UCB to Acquire Neurona for $1.2B, Targeting Seizure Cell Therapy
UCB, betting on seizure cell therapy, to buy Neurona for up to $1.2B https://t.co/LxI1Omodan by @realJacobBell $UCB
Nanobody Fixes CFTR Misfolding, Boosts Cystic Fibrosis Therapy
A cell-penetrating nanobody repairs misfolded CFTR proteins in cystic fibrosis cells, restoring chloride channel function and showing strong synergy with existing therapies, potentially advancing treatment for protein misfolding disorders. biotechnology
Exercise Aligned with Your Chronotype Reduces Heart Disease Risk
Timing exercise to match body clock chronotype may lower cardiovascular disease risk https://t.co/RhtM0ZlW1k via @medical_xpress #exercise #CardioTwitter #MedTwitter #health #lifestylemedicine
Start High‑Dose Folic Acid Pre‑Pregnancy Cuts Birth Defects 45%
Initiating high-dose folic acid before pregnancy is linked to a 45% lower risk of major birth defects in children of women using antiseizure medication, with no protective effect observed if supplementation begins after pregnancy starts. epilepsycare
AI and Cheap Sequencing Will Unlock Health Risk Genomics
Our use of genomic data is woefully minimal for establishing health risks but the low cost of sequencing along with improved AI analytics can get this moving forward. Nice example here
Pancreatic Cancer Study May Usher New Treatment Era
A pancreatic cancer expert on why Revolution Medicines’ study could ‘open up a new era’ of treatment https://t.co/npSBO8iR7n via @statnews
Target the Right Patients, Not More, for Growth
Healthcare marketing is shifting from broad campaigns → pinpoint precision. Ty Allen from RLDatix explains how targeting the RIGHT patients (not just more patients) drives growth. Learn more: https://t.co/KJad77QKHj @socialclimb_1 #PrecisionMarketing #hcmktg
Seguro Popular Gave Free Health Coverage to Half of Mexicans
Mexico’s Seguro Popular (SP), introduced in the early 2000s, was one of the most ambitious efforts. It extended free public health insurance to those outside the formal sector, covering nearly half the population that previously lacked insurance. https://t.co/ON5TubBVfN
China’s Drug Innovation Surge Defies Industrial Policy Narrative
China Is Now a Global Drug Innovation Powerhouse. Industrial Policy Had Little to Do with It. .....industrial policies like Made in China 2025 played a negligible role... https://t.co/MKyZ6auvAS
Blood Test Identifies Molecules Predicting Short‑term Survival
New Blood Test Signals Who is Most Likely to Live Longer, Study Finds Research finds tiny molecules in blood strongly predict short‑term survival in older adults https://t.co/8bv3I5CCXE https://t.co/IdZ5eYOmwe
Kennedy Misstates Danish Tylenol Data, Ignoring Prescription Surge
This appears to be a case of Secretary Kennedy speaking without having full command of the facts. He calls the Danish study that "garbage" because it tracked whether women got Tylenol by whether they were prescribed it -- but he...
Epic's AI Suite Crowds Out Third‑Party Tools in Healthcare
My new Substack: Epic, the leading EHR vendor, has released >100 AI tools. Choosing them over third-party tools has become the safe choice for many health systems. I explore why, and the bigger questions: can – and should – something be done about...
No Evidence Vitamin K Shot Causes Jaundice, Cancer
Vitamin K shot - quick facts: * Package inserts # proof of causation. * There is no evidence the vitamin K shot causes jaundice, cancer, or SIDS. * It is not a
When Diet Fails: Iron Infusions for Athletes
Iron deficiency is common among athletes. Under certain scenarios, diet and supplementation may not be sufficient. This blog describes scenarios where iron infusion or injection may be an appropriate treatment option https://t.co/1ybdvV0t1g https://t.co/GQJ8YmacvU
Rejecting Life Extension = Costly, Intentional Aging Choice
"If you have access to life extension therapies and decline them, you’re making a deliberate choice to age and die on an old biological timeline." -- the additional medical cost associated with NOT choosing these therapies, may make it an...
Inside Moderna's Vision: Trust, Safety, and mRNA Future
Awesome to see @WSITYpod interview @moderna_tx president Stephen Hoge A great and wide reaching interview about trust, mRNA vaccines, spike protein, adverse events and what the future of mRNA technology is A candidate interview worth listening too.
AP-1 Activation Emerges as New Cancer Resistance Target
The knowledge of the many mechanisms by which cancer proves resistant to treatments keeps expanding. This week @Nature highlights activation of the AP-1 transcription factors, representing a new target https://t.co/UWSYDFM0IK https://t.co/6l4TISQonQ
AI Wristband Reads Muscles, Directs Robots Like Hands
MIT engineers built an AI wristband that controls robots by reading your hand muscles. It works by using an ultrasound to capture images of the muscles and tendons in your wrist. An AI algorithm then translates those images into the exact position...
Secure Genuine Champion Buy‑in Before Launching Digital Health
The Digital Health implementation almost blew up in our face as the Department Chief walked out in frustration halfway through our Kick Off meeting. With 20+ stakeholders watching, it couldn't have gone any worse. We had gotten brought into a health...
Anemia May Heighten Alzheimer’s Risk Alongside P‑tau217
In evaluating p-tau217 and other biomarkers for risk of Alzheimer's disease, keep an eye on anemia, which may add to the risk, as seen in this new report https://t.co/ezbcLr4HIf https://t.co/TOKLRVBM4f
Human‑scale Data Aims to Close Drug Trial Gap
90% of drugs that enter clinical trials fail. A big part of why: the models they're based on weren't trained on human biology. Mouse data, non-representative cell lines, sparse perturbation coverage. The gap between in silico predictions and what actually happens...
Gut Microbiome Predicts Melanoma Recurrence Post-Immunotherapy
Gut microbiome markers predict recurrence of cancer after immunotherapy for metastatic melanoma @CellCellPress https://t.co/k5YuNnqfvt https://t.co/9UbuNAcYJh
Lilly's Obesity Pill Gains Momentum; OpenAI Launches Discovery Tool
Lilly’s obesity pill off to a strong start; OpenAI debuts new drug discovery tool https://t.co/upwygATKAv $LLY $GILD $JANX #biotech
US Measles Cases Surge to 2026 Record High
#Measles: Confirmed cases in the US have hit 1748 so far this year. All but 10 are infections contracted in the US. For some context: In the first 3.5 months, 2026 has racked up 76% of the cases accrued in all...
Interferon Pathway Drives Inflammaging, Offers Epigenetic Target
We've known inflammaging is a big part of why the human aging process accelerates. Now the interferon pathway is invoked as having a causal role (via epigenetics) and potential for targeting https://t.co/0Di0xiLGyy
Stopping Meds Causes Rebound, Not
You gain weight back after stopping a GLP-1 that means it’s bad. I guess my thyroid medicine is bad because if I stop it my thyroid levels will be nothing anymore and I’ll feel terrible.
Smart Experts Reveal Future of Cancer Treatment at AACR
Join us at AACR as a bunch of smart people explain what's next in cancer treatment
Ultra-Processed Foods Boost Death Risk for Cancer Survivors
As a medical school professor, this study should be front-page news. Researchers tracked cancer survivors and found those eating the most ultra-processed food had: -- 48% higher risk of death from any cause -- 57% higher risk of... https://www.youtube.com/@RobertLufkinMD https://www.aacr.org/about-the-aacr/newsroom/news-releases/high-consumption-of-ultraprocessed-foods-may-be-linked-to-cancer-survivors-risk-of-death/ CancerPrevention #UltraProcessedFood #MetabolicHealth #Nutrition #Longevity
Clinicians Graded on Metrics They Never Learned
Your primary care clinician is being graded on a system they were never taught to navigate. Primary care physicians, PAs, and NPs are now compensated partly on quality dashboards. Mammogram rates. A1C control percentages. HCC coding accuracy. Colonoscopy completion. Almost...
India Discharges Knee Replacements in Days, Not Months
WHY YOU SEE MANY FOREIGNERS IN INDIAN HOSPITALS 🥼🩺 Knee replacement surgery waiting times 🇵🇱 Poland – 253 days 🇦🇺 Australia – 209 days 🇪🇸 Spain – 147 days 🇨🇦 Canada – 122 days 🇬🇧 UK – 98 days 🇮🇳 India...
Racist Claim Blames Parenting, Ignores Black Mental Health Disparities
Why do I say this statement is not only wrong, but racist? 1. It implies Black children's mental health problems are all due to parenting, & that the only answer is to adopt them out. 2. It ignores actual disparities in care,...
Essential AI Visual Guide for Modern Physicians
A visual guide to machine and deep learning subtypes that is from our npj Digital Medicine paper: A short guide for medical professionals in the era of artificial intelligence. In that, we aimed to create a short, visual and digestible repository...
Metformin Misses Target in Type 1 Diabetes Trial
As a medical school professor, I love when medicine humbles us. Metformin has been around for a century. We thought we understood it. We were wrong. A new clinical trial gave metformin to people with type 1 diabetes -- not type 2....
Join Dr. Robert Califf on Future of Drug Regulation
We are so excited to host Dr. Robert Califf on April 20th, 2026, at 3pm EST. From leading the U.S. Food and Drug Administration to shaping the future of clinical research and drug regulation, Dr. Califf has been at the center...
Women Experience Faster Tau Buildup and Cognitive Decline
Women show greater tau buildup and faster cognitive decline than men in Alzheimer's https://t.co/5GKfzXZPSo https://t.co/8L9wxDsFAp
Cast Works as Well as Surgery for Kids' Wrist Fractures
Most children with severely displaced wrist fractures can achieve similar long-term recovery with a plaster cast instead of surgery, minimizing risks and reducing healthcare costs. pediatrics
High SHBG Increases Sarcopenia Risk; Free Hormones Protect
Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women’s Health Initiative "Among postmenopausal women, higher SHBG concentrations at baseline were associated with lower lean body mass and a higher odds of sarcopenia,...
Never Withdraw Care without Direct Observation
Why I would never compromise on withdrawing care until I saw it firsthand [PODCAST] http://dlvr.it/TS4mMD Podcast #PalliativeCare
PET‑CT Leak Linked to Staff Cancer Cases
The 3D precision of a PET-CT scan is designed to find cancer, but at one government teaching hospital, the machine itself is being blamed for causing it. Seven personnel in a single radiology department have developed cancer or thyroid diseases. You...
Leiden University Seeks Postdoc for Next‑gen GPCR Drug Discovery
🚨 Hiring Postdoctoral candidate for next generation GPCR drug discovery Leiden University The Faculty of Science and the Leiden Academic Centre for Drug Research (LACDR) are looking for a:Postdoctoral candidate for next generation GPCR drug discoveryAre you excited about developing cutting-edge drug...
New Rogan‑Spotify Alliance Fuels Anti‑vax Disinformation, Endangering Children
I’m not happy about this new toxic alliance between Children’s Health Defense and Rogan-Spotify. Both are powerful anti-science disinformation organizations, and they don’t care about you or your family. We already had >200,000 needless American deaths from pushing ivermectin and...
Weekly System Review Fuels MYRESET’s Patient Care
Founder Diaries Day 5? — Weekly regroup of our systems, targets & goals for MYRESET at our favorite lounge 💉💚⏰ (We’re also “on call” for our patients booked in for consults all the time. We make sure our doctors are...
Celebrating Science: Discussing #ScienceUnderSiege with Neil Tyson
After so many dark months of countering RFK Jr and the ACIP/HHS/Children’s Health Offense pseudoscience disinformation campaign it was a real joy to spend an evening with @neiltyson discuss our book #ScienceUnderSiege @MichaelEMann @PeterHotez https://t.co/49e3hC7bSz
Kailera Raises $625M in Major Biotech IPO
From @gwendolynawu: Kailera nets $625M in one of biotech’s biggest-ever IPOs https://t.co/SJWx2QBmSn $KLRA #biotech $LLY $NVO $GPCR $VKTX #IPO
7‑8 Hours Nightly Cuts Type 2 Diabetes Risk
This Is How Much Sleep You Need to Lower Your Type 2 Diabetes Risk https://t.co/UI9VyQiv3a https://t.co/ac9eBXPIBu
Review Panel Finds Anti‑amyloid Alzheimer Drugs Offer Little Benefit
Medical Review Group Questions Usefulness of Some Alzheimer’s Drugs Group says anti-amyloid treatments don’t offer noticeable benefits https://t.co/Z9tRQquyZX
GLP‑1 Drugs Show Promise for Treating All Addictions
GLP-1 medications get at the heart of addiction: study Diabetes and obesity drugs show promise in treating and preventing all substance use disorders https://t.co/buHywnw9Wk https://t.co/0lunbQbjsb
Mitochondrial Transplantation Reverses Cell Degeneration
In terms of my top bets for rejuvenation-based therapies, mitochondrial transplanation has entered the chat Cell-type-targeted mitochondrial transplantation rescues cell degeneration https://t.co/izvDaRk7kz
Cellular Stress Drives Stem Cell Aging, Revealing Therapy Targets
Beyond Cell Death: The Hidden Drivers of Stem Cell Aging “The findings shed light on how cellular stress shapes stem cell aging and highlight potential pathways for developing therapies to counter age-related decline...” https://t.co/hBUchsNtQ4 https://t.co/6HyOSZZ6ZS
Choose the Right Design, Not One‑Size Truth
n=1 is can work for cancer and infectious disease, but often you need a clinical trial. We need to always be asking what the best tool is to get to truth. Don't assume that one experimental design is always correct. And don't...