely changed my life. What was the strategy, and why did it work? For a very long time I had no idea,...
Stop Overthinking, Publish Content Instantly
Improv rule “Don’t Think” translates into “ don’t let overthinking keep you from creating content” Day 2 of my 75 day challenge, filmed at the Hearthstone castle on the Ives Trail in Fairfield County, designated as one of the most...
75‑Year‑Old
An intriguing case of “exceptional resilience” against dementia A 75-year-old man free of dementia despite a dominant Alzheimer’s mutation — and a possible hint for the rest of us https://t.co/lWn9gCKrEm https://t.co/jq0L2NtZ27
Engineering Smarter, Healthier Babies Through Embryo Selection
The man engineering smarter, healthier babies before they're born: Jonathan Anomaly. This philosopher-turned-biotech founder says the future of your child's health starts at the embryo. Here are 9 things you need to know about embryo selection: https://t.co/XVQF5le4bE
Exploring Perceptual Diversity at SXSW Panel and Award
Off to @sxsw for a panel on "perceptual diversity: art and neuroscience in design (Mon 16th, 4pm, Marriott Downtown, https://t.co/FFxuhtbxos), & then the @berggruenInst Essay Prize Award Ceremony (Tue 17th, 6pm, The Line, https://t.co/tYxorhMatq) ⭐️
Multidimensional Resilience Boosts Workplace Thriving
#Webinar Resilience at Work: a multidimensional approach to thriving at work @ABPsychologists https://t.co/y1LNMfu5K0 #HCM #HRM #HumanResources #HRTech #CHRO #FutureofHR
Insulin-Like Peptide Trades Combat for Survival in Beetles
Insulin-like peptide has antagonistic pleiotropic effects on male combat traits and survival traits in an armed beetle https://t.co/7Re0I2vcDW
Front Rack Lunges & Snatch Grip RDL: Underrated Man Makers
In a world of never ending variants… 1. Front Rack Reverse Lunges 2. Snatch Grip RDL/Deadlift Getting Slept on, dare I say it “man makers”.
Epic Type7 Rally Celebrates Luftgekuhlt Culture in Chiba
Dream day on the @type7 rally to @themagarigawaclub 🏁 Thank you to roundcatracing, luftgekuhlt and @pectokyo for your organization and support of this epic day in Chiba prefecture. Once in a lifetime to share this week together in celebration of luftgekuhlt...
NewBridge Newcastle: Beyond a Simple Third Space
More than just a third space. I've written about the NewBridge project in Newcastle for @worldofFAD https://t.co/ojM6hSw2Ub
Choose Growth or Pay—If Neither, Move On
My best career advice when you’re starting out: At every job you should either learn a lot and grow or earn a living. Either is okay. Both is ideal. But if you’re doing neither, look for a better opportunity.
Finding Calm After Fashion Frenzy with Custom Silver Spoons
Despite the visual overstimulation of the past three weeks of fashion shows, presentations, showroom re-sees, I still found myself seeking something beautiful to calm my mind once back. So I went to moukimoulondon and these thaliamariasilver spoons did the trick....
Travel Reveals Hidden Realm Within the Landscape
✨ Latest Digest: "During my recent journey through Northumberland and the Highlands of Scotland, the intangible qualities of place came so near that, alongside the visible and the manifest, I felt myself entering something parallel - another realm.." https://t.co/SUoJGbKuTK https://t.co/U8tQMZDHAg
Prioritize Core Work, Protect Time From Distractions
Your calendar should reflect what truly matters. Not everyone else’s urgencies. ⏳ Too often, we fill our days with meetings, requests, and “just one more thing” until the work that actually matters gets buried. Real productivity begins when you clearly define...
Embrace Your Unique God‑Given Design, Not Others' Lives
Stop trying to be someone else. God made you ACCORDING TO YOUR KIND. Your calling is unique. Your design is unique. Your assignment is unique. Are you trying to live someone else's life, or are you walking in YOUR unique design? The Life Audit 👇 shows...
Clarify Your WHY, Unlock Confidence and Action
At the Discover Your WHY session, participants explored the deeper purpose behind their work, decisions, and goals. Because when your WHY becomes clear, direction, confidence, and action follow. Here’s what some of them had to say. ✨ [business coaching India] [discover your...
Simplify Productivity with the COD Framework
If productivity feels overwhelming, it’s usually because the system is too complicated. The truth is, a great productivity system should simplify your life, not add more stress to it. That’s where COD (Collect, Organise, Do) comes in. A simple framework that helps you: ✔...
St. Vincent’s SXSW Mashup Makes Bodies Levitate
In her SXSW DJ set St. Vincent dropped “Berghain” into “Idioteque” and my body hasn’t levitated like that in a while