BioAge Labs Provides Business Updates
BioAge Labs reported full‑year 2025 results, highlighting positive Phase 1 data for its oral NLRP3 inhibitor BGE‑102, which achieved up to 86% reduction in hsCRP and strong suppression of IL‑1β, IL‑6, and fibrinogen. The company announced a Phase 2a cardiovascular risk trial for early 2026 and an ophthalmology proof‑of‑concept study in diabetic macular edema slated for mid‑2026. It also advanced its APJ agonist program toward an IND filing by year‑end 2026. An upsized $132.3 million follow‑on offering extends BioAge’s cash runway through 2029.
How Hindsight Bias Distorts Clinical Medicine
The article warns that hindsight bias distorts clinical medicine by making adverse outcomes appear inevitable after the fact. Physicians often face ambiguous symptoms, limited data, and time pressure, yet retrospective reviews rewrite cases as if certainty existed from the start....
KeyCare Deploys NVIDIA Nemotron to Power AI-Driven Clinical Intake at Scale
KeyCare, the nation’s only Epic‑based virtual care group, has launched NVIDIA’s Nemotron large language model in production to power its AI‑driven patient intake agent. The agent, embedded in KeyCare’s virtual waiting room, captures and summarizes clinically relevant Epic data before...
Alnylam Advances Future of ATTR-CM Care Through Strategic Collaboration with Viz.ai and Support for the American Heart Association
Alnylam Pharmaceuticals announced a strategic partnership with Viz.ai to develop an AI‑enabled care pathway for earlier detection of transthyretin amyloid cardiomyopathy (ATTR‑CM), launching the AWARE study in five health systems. The company also pledged support for the American Heart Association’s...
Syncope Case Studies: Real Failures, Real Consequences
Two recent lawsuits illustrate the deadly cost of ignoring vasovagal syncope during phlebotomy. In Georgia, a medical assistant left a truck driver upright on an exam table despite dizziness, resulting in a broken neck and a $15 million verdict for lifetime...
Governance by Ideological Whim Meets the Rule of Law
A federal district court in Massachusetts issued a temporary stay halting HHS Secretary Robert F. Kennedy Jr.'s sweeping overhaul of the U.S. childhood vaccine schedule. The judge ruled the changes violate the Administrative Procedure Act because Kennedy replaced career experts...
OnMed Named to Fast Company’s Annual List of the World’s Most Innovative Companies of 2026
OnMed has been named to Fast Company’s World’s Most Innovative Companies list for 2026, earning a No. 14 ranking in North America. The company’s AI‑enabled CareStation™ platform has expanded into rural states, schools, an airport hub, and Puerto Rico over the...
It’s Not ‘Racism’, It’s Statistics…
CVS has begun locking darker foundation and concealer shades behind anti‑theft devices, citing shoplifting data rather than racial intent. Retail theft in the U.S. surged 19 percent year‑over‑year, with projected losses near $48 billion for 2026, prompting chains to protect high‑risk items....
The Scrapers At MyChart's Gate
Fan Pier Labs released an open‑source MyChart connector that automates login, 2FA, and exposes 35+ tools to read and write patient data via the web UI. Unlike official FHIR APIs, it can perform any action a patient can, including messaging providers and...
Experian Health’s 2026 State of Patient Access Survey Reveals Patient Experience Is Improving, but Big Challenges Remain for Healthcare Providers
Experian Health’s 2026 State of Patient Access Survey shows modest gains in perceived access, with 46% of providers saying access improved versus only 18% of patients. Operational efficiencies and digital tools are helping, but staffing shortages now affect 64% of...
The Displaced Valve: Recognizing Ebstein's Anomaly on Echo
Ebstein's anomaly is a congenital malformation where the tricuspid valve remains tethered to the ventricular wall, causing apical displacement. The condition may be identified at birth or remain silent until adulthood, often presenting as right‑heart remodeling on imaging. Echocardiography is...
Palm Primary Care Expands in Tarrant County with Acquisition of Two Clinics in Azle
Palm Primary Care, backed by MBF Healthcare Partners II, has acquired two primary‑care clinics in Azle, Texas, expanding its Texas network to nine locations across Tarrant and Dallas counties. The two sites, Azle Central and Azle Parkway, will continue operating...
How Trump Is Trying to Make 'Fraud' The New DOGE
President Trump has turned fraud into a political rallying cry, using unverified claims that Minnesota’s Medicaid program lost $19 billion to justify withholding $259 million in federal funds. The administration’s new executive order creates a fraud task force that focuses on blue‑state...
Pharma Pulse: A Rare Disease Drug Approval and the Evolving Scope of Pharmacy Practice
The FDA has broadened approval for Imcivree (setmelanotide), creating the first targeted therapy for acquired hypothalamic obesity and reporting an 18.4% placebo‑adjusted BMI reduction in Phase III trials. Parallel research shows that deploying pharmacy technicians as vaccine injectors dramatically improves uptake...
Why CMS Is Tightening ASP Reporting and What Manufacturers Must Get Right
CMS will require pharmaceutical manufacturers to submit the "reasonable assumptions" used to calculate their quarterly Average Sales Price (ASP) beginning in 2026. The move formalizes the estimation process that underlies ASP, covering rebates, bundled discounts, free‑goods programs, 340B sales and...
The 2026 ISA: ONC Drops a Catalog, Founders Should Read It Like a Term Sheet
The Office of the National Coordinator released the 2026 Interoperability Standards Advisory (ISA), a stable catalog that maps health‑data standards to use cases. It arrives alongside a draft USCDI v7 adding 30 new data elements, the HTI‑5 rule pushing a FHIR‑first...
The Rise of the Modern Hospital and Early-Life Health: Evidence From the Hill-Burton Act
The Hill‑Burton Act funded over 300,000 new hospital beds between 1948 and 1975, doubling U.S. hospital capacity. This public‑sector expansion coincided with a sharp decline in out‑of‑hospital births, falling from 14% to 1%, and a 50% reduction in infant mortality....
The Competitive Edge in Pharma Logistics: Sustainability, Safety, and Precision Delivery
Marken UPS Healthcare Precision Logistics argues that sustainability, safety, and precision delivery are the new competitive differentiators in pharmaceutical logistics. The company is rolling out carbon‑neutral transport, renewable‑energy‑powered warehouses, and AI‑driven routing to cut emissions and improve speed. Real‑time IoT...
![Insulin Resistance Is a Survival Mechanism, Not a Broken System [PODCAST]](/cdn-cgi/image/width=1200,quality=75,format=auto,fit=cover/https://kevinmd.com/wp-content/uploads/Design-1-1-scaled.jpg)
Insulin Resistance Is a Survival Mechanism, Not a Broken System [PODCAST]
In a recent KevinMD podcast, metabolic educator Kevin Whitt argues that insulin resistance is not a disease but a natural survival mechanism explained by the 1963 Randle cycle. He contends that the mixed macronutrient Standard American Diet constantly activates this...
The Affordable Care Act Turns 16: What's at Stake in 2026 #CareTalk
Sixteen years after its enactment, the Affordable Care Act (ACA) remains a cornerstone of American health policy. In a new CareTalk episode, the host and guests Diane Archer of Social Security Works and Louise Norris of HealthInsurance.org dissect the law’s...
Top 5 Fastest Growing Pharma & Biotech Companies in Europe in 2026
A Financial Times analysis of Statista data identifies Europe’s five fastest‑growing pharma and biotech firms between 2021 and 2024. Italy’s Itaste Medical surged to €18.4 billion in sales, a 2,035% absolute growth, while the UK‑based Grow Group expanded cannabis‑based medicines to...
Top 3 Medtech Companies to Work for in Asia in 2026, Per Financial Times
Asia’s medtech sector is gaining momentum as Singapore became the first nation to achieve the WHO’s highest maturity level for medical‑device regulation, signaling stronger oversight across the product lifecycle. The Financial Times’ 2026 ranking spotlights three leading employers—Baxter International, Medtronic,...
Plastic Waste Transformed Into Parkinson’s Drug in Bioengineering First
Researchers at the University of Edinburgh have engineered bacteria to transform PET plastic waste into levodopa, a primary treatment for Parkinson’s disease. By inserting a seven‑gene, four‑step biosynthetic pathway into Escherichia coli, the team converted both industrial PET feedstock and...
How Competency-Based Education Is Driving Medical Education Reform
Competency‑based education is reshaping U.S. medical training by challenging the traditional reliance on grades, USMLE scores, and honor societies. Evidence shows these metrics poorly predict resident performance, prompting accreditation bodies to adopt Milestones and entrustable professional activities (EPAs) as more...
Europa Biosite Introduces Rapid RNA Production Technologies
Europa Biosite has formed a strategic distribution partnership with Quantoom Biosciences to bring Quantoom’s Ntensify® mano and micro RNA production technologies to European researchers. The deal also anticipates future distribution of Quantoom’s Ncapsulate® LNP formulation kits. By adding rapid, high‑quality...
FDA Approves Expanded Indication for Imcivree as Treatment for Hypothalamic Obesity
Rhythm Pharmaceuticals' Imcivree (setmelanotide) received FDA approval as the first treatment for acquired hypothalamic obesity, expanding its indication to adults and children aged four and older. The Phase III TRANSCEND trial demonstrated a 15.8% mean BMI reduction at 52 weeks, an...
How to Fix the Handoffs Where Prior Authorization Workflows Break Down
The interview with Tina Valbh highlights how prior‑authorization workflows crumble at every handoff, from clinicians to multiple vendors, creating delays and patient confusion. She points out that patients rarely receive real‑time updates, leaving them unaware of denials or required actions....
Building the Anti-Epic Regulatory Machine
FTC Chairman Andrew N. Ferguson announced a new Healthcare Task Force that merges the Bureaus of Competition, Consumer Protection, Economics and the Offices of Policy Planning and Technology. The effort implements President Trump’s February 2025 executive order to boost competition,...
Harris Health Alliance Acquires eRedbook to Enhance Digital Child Health Across the NHS
Harris Health Alliance (HHA) completed an asset purchase of eRedbook from Heathersoft, adding the UK’s most established digital parent‑held child health record to its portfolio. eRedbook captures health and development data from birth to age five, linking parents with NHS...
QPX7728
Xeruborbactam (QPX‑7728) is a broad‑spectrum β‑lactamase inhibitor designed to revive the activity of β‑lactam antibiotics against multidrug‑resistant Gram‑negative bacteria. Developed by Qpex Biopharma and Shionogi, the molecule targets both serine‑ and metallo‑β‑lactamases, addressing a key resistance mechanism. Preclinical data show...
Integrated DNA Technologies Expands Into Clinical Diagnostics with First In Vitro Diagnostic
Integrated DNA Technologies (IDT) announced the launch of two in‑vitro diagnostic kits, Archer FUSION Plex‑HT Dx and VARIANT Plex‑HT Dx, marking its entry into the next‑generation sequencing (NGS) IVD market. Built on IDT’s proprietary anchored multiplex PCR chemistry, the kits offer targeted DNA and RNA...
Cencora to Expand Retina Consultants of America Through Acquisition of EyeSouth Partners’ Retina Business
Cencora, Inc. announced a definitive agreement to acquire EyeSouth Partners’ retina business for $1.1 billion, integrating the physicians into its Retina Consultants of America (RCA) network. The acquisition is expected to be slightly accretive to adjusted diluted EPS within the first...
"There Will Be No More Gaming the System" - Oz Reacts to Latest MaineCare Fraud Scandal
CMS Administrator Dr. Mehmet Oz warned Maine that Medicaid fraud will no longer be tolerated after reports that Paradise Residential Services billed over $16 million in inflated rates, charging twice the national average for autism residential care. The provider, accused of...
Why Pharma Is Exploring Direct-to-Employer Benefit Models
Pharmaceutical manufacturers are re‑examining traditional PBM‑centric distribution by offering direct‑to‑employer drug purchasing models. Companies like Andel charge a per‑prescription transaction fee and eliminate administrative or per‑member fees, aiming to lower drug spend for employers. Their platform centralizes prescription intake, routes...
Oryon Cell Therapies Reports Phase 1b/2a Data Showing Sustained Motor Improvements in People with Parkinson’s Disease
Oryon Cell Therapies presented interim Phase 1b/2a data showing that its autologous dopaminergic neuron‑replacement therapy produced sustained motor improvements in Parkinson’s patients. Five participants experienced 29‑62% reductions in OFF‑state MDS‑UPDRS Part III scores over 6‑18 months, with continued gains beyond six months....
If Gene Therapies Are so Revolutionary, Why Does No One Want to Pay for Them?
Gene therapies promise one‑time cures for diseases like sickle‑cell and inherited blindness, but their price tags—often $1 million to $3 million per patient—clash with the U.S. insurance model. More than half of new cell and gene therapies face coverage restrictions because insurers...
Measles Is on the Rise. Have You Reviewed Your Vaccine Policies Since Covid?
Measles cases in the United States are climbing sharply, with 2025 recording over 2,200 infections—the highest in two decades—and 2026 already reporting nearly 1,500 cases across 27 states. The CDC has identified 14 new outbreaks this year, and the nation...
AI Bias in Healthcare: When Algorithms Erase Black Professionals
Physician executive Seleipiri Akobo recounts how generative AI rendered her as a white woman, and when her race was added, as a stereotypical Black superhero. The incident illustrates how AI models default to white norms and treat Black identities as...
Latent-Y: The Autonomous AI Agent for Drug Design at Scale
Latent Labs unveiled Latent‑Y, an autonomous AI agent that designs therapeutic antibodies from natural‑language prompts. Powered by the Latent‑X2 generative model, the platform compresses weeks of expert work into hours and can run multiple design campaigns in parallel. In three...
CT Bill Would Expand Healthcare Access as Republicans Push 100,000 Off Medicaid
Connecticut Democrats advanced Senate Bill 3, a $200 million health‑care initiative aimed at expanding tax credits after the ACA subsidies lapsed. The bill extends premium subsidies to families earning up to 600 % of the federal poverty level and creates a state‑run...
One Company’s Million-Dollar Gambit to Turn the Healthcare Crisis Into a Gold Mine
HealthEquity, the largest U.S. health‑savings‑account administrator, announced record HSA sales and expanding margins in its March earnings call. The company credited the Trump‑era "One Big Beautiful" bill for broadening HSA eligibility, adding roughly 10 million new potential participants. Shortly after, HealthEquity...
Advancing Patient-Centred AI with Adaptive Machine Learning
The paper highlights that fragmented, inequitable health‑care data hampers patient‑centred AI, limiting personalization and equity. It critiques three existing AI pathways and proposes Adaptive Machine Learning (AML) as a fourth, continuously updating models with real‑world, context‑sensitive data. AML rests on...
NHS Supply Chain Commits to Adoption of Value Based Procurement
NHS Supply Chain has formally committed to applying a new value‑based procurement methodology, co‑created with the Department of Health and Social Care, to all its purchasing activities. The framework, developed over three years, will be rolled out across England and...
What an End-to-End Model Changes for Patients
CareTria is launching an end-to-end patient support model that acts as a single point of contact, promising one‑call resolution and uninterrupted therapy access. The strategy blends AI‑driven automation with human interaction to handle routine tasks while preserving empathy for complex...
How Do Recent Actions From FDA Provide Insight to the Agency's Enforcement Posture?
The FDA’s Rare Disease Evidence Principles (RDEP) introduce flexible trial designs, allowing sponsors to use natural‑history data and novel biomarkers as endpoints. These guidances aim to accelerate approvals for rare‑disease therapies while maintaining safety as a top priority. However, analysts...
Licensing and Credentialing Nonsense with Assured | Out-Of-Pocket
Assured offers a software platform that combines AI‑driven automation with credentialing experts to streamline provider licensing, credentialing, and payer enrollment across multiple states. The service automates data collection, screen‑scrapes portals, and manages follow‑up, charging a base SaaS fee plus usage‑based...
Galderma Receives U.S. FDA Approval for Restylane® Contour™ for the Correction of Temple Hollowing
Galderma announced that the U.S. FDA has cleared Restylane Contour for the correction of temple hollowing in adults over 21, extending its existing cheek and mid‑face indications. Clinical studies demonstrated a 91% responder rate at three months, with efficacy persisting for...
How to Build Patient Trust in Medical AI
A JAMA Network Open study of 3,000 U.S. adults examined trust in AI‑assisted medical visits for a moderate‑risk rash. Participants favored AI that outperformed specialists, increasing visit preference by 32.5%, while doctor presence only added 18.4%. FDA approval and other...