Genetically Switched Microbes Aim to Cut Synthetic Nitrogen Use
Nitrogen fertilizer feeds 4 billion people. It also uses 2% of global energy to produce and loses nearly half of what's applied to runoff. Biology has promised a fix for decades. The problem: engineered microbes that make nitrogen can't also compete to survive on plant roots. They burn their energy on one or the other. @SwitchBioworks solved it with a genetic switch. Microbes colonize first, establish themselves, then flip on nitrogen production. Their target: replace 25% of chemical nitrogen at yield parity, at a manufacturing cost of $1 per acre at scale. Tim Schnabel, @Forbes 30 Under 30 and founder of Switch Bioworks, presents at SynBioBeta 2026, May 4-7 in San Jose. @SynBioBeta 2026 is May 4-7th in San Jose, California, you can learn more about the conference and get your tickets here: https://t.co/8abYWJ1GbK
Take Time to Nourish Your Mind And
What have you done to nourish yourself? Take time for yourself. 🧡 #TuesdayThoughts #JoyTRAIN #health #selfcare #mentalhealth #stressless #WellnessJourney https://t.co/UAAJcpQpYO
New Trailer Reveals AI Consciousness Thriller ‘A.I.’
New Trailer for AI Consciousness Sci-Fi Film 'A.I.' with Josh Stamberg https://t.co/vQCLlW6JUl #scifi #AI #JoshStamberg #IanSharkey #ArtificialIntelligence https://t.co/kYbBJz8wQX
Three Glute Days Outperform Mixed Leg‑Glute Sessions
In this reel I explain why I program the way I do for my Booty by Bret app, and why I think three Glute days is better than a quad, ham, and glute day. To me, it’s very obvious. Even if...
Deep Cuts for 2026 Hall of Fame Inductees
my deep album cut playlists for the rock & roll hall of fame class of 2026: phil collins https://t.co/c3ceORsBaD billy idol https://t.co/Brr3yT5LCK iron maiden https://t.co/DTh3oaMM2o mc lyte https://t.co/nrBv0TD2TH new order https://t.co/rU2vxwJOrJ
Sar
Hassett: So sorry your life is more expensive. But Midland is about to get another Rolls Royce dealership, so it all works out.
Identifying Gaps in Longevity Philanthropy Landscape
What philanthropies are missing from longevity science and medicine? Is the ecosystem of foundations and nonprofits actually complete, or are there glaring gaps no one’s filling? Drop your essay (or a one-liner) below. ✍️ Or repost. 👨🏻⚕️⚕️ https://t.co/46hZGxnIQx
Grunge‑Era Memoir of Hampshire College’s Hallowed Halls
Hampshire College, Rest in Slack.. My memoir of my grunge era youth in its hallowed halls.. https://t.co/zu3RspX5jK
How We Release Consciousness Shapes Reality and Morality
"The choice we make of how we dispose our consciousness is the ultimate creative act: it renders the world what it is. It is, therefore, a moral act: it has consequences." Superb read: https://t.co/4ta2eRQ0ez
Long Hours Don't Equal Founder Freedom
Hustle ≠ Freedom Working 80-hour weeks doesn't make you a founder. It makes you an employee of your own company.
Black Instantly Upgrades Any Room’s Luxury Feel
Most people are terrified of using black in their home. They think it’ll feel dark, heavy, or like they’re living in a cave. They’re wrong. Black is the single fastest way to make any room look more expensive and more...
ADHD Flips Focus: Chaos when You Need Calm
ADHD in a nutshell: My brain during a day when I really need it to focus: ".... please leave a message at the sound of the tone ..." My brain randomly on a weeknight at 11pm, as I'm trying to sleep: "Here...
GLP‑1 Drugs Show Weight‑loss‑independent Benefits, Study Finds
Great work by @DanielJDrucker and team; biologically plausible mechanism of GLP1-RA benefit independent of weight loss. Excellent article by @megtirrell @CNN describing the publication. Could it justify new approaches for these drugs? I think so. https://t.co/pHudk7lkAR
Fight-or-Flight Narrows Perception to Threat‑only Filter
Your nervous system is your filter for reality. When in fight or flight, your energy is narrow, rigid, and hyperfocused. You can only "see" what's delegated by your threat response. Your awareness cuts off everything that isn't "useful."
Aging May Be a Software Issue, New Primate Study Shows
Cool new paper: Cellular aging biomarkers in primates - increasingly supportive of aging being a software problem But what kind of software? And can an update be reinstalled? 🧵 https://t.co/1CKLNtHwZ4
Train to Absorb Force, Not Just Deliver Power
Understand physics. When you impact a bag or person you absorb the same force. Newton’s 3rd law- Every action has an equal and opposite reaction. This is a teeny bit different based on if you’re hitting a soft bag or a...
Mixed Metals Transform Morning Coffee Ritual
MIXED METALS My morning triple macchiato is a ritual, a quiet pause before the day begins. I’ve always been drawn to mixed metals for the beautiful tension they hold. Stainless steel reads crisp and exacting, brass softens with warmth and depth....
Questioning Kids' Behavior vs My Overstimulation
My morning mantra: “are my kids actually doing anything wrong / being annoying or am I just overstimulated?”
Retirement Needs Purpose, Not Just Money Planning
Most people plan their finances for retirement… but forget to plan their life. And that’s where the real struggle begins. Purpose doesn’t just appear—you design it. 👉 Learn how to build a meaningful retirement. Enrol today. https://t.co/Rc3LUwe2Ys https://t.co/936Rcwe5RH
Success Isn’t a $1M Target, It’s Personal Goals
Every time a client tells me they want to hit $1M in revenue, I casually ask why. Why THAT number? *Usually* no math was done to get to that number, it just sounded good. Seemed reasonable. Makes them a 7...
New Trailer Reveals Attenborough’s Epic Life on Earth Journey
Doc 'Making Life on Earth: Attenborough’s Greatest Adventure' Trailer https://t.co/UdVOBAzKJj #docs #DavidAttenborough #LifeonEarth #MakingOf #GreatestAdventure #BBC https://t.co/nhp53xiXh0
China's Wind Tunnel Delivers Real Flight Sensation
Experience Real Flight Without Wings in China’s Wind Tunnel by @tweetciiiim #EmergingTech #Technology #Innovation https://t.co/NMdB8FWINg
Breast Milk’s Living Stem Cells May Reach Infant Brain
Breast milk contains living stem cells. In animal studies, these cells survived digestion in newborns, entered the bloodstream, and were found in multiple tissues including the brain. Whether this happens in humans is still being studied, but the animal data...
25 Years of Automated Science: Ross King’s Future Vision
What I’ve learned from 25 years of automated science, and what the future holds: an interview with Ross King https://t.co/ptzfGTRXsX
Google Invites Proposals for Early Willow Quantum Access
@GoogleQuantumAI is currently accepting proposals for early access to the Willow quantum processor. This hardware is not yet publicly available, so this a notable opportunity for research groups looking to run experiments on state-of-the-art superconducting quantum hardware.
Better Forecasts Cut Heat‑related Deaths Significantly
Really cool paper on the value of improved weather forecasts for reducing heat-related mortality. https://t.co/AegtRfLJnR
Avoidance Costs More Than Effort; Seek Alignment
Avoidance is expensive. Not immediately—but over time. You can keep earning, investing, and moving forward and still feel unclear, because the issue isn’t effort. It’s alignment. Wrote about where that changes.
Classic Lymphadenopathy Differential Diagnosis Table Highlights Key Features
Lymphadenopathy [2000] Habermann & @DavidSteensma @MayoProceedings https://t.co/56RvIsHEG3 <- a classic esp DDx Table 3 #lymsm #hemeonc https://t.co/PlvEKQVoiG
Danna And
Danna and @luisasonza on the show this morning… going live in 30 let’s gooo https://t.co/4bdr4A5q06
Co-Lead December Moose Photography Workshop in Tetons
ANNOUNCEMENT: I'm helping co-lead a new wildlife workshop in December, photographing bull moose in the Tetons - just added to the calendar, December 3-6, 2026 👇 https://t.co/Xz5WKnrtoK https://t.co/NHsp8lEABr
Unexplained Splenomegaly Study Reveals Preliminary Findings
The Challenge of Unexplained Splenomegalies: Preliminary Data of the French Prospective Multi-Center Splenomegaly Study (SMS) [Nov 29, 2018] Guillaume Denis, MD etal. @BloodJournal 32 (Supplement 1): 4815 #ASH18 https://t.co/N0PeoI1agT #SMUS
Living Confidently in God’s Validation, Not Others’ Approval
I’m no longer looking for validation on what God has already validated. I’m not second-guessing what I was called to do. I’m not shrinking to make others comfortable. I’m not explaining myself to people committed to misunderstanding me. God already approved me. God already equipped...
Podscan Turns Podcast Mentions Into Instant Book Recommendations
Oooh, big use case for Podscan, and one that intersects my two favorite pastimes: reading and podcasts. Check out Simon's Podshelf, this is a genius approach to trans-media-referencing. Extracting book recommendation as soon as they're mentioned on shows.
Author’s “Age of Extraction” Shortlisted for Donner Prize
Happy to say that my book "the Age of Extraction" has been short-listed for The Donner Prize -- award given to best public-policy book by a Canadian (I'm a dual-citizen) https://t.co/iV3sumzR7F
Lin-Manuel Miranda Announces Star-Studded Octet Cast
Lin-Manuel Miranda’s ‘Octet’ Movie Musical Sets Cast: Amanda Seyfried, Rachel Zegler, Tramell Tillman and More https://t.co/5hbSiDAuZs via @variety
Stop Avoiding: True Clarity Begins with Facing Reality
Avoidance doesn’t look like failure. It looks like progress that doesn’t feel right. Clarity starts when you stop avoiding where you are.
Ask Deeper Questions, Build Stronger Friendships
Want deeper friendships? Ask deeper questions. As Angela Haupt reports in @TIME, not defaulting to small talk with friends can create greater connection. And it doesn’t require a big change: just ask one deeper-than-usual question in your next conversation with a...
Red Plaid Tie Habit Fuels $30B Hedge Fund
Who wore the same red plaid tie every day — and built a $30 billion hedge fund on 3am wake-ups?
Mass Alone Determines Planets, Stars, and Brown Dwarfs
Everything in the Universe changes by adding enough mass What sets the dividing line between rocky planets, gas giants, brown dwarfs, and stars of different colors and lifetimes? One parameter alone, mass, explains almost all of it. https://t.co/I3pkaf2lX7
Real-World Data Reveal Molecular Profile of Metastatic ILC
Molecular Characterization of Patients with Metastatic Invasive Lobular Carcinoma: Using Real-World Data to Describe This Unique Clinical Entity [Sep 10, 2025] Davis et al. @CCR_AACR https://t.co/eY0etUfQhQ #bcsm #PrecisionMedicine #camoldx @TempusAI https://t.co/oDkC1Ua6DS
PurIST Classifier Validated for Pancreatic Cancer Therapy
Real-World Validation of the Purity Independent Subtyping of Tumors Classifier for Informing Therapy Selection [PurIST @TempusAI] in Pancreatic Ductal Adenocarcinoma [Sep 4, 2025] @stephwen et al. @JCOPO_ASCO https://t.co/R24DErvaB4 #pancsm #PrecisionMedicine https://t.co/40LqNDQJHo
Somatic Immune Cell Mutations Linked to Autoimmunity
New evidence that somatic mutations in immune cells can be the basis for autoimmune disease @Nature https://t.co/GvzxLYgvfw
Create Your Own Path as Systems Lag Behind
I recently came across my new favorite Latin phrase: “Aut viam inveniam aut faciam.” I will find a way, or I will make one. It's a perfect description of the life philosophy I've had long before I had language for it. As a rambunctious...
Iron Deficiency Anemia Often Triggers Thrombocytosis
Thrombocytosis in Iron Deficiency Anemia [Nov 28, 2018] @hemen_712 et al. @BloodJournal https://t.co/BCqznWwhki #hemeonc #anemia
RUNX1 Identified as Key to Rejuvenate Aging T Cells
Discovery of a factor (RUNX1) that pinpoints T cell senescence and restoring its functionality achieves T cell rejuvenation. Significant implications in older adults with loss of immune system protection. https://t.co/X58DvzIUXY @ImmunityCP https://t.co/hzL3zFiPMm
Managing Managers Requires Different Rules Than Managing Teams
Going from IC to manager is hard… But becoming a manager of managers is next level. You’re no longer managing the work. You’re managing the people who manage the work. Throw your vanilla management advice out the window. Instead, focus on these...
Stop Pleasing All, Start Being True to Yourself
When you stop trying to become everything for everyone, you will become something for yourself.
Flying Still Means Two‑Hour Drive From Norfolk
Just saw the new Abbott Elementary with Greg and Janine fighting about how to get to the Outer Banks (by plane or driving) and I want to reassure them that they will both be the winners here. The closest major...
GLP‑1 Receptors Protect Liver in Mouse MASH Model
Adding to the GLP-1 drug weight-loss independent effect benefit : impact on liver sinusoidal endothelial cell GLP-1 receptors for liver protection in mouse MASH model @Cell_Metabolism @DanielJDrucker @ChusaGzlzRellan https://t.co/0A13QYgm05
Imposter Syndrome: Old Self Battling Your Evolving Identity
Your "imposter syndrome" is just: Your old identity fighting your new one. The person you were can't comprehend who you're becoming. Destroy the old self or stay stuck.