Today's Healthcare Pulse
Abridge teams with Eli Lilly and Nvidia to expand AI scribe platform
Abridge announced a strategic investment from Eli Lilly and a partnership with Nvidia to build a foundation model for clinical conversations. The AI‑scribe provider now serves over 300 health systems and plans to integrate its platform with payers and broader care settings.
Also developing:
By the numbers: Kardigan targets $1.4B IPO valuation
System Isolates Single Extracellular Vesicle Surface Proteins to Map Function
UC Davis engineers unveiled VESSEL, a cell‑free platform that produces extracellular vesicles bearing a single surface protein. By isolating individual proteins, the system enables direct functional mapping, exemplified by the discovery that CADM1 promotes vesicle uptake. The approach is scalable and accessible, offering a “biological dictionary” for EV biology. Researchers anticipate that VESSEL will accelerate engineered EV therapeutics for cancer, neurodegeneration, and regenerative medicine.
Cytokinetics Inc (CYTK) Q4 2025 Earnings Call Transcript
Cytokinetics announced rapid global regulatory clearance for MYCorzo, securing FDA, China NMPA, and European Commission approvals within a single week. The company launched the drug in the U.S. with over 700 REMS‑certified physicians and more than 12,000 customer engagements in...
Standard BioTools Inc (LAB) Q4 2025 Earnings Call Transcript
Pacific Biosciences reported Q4 2025 revenue of $44.6 million, a 14% year‑over‑year increase, driven by record consumable sales and higher Vega system placements. Consumables generated $21.6 million, up 15% YoY, pushing non‑GAAP gross margin to 40% for the quarter and the full...
Orthofix Medical Inc (OFIX) Q4 2025 Earnings Call Transcript
Orthofix Medical reported fourth‑quarter 2020 net sales of $118 million, a 3% decline year‑over‑year but a 6% sequential increase. Spine implant revenue grew 9% YoY, propelled by an 11% rise in U.S. M6 disc sales, while motion‑preservation revenue jumped 129% YoY....
CareDx Inc (CDNA) Q4 2025 Earnings Call Transcript
CareDx reported Q4 2025 revenue of $108.4 million, up 25% year‑over‑year, propelled by testing services and a 47% surge in patient‑digital solutions. Adjusted EBITDA fell 34% because of a $6.7 million one‑time executive bonus, while cash balances reached $201 million and the company...
BridgeBio Pharma Inc (BBIO) Q4 2025 Earnings Call Transcript
BridgeBio Pharma reported Q4 2025 revenue of $120.7 million, a surge driven primarily by Attruby net product sales of $108.1 million and expanding royalty streams. The company announced statistically significant Phase III readouts for BBP-418 in limb‑girdle muscular dystrophy and...
Harmony Biosciences Holdings Inc (HRMY) Q4 2025 Earnings Call Transcript
Harmony Biosciences reported $714.7 million net product revenue for 2024, a 23% year‑over‑year increase, with Q4 sales of $201.3 million driven largely by its flagship narcolepsy drug Wakix. The company announced a generic settlement with Novogen that postpones competition until at least...
Avanos Medical Inc (AVNS) Q4 2025 Earnings Call Transcript
Avanos Medical reported $178 million net sales for the quarter, with organic sales in its strategic segments rising 10% year‑over‑year. The Specialty Nutrition Systems segment posted 14.5% organic growth, while the radiofrequency ablation business achieved double‑digit expansion. The company completed the...
Establishment Labs Holdings Inc (ESTA) Q4 2025 Earnings Call Transcript
Establishment Labs reported $53.8 million revenue for Q3 2025, a 33.7% year‑over‑year increase, and achieved a 70.1% gross profit margin, the first time surpassing the 70% benchmark. The company posted its inaugural positive adjusted EBITDA of $1.2 million, reversing losses of...
Vaxcyte Inc (PCVX) Q4 2025 Earnings Call Transcript
Incyte reported a strong Q4 2025, delivering $1.51 billion in revenue, a 28% year‑over‑year increase, and $5.14 billion for the full year, up 21%. Core products drove the surge: Jakafi posted $828 million in Q4 sales, Opsilura $207 million, and hematology/oncology sales jumped 121%...
Abcellera Biologics Inc (ABCL) Q4 2025 Earnings Call Transcript
AbCellera Biologics reported a transformative 2024, shifting from a partnership platform to a clinical‑stage biotech. The company advanced two internal antibody programs, ABCL635 and ABCL575, toward CTA filings in Q2 2025 and highlighted a $800 million liquidity position. It outlined a...
Henry Schein Inc (HSIC) Q4 2025 Earnings Call Transcript
Henry Schein reported $3.4 billion in Q4 2025 sales, a 7.7% increase and the strongest growth in over three years. Non‑GAAP operating margin held at 7.42% while cash flow from operations jumped to $381 million. Cloud‑based Dentrix Ascend reached over 11,000 subscribers,...
Iovance Biotherapeutics Inc (IOVA) Q4 2025 Earnings Call Transcript
Iovance Biotherapeutics reported third‑quarter product revenue of about $68 million, a 13% sequential increase, driven primarily by $58 million in Amtagvi sales and $10 million in Proleukin revenue. Gross margin improved to roughly 43% after a restructuring that cut cost of sales by...
Fulcrum Therapeutics Inc (FULC) Q4 2025 Earnings Call Transcript
Fulcrum Therapeutics reported a strong fourth‑quarter, posting $1.51 billion in revenue, a 28% year‑over‑year increase, and a full‑year 2025 revenue of $5.14 billion, up 21%. Core product sales accelerated, led by Jakafi’s $828 million Q4 revenue and Opsilura’s 28% sales jump to $207 million....
Adapthealth Corp (AHCO) Q4 2025 Earnings Call Transcript
American Well Corp (AHCO) reported Q4 2025 revenue of $55.3 million, a 22.1% YoY decline, as the company completed its pivot from a multi‑product telehealth provider to a pure SaaS platform. Subscription revenue now represents 53% of total revenue, reflecting...
Supernus Pharmaceuticals Inc (SUPN) Q4 2025 Earnings Call Transcript
Vanda Pharmaceuticals reported a 9% rise in total revenue to $216.1 million for 2025, driven primarily by a 24% jump in Fanapt sales and a successful bipolar disorder launch. The company secured FDA approval for tradipitant (Nirius) for motion‑sickness prevention, marking...
Option Care Health Inc (OPCH) Q4 2025 Earnings Call Transcript
Centene reported full‑year 2025 adjusted diluted EPS of $2.08 and a Q4 loss of $1.19 per share, impacted by a $389 million Magellan divestiture charge. Management forecast 2026 adjusted EPS above $3, implying more than 40% year‑over‑year growth, driven by Medicaid...
Globus Medical Inc (GMED) Q4 2025 Earnings Call Transcript
Globus Medical reported a record $2.519 billion revenue for 2024, up 61% year‑over‑year, and a non‑GAAP EPS of $3.04, a 31% increase. Free cash flow surged 145% to $405 million, allowing the company to eliminate its remaining $1 billion merger debt by Q1 2025....
Evolent Health Inc (EVH) Q4 2025 Earnings Call Transcript
Evolent Health reported $2.55 billion in 2024 revenue, a 30% year‑over‑year increase, with adjusted EBITDA of $160.5 million landing at the low end of its guidance due to elevated oncology costs. The company announced two major contracts—a New England health plan covering...
Ceribell Inc (CBLL) Q4 2025 Earnings Call Transcript
Ceribell reported a 34% year‑over‑year revenue increase to $24.8 million in Q4 2025, reaching $89.1 million for the full year. Gross margins remained high at 87% for the quarter, with a cash balance of $159.3 million, while net loss widened to $13.5 million due...
Vevye Rapidly Narrows Gap to Miebo Despite Head Start
So the key here is look at how quickly $HROW's Vevye is catching up with $BLCO's Miebo - this is happening despite the Miebo head start (which provides a waterfall effect from refills) and way more extensive detailing and DTC...
![[Correspondence] Internet Shutdowns in Iran and the Right to Health](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/69e5c876c0c0e081e3156d4b1214d794.webp)
[Correspondence] Internet Shutdowns in Iran and the Right to Health
In January 2026 Iran imposed a nationwide internet blackout that remains heavily filtered, coinciding with a violent crackdown on protesters and attacks on hospitals. The shutdown has crippled emergency medical coordination, tele‑medicine, and public‑health reporting, contributing to thousands of preventable...
![[Correspondence] Student Suicide Risk and Counselling in the Kurdistan Region of Iraq](https://hixhlmpcokxhartfkpyi.supabase.co/storage/v1/object/public/images/thumbnails/17d1d078e9209eeedbbafde30ade8668.webp)
[Correspondence] Student Suicide Risk and Counselling in the Kurdistan Region of Iraq
A growing body of evidence shows that suicide and related behaviors are increasingly common among medical students worldwide, posing a serious challenge for education systems. The issue is especially acute in the Kurdistan Region of Iraq, where chronic crises exacerbate...
India Expands Digital Health Impact Domestically and Globally
India reaffirmed its commitment to digital health at the IGSTC Strategic Conclave 2026, spotlighting telemedicine advancements for the Armed Forces and the broader public. The event announced expanded collaboration with Germany and highlighted the integration of telehealth into the Ayushman...
Android Mental Health Apps with 14.7M Installs Filled with Security Flaws
Security firm Oversecured scanned ten Android mental‑health apps with more than 14.7 million combined installs and uncovered 1,575 vulnerabilities. The flaws include 54 high‑severity and 538 medium‑severity issues such as insecure intent handling, plaintext API keys, and weak random number generation....
Animal Muscles Inspire Biomaterial Design for Agriculture, Fabrics and Medicine
Researchers at Washington University in St. Louis have engineered muscle‑inspired protein fibers using synthetic biology, creating filamin‑based threads that combine high tensile strength, toughness, damping and shape‑memory. By growing genetically modified microbes in bioreactors, they achieved higher protein yields and...
Skilled Nursing Dealbook: 280 Beds Realigned in Ohio as 80-Bed Nebraska Nursing Home Changes Hands
Senwell Senior Investment Advisors completed a multi‑party realignment of more than 280 skilled‑nursing beds across Ohio, moving capacity from overbedded counties to operators targeting high‑demand markets. The transaction involved 12 unnamed sellers and multiple buyers seeking growth or new facility...
Care.com and Headspace Launch Mental Health Partnership for Caregivers
Care.com and Headspace announced a partnership to bolster mental‑health support for family caregivers. The collaboration introduces ten exclusive micro‑mindfulness videos, each under three minutes, and provides free Headspace subscriptions to Care.com members. The initiative responds to data showing roughly one‑third...
Denifanstat Posts Positive Phase III Results for Acne Treatment
Ascletis Pharma announced that its oral fatty‑acid‑synthase inhibitor denifanstat (ASC40) achieved positive Phase III results in moderate‑to‑severe acne vulgaris. In a 480‑patient double‑blind trial, 33% of participants reached clear or almost‑clear skin versus 15% on placebo, and an open‑label safety study...
Accelerating Next Generation Medicine with New Drug Delivery Platform
Scientists at the University of Nottingham have unveiled a modular materials platform that self‑assembles with RNA to form nanoscale delivery particles. The system uses reversible host‑guest linkages, allowing rapid tuning of stability and behavior for diverse therapeutic needs. In pre‑clinical...
Worsening CAC Tied to Cognitive Decline in Midlife: CARDIA
A new analysis of the CARDIA cohort shows that progression of coronary artery calcium (CAC) over roughly a decade is linked to measurable declines in processing speed and global cognition among middle‑aged adults. The relationship holds regardless of baseline CAC...
Prime-Edited Therapy Restores Immune Function in Teen
Below is the story of the first patient treated with a prime-edited therapeutic, developed by @PrimeMedicine in a trial led by Dr. Élie Haddad and his team at CHU Sainte-Justine. This teenager suffered from chronic granulomatous disease (CGD), an immunodeficiency,...
AHA Comments to CMS on GLOBE Payment Model
The American Hospital Association (AHA) submitted comments to the Centers for Medicare & Medicaid Services on the proposed Global Benchmark for Efficient Drug Pricing (GLOBE) model, a mandatory Medicare Part B payment framework that would apply most‑favored‑nation pricing to select drugs...
AHA Podcast: Rebuilding Georgia’s Rural Pediatric Pipeline — Part One
The American Hospital Association’s podcast episode "Rebuilding Georgia’s Rural Pediatric Pipeline — Part One" examines the acute shortage of pediatric specialists in Georgia’s underserved counties and outlines strategies to attract and retain providers. It highlights federal initiatives such as the...
Future Leader: Carrie Hyde, MD, Chief Medical Officer of Palliative Care, Gentiva
Carrie Hyde, MD, Chief Medical Officer of Palliative Care at Gentiva, has been named a 2025 Future Leader by Hospice News. In a candid interview she explains her draw to hospice and palliative care, the leadership lesson of listening first,...
ASE Promoting 3D Echo as a Better Way to Treat Congenital Heart Disease
The American Society of Echocardiography (ASE) is championing 3‑dimensional echocardiography as the preferred tool for diagnosing and guiding treatment of congenital heart disease. ASE is standardizing image display and terminology to align imagers, interventional cardiologists, and surgeons, and will deliver...
Q&A: Datavant on AI Hype and Stock Market Volatility
Datavant CISO Dan Walsh told MobiHealthNews that AI is not in a bubble but is over‑hyped, and its true value will emerge as a productivity tool rather than a market disruptor. He likened current hype to past tech cycles, noting...
The Future of Senior Living Requires Better Care Coordination
PointClickCare’s senior‑care chief medical officer warns that senior‑living occupancy has surged to 90‑95%, rendering the old fee‑for‑service, staff‑driven model untenable. The industry must move from reactive emergency‑department transfers to proactive, in‑place care coordination. Success hinges on comprehensive digital resident records,...
Take Back Our Food System: Choose Whole, Demand Better
Even our junk food is getting worse. Our food system has been hijacked, but we can take it back. Read labels. Choose whole foods. Demand better. h/t @drmarkhyman
Why Death Certificates Fail to Capture the Reality of Aging
The article argues that traditional death certificates, which require a single primary cause, fail to reflect the complex, multifactorial nature of mortality in the elderly. It uses Ella’s case to illustrate how chronic conditions, functional decline, and repeated infections intertwine,...
Copan’s PhenoMatrix Software Gets FDA 510(k) Clearance
Copan Group’s PhenoMatrix software, an AI‑driven image assessment tool for bacterial culture plates, received FDA 510(k) clearance as a Class II in‑vitro diagnostic device. The clearance covers analysis of blood, chocolate, MacConkey and ChroMagar agar plates, enabling semi‑quantitative colony counting and...
Gen AI Is Coming for Medical Bills; 3 Ways to Prepare
Patients are turning to generative AI tools like ChatGPT to question and dramatically reduce their medical bills, with high‑profile cases showing savings of over $150,000. OpenAI reports nearly 2 million weekly messages about health insurance, indicating a surge in consumer‑driven AI...
ONC Contest: Make Patient-Exported EHI More Usable
The Office of the National Coordinator for Health IT (ONC) has launched the EHIgnite Challenge, a $490,000 competition aimed at turning raw patient‑exported electronic health information into usable, actionable insights. Phase 1, closing May 13, 2026, seeks concept and design submissions that provide...
AI Personal Trainer Revolutionizes Strength Training
I love my new AI personal trainer. In addition to knowing all my metabolic parameters & strength of each of my muscle groups, she also identifies imbalances and helps me correct it. Is this the future of strength training? https://egym.com/us
Engage Caregivers Early to Make AI a Support Tool
AI adoption in healthcare coding starts with people. Nick Judd of Cleveland Clinic shares why engaging caregivers from day one helped teams see generative AI as a support tool—not a replacement. 🔗https://t.co/cMNcrP9ZWl @ClevelandClinic @DukeHealth #AKASA #AHIMA25 #HITSM https://t.co/FtfPW5BWKP
Relationships Between an Aged Oral Microbiome and Harms Done by Senescent Cells
A new open‑access study investigates how the aging oral microbiome influences senescent cells and their SASP secretions, proposing a systemic oral‑microbiome‑senescence axis. The authors outline evidence that dysbiotic oral communities can exacerbate chronic inflammation and accelerate age‑related pathologies, yet they...
Value-Based Models, Medicaid Driving Palliative Care Changes in 2026
In 2026, value‑based reimbursement models and expanding Medicaid coverage are reshaping palliative care delivery. State initiatives in California, Hawaii and New Jersey signal growing payer acceptance, while partnerships with ACOs are establishing benchmarks for sustainable financing. Industry leaders note a...
Why Red Teaming Is Vital for Health Systems, and Not Just for Cybersecurity
Red‑team exercises simulate real cyber‑attacks to test how healthcare organizations respond under pressure. Pieter Ceelen of Fortra explains that these engagements uncover hidden vulnerabilities such as credential sharing, unpatched legacy medical IoT, and unclear emergency procedures like shutting down internet...
Palantir Deals Are a Threat to Our Data Rights as UK Citizens | Letters
Palantir Technologies, the US data‑fusion and AI firm, has secured contracts with the UK National Health Service and the Ministry of Defence. Critics argue the deals give a surveillance‑focused company access to sensitive citizen data. The firm’s platforms, already employed...
Space Medicine Framework Can Redefine Value-Based Care Strategy
Shannon Kennedy will present a HIMSS 2026 workshop that applies space‑medicine constraints to redesign value‑based care. She introduces the "Orbital Quintuple Aim" framework, which evaluates five interdependent dimensions of health delivery under extreme resource limits. Participants act as spacecraft medical...