E201: The Small Molecule Revolution: ProPhet's Tom Shani on AI-Powered Drug Discovery
In this episode, Tom Shani, CEO and co‑founder of ProPhet, explains how AI—particularly machine learning models, transformers, and novel molecular representations—is transforming small‑molecule drug discovery by tackling slow timelines, high failure rates, and massive R&D costs. He shows how AI can learn from noisy biological data to rapidly identify viable targets and molecules, compressing discovery cycles from decades to years while improving safety predictions. Shani also emphasizes why small molecules remain central to medicine and discusses the remaining hurdles of trust, regulation, and validation for AI‑driven approaches.
From Evidence to Adoption: How datosX Is Redefining Digital Health Validation
In this episode, Unity Stoakes interviews Robin Roberts, CEO of datosX Digital Health Labs, about transforming digital health validation from a bottleneck into a catalyst for adoption. Roberts explains how datosX leverages tier‑1 health system partnerships to run regulatory‑grade validation...
ChatGPT Apps Are About to Be the Next Big Distribution Channel: Here’s How to Build One
In this episode, Colin Matthews explains how ChatGPT‑native apps are emerging as a new distribution channel, with discovery shifting to contextual interactions inside the chat interface. He outlines the three UI modes, the "one widget per message" constraint, and how...
Agent Psychosis: Are We Going Insane?
In this episode, Armin Ronacher warns that AI agent psychosis could be making us collectively uneasy, while Dan Abramov breaks down the AT Protocol as a social filesystem for decentralized apps. RepoBar is highlighted as a tool that surfaces your...
EP259 Why Google Built a Security LLM and How It Beats the Generalists
In EP259, Distinguished Scientist Elie Burstein from Google DeepMind explains why Google built a security‑focused large language model (SecLLM) and how it outperforms generic LLMs for threat detection, code review, and incident response. He details the model’s specialized training data,...
Claude Code for Product Managers: Research, Writing, Context Libraries, Custom To-Do System, and More | Teresa Torres
In this episode, Teresa Torres walks listeners through how she transformed her productivity by building a custom task‑management system in Claude Code, moving from Trello to a markdown‑driven workflow integrated with Obsidian. She demonstrates automating daily research digests, organizing context...
The Future of Risk: Integrating AI and Human Intelligence for Proactive Mitigation with Garry Singh
In this 29‑minute episode, Garry Singh, President of IIRIS Consulting, explains how AI can shift risk management from a reactive to a predictive discipline. He outlines practical steps for leaders to embed machine learning into risk identification, while emphasizing the...
Megan Engel: Harnessing Machine Learning to Build Better Molecular Models
In this episode, Professor Megan Engel discusses how machine learning and modern optimization techniques can streamline the creation of coarse‑grained molecular models, building on the challenges faced by the original oxDNA developers. She explains shortcuts that reduce the labor‑intensive parameterization...
Jonathan Haidt Strikes Again + What You Vibecoded + An Update on the Forkiverse
In this episode the hosts dissect Jonathan Haidt's latest commentary on the cultural clash over social media, explore the viral "What You Vibecoded" trend as a lens on algorithmic self‑presentation, and provide an update on the Hard Fork community’s "Forkiverse"...
Episode 140: Robot Balance and Agility - Amir Patel
In this episode, Claire interviews Associate Professor Amir Patel about his work replicating the cheetah's speed and agility in robotic systems. Patel explains how sensor fusion, computer vision, mechanical modeling, and optimal control are combined to study high‑speed animal locomotion...
Market View: Is the AI Trade Back On?
The episode examines whether the AI trade is resurging, focusing on the surge in semiconductor stocks and banks benefiting from AI‑related demand. It analyzes TSMC’s record earnings and what they reveal about the durability of AI‑driven chip supply chains, while...
Building an Autonomous Car Utopia with Rivian's RJ Scaringe
Alex and Ellis open with a discussion on Meta's metaverse layoffs and the potential shift to Claude Cowork over ChatGPT, then sit down with Rivian CEO RJ Scaringe to explore the future of autonomous vehicles. Scaringe explains how large driving models...
Unprecedented AI Math Discoveries
The episode explores how AI is now generating novel mathematical methods rather than merely solving known problems, highlighting groundbreaking discoveries that could reshape research. Hosts discuss tangible performance improvements and cost savings achieved by applying these AI-driven approaches in real-world...
Teaching AI How to Forget
In this episode Ben Lorica interviews Ben Luria, CEO and co‑founder of Hirundo, about the rising importance of machine unlearning for enterprise AI systems. They explore how organizations can remove or forget specific data points from trained models to comply...
AI and the Future of Warfare with US Under Secretary of War Emil Michael
In this episode, Under Secretary of War Emil Michael explains how the Department of War is deploying a generative AI platform, GenAI.mil, to over a million users within its first month, leveraging models like Gemini and Grok to boost decision‑making...
The CFO Case for Probabilistic Forecasting With AI | Bruno Annicq
In this episode, CFO Bruno Annicq of Wellhub shares how he transformed the company’s forecasting by adopting an AI‑driven probabilistic ensemble model, moving the finance team beyond single‑scenario planning. He outlines his EMPOWER planning framework, emphasizing cash discipline, sustainable growth,...
America Under Surveillance with Michael Soyfer
In this episode, Kevin Ball talks with Institute for Justice attorney Michael Soyfer about the rapid expansion of surveillance technologies such as automated license‑plate readers, facial‑recognition cameras, and predictive policing tools across U.S. municipalities. Soyfer explains the Fourth Amendment challenges...
286. The Cigna Group’s Brian Evanko on Improving Affordability and Prevention in Healthcare
In this episode, Cigna Group President and COO Brian Evanko discusses the twin challenges of healthcare affordability and prevention, emphasizing the disproportionate spend on chronic care in the U.S. He outlines how Cigna’s two growth platforms—Cigna Healthcare and Evernorth—are leveraging...
Ecommerce: The Year Ecommerce Got Back to Normal
Mark and Ian review 2025, declaring it the first post‑COVID year of "normal" ecommerce and highlighting how agile, lean brands outperformed larger incumbents. They note AI‑driven ad creative shifted from a novelty to a necessity, and that small "skeleton" teams...
AI Predictions for 2026 — Agentic Browsers, In-Chat Purchases, and What Marketers Should Actually Prepare For
In this episode, Paul and Martin forecast AI’s impact on marketing for 2026, highlighting the imminent launch of Google’s Gemini‑powered agentic Chrome, the rise of in‑chat purchasing via protocols like Google Agent Payments and Microsoft Copilot Checkout, and the emergence...
Safer, Smarter Construction Sites with Edge AI and Caterpillar Autonomous Machines - Ep. 285
In this episode, Brandon Hootman, Caterpillar’s Vice President of Data and AI, discusses how NVIDIA’s AI Factory, Omniverse, and edge AI are transforming heavy equipment by creating digital twins, enabling safer autonomous operations, and providing in‑cab AI copilots for operators....
#487 - AI Amazon Product Images in Minutes
In this episode Shivali Patel and AI expert Kamaljit Singh discuss how sellers can transform a few phone photos into a full Amazon image stack and A+ Content using AI-driven systems. Kamaljit outlines his "Image Framework" for crafting effective prompts—covering...
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In this episode, Tomaso Poggio discusses extending Marr's three levels of analysis by adding learning as a fourth level, arguing that understanding intelligence requires both engineering breakthroughs and theoretical foundations—much like the era between Volta's battery and Maxwell's equations. He...
E200: Podcast with Cures & Capital Part 3
Dr. Andre Bates, founder and CEO of Eularis, joins the Cures & Capital hosts to cut through AI hype in biopharma, highlighting the low‑hanging fruit such as regulatory document automation, clinical trial optimization, and medical affairs. He explains how AI...
Top AI Tools and Releases of 2025
In this episode, Jordan Wilson surveys the most impactful AI tools and model releases of 2025, explaining the selection criteria and ranking them across four tiers. He highlights breakthroughs such as Canva Visual Suite 2.0, ChatGPT's Atlas browsing and Deep...
Linus Torvalds Gets the AI Coding Bug
In this brief episode, Linus Torvalds shares his experience of inadvertently committing AI‑generated code, sparking a discussion about the growing role of AI in software development. Jerod Santo highlights the rise of self‑hosting as a pivotal trend for 2024, while...
Gemini Powers New Siri
The episode examines Google's Gemini becoming the core AI engine for Apple's upcoming Siri, highlighting why Apple chose to partner with Google and what this means for users accustomed to OpenAI and other models. It discusses the strategic benefits for...
“A Full Software Engineering Teammate”: OpenAI Product Lead on Getting the Most Out of Codex | Alexander Embiricos
In this episode, OpenAI Codex product lead Alexander Embiricos walks listeners through practical workflows for using Codex—from simple VS Code prompts to parallel coding with Git worktrees and detailed implementation plans via a Plans.md approach. He shares how OpenAI built the...
Anthropic, XAI Secure Multi-Billion Dollar Funding
The episode examines the recent multi-billion-dollar funding rounds secured by AI firms Anthropic and XAI, discussing how the capital influx will shape their development paths and competitive positioning. It highlights the strategic motivations behind the investments, including scaling safety research,...
NVIDIA Tightens China Chip Sales, Expands AI Footprint
The episode examines NVIDIA's recent policy requiring upfront payments for its H200 AI chips sold in China, highlighting how geopolitical tensions and export controls are shaping the company's sales strategy. It also covers NVIDIA's push into "physical AI" by partnering...
OpenAI Acquires Convogo as Elon Musk Preps Lawsuit
The episode explains OpenAI's recent acqui-hire of Convogo's executive‑coaching team, noting that the Convogo product will be shut down as OpenAI integrates the talent into its broader infrastructure and talent strategy. It also examines the escalating legal clash with Elon...
The AI Glasses Race Is Heating Up.
Alex and Ellis recap the oddball gadgets, taglines, and even scents that defined CES, then sit down with Meta’s head of wearables, Alex Himel, to explore the accelerating smart‑glasses market. Himel shares lessons from the Meta Ray‑Ban Displays launch, discusses...
Grok’s Undressing Scandal + Claude Code Capers + Casey Busts a Reddit Hoax
The episode examines three major AI controversies: the "Grok" scandal where a language model was allegedly used to target and marginalize women in political discourse, the "Claude" code generation issues that raised concerns about intellectual property and model reliability, and...
Instagram Puts Burden of AI Slop on Creators (514)
Joe and Robert discuss a stabilizing U.S. labor market and the impact of permanent corporate tax cuts on 2026 profits, then turn to Instagram's stance on AI-generated content, arguing the platform is shifting the burden of authenticity onto creators. They...
OpenAI Unveils "ChatGPT Health" With 230M Weekly Health Chats
The episode breaks down OpenAI's launch of ChatGPT Health, a new feature aimed at the 230 million weekly users who already ask health‑related questions. It explains how the specialized model could improve the accuracy, safety, and accessibility of everyday health information,...
Inside the $41B AI Cloud Challenging Big Tech | CoreWeave SVP
In this episode, CoreWeave SVP discusses how the company has built a $41 billion AI cloud infrastructure that rivals the big tech giants, focusing on its strategy of offering flexible, high‑performance GPU compute and specialized AI services for enterprises. He explains...
How to Show up in AI Results in 2026 with Elizaveta Shutova (NEWBIE)
Elizaveta Shutova explains that in 2026 SEO must target both traditional rankings and AI-generated search snippets, as AI overviews now appear in over 23% of queries and pull data from a wide range of sources like Reddit, Wikipedia, and YouTube....
Data Solutions for Tailoring Agronomic Support to Meet Regional Needs - with Tami Craig Schilling of Bayer Crop Science
In this episode, Matthew DeMello interviews Tami Craig Schilling, Bayer Crop Science’s VP of Agronomic Digital Innovation, about how generative AI is used to deliver hyper‑local agronomic recommendations throughout the planting cycle. They discuss tools like the zip‑code‑based ELI platform...
The Strangest AI Announced at CES 2026
The episode spotlights the most outlandish tech revealed at CES 2026, dissecting quirky AI-driven gadgets and sci‑fi‑like innovations that captured global attention. The host explains why each invention is unusual, highlighting their novel functionalities, market hype, and potential impact on...
Groq Leadership, Tech to Nvidia for $20 Billion
The episode explains Nvidia's $20 billion acquisition of Groq, focusing on how Groq's inference leadership and its LPU chiplet architecture dramatically boost memory bandwidth and lower latency for large language model serving. It highlights the strategic value of Groq's technology and...
Work in the Age of Infinite Agents
The episode examines how AI agents, rather than just speeding up tasks, expand the scale of knowledge work, enabling organizations to operate beyond human rhythms, meetings, and bottlenecks. Drawing on essays by Ivan Zhao and Aaron Levie, the hosts argue...
Claude Launches Agent Plugin for Chrome—Risk Warning
The episode examines Anthropic's new Claude Agent plugin for Chrome, highlighting its broad tab manipulation and storage access capabilities that enable powerful agentic browsing but also introduce significant security risks. The host explains how the plugin's design allows stealthy data...
![[NeurIPS Best Paper] 1000 Layer Networks for Self-Supervised RL — Kevin Wang Et Al, Princeton](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://assets.flightcast.com/static/01K4D8FDXRRRRZG0EBGNDF3SD3.jpg)
[NeurIPS Best Paper] 1000 Layer Networks for Self-Supervised RL — Kevin Wang Et Al, Princeton
The episode explores the NeurIPS Best Paper on RL1000, where Kevin Wang and his Princeton team demonstrated that scaling reinforcement learning networks to 1,000 layers using a self‑supervised, contrastive objective unlocks dramatic performance gains. They explain why traditional value‑based RL...
Our 2026 Tech Resolutions + We Answer Your Questions
The episode outlines the team’s 2026 tech resolutions while fielding listener questions, covering practical AI usage tips, the limits of AI in scientific breakthroughs, and major industry updates such as Google’s Gemini 3 launch, OpenAI’s platform ambitions, and Roblox’s new AI‑driven...
AI New Year’s: The 10-Week AI Resolution
The episode presents a hands‑on 10‑week AI fluency program, with each weekend dedicated to a bite‑sized project such as model mapping, data analysis, visual reasoning, automation, context engineering, and building a functional AI‑powered app. It emphasizes practical habit formation and...
VC's AI Predictions for 2026
The episode examines why venture capitalists are forecasting 2026 as the breakthrough year for enterprise AI adoption, contrasting these hype cycles with current data that shows many firms still struggle to achieve ROI from AI projects. It highlights key barriers...
E198: Podcast with Cures & Capital Part 1
Dr. Andre Bates, founder and CEO of Eularis, explains how AI has progressed from early digitisation to the generative AI era and why ChatGPT marked a turning point for pharma executives. She identifies common pitfalls that keep organisations stuck in...
[State of RL/Reasoning] IMO/IOI Gold, OpenAI O3/GPT-5, and Cursor Composer — Ashvin Nair, Cursor
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Who Gets Written Out of the AI Future?
The episode examines how AI systems systematically exclude marginalized groups, highlighting biases that arise from skewed training data and the perspectives of those who supervise models. It discusses concrete examples such as AI misrepresenting Black hairstyles and the dangers of...
Why Post-Merger Integrations Fail Without Data Governance - Sandro Venturini of UBS
In this episode, Sandro Venturini, Executive Director at UBS Asset Management, explains how fragmented fund data undermines post‑merger integrations and why establishing a single source of truth through data governance is essential for successful AI‑driven compliance and reporting. He illustrates...