Blog•Dec 20, 2025
Open This Before Jan 2
The episode highlights the rare, distraction‑free period between Christmas and New Year’s as an ideal time to decide whether to ship a real AI product in the coming year. It outlines a two‑part learning path—a free 10‑hour LLM Primer and a full‑stack AI Engineering course—designed to give listeners practical judgment on prompting, retrieval‑augmented generation, evaluation, and agent use, then guide them to build and deploy a production‑grade LLM pipeline. The host emphasizes that completing this bundle by Jan 2 will turn holiday resolutions into tangible proof of capability, positioning listeners to start 2026 as effective AI engineers rather than just theorists.
By Louis Bouchard
Blog•Dec 20, 2025
🧠 Community Wisdom: What PMs Need to Master in the Age of AI, Testing Product Activation with AI Browsers, Splitting...
The episode explores how product managers must adapt to AI, covering practical uses like testing product activation with AI-driven browsers and balancing traditional PM responsibilities with prompt engineering. It compares analytics platforms Mixpanel and PostHog, highlighting strengths and trade‑offs for...
By Lenny Rachitsky
Blog•Dec 19, 2025
November 2025 Patent Highlights
The November 2025 Patent Highlights post serves as a gateway to Drug Hunter’s most‑read resources, including top‑10 lists of popular articles, reviews, and case studies from the year. It spotlights a detailed review of FcRn biology and the push toward oral...
By Drug Hunter
Blog•Dec 19, 2025
Dismantling Defenses: Trump 2.0 Cyber Year in Review
The Trump administration’s 2025‑2026 policy agenda has dramatically reshaped U.S. cyber, privacy and law‑enforcement priorities. New directives such as NSPM‑7 and a FBI cash‑reward program broaden the definition of domestic terrorism to include political dissent, while travel‑screening rules force tourists...
By Krebs on Security
Blog•Dec 19, 2025
Criminal IP and Palo Alto Networks Cortex XSOAR Integrate to Bring AI-Driven Exposure Intelligence to Automated Incident Response
The episode announces the integration of AI‑powered threat intel platform Criminal IP into Palo Alto Networks’ Cortex XSOAR, enabling real‑time exposure intelligence and multi‑stage scanning within automated playbooks. It explains how this AI‑driven enrichment—covering IP/domain behavior, port exposure, CVE links, and SSL...
By Security Ledger
Blog•Dec 19, 2025
Number of the Day - $100m Private Investment
Surgical‑robot pioneer Fred Moll has committed roughly $100 million of personal capital to a portfolio of about 15 early‑stage medical‑technology companies. His investments target robots for brain, eye, gastrointestinal, cardiac and blood‑collection procedures, including stakes in XCath, Neptune Medical, ForSight Robotics,...
By SurgRob
Blog•Dec 19, 2025
Together, We Can Make 2026 a Turning Point for AI
In this episode, Daniel Barcay hosts Ethan Mollick and Molly Kinder to dissect AI's real‑time impact on the labor market, separating hype from data‑driven realities. They highlight emerging risks—such as job displacement and erosion of human connection—while emphasizing that policy...
By Tristan Harris
Blog•Dec 19, 2025
Is Zendesk Building a Glean Competitor with Its Unleash Acquisition? Not Exactly, But Here’s What’s Really Happening
Zendesk announced the acquisition of Unleash, an Israeli AI‑powered enterprise search startup with more than 70 connectors, to embed permission‑based retrieval‑augmented generation (RAG) and AI agents directly into Slack and Microsoft Teams. The move targets internal employee‑service workflows—IT, HR, and...
By SaaStr
Blog•Dec 19, 2025
Dr. Vinay Prasad “Called For” RCTs. Dr. Peter Marks Delivered Them.
Dr. Vinay Prasad claims he was among the few who called for randomized controlled trials (RCTs) of COVID‑19 vaccines, yet the blog argues that it was his predecessor, Dr. Peter Marks, who actually designed and executed the pivotal trials that...
By Science-Based Medicine
Blog•Dec 19, 2025
News Alert: INE Expands Partnerships to Scale Hands-On Cyber Training Across Middle East, Asia
INE Security announced a strategic expansion across the Middle East and Asia, adding new academy partners in Saudi Arabia, the United Arab Emirates, Egypt, and other high‑growth markets. The company’s subscription‑based, hands‑on training platform—featuring unlimited virtual labs and the Skill...
By The Last Watchdog
Blog•Dec 19, 2025
Wolfram Automattica
Stephen Wolfram has joined Automattic as a special advisor, bringing his computational expertise to the WordPress ecosystem. Wolfram, known for the Wolfram Language and the knowledge engine behind Wolfram|Alpha, has been engaging with Automattic teams since early 2024. The partnership...
By Matt Mullenweg
Blog•Dec 19, 2025
👾 Universal Basic Income Focuses on Stability Not Replacing Work
The article argues that universal basic income (UBI) is a stability floor, not a plan to replace work, especially as AI accelerates job insecurity. It cites forecasts that 22% of jobs could be disrupted by 2030 and that up to...
By Matthew Berman
Blog•Dec 18, 2025
GOP Lawmakers Ask RFK Jr. To Make FDA Unleash Risky Peptides Like BPC-157
GOP Representative Diana Harshbarger, a pharmacist, wrote FDA Commissioner RFK Jr. urging the agency to use enforcement discretion to loosen restrictions on six unapproved wellness peptides, including BPC‑157 and CJC‑1295. The request echoes a similar appeal from Senator Tommy Tuberville, signaling...
By The Niche
Blog•Dec 18, 2025
Targeting NLRP3: DFV890 and Beyond
The article reviews the NLRP3 inflammasome inhibitor DFV890, highlighting its Phase 2 data in acute coronary syndrome and its mechanism of selectively blocking NLRP3 activation. It also examines emerging NLRP3‑targeted programs, including covalent inhibitors and PROTAC degraders, and discusses the broader...
By Drug Hunter
Blog•Dec 18, 2025
ALS and the Market for False Hope
The post outlines ALS as a progressive neurodegenerative disease with no cure and only modestly effective drugs such as riluzole and edaravone. It highlights how multidisciplinary ALS clinics deliver the greatest survival benefit, while a booming market of unproven supplements...
By Science-Based Medicine
Blog•Dec 18, 2025
How Caption Strategy Can Triple Your Video Views
A well‑crafted caption strategy can boost video views up to three times by turning scroll‑stoppers into engaged viewers. The article outlines how short hooks, clear benefits, story‑based lines, and direct calls‑to‑action guide emotions and prompt interaction. It stresses systematic testing...
By Lilach Bullock’s Blog
Blog•Dec 18, 2025
How to Diagnose and Fix Google Maps Ranking Drops
The guide outlines a step‑by‑step framework for diagnosing sudden drops in Google Maps visibility for a Google Business Profile. It teaches marketers how to confirm a real ranking decline using Insights, GA4, Search Console, and local rank‑tracking tools. Once verified,...
By Moz
Blog•Dec 17, 2025
What Is an Influencer? A Guide to Influencer Marketing
Influencer marketing has become a core growth channel, with 92% of consumers trusting creator recommendations over traditional ads. The global market reached $30 billion in 2025 and is projected to exceed $120 billion by 2030. Brands of all sizes, including B2B, are...
By Neil Patel
Blog•Dec 17, 2025
Securing the Road Ahead: The Intersection of Cybersecurity and Intelligent Transportation
The blog highlights the growing convergence of cybersecurity and intelligent transportation, emphasizing that autonomous vehicles and connected infrastructure are becoming "data centers on wheels." It outlines three core risk areas—V2X communication vulnerabilities, AI‑driven sensor attacks, and infrastructure resilience—and presents strategic...
By Erdal Ozkaya’s Cybersecurity Blog
Blog•Dec 17, 2025
Mirdametinib (PD0325901)
Springworks Therapeutics and Pfizer announced FDA approval of mirdametinib (PD0325901), an oral, brain‑penetrant MEK1/2 inhibitor for treating neurofibromatosis type 1‑associated plexiform neurofibromas (NF1‑PN) in both adults and children. The drug was optimized from an earlier in‑vitro tool compound to improve potency...
By Drug Hunter
Blog•Dec 17, 2025
Top 10 Duct Tape Marketing Podcast Episodes of 2025
John Jantsch’s year‑end roundup spotlights the ten most influential Duct Tape Marketing Podcast episodes of 2025. The selected shows capture how small‑business marketers navigated rapid AI adoption, evolving privacy rules, and the rise of voice‑first search. Each episode delivers actionable...
By John Jantsch
Blog•Dec 17, 2025
Databricks Vs. Snowflake at $5B ARR: Same Revenue, 2x Valuation Gap. Here’s Why.
Databricks and Snowflake have converged at roughly $5 billion in annual recurring revenue, but Databricks is growing at over 55% while Snowflake trails at about 29%. The faster growth translates into a valuation multiple nearly twice Snowflake’s, driven by Databricks’ stronger...
By SaaStr
Blog•Dec 17, 2025
The Best Growth Tactics of 2025
The episode distills the top growth experiments of 2025, revealing that outbound/ABM, partner ecosystems, and events/community dominate despite AI hype, while tactics span content, PLG, launches, and paid ads. Readers shared 50+ real‑world tactics—from LinkedIn engagement outreach and intent‑based ABM...
By Kyle Poyar
Blog•Dec 17, 2025
SHARED INTEL Q&A: This Is How ‘Edge AI’ Is Forcing a Rethink of Trust, Security and Resilience
Edge AI is moving real‑time inference workloads from centralized clouds to embedded devices, demanding far greater compute, memory, and energy efficiency at the silicon level. Infineon’s Thomas Rosteck explains that this shift forces a redesign of trust models, embedding hardware‑root‑of‑trust...
By The Last Watchdog
Blog•Dec 17, 2025
Weekly TechBio News
The episode highlights four major tech‑bio developments: LatchBio’s launch of agent.bio, an interactive sandbox for spatial biology analysis across five platforms; Chai Discovery’s $130 M Series B raise to build an AI‑driven CAD suite for drug design, backed by OpenAI; Accenture Ventures’...
By Metaphysical Cells
Blog•Dec 16, 2025
News Alert: Link11’s Top 5 Cybersecurity Trends Set to Shape European Defense Strategies in 2026
Link11’s European Cyber Report identifies five 2026 cybersecurity trends that will reshape defense strategies across Europe. The report warns that DDoS attacks will increasingly act as diversion tactics, while API‑first architectures expose new misconfiguration and business‑logic abuse risks. It predicts...
By The Last Watchdog
Blog•Dec 16, 2025
Fenebrutinib (GDC-0853)
Fenebrutinib (GDC‑0853) is an oral, reversible Bruton’s tyrosine kinase (BTK) inhibitor that entered Phase 3 trials for multiple sclerosis in a November 2025 press release. The drug was discovered through ATP‑site‑directed compound library screening and subsequently optimized by Roche and Genentech. Its...
By Drug Hunter
Blog•Dec 16, 2025
UltraMarathonRT: When Your Reverse Transcription Must Go Long
RNAConnect has launched a new kit for Oxford Nanopore direct‑RNA sequencing that uses UltraMarathonRT, a group II intron‑derived reverse transcriptase. Unlike traditional AMV or M‑MLV enzymes, UltraMarathonRT is highly processive, can copy RNA longer than 30 kb, and works at a gentle...
By Omics! Omics!
Blog•Dec 16, 2025
The $7,500 Migration Fee That Just Cost a Vendor $80,000 ARR. Really, $240,000.
An $80,000 ARR SaaS deal was lost when the vendor imposed a $7,500 migration fee, pushing the contract into the following year. The author argues that such fees create friction, extending ROI timelines and giving incumbents a chance to retain...
By SaaStr
Blog•Dec 16, 2025
Most Parked Domains Now Serving Malicious Content
Researchers at Infoblox discovered that more than 90% of parked domains now redirect visitors to scams, malware, or unwanted software. The malicious redirects are triggered primarily for users on residential IP addresses, while VPN traffic often receives a harmless parking...
By Krebs on Security
Blog•Dec 16, 2025
Link11 Identifies Five Cybersecurity Trends Set to Shape European Defense Strategies in 2026
Link11 forecasts five cybersecurity trends that will shape European defense in 2026, highlighting a surge in DDoS attacks used as diversion tactics, growing exposure from API‑first architectures, and the shift toward integrated WAAP platforms. The report stresses that AI‑driven DDoS...
By Security Ledger
Blog•Dec 16, 2025
Klaviyo Adds Co-CEO To Get Back To Product. The Dream, But Does It Work?
Klaviyo announced a co‑CEO structure, pairing founder Andrew Bialecki with former Workday co‑CEO Chano Fernandez. Bialecki will focus on engineering, product, and AI‑driven vision, while Fernandez will lead go‑to‑market, operations, and finance. The company recently crossed $1.2 B in revenue run‑rate,...
By SaaStr
Blog•Dec 16, 2025
🧑🚀 UBI in the AI Age, U.S. Tech Dominance, & NVIDIA's Nemotron
Today NVIDIA unveiled the Nemotron 3 family of open AI models, featuring a hybrid mixture‑of‑experts design that promises higher throughput and lower inference costs, with the Nano version already available and larger variants slated for 2026. The company also signaled a...
By Matthew Berman
Blog•Dec 16, 2025
Cloudflare CMS Stats
Cloudflare’s Radar 2025 report examined the top 5,000 domains to map CMS usage. WordPress leads the open‑source segment with a 47 % share, while Drupal lags at 4.7 %. In the proprietary arena, Adobe Experience Manager accounts for 16 %, Contentful 8 %, and...
By Matt Mullenweg
Blog•Dec 16, 2025
The Bifurcation in the AI Market
The AI market is splitting into two distinct camps: open‑source models, which remain roughly 22‑25% of usage despite being 10‑100× cheaper, and proprietary providers that retain pricing power for high‑value workloads. Open‑source share held steady, briefly spiking to 35% during...
By Tomasz Tunguz
Blog•Dec 15, 2025
Unlock AI’s Hidden Power: Why This Simple Prompt Hack Gets You Better Results Every Time
In this episode, Christopher S. Penn explains why structuring prompts as "think, explain, then answer" yields better results than "think, answer, then explain". He reveals that because large language models predict each token sequentially, providing an explanation first gives the...
By Christopher S. Penn
Blog•Dec 15, 2025
GAS41 Revisited: A Chemical Probe
Researchers at the University of Michigan have refined a fragment‑based series into DLG‑41, a monomeric chemical probe targeting the YEATS domain of GAS41. The probe exhibits ~1 µM affinity by ITC and nanomolar potency in a NanoBRET cellular assay, confirming both...
By Practical Fragments
Blog•Dec 15, 2025
Patenting Strategies for Small Molecule Drugs
The article reviews patenting strategies for small‑molecule drugs, emphasizing the need for early and comprehensive protection. It outlines the typical patent lifecycle—from provisional filings through PCT applications to national‑phase prosecution—and the legal standards of utility, novelty, and non‑obviousness. Real‑world examples...
By Drug Hunter
Blog•Dec 15, 2025
The FDA Under MAHA Control: Weakening the Quack Miranda Warning on Supplements
The FDA, under the Make America Healthy Again (MAHA) agenda, is considering a rule change that would let supplement manufacturers place the DSHEA disclaimer on a single panel instead of every claim‑bearing panel. The proposal follows a December 11 letter...
By Science-Based Medicine
Blog•Dec 14, 2025
Number of the Day - $45.87 Bn
The global robotic surgical procedures market is forecast to reach $45.87 billion by 2035, driven by rising demand for minimally invasive surgeries and advances in artificial intelligence. Analysts project a compound annual growth rate of roughly 12% from 2024 through 2035....
By SurgRob
Blog•Dec 13, 2025
SaaStr AI App of the Week: Kintsugi — The AI That Puts Sales Tax on Autopilot
Kintsugi is an AI‑native platform that automates sales‑tax compliance for high‑growth B2B and e‑commerce firms. It monitors nexus thresholds, registers businesses, classifies products, files returns and remits payments across all U.S. states and many countries. Since its August 2023 launch the...
By SaaStr
Blog•Dec 12, 2025
Processing 630 Million More Pwned Passwords, Courtesy of the FBI
The FBI has supplied Have I Been Pwned (HIBP) with an additional 630 million compromised passwords, expanding the service’s corpus beyond the 1.26 billion monthly searches it already handles. Roughly 7.4% of these passwords—about 46 million—were previously absent from HIBP, boosting the database’s...
By Troy Hunt’s Blog
Blog•Dec 12, 2025
B2B Marketing Strategies: A Complete Guide
Neil Patel’s B2B content marketing guide argues that volume‑driven tactics no longer deliver pipeline. He proposes a revenue‑first system where every piece is filtered by its impact on sales and aligned with buyer intent. The post outlines proven tactics—pain‑first topics,...
By Neil Patel
Blog•Dec 12, 2025
Stockpicker’s Paradise
The episode reflects on the rise, fall, and resurgence of specialist financial-sector investing, recounting the host’s hedge fund closure after a decade of long/short bets across global banks and fintechs. It highlights how recent market conditions have revived outsized returns...
By Net Interest
Blog•Dec 12, 2025
A Compendium of Pharmaceutical Salts to Help Flavor Your Drug Formulation
The article presents a comprehensive list of pharmaceutical salts that can be leveraged to enhance the taste, solubility, and overall patient acceptability of oral drug formulations. It outlines the physicochemical properties, regulatory status, and typical applications of both traditional inorganic...
By Drug Hunter
Blog•Dec 12, 2025
Critical React2Shell Vulnerability (CVE-2025-55182) Analysis: Surge in Attacks Targeting RSC-Enabled Services Worldwide
The episode breaks down the critical React2Shell (CVE‑2025‑55182) vulnerability that enables unauthenticated remote code execution in React Server Components, highlighting its CVSS 10.0 severity and the rapid emergence of exploitation attempts after disclosure. It explains how the flaw affects the...
By Security Ledger
Blog•Dec 12, 2025
Flickstop
Recent posts titled "Flickstop" showcase the rapid evolution of robotic telesurgery, highlighting a six‑armed robot from Ottava and the SSI Mantra 3 system used for remote hernia repair. Images illustrate a medical team operating a robot and a cross‑city internet link...
By SurgRob
Blog•Dec 12, 2025
The First $100,000,000 ARR at Samsara: How Founder CEO Sanjit Biswas Built a Platform Giant by Digitizing the Physical World
Vertical SaaS leader Samsara has surpassed $1.75 billion in ARR, up 29% YoY, after scaling from its first $100 M ARR milestone. Founder‑CEO Sanjit Biswas leveraged a beginner’s‑mind approach, reassembled his Meraki team, and pivoted based on customer feedback to build a...
By SaaStr
Blog•Dec 12, 2025
Fed Rate Cut Tailwind, Lilly’s Triple Agonist Delivers Big, Vaccine Policy Turmoil — This Week in Biotech #81
The episode highlights how the Fed’s recent rate cut creates a macro‑tailwind for biotech, reviving valuations and financing opportunities. It discusses mixed public‑health signals around COVID‑19 vaccination in children and warns that U.S. skepticism could erode its mRNA leadership. Landmark...
By Biotech Blueprint
Blog•Dec 11, 2025
News Alert: INE Sees Surge in Q4 Budget Shifts as Enterprises Embrace Hands-On Training for AI Roles
Enterprises are reallocating Q4 learning‑and‑development budgets toward hands‑on, performance‑based training as AI reshapes cybersecurity, cloud, and IT operations. INE reports a surge in demand for immersive labs, simulations, and AI‑adaptive pathways that promise faster competency and measurable ROI. The shift...
By The Last Watchdog