Engineered Astrocytes Use CAR‑A to Remove Amyloid Plaques
New @ScienceMagazine Engineering the brain's astrocytes to clear amyloid plaque! "CAR-A," in mouse model https://t.co/u9zJGnCLUj https://t.co/eIrrFx7iTg https://t.co/x56FDtuVW2
Shift Energy, Not Intensity, for Faster Swim Gains
Breakthrough Swimming is today's topic on Endurance Essentials The key thing I want to highlight is the need to shift total energy, not additional intensity, towards your swim program In the short-term requires you to back off with your other sports Big picture:...
Perfect Motherhood Doesn't Exist; You’re Already Enough
Motherhood rarely looks perfect. But that doesn’t mean you’re doing it wrong. 🤍 Some days feel beautiful. Some days feel messy. Some days feel exhausting. And that’s normal. Social media shows the highlights… but real motherhood also has sleepless nights, messy homes, and emotional days. If you are...
True Self Lies Directly Within—No Path Required
‘The Pathless Path is the apparent journey you take from the person you seem to be to that which you truly are. In fact, there is no distance between the person you seem to be and that which you truly...
Escape Algorithmic Tyranny with Marginalian’s Human‑Centred Newsletter
For an act of resistance to the tyranny of algorithms, try the Marginalian newsletter—undistracted notes on the search for meaning, free, ad-free, AI-free, fully human since 2006: https://t.co/8ApDA5YPF6
Injuries Add Mental Barriers—How to Overcome Them
It reaalllyyyyy sucks to get injured when you’re lifting. Because you’re trying to take care of your body, so it can feel like your body is revolting or not cooperating. And when it’s already challenging to show up, an injury or tweak...
Motherhood's Hidden Mental Load: Exhaustion, Guilt, and Resilience
Nobody prepares you for THIS part of motherhood ♥️ Not the cute photos. Not the baby milestones. But the mental load. The silent tears. The guilt for resting. The exhaustion you don’t talk about. Motherhood is beautiful — but it is...
Runners Swear By OOFOS Sandals for Recovery
Thoughts on OOFOS sandals? I have a lot of sandals but the more I talk to runners, the more they swear by them
Aging Cells Harbor Protective Mutations That Inspire New Drugs
We're chock full of somatic mutations in our cells and tissue as we age. Some even protect us from disease! And we can learn from them to discover new medications. @CellCellPress https://t.co/mnUsarpYoR https://t.co/4c5XOD7NuC
Four‑Minute Black Truffle‑Morel Omelette Lunch Delight
My 4 minutes-delicious lunch in 4 pictures: Black truffle-morel omelette. Thank you lebernardinny Team egestel68 for spoiling me 🙏
Iran War Exposes Fossil Fuel’s Hidden Global Costs
On The Climate Brink, my latest post is on what the war in Iran tells us about the hidden costs of fossil fuels https://www.theclimatebrink.com/p/the-war-in-iran-shows-us-another
AI Generalist Excels Across Diverse Medical Imaging Modalities
Can an AI model be a generalist to work and perform well for all types of medical images? Just published, our MedVersa paper @NEJM_AI Led by @pranavrajpurkar Free access https://t.co/5llNf94hAF https://t.co/Bf01zUZ1sk
Discover Your Boundless Home Through Awake Awareness
Meditation: Inhabiting Awake Awareness (21:49) 💕🙏 This meditation begins with collecting attention with the breath, and awakens us to the experience of aliveness and inner space by scanning the body. We then open to receive all the senses in awake...
AI Novel Apps Are Gimmicky, Not Creative Boosts
Every week, someone asks me to promote their “AI for novelists” app. I decline them all, and if the main function is to generate the text/story, I die a little. But I’m genuinely curious: is anyone finding these apps helpful? Not...
Yamanaka Stem Cells Earn Conditional Approval for Heart and Parkinson's
20 years of Yamanaka stem cell factor research culminates in 2 conditional approvals for heart disease and Parkinson's disease in Japan https://t.co/8oxKxXYafu by Shinya Yamanaka @CellStemCell https://t.co/U878IxSfSi @ScienceMagazine https://t.co/HCCPaTEP7e
Fuel Yourself, Inspire Others: Self‑care Wins for All
You’re fueling for your health AND performance, yes. But you’re also inspiring runners around you to take care of themselves. Last year a runner came up to me at the finish line to thank me for reminding her to fuel during...
Morning Sun, Exercise, Caffeine Trim Daily Cortisol Spikes
One of the most overlooked benefits of morning bright (sun)light, exercise & caffeine is how it reduces the duration of any cortisol peaks in response to stress (should they happen) later in the day… and it’s ability to reduce nighttime...
Check Melanotan Results First; Prefer Sunlight over Peptides
Before you bullish-on-peptides folks inject melanotan, make sure you do a web search to look at some before and after photos…! Here is a case where unless there’s a *real clinical need* I highly recommend you intelligently use sunlight instead.
Western Medicine Meets Eastern Practices for Stress Resilience
Quickly becoming one of our most popular episodes ever. Merges western medicine (guest is practicing MD) and eastern practices for brain, plasticity, long duration stress resilience. @HealthyGamerGG on Huberman Lab podcast out now:
800m Blends XC Speed; 400m Pure Sprint
Just answered a question about 400-800 training. Generally speaking, the 800 is a hybrid race where fast XC runners are elite 800 runners. The 400 is a sprint where the fastest sprinters are the fastest 400 runners. (200 PR x2...
Show Characters' Inner Worlds: Practical Steps for Interiority
Some readers asked me how to practically add interiority to fiction. So, I wrote a post on it that is probably writing 101 for many but hopefully of interest to others: https://countercraft.substack.com/p/the-view-from-inside-on-adding-interiority
Explore Continuous Glucose Monitoring for Athletic Performance
NEW webinar on Continuous Glucose Monitoring in sport. Register for the webinar and learn about this fascinating technology. https://t.co/w7k7zUSoOY https://t.co/JqfK90gkGN
Reading Goals: Diversity Over Competition
Last year was STACKED 📚 Grateful to be featured in @guardian chatting all things reading goals, particularly the importance of reading diversely and only competing with yourself Photos by misskatiepeters Words by @emmalofty Clothes by cathcartlondon
Lead Confidently Under Pressure: Decision‑Making Mastery
We’ve all faced those moments—when the pressure is on, and your team is looking to you for direction. How do you stay calm? How do you make the right decisions when it matters most? At a live event with LinkedIn...
LA Art Gold Rush Ends, Future Market Uncertain
The Art World’s Los Angeles Gold Rush Is Over. What Comes Next? My latest column on @artnet @artdetective @friezeofficial #artmarket https://t.co/E8tNfMFfwX
First National Book Ban Targets Trans Youth, Act Now
I wrote about the first national book banning bill, which effectively seeks to erase trans people. At the end I include a link to let your reps know that you oppose this bill and all it stands for. https://lithub.com/why-we-must-fight-to-stop-hr-7661-before-it-destroys-the-lives-of-american-children/
Prioritizing Donut Debate Over School PE Mandates
RFK/MAHA: dunkin donuts is the enemy... Also RFK/MAHA: still no mandatory daily physical education requirement in public schools... https://t.co/DxhEGNvCs0
Use Principles Over Formulas to Structure Your Story
Try searching for “how to structure a story” and you'll get a panoply of instructions: Hero’s Journey Three-act structure Save the Cat Snowflake method Freytag’s Pyramid Fichtean Curve What do you do with them? Tiffany Yates Martin advises: https://janefriedman.com/base-your-story-structure-on-principles-not-systems/
Knee Pain Signals Years of Inactivity, Not Surgery Need
The hardest conversation I have in my office isn't about surgery. It's about time. A 58-year-old sat across from me with knee pain. She’s otherwise healthy, but menopause has been rough on her. Her MRI shows some cartilage changes — age-appropriate,...
Bent‑over Rows Are Fading—
We don’t talk about the disappearance of the bent over row enough. 5 x 5 lunchtime today. https://t.co/SwES1NaMQh
Master Sodium Use: Decision Tree Webinar Guide
Join the webinar and walk away with a clearer understanding and a no-nonsense decision tree to guide when to use sodium, how to dose it, and when not to bother. Secure your spot: https://t.co/qvjELFGgfZ https://t.co/R3SCs3n4vx
Beyond Nautilus and Royal Oak: Exploring Other Perpetual Calendars
Perpetual calendars. Nautilus, Royal Oak, Overseas. The mainstays, but what else is there? 🥂🫶🏼 #piaget #jaegerlecoultre #iwc #hmosercie #perpetualcalendar
Sweat Sodium Varies Beyond Salt Intake: Diet, Rate, Acclimation
Is the sodium in your sweat simply a reflection of how much salt you eat? This blog explores why sweat sodium concentrations vary between and within individuals, and how factors such as diet, sweat rate and heat acclimation influence losses....
Supaspinal CNS Fatigue Key to Optimal Strength Training
Understanding how supaspinal CNS fatigue works during exercise is essential to optimal strength training programming. See more in this week's free Patreon article. https://t.co/s5U5Z5gR8G
Project Hail Mary: Visually Spectacular, Hopeful IMAX Must‑See
#ProjectHailMary is a beacon of happy, feel-good hope when we all need it the most. Might be the most visually spectacular film this year. A towering achievement & a must see in IMAX. Greig Fraser’s cinematography & Daniel Pemberton’s score...
Kundera Explores Life’s Ambivalence and Love’s Uncertainty
How do we know what we want – Milan Kundera on the central ambivalences of life and love https://t.co/YiTk12J73j
Success Comes From Easy, Gradual Running, Not Overtraining
Running improvement isn’t complicated. But most beginner runners make the mistake of doing too much too soon. Running every session hard. Increasing mileage too quickly. Ignoring strength training. The best runners build fitness the opposite way. Mostly easy running. Gradual progression. Consistent training. Do that long enough and performance...
Child's Night Sleep Reveals Hidden Neurodivergent Signals
How your child sleeps at night tells you more than their daytime behavior ever will. This is exactly what I break down inside my Neurodivergent Kid Sleep Mini Course: the root causes, the red flags, and what to actually do next. Comment...
Self‑Endorsed Goals Turn Pressure Into Victory
Alysa Liu’s comeback is a great example of psychology’s overjustification hypothesis. When something you love becomes dominated by external pressure, rewards, and expectations, you lose your autonomy, and it loses its joy. So she retired. That’s why when she decided to come...
Introduce High Schoolers to Aging Careers Early
Is it time to start exposing high schoolers to the aging/longevity field: basic reasons it's important & a worthy potential career area? High schools have career days where adults jobs & careers. I just did a 1hr intro to aging &...
Ackermann Reimagines Business Suit with Playful Contrast Collars
Haider Ackermann was cooking with these contrast collar dress shirt and tie combos A genuinely fun riff on a business suit classic without being too literal https://t.co/sm92AqPlK6
Snoring & Couch Sleeping Ruin Couple Sleep—Find Fix
Snoring isn't cute. Neither is sleeping on the couch. Save this for your partner 🫶 Comment SLEEP FIX and I'll send you the solution 👇 #SnoringProblems #SleepFix #CoupleGoals #SleepApnea #SleepDoctor
Stay in Performance Mode, Measure Meaningful Progress
Don’t go through the motions in training. Tired is the enemy. 💥 Perform in practice 💥 Never drift from a state of performance. 💥 Measure meaningful things to make meaningful things more meaningful. 💥 Record, Rank, Publish 💥 Self-awareness ➡️ Self-improvement...
Protein From Food Beats Supplements—No Hot Take Needed
It shouldn’t be radical, controversial or a “hot take” to meet your protein needs from food and not supplements.
Great Ideas Bloom During Boring, Unproductive Moments
The best ideas I’ve ever had came when I was deeply, embarrassingly unproductive. Not in a “romanticizing laziness” way. In a “my brain needed to be bored to actually create something” way. The hustle content is lying to us and...
Buy Art After Silent Home Trial, No Distractions
There's so much noise around how art is presented these days both online and in person. Soundtracks, celebs, influencers, reveals, opulent interiors, extravagant blather, etc. But here's the deal: You can't take any of that home with you. It'll be...
Understanding Interoception: Reconnect with Your Body’s Signals
Have you ever heard of the word "interoception?" Interception is your body's ability to sense what's happening on the inside. Hunger, fullness, thirst tension, your heart racing... It's the system that tells you what your body needs. And for a lot of people...
Healthy Boundaries: ‘AND’ Means Growth, Not Control
Reflect on the nuance here. The “AND” is not an invitation for control. We have to check ourselves and get curious. The AND is about healthy, integrated boundaries that are designed for the relationship’s health, healing, and expansion. #mindfulmft
Weasel Wisdom: Annie Dillard's Guide to Living
What a weasel knows that we forget – Annie Dillard on how to live https://t.co/bZ2czI9bc3
Greek Tragedy Meets Australian Outback in Stedman's Novel
M.L. Stedman’s new novel feels like a Greek tragedy transplanted to the Australian outback. My review of “A Far-Flung Life”: https://roncharles.substack.com/p/ml-stedman-is-back-with-another-impossible