Stopping Alzheimer’s Drugs Speeds Decline, Raises Death Risk
Long-term effect of discontinuing anticholinesterase treatment on cognitive decline and mortality in Alzheimer's disease in France: a quasi-experiment and target trial emulation study https://t.co/YUcSc7w9HG
Kids Endured Prolonged Covid Restrictions Despite Adult Noncompliance
The primary “failure” was that Covid measures lasted until the Summer of 2022, especially as they were enforced on children and public school & daycare Well after adults (with a choice) had stopped complying, little kids were masked for 8 hours/day...
Frontline Voices Unfiltered: Healing Healthcare Through Stories
The modern health care system cannot be fixed with more academic jargon or sterile clinical lectures. We have enough data. What we lack are the raw human stories behind the stethoscope. For too long, the diverse voices that actually make up our...
Microtubule Nexus Unites Amyloid and Tau in Alzheimer’s
The microtubule nexus linking amyloid beta and tau: A simple and unifying theory for the underlying cause of Alzheimer's disease https://t.co/dRJUJku6yu
Rapamycin Lessens Age‑related Motor Decline, Varies by Sex
Chronic rapamycin treatment attenuates age-related motor deficits in sex-dependent manner in UM-HET3 mice 👉"Our results are consistent with the idea that rapamycin’s beneficial effects are mediated, at least in part, by reducing oxidative stress and ER stress-mediated apoptosis... https://t.co/b8EZwrDTXP
Atrial Fibrillation Impairs Brain Waste Clearance, Predicts Worse Outcomes
Heart-Brain Axis Atrial fibrillation leads to reduced brain glymphatic flow, decreased washout of waste metabolites. https://t.co/2PNjoDl4Om Today #ACC26 @JAMACardio Serum Neurofilament (sNfl), a marker for brain cell injury, is associated with adverse CV events and mortality in patients with atrial fibrillation https://t.co/fWNg8zks0C
Genetic IL6R Blockade Shows No Impact on Disease or Longevity
Genetic interleukin-6 receptor blockade, chronic disease risk, and longevity: results from the women’s health initiative Lay Summary: "The role of interleukin-6 receptor (IL6R) blockade in reducing chronic-disease risk and improving longevity is uncertain. In a study of 38 807 postmenopausal women followed for...
GLP‑1 Drugs Now Help Psoriatic Arthritis Beyond Weight Loss
The list of conditions for which GLP-1 drugs provide benefit independent of weight loss keeps growing. Add psoriatic arthritis #AAD26 @AADskin https://t.co/kJej6osXTS
Treatable Genitourinary Syndrome of Menopause: Options Available
Perimenopause and menopause can alter vaginal and urinary tissue through loss of local hormonal support. The result can be dryness, burning, pain with sex, urinary symptoms, and recurrent UTIs. This is not simply “aging.” It is often genitourinary syndrome of...
Vitamin K Deficiency Bleeding: Preventable, Real Pediatrician Stories
Vitamin K deficiency bleeding is a preventable condition. These are real stories from real pediatricians. The risk is 1/60 of bleeding in the first few months o
Insurers' AI Denials Delay Life‑saving Cancer Care
The mother of an angiosarcoma patient reached out this weekend to see if I could help her daughter get a second opinion at Dana-Farber after it was rejected by her insurer. I'll do what I can. Dana-Farber has made a...
ICU Medicine Bills Soar to ₹50K Daily in India
In ICU ₹50,000/day only for medicine cost? The viral post on 'X' went viral, which raises concerns about the Indian healthcare system. A man shared his friend's experience. His friend's grandmother was admitted to the ICU in a private hospital. She was admitted in...
Doctor Multiplies 5‑star Reviews, Triples Patients in 3 Months
"Doctors, every patient checks reviews before visiting. Here’s how one of my clients, A Doctor grew from 12 reviews (4.8 stars) to 712, 5-star reviews—and tripled their patient footfall within 3 months. These are the exact same hacks I’ve shared with...
Robots Assist, Humans Provide Empathy in Healthcare
Robots are starting to enter one of the most sensitive environments we have. Healthcare. Unitree’s systems being used as caregivers and assistants show how robotics is moving beyond factories into real-world human settings. The value is clear: Supporting staff with repetitive tasks Assisting with logistics...
COVID Likely Zoonotic; Prioritize Broad Pandemic Preparedness
Concur that COVID was very likely zoonotic in origin. That's always been the most likely scenario, and the evidence has just grown stronger. (See below.) From a policy standpoint, I don't think it matters much. 1. Some past pandemics have originated...
Cartel Arrests Won’t Curb Synthetic Opioid Crisis
The synthetic opioid market: Why cartel arrests do not stop the crisis http://dlvr.it/TRlsbG Conditions #PainManagement
Epigenetic Dysregulation Fuels Aging, Offers Therapeutic Target
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target 👉 “By providing mechanistic clarity on how epigenetic dysregulation drives ageing phenotypes, we aim to enable rational design of therapeutics that target the epigenetic systems that fail during ageing,...
Half of US Spine Surgeries Unnecessary; Exercise Beats Surgery
Over HALF of all spine surgeries performed in the US are unnecessary. We know this because spine surgeons said so. When patients got a second opinion, 60% were told the surgery they were recommended didn’t need to happen. The best non-surgical treatment for...
Euthanasia for Depression Equals State‑Sponsored Murder
Offering euthanasia to depressed people is state-sponsored murder. There is no ambiguity. It is murder.
Insurance Should Sue for NP‑only “Doctor Visit” Scams
Insurance companies should sue doctors offices and hospitals that bill them for a “doctor visit” when the patient only sees a Nurse Practitioner. Personally I’m tired of the Nurse Practitioner scam. And it is a scam. They pay them far less...
MAID Driven by Government Cost Savings, Not Dignity
The purpose of MAID is not to let people die with dignity. The purpose of MAID is to save the government money. They will keep pushing death on everyone they can push it on, in order to save the government...
Hib Vaccine Shields Against Meningitis, Pneumonia, Epiglottitis
The Hib vaccine protects against Haemophilus influenzae type b (Hib) bacteria, which can cause severe illnesses like meningitis, pneumonia, and epiglottitis. Th
FDA Greenlights Viagra: A Pivotal HealthTech Milestone
#ThisDayInTechHistory. March 27, 1998. The FDA approved Viagra developed by Pfizer. (Untold Story) #HealthTech #JVGpost https://t.co/GJea9vd0v9
FDA Confirms Myocarditis Risk, Validating Parents' COVID Concerns
Great thread and one addition: Increased risk of myocarditis in young boys. The demonization of parents who asked, the denials by healthcare professionals and bureaucrats, and ultimately, the admission and subsequent FDA warning proving parents worst fears correct. It will take...
Psilocybin Emerges as Promising Longevity Therapy
When I started Don't Die in 2021, we evaluated all the scientific evidence for the most powerful anti-aging therapies. Psychedelics were no where to be found. A wild turn of events that they're now front and center for us....
Microbial Phenolics Mediate Oats' Cholesterol‑lowering Power
Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial "Here we show that microbial phenolic metabolites are driving factors for the cholesterol-lowering effect of oats.." https://t.co/Y6fmNYStmZ
PCSK9 Inhibitor Cuts Cardiovascular Events in Diabetics
In a randomized trial of a PCSK9 inhibitor [for LDL cholesterol lowering] vs placebo for patients with diabetes and no known heart disease, there was significant reduction of major cardiovascular events including deaths #ACC26 @JAMA_current https://t.co/mzuI79c4IN https://t.co/16Cpxf7IBx
Intensive LDL < 55 Mg/dL Cuts Cardiovascular Events
Validation of aggressive LDL lowering to reduce major adverse cardiovascular events, a randomized trial targeting LDL < 55 mg/dl. In participants with atherosclerotic cardiovascular disease (secondary prevention) @NEJM #ACC26 https://t.co/oLnkqhawOd
Strong Social Ties Boost Health and Longevity
social disconnection is not just painful emotionally, it puts the body under biological stress. It is linked to higher inflammation, worse cardiovascular health, and a higher risk of early death, while stronger social relationships are consistently associated with better survival....
Women Leading the Way at GI Conference
In a field long defined by gender imbalance, it’s refreshing to be in the minority in this picture. Grateful to be part of this moment at the @AmerGastroAssn Women in GI Conference today in Atlanta, where leaders are shaping what comes...
Hard-to-Measure ROI Stifles Life‑Saving Healthcare Innovation
I've seen hospital CEOs cancel innovations that reduced readmissions and ED visits. The outcomes were incredible - but the financial ROI was too hard to prove. And since "ROI is needed to justify everything right now in healthcare" many great innovations...
MARCUS: First Visual Language Model for Cardiac Imaging
MARCUS, the first visual language model trained on raw ECG, echocardiography, and MRI video imaging data that reasons interactively with clinicians. From @EuanAshley et al @StanfordMed https://t.co/nlwXin0G1b
Classifying Aging Doesn't Affect Need for Research Investment
Though authors acknowledge (as I have argued before), even *if* they are right, “classification of aging is not relevant to the importance of investing in aging research to alleviate its burden” [nor targeting it, I might add] 👨🏻⚕️
Canada Proposes Minors' Right to Choose Assisted Death
Brochure for assisted suicide for children and teens in Canada. The 2023 Special Joint Committee on MAiD recommended allowing "mature minors" (capable children, often referenced as 12+) access if death is reasonably foreseeable, consulting parents "where appropriate" but letting the child's...
US Obesity Prevalence Rises to 69% with New Metrics
Obesity (in the US) is much more common than prev thought: 69% vs. old 43% stat Based on new better definition that uses not only BMI but also anthropomorphic measures such as waist & ratios of it, which more accurately shows higher...
US Health Care Costs Begin to Flatten, Tech Helps
Will generate discussion: new @BrookingsInst report from David Cutler & @LevKlarnet (h/t @peter_orszag) suggesting early evidence that we're starting to bend US HC $ curve https://t.co/KUH3muQRFz @ScottGottliebMD @amitabhchandra2 One potential factor: tech... @DanielSodickson https://t.co/Ux1PT7QsgU
Taxpayers Fund Everything Except Our Health Debt
Let me help rephrase for you Bernie. Need a loan for college so you can party for a semester and drop out? Taxpayers will loan you money for it. Need an SBA loan for your business ? Taxpayers will...
Biological Age Outperforms Chronological Age in Outcome Prediction
In the era of molecular and organ clocks and marked inter- and infra-individual variability of the aging process, we need to move beyond chronological age. "biologic measures predict outcomes more robustly than chronologic age" @NEJM https://t.co/DKmIfdJJUF https://t.co/d5Gc6xGKqn
GLP‑1 Drugs Could Help Prevent Cancer, Study Shows
As a medical school professor, I've watched GLP-1 drugs transform diabetes and obesity treatment. Now a Nature Cancer review reveals they may suppress cancer too. GLP-1 drugs reduce insulin resistance, lower inflammation, and cut body weight -- three of the biggest...
Sleep Deprivation Triggers Hormone That Fuels Heart Disease
Sleep loss can causally drive heart disease. 1/2) Here's how it works: Sleep loss causes release of a brain hormone (hypocretin) --> goes to bone marrow to simulate the production of inflammatory cells --> these go to arteries and drive atherosclerosis But...
15‑Minute Walks Cut Heart Risk for Sedentary Adults
Instead of only short bursts of movement, add walks that last 15+ minutes. Among people averaging <8,000 steps/day, those who got most of their daily steps from walks lasting 15+ minutes had the lowest cardiovascular risk and among the lowest mortality...
Your 70‑year‑old Self Depends on Today's Activity
A patient asked me yesterday why so many orthopedic surgeons seem to be in good shape. I told her... Because we know what happens to the human body when we're not. We see it every day. The loss of muscle that...
Β‑Hydroxybutyrate's Dual Impact on Colorectal Cancer
β-Hydroxybutyrate, a primary metabolite of ketogenic diets and its dual role in modulating colorectal cancer: from molecular mechanisms to therapeutic insights https://t.co/pPCdm2AcFo https://t.co/mPtz1Xqiep
AI Delivers Rapid, Clear Interpretation of Newborn Test Results
My son was 11 days old and his blood test came back "abnormal". In the past, I would've spent six hours sick with worry waiting to hear from his doctor. Instead, AI got me the answer first - and explained...
AI's Potential to Transform Global Public Health
Can #AI improve public health and support global well-being? by @antgrasso #Healthcare #HealthTech #Tech #Technology https://t.co/Heo0OAXBDq
From Weight Loss to Longevity: Medicine Shifts Toward Prevention
It’s interesting how quickly the conversation has shifted. Not long ago, people were hesitant about weight loss injections. Now the question is whether GLP-1s should be used… for longevity. That shift alone is worth paying attention to. Because it reflects something deeper — we’re...
Mass‑following Cardiologists After Family’s Doctor‑search Struggle
anyways spending my Friday night mass-following cardiologists. a family member had the worst time finding one and finally getting in to see one so I’m trying to get a head start.
Balancing Innovation and Trust in Healthcare AI
Ethical #AI In #Healthcare: Drawing The Line Between Innovation And Trust by James Lindsey @Forbes Learn more: https://t.co/VJnZanmoeM #HealthTech #EmergingTech #TechForGood #Innovation https://t.co/MuJpcPq8ya
Meningitis Kills 259k, Hits Children in Poor Regions
Meningitis caused 259,000 deaths and 2.5 million infections worldwide in 2023, with young children most affected and low-income regions bearing the highest burden, highlighting the need for expanded vaccination and improved healthcare access. publichealth
High Cardiovascular Risk Predicts Major Fractures in Postmenopause
A new analysis shows that postmenopausal women with higher cardiovascular risk, as measured by the PREVENT score, are significantly more likely to experience major bone fractures, highlighting a close link between heart and bone health. womenshealth