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Enodia Therapeutics, a Paris‑based biotech, secured €20.7 million in seed funding led by Elaia, Pfizer Ventures and Bpifrance. The capital will accelerate its machine‑learning‑driven small‑molecule platform that selectively modulates the SEC61 translocon to degrade target proteins at synthesis. By intervening upstream of the secretory pathway, Enodia aims to halt disease‑causing proteins before they become functional. The round also includes strategic investors such as Institut Pasteur and Argobio Studio, underscoring confidence in the approach.
What are some ways buyers try to get an unfair advantage in a process? 1. Create artificial deadlines for the founder to give them exclusivity. 2. Encourage founders to sign an LOI early, without providing much detail on what the...
The founders of Paperspace (YC W15) just announced Autonomous (@a____t____g), an AI-native wealth strategist that brings elite strategies used by the ultra-wealthy, now available to everyone at 0% advisory fees. Millions of people already ask AI what to do with money....
New pod with @kevinhartz - why he backs so many teen founders - lessons from the PayPal Mafia - AI is the mother of all bubbles yet still underhyped - how Palantir, Xoom, and Eventbrite evolved from PayPal - sizing a hidden TAM - having kids...
Ideally, you'd start in venture around 13-14 years old That way, in 20 years, when the carry checks finally get material, you still have time to spend it
After Sarah Rowell and Scott Mackenzie spent five years increasing Kantola Training Solutions' revenue, client retention, and learner engagement, they saw the market starting to consolidate and decided to make a strategic move to maximize value; either through acquisition or...
Stoke Space is racing to build the world's first fully reusable rockets that can launch, survive reentry, and fly again almost right away. In this episode of Hard Tech, @aaron_epstein sits down with @stoke_space co-founders @AndyLapsa and @Rkt_Da to find out...
I often cold outbound mega CEOs to come on 20VC: The upstarts who are crushing, taking incumbent share and moving fast; respond and take it themselves. The incumbents; forward it to comms, who send me BS emails a week later...
Getting to know potential acquirers in your space does increase the odds they acquire you — if you do it for the right way. Why? Because it builds trust. And a big part of M&A is trust. Will the team we just...
In this episode, Katlin Smith recounts how she turned a humble almond‑flour muffin experiment into Simple Mills, a clean‑snack brand that grew into a $800 million exit. She discusses the challenges of scaling a health‑focused food company, the strategic decisions that...
It’s easy to normalize rapid progress, but it’s worth pausing to appreciate how far we’ve come. We now have systems that: 🧠 learn end-to-end 📚 transfer knowledge across domains 🌍 operate in new environments with no explicit programming From vision to language to robotics, this...
Congrats to Travis Harvego , Joe Hoffman , and the ROOFLE team for their recent acquisition by SalesRabbit . Best of luck as you kick off the next stage in your journey. Glad we could help. Check out the press...
Niko Bonatsos, who built General Catalyst’s seed strategy and backed Discord and the $10 billion AI startup Mercor, announced his departure in January 2026. He plans to start a new early‑stage venture firm with a group of top founders and investors,...
Rep. Khanna reached out to me to discuss the proposed California wealth tax; and while I am against the proposed tax, I'm always open to dialogue with our elected leaders. The proposed CA wealth tax is badly designed in so many...
Your business is not your baby, child, or another human you are in a relationship with. It is an organization. That distinction matters more than founders want to admit. Organizations exist to convert decisions into outcomes at scale. They rely on clear...
STRM.BIO, a Cambridge‑based biotech specializing in non‑viral delivery platforms for cell and gene therapies, announced an $8 million Series Seed 2 financing. The round is led by Recordati and includes continued participation from Boehringer Ingelheim Ventures and Delos Capital, with new capital...
Storytelling is often an underappreciated strength of a great finance leader, and Samsara 's Dominic Phillips is one of the best. Tune in to tomorrow's Run The Numbers to hear some bangers and learn more about building a durable finance...
I’ve been around long enough to see how most M&A paths actually unfold. Some work exactly as hoped. Others resolve quietly. A few fall apart late for reasons that never make it into a postmortem. I’ve been on the acquiring side, the...
DayOne Data Centers Limited announced a US$2 billion Series C funding round. The round was led by Coatue with participation from Indonesia Investment Authority, Indonesia’s sovereign wealth fund. Combined with the earlier US$1.9 billion equity raises and a €1 billion mezzanine facility, total capital...
2025 reinforced what I've always believed: the best ideas and founders emerge from everywhere. We at Notable Capital backed founders building companies that transcend borders and categories—I am excited for dub and K Health for democratizing financial investing and personal...
Valuations of software companies are highly dependent on the predictability of revenue. In other words, different classes of revenue are valued differently depending on their predictability. The more predictable, the better. To help founders distinguish between the different classes of...
Swedish consumer‑health startup Sigrid announced a $5 million financing round, though the investors remain unnamed. The capital will fuel both operational scaling and intensified research and development. Sigrid’s core offering is its patented SiPore technology, a non‑systemic, mechanically active platform that...
Filtrabit, a Finnish cleantech firm specializing in dust‑extraction systems, secured €2 million in a financing round led by Ajanta Innovations 2 Ky. The capital will accelerate research and development while funding geographic expansion across the Nordics, Central Europe and India. The technology removes...
Not every startup is ready to sell the first time it hits the market. In 2022, a founder listed a promising startup on @acquiredotcom that went nowhere. No real buyer interest. No momentum. The issue wasn’t demand. It was structure. So they...
In this episode, Michael Brehm of Redstone explains how the firm backs a single investment across 200 European ventures, creating a new model for VC access that spreads risk and capital efficiently. He discusses the rationale behind concentrating capital, the...
In this episode, a16z partner Joel de la Garza talks with Keycard CEO Ian Livingstone about the rapid shift from AI copilots to fully autonomous agents expected in 2026, and why enterprises will be the first adopters. They explore the...
AI removed the natural friction that used to separate thinking from output. Writing, design, analysis, code, and planning now move fast enough that effort is no longer a credible signal. When anyone can produce something quickly, speed stops being impressive. What...
Interos.ai announced a $20 million funding round led by Blue Owl Capital and Structural Capital. The new capital will accelerate development of its AI‑powered Operational Resilience Cloud, which visualizes and monitors global supply chains down to individual suppliers. The platform also...
A portfolio co is building Cursor 2.0. If any Series A+ founders or eng leaders are open to sharing early feedback as a favor for me, DM me. :)
If you are not bullish on Europe right now I can categorically tell you, you have s*** dealflow and need to improve. Never been more great entrepreneurs building mega European businesses.
Mario Götze, the 2014 World Cup hero, has built a parallel career as an angel investor through his vehicle Companion M, which now backs more than 70 startups. Two of those companies, Danish fintech Flatpay and German AI firm Parloa,...
Project Europe has been live for 10 months. 12 Project Europe companies. 4 have raised significant up rounds from Tier 1s. 1 has been acquired by category leader. Never been more confident that Project Europe will be the dominant entry...
Anthropic from 0 to $350 Billion Valuation. Is this the fastest ever from founding? The data says yes. Time to $350B: 🥇Anthropic: 4.5 years (founded 2021) 🥈OpenAI: ~10 years (founded 2015) 🥉SpaceX: 22 years (founded 2002) Anthropic is reaching SpaceX-level valuations roughly 5x faster. Even crazier:...
Meritz Securities announced a strategic partnership with AI‑focused firm WNSTN to embed compliant, infrastructure‑grade artificial intelligence into its next‑generation digital investing platform. The collaboration makes Meritz the first major Korean brokerage to deploy WNSTN’s real‑time, multi‑agent financial AI across client‑facing...
Vizgen, a Waltham‑based spatial multi‑omics firm, announced a $48 million financing round. The investment was led by ARCH Venture Partners, M Ventures and Northpond Ventures, with participation from existing backers. The capital will fund global researcher support and scale manufacturing capabilities....
In Episode 111, host discusses the evolution of online knowledge sharing with Wikipedia co‑founder Jimmy Wales, covering the platform’s impact on information accessibility, challenges around misinformation, and the future of open‑source collaboration. Wales shares insights on the balance between community...
Phylicia Koh, GP at Play Ventures, explains how gaming mechanics are becoming the operating system for consumer apps, with in‑app purchases in non‑gaming sectors now outpacing traditional gaming spend. She outlines Play Ventures' $142 M thesis focused on "playable apps" that...
Every day a deal stays in due diligence is another day for "market events," "cold feet," or "competitor moves" to blow it up. For a fast-growing marketing agency recently listed on @acquiredotcom, the goal was a premium 3.8x EBITDA multiple. We hit...
An issue I’m seeing pop up with new AI companies - they pay reps on “ARR” that’s really a series of three month pilot deals. The rep sells something for $3K and they call it $12K in ARR. Oh, and...
Kate Lowry, a former vice president at Insight Partners, filed a lawsuit in San Mateo County alleging disability discrimination, gender discrimination, and wrongful termination. She says her supervisor demanded constant online availability, subjected her to harassment, assigned redundant tasks, and...
Linker Vision, a Taipei‑based AI software platform, closed a $35 million Series A round led by Abico Group, with participation from NVIDIA and several Taiwanese venture funds. The capital will fund a rapid global expansion into the United States, Latin America, Asia,...
💥 Now that we’ve packed up the holidays and turned the corner into 2026, it’s a good time to take stock of the spaces we live in. This The New York Times piece highlights how Havenly Brands (Havenly, Interior Define,...
I sat down with @mjmauboussin to connect his unconventional career to Runnin’ Down a Dream—then used history, not hype, to frame the current AI investment world. Pre-order the book to unlock the full video here: https://t.co/HlNDfpEy66 #runnindownadream https://t.co/AhjQL3BGAO
1/ Big news today from Lux family co Variant Bio 🧬📈@VariantBio Announced its new Inference platform is now available to research partners + has collaborations with several pharmaceutical companies in deals totaling more than $200 million including Boehringer + Novo...
strategy should hurt. if you aren't making painful trade-offs, you haven't prioritized. • one goal, one owner • shared ownership = no ownership molly graham on @lennysan: https://t.co/RW7eAWk6kI
A good reminder that outside of the tech bubble, we must expand our efforts to (1) show tangible AI superpowers to many people, and (2) address the concerns and fears they have about AI growth, both environmentally and economically. Failing...
Different buyers value companies differently. Only by talking to a broad spectrum of buyers will you ensure that you: * Uncover all potential synergies * Make the process hyper-competitive * Unlock the best outcome #founders #pathtoexit
Will today's leading foundational LLMs be the DEC,Cray, Wang, Radio Shack, Sun, Data General, Compaq, etc of tomorrow ? GenAI LLMs want to be the operating systems of today and tomorrow. It's possible they will be the CP/M, DOS,...
There are no moats anymore. Yesterday's product moats are today's Claude prompts. There are only current gaps, headstarts, and leaders and laggers. And there is speed. No one can rest on their laurels. Act accordingly.
At 70+ I feel like I'm thirty backing exciting innovators/innovations making the impossible possible and from improbable ideas to world-changing socially impactful companies. Never had such a fast learning rate in my life or felt I could have so much impact, which is exciting. https://t.co/3BTsDx4Gr7
