Today's Healthcare Pulse
Allogene Therapeutics CEO David Chang to step down
Allogene Therapeutics announced that chief executive David Chang will leave his role. The news was reported by STAT+ and echoed in a follow‑up piece covering broader pharma updates.
Also developing:
By the numbers: Boston Scientific invests $1.5B for 34% stake in MiRus
Mont. Hospital System Brings 24/7 Ambulance Service to Rural County
Intermountain Health will begin providing 24/7 emergency medical services to eastern Yellowstone County, Montana, starting July 1. The partnership with Yellowstone County and the Worden and Shepherd fire districts includes purchasing two ambulances and hiring ten paramedics and EMTs. It addresses a long‑standing EMS gap caused by a 50% drop in volunteer responders over the past decade. Officials expect response times to improve by 10‑15 minutes for residents of Huntley, Worden and Ballantine.
In China, Phase 2 Study of Relma-Cel in R/R MCL Finds Durable Responses
A phase‑2 trial of relmacabtagene autoleucel (relma‑cel), a CD19‑directed CAR‑T therapy, enrolled 59 Chinese patients with relapsed/refractory mantle‑cell lymphoma after BTK‑inhibitor failure. The study reported a 71.2% overall response rate and a 59.3% complete response rate, with median time to...
Environmental Factors Affect Community Participation Among Individuals With MS
A mixed‑methods study of 505 people with multiple sclerosis (MS) found that personal factors dominate community‑participation outcomes, but environmental factors still contributed an additional 11 % to satisfaction and GPS‑tracked activity. Financial resources, social support and neighborhood safety were linked to...
Paper on Target Trial Emulation Overlooks Confounding by Indication
How is it that a paper that claims to show how to do target trial emulation does not address confounding by indication and its ramifications for data collection? https://t.co/dzGZZdpBoc #Statistics
This Is the $8 Trillion Investment Opportunity VCs and Founders Can’t Ignore
The longevity economy is set to reach $8 trillion by 2030, driven primarily by healthspan – the years lived in good health. A UBS report shows the market expanding from $5.3 trillion in 2023, outpacing AI growth forecasts. Preventative health solutions are...
Recent Advances Raise Hopes of Better Addressing Richter Transformation
A new review synthesizes recent advances that clarify the biology of Richter transformation (RT), the aggressive lymphoma that develops in 2%‑10% of chronic lymphocytic leukemia (CLL) patients. The analysis confirms that 70%‑80% of RT cases are clonally related to the...
Pregnancy Biomarkers Reveal Long-Term Cardiovascular Risk in Women
A Danish registry‑linked cohort linked pregnancy biobanking with long‑term health records, showing that third‑trimester high‑sensitivity cardiac troponin I (hs‑cTnI) and soluble fms‑like tyrosine kinase‑1 (sFlt‑1) independently predict maternal cardiovascular disease (CVD) over a median 12‑year follow‑up. Adding week‑29 sFlt‑1 to...
Accelerating CAR Engineering Shows Promising Cancer Immunotherapy
Some very good news about engineering our cells vs cancer (accelerating the CAR). A short thread 1. For background, a new 5★ review on cancer immunotherapy @Cancer_Cell https://t.co/1Qz2rCs8I5 https://t.co/sJ6BwaXyjk
Single-Cell Atlas Links Marrow Immune Dysregulation to Myeloma Outcomes
A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma https://t.co/5t0M2eX0fB https://t.co/p3kv8LEzrC
Analysis Finds Efficiencies, Savings of Using a Single Bispecific for DLBCL and FL
A new analysis quantifies the operational and financial benefits of using Genmab’s epcoritamab, a dual‑indication bispecific antibody, for both relapsed/refractory diffuse large B‑cell lymphoma (DLBCL) and follicular lymphoma (FL). In a community‑practice model of 100 patients, the study projects 3,110...
Alcohol-Associated Liver Disease Conveys Greater Cirrhosis Risk Than Metabolic Disease
A new VA study of 1.5 million veterans shows alcohol‑associated liver disease (ALD) carries the highest cirrhosis incidence (0.66 per 100 person‑years), outpacing metabolic dysfunction‑associated steatotic liver disease (MASLD) and metabolic‑and‑alcohol‑associated liver disease (MetALD). MASLD patients with obesity and diabetes face...
Advanced CKD Linked With Cognitive Impairment
A new JAMA Network Open analysis of 5,607 chronic kidney disease (CKD) patients found that higher urinary protein‑to‑creatinine ratios (UPCR) and lower estimated glomerular filtration rates (eGFR) independently raise the risk of cognitive deficits, especially in attention, processing speed, and...
Mixed Immune Signature Identified in Chronic Hand Eczema
A phase‑2b trial enrolling 94 adults with chronic hand eczema (CHE) without etiologic pre‑selection uncovered a mixed immune signature spanning type 2, type 3 and type 1 pathways. Dupilumab, an IL‑4Rα antagonist, delivered a 59.8% mean improvement in modified Total Lesion Symptom Score...
Ilinois Hospital Breaks Ground on New EMS Transport Hub
Deaconess Illinois Medical Center in Marion has broken ground on a new EMS transport hub slated for completion in May. The 4‑ambulance facility will relocate EMS operations from Harrisburg to a centralized Marion campus, providing on‑site crew living space. Hospital...
Benefits of a Virtual Asthma Self-Management Education Program
A prospective cohort of 60 adults completed the Virtual Asthma Self‑Management Education Program (VASMEP), a six‑session, educator‑led telehealth curriculum. Twelve weeks after enrollment, 78% showed improved Asthma Control Test scores and 52% reduced systemic corticosteroid use. The free program targets...
Can Cold Plasma Improve Surgery Recovery? Study Suggests Faster Healing, Less Fat
Researchers at Thomas Jefferson University demonstrated that an FDA‑approved cold plasma device can speed muscle wound healing in rats. Within six hours, plasma treatment boosted neutrophil infiltration and activated repair‑related gene pathways, and after two weeks it reduced fat deposition...
Does Lowering Cholesterol Harm the Brain?
The brain houses about 20‑25% of the body’s cholesterol, yet it relies on local synthesis because circulating cholesterol cannot cross the blood‑brain barrier. Although some patients report transient brain fog on statins, large observational studies generally show neutral or even...
GLP-1 News Galore; Top 100 Venture Investors; Doug Ingram to Step Down; and More
This week’s Endpoints Weekly highlighted a surge of GLP‑1 developments, including new trial data and expanded indications that reinforce the class’s dominance in obesity and diabetes treatment. The newsletter also released its annual Top 100 venture investors list, showing a notable...
The Convergence of Clinical Intelligence and Patient Outreach: Analysis of OpenEvidence’s AI Integrated Telehealth Ecosystem
OpenEvidence launched its AI‑Integrated Doctor Dialer™, a HIPAA‑secure app that merges voice, messaging, fax and voicemail with real‑time clinical decision support powered by a medical‑specific large language model. The platform embeds deterministic, citation‑backed recommendations directly into patient communications, eliminating the...
Secretary Kennedy Appoints Two Physicians to CDC's Advisory Committee on Immunization Practices
The U.S. Department of Health and Human Services and the CDC announced the appointment of two physicians to the CDC Advisory Committee on Immunization Practices (ACIP). Dr. Sean G. Downing, an internal medicine and pediatrics specialist from Florida, and Dr....
GSMA Foundry, NUHS Partner to Drive 5G and AI Innovations in Healthcare
The GSMA announced a strategic partnership between its Foundry innovation hub and Singapore’s National University Health System (NUHS) to accelerate 5G‑enabled, AI‑driven healthcare solutions. The collaboration will focus on private 5G networks, digital twins, XR, IoT and ambient AI to...
EMA’s CHMP Recommends Three New Orphan Drugs, Rebuffs Two FDA-Approved Programs
The EMA’s Committee for Medicinal Products for Human Use (CHMP) recommended six new medicines, including three orphan drugs already approved by the FDA—Ojemda for pediatric low‑grade glioma, Palsonify for acromegaly, and Xolremdi for WHIM syndrome. The agency also gave a...
Tylenol Not Linked to Autism Genes, Study Shows
There are a few known chemical exposures in early pregnancy that interact with autism genes. But not Tylenol. I’ve spoken to RFK Jr about them but he had no interest, and he can’t process scientific information. Here’s my article https://t.co/pxLaDLInlf
Emerging Models Point to a New Operating System for Rare Disease Innovation
BioCentury’s cookie policy details five categories of cookies—strictly necessary, functional, marketing, advertising, and analytics—each serving distinct purposes on its website. Strictly necessary cookies support authentication, registration, and navigation, while functional cookies enable personalization of services. Marketing and advertising cookies help...
Former Nuance Employee Admits Breaching More than 1.2M Geisinger Patient Records
Max Vance, a former Nuance Communications employee, admitted to illegally extracting protected health information from Geisinger Health System, affecting over 1.2 million patients. The breach continued after his termination, indicating he retained access to the provider’s network. Vance pleaded guilty in...
![[Review] Autosomal Dominant Polycystic Kidney Disease](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/e5c772f073be33a83118f46a1ac91f13.webp)
[Review] Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) remains the most common hereditary cause of chronic kidney disease, imposing substantial morbidity, mortality, and healthcare costs worldwide. Recent advances in molecular genetics and high‑resolution imaging have sharpened diagnostic criteria and enabled more accurate...
![[Correspondence] The Need for Improved Sexual Health Among Survivors of Sex Trafficking](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/04645a085bb87edb4aad0a8fbd1e7c81.webp)
[Correspondence] The Need for Improved Sexual Health Among Survivors of Sex Trafficking
The correspondence underscores a critical gap in sexual‑health care for survivors of sex trafficking, who experience STI rates 22‑111 times higher than the general population and elevated pregnancy and abortion risks. It advocates for decentralized, trauma‑informed services—including at‑home STI kits,...
![[Comment] Safeguarding Genomic Integrity in Pluripotent Stem-Cell Therapies](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/fba52b2aab9c591bf0e059f57acce9ea.webp)
[Comment] Safeguarding Genomic Integrity in Pluripotent Stem-Cell Therapies
Human pluripotent stem cells (hPSCs) are emerging as a transformative platform for Parkinson’s disease, with recent phase I/II trials showing successful engraftment of hESC‑ and iPSC‑derived dopaminergic neurons. Yet extensive data reveal that cultured hPSCs frequently acquire recurrent genetic lesions—most...
Aspirin Risks Kids: Choose Acetaminophen, Vaccinate
Reye’s syndrome is a well known condition that causes life-threatening cerebral swelling in children infected w/ certain viruses like chickenpox or Flu; it’s associated w/ treating the fever w/ aspirin. Prenatal cases are extremely rare. Baby aspirin is used in...
RevolutionEHR Launches RevPay, Redefining How Optometry Practices Manage Cash Flow
RevolutionEHR introduced RevPay, an embedded payments solution that integrates checkout, patient records, and reporting within its AI‑native platform. The tool supports card, ACH, digital wallets and offers optional patient surcharging, promising to reduce processing fees that can cost $10,000‑$18,000 annually...
AHR Lauds Trilogy Gains, Medicare Advantage Rate Momentum for Nursing Homes During Leadership Transition
American Healthcare REIT (AHR) posted a strong Q4 2025, turning a $32.4 million loss into a $10.9 million profit, driven by its Trilogy senior‑care campuses. Trilogy’s same‑store NOI rose 18.4% year‑over‑year and occupancy hit 90.6% in the quarter, while Medicare Advantage rates...
FDA Flags Safety Risk with Boston Scientific Stents
The FDA has classified Boston Scientific’s recall of certain Axios Stent and Electrocautery‑Enhanced Delivery Systems as a Class I recall, the agency’s most serious designation. The recall follows multiple reports of deployment and expansion failures during stent placement, resulting in...
University of Utah Health Helps ‘Reimagine’ the EHR
University of Utah Health researchers are leveraging AI and machine learning to "reimagine" electronic health records (EHR) through the federally funded Reimagine EHR initiative. Backed by roughly $35 million in federal grants and corporate partnerships, the program has produced eight AI‑driven...
FDA Approves Next-Generation CardioMEMS Reader for Heart Failure Monitoring
Abbott received FDA approval for its next‑generation CardioMEMS HERO reader, a pulmonary artery pressure device for heart‑failure patients. The HERO unit is 60% lighter than earlier readers and incorporates built‑in Wi‑Fi and cellular connectivity, allowing measurements anywhere. The upgrade builds on...
University of Mississippi Medical Center to Resume Clinic Operations After Cyberattack
University of Mississippi Medical Center announced that its outpatient clinics will resume normal operations statewide on March 2, following a cyberattack that shut down its IT systems on Feb. 21. The center has regained access to patient records and will...
STAT+: Minnesota Report Shows Large Hospitals Continue to Dominate the 340B Drug Discount Program
Minnesota’s Department of Health reports that hospitals and clinics in the state earned at least $1.34 billion in 2024 from the 340B drug discount program. Participants received $3.045 billion in discounted medicines but paid $1.53 billion plus $165 million in administration fees. The largest...
The Science of Controlling Drug Release in Implants with Ultrasonic Spray Coating
Ultrasonic spray coating is emerging as a core engineering discipline for drug‑eluting implants, with parameters such as drug‑to‑polymer ratio, nitrogen carrier‑gas flow, nozzle height, and spray power dictating coating thickness, profile, and elution behavior. The article explains how variations in...
Promoters and Enhancers: Tool Catches Gene-Controlling DNA Sequences Doing Each Other's Jobs
Researchers at Cornell’s Weill Institute introduced QUASARR‑seq, a high‑throughput assay that measures promoter and enhancer activity simultaneously. The study found that most human regulatory elements can function as both promoters and enhancers, following a unified regulatory logic. A bidirectional feedback...
Cybersecurity and AI in the Era of Home-Based Care Logistics
Kenco’s vice‑president of life sciences, Tim McClatchy, detailed how the firm is hardening cybersecurity across its manufacturer‑to‑home delivery network while deploying AI to streamline labor planning and route optimization. He explained the specific encryption and verification steps used at each...
Cyberattacks on Hospitals Cost Lives. Here’s How to Fight Back at Machine Speed.
Morpheus is an AI‑driven platform that ingests alerts from a hospital’s existing security stack—SIEM, EDR, firewalls, NDR, email security, DLP and identity tools—and stitches them into a single ransomware kill‑chain view. By correlating these signals, it can surface an attack...
STAT+: Trump Most-Favored Nation Drug Pricing Deals End After Three Years for some Companies
President Trump’s "most‑favored nation" (MFN) drug pricing agreements, touted as a safeguard against excessive prescription costs, have been revealed to run for three years for several participants. SEC filings show that 16 pharmaceutical firms have entered these deals, each with...
CMS Eyes AI To Tackle Coding Under ‘CRUSH’ Anti-Fraud Plan
The Centers for Medicare & Medicaid Services (CMS) is evaluating artificial‑intelligence tools to improve the precision of Medicare Advantage coding and hospital billing. The initiative is part of the Trump administration’s proposed CRUSH (Combatting and Reducing Unnecessary Spending and Healthcare...
Life Mirrors Art: Ransomware Hits Hospitals on TV & IRL
The recent episode of HBO’s drama "The Pitt" portrayed a hospital’s IT systems being shut down by ransomware, forcing clinicians to revert to paper‑based processes. Hours later, the University of Mississippi Medical Center confirmed a real ransomware breach that crippled...
Median Technologies to Present at the TD Cowen 46th Annual Health Care Conference
Median Technologies announced it will present at TD Cowen’s 46th Annual Health Care Conference in Boston from March 2‑4, 2026. CEO Fredrik Brag will discuss the company’s latest AI‑driven SaMD developments and upcoming milestones on March 4 at 11:10 am ET. The presentation will be...
ViVE 2026: The Federal Policies and Priorities Shaping Healthcare IT
The federal government unveiled a $50 billion Rural Health Transformation Program, allocating $10 billion per year to states for preventive care, workforce development, and technology upgrades. HHS also announced stricter enforcement of information‑blocking rules, creating a portal for patient‑data complaints. Simultaneously, officials...
AHA Shares Recommendations with ASTP/ONC on HTI-5 Proposed Rule
The American Hospital Association (AHA) submitted formal recommendations to the Assistant Secretary for Technology Policy and the Office of the National Coordinator (ASTP/ONC) regarding the Health Data, Technology and Interoperability (HTI‑5) proposed rule. The rule seeks to deregulate certification criteria,...
AHA Releases Agenda for New Healthier Together Conference
The American Hospital Association (AHA) unveiled the agenda for its first‑ever Healthier Together Conference, set for May 12‑14 in Dallas. The three‑day event will host more than 40 sessions delivered by nearly 200 speakers representing over 100 organizations from 20 states....
Size-Shifting Nanoparticles Successfully Deliver mRNA Medicine to the Pancreas
Researchers have engineered size‑shifting lipid nanoparticles that grow from ~100 nm to >300 nm after intraperitoneal injection, exploiting a capsule‑filter mechanism that blocks entry into the liver and spleen while allowing passage to the pancreas. The enlarged particles deliver mRNA payloads—including CRISPR‑Cas9...
AI Helps Identify Risk in Adults with Congenital Heart Disease
Survival rates for congenital heart disease (CHD) have risen, creating an estimated 1.4 million adult patients who often require repeat surgeries. At the 2026 Society of Thoracic Surgeons meeting, Mayo Clinic researchers presented a machine‑learning model that isolates 15 key variables...
AI‑Biotech IPO Slumps 23% on Opening Day
A leader of this next wave of AI-focused biotechs has completed its IPO, a milestone tarnished by a brutal first few hours of trading. Day 1 for $GENB: -23% https://t.co/u3WQcDD3jL