Novavax Targets S1 and S2 for Broader Protection
Novavax (unlike the mRNA vaccines) generates antibodies to both S1 and S2 units of the spike protein - explaining why it provides somewhat broader protection. I've personally gotten Novavax every time it was available at vaccine time.
CRISPR Unlocks Causal Insights Into Immune Complexity
The complexity of our immune system is daunting. But there's a path to deconvolute it and understand causal relationships. It's CRISPR. open-access @JExpMed https://t.co/QF6Cvkbfz2 https://t.co/OTL2z1fow0
16‑Hour Fast Supercharges T‑Cells for Cancer Therapy
16-Hour Fasting: A Game-Changer for Cancer Immunotherapy 🧬⏱️ New clinical data in Cell Metabolism (Feb 2026) reveals that strategic fasting is more than just a metabolic trend—it's a powerful tool in oncology. The Key Findings: A 16-hour fasting window "reprograms" T cells,...
Clinician Startups Fail Because Product, Not Sales, Misses Market
When Clinician Entrepreneurs can’t get adoption, the Number 1 mistake is to think: “It’s not a product problem, it’s a sales problem.” Sorry but 99% of the time it IS a product problem. I’ve seen it over qnd over again from...
Doctor‑Led Online Weight Management – Limited Slots Open
For Malaysians, wherever you are in Malaysia. 💚⚖️ Doctor-led, structured, medical weight management, fully online. We’re opening a limited number of first patient slots for our starting launch phase. 🔑 Welcome offer access closes soon. www.getmyreset.com Important: Prescription treatments are provided only after doctor...
Earn Free ANCC Credits While Exploring Nursing Innovation
Learn more about #nursing and healthcare innovation through our See You Now podcast designed specifically for nurses. Stream to earn 4 free ANCC Credit Hours per bundle. https://t.co/bDFxS8h9cx Bundle topics include: ✅ Advocacy to Activism ✅ Nurses Inspiring Nurses...
Study Lacks Equipoise: Control Babies Likely Infected
The key point here is that the proposed study would not have equipoise because almost certainly some babies in the control arm would get hepatitis from their infected mother.
Most Health System Innovations Die Before Scaling
Many accuse health systems of not being willing to innovate. The truth? Lots of innovation is being explored all the time - you just don’t hear about them because most never make it to system-wide scale. For every 100 ideas that...
Two Authors Shouldn't Qualify for Major Trial Abstract
Submitting an abstract for a late-stage large clinical trial for review at a major conference, where you're asking for an oral, but only having 2 authors should be disqualifying. Really, only *2* people acquired ALL the data for this? Disgraceful...
Markets Switch to AI When It Outperforms Tradition
The market doesn’t care how long you’ve done it “the old way.” If AI can do it faster, cheaper, better — the switch will happen. https://t.co/zQCFnB0Dpd
Weekly BioTech Roundup: Top Posts Curated by BiopharmIQ
Here is my favourite weekly 🧵- made by my dear friend @BiopharmIQ - which is a comprehensive recap of the past week in BioTech. This 🧵 gathers the best BioTech posts written by some of the best & brightest 𝕏...
Combined DNA and Methylation Analysis Reveals Colon Cancer Risks
By systematically assessing both DNA sequence variants and methylation, we're learning a lot more about risk of (and protection from) colon cancer @ScienceAdvances https://t.co/eA0Y0lrntr https://t.co/5iL4sg0rRC
Stories, Not Data, Drive Health Tech Adoption
We want Health Tech to be evidence-based, but the truth is that adoption is ultimately driven by stories - NOT data. Here’s what I’ve seen play out over the past 13+ years over and over again: → Health system execs will choose...
Teclistamab‑Daratumumab Shows Strong Benefit in RRMM
Teclistamab–Daratumumab in Relapsed or Refractory Multiple Myeloma [Feb 18, 2026] @End_myeloma et al. @NEJM https://t.co/PTSmdrV2zp #mmsm #tcellrx #ImmunoOnc QUICK TAKES: New phase 3 trial results are summarized in a short video.
Exposure‑Response Guides Belantamab Dose in RR‑MM
Exposure–Response Analyses for Therapeutic Dose Selection of Belantamab Mafodotin in Patients with Relapsed/Refractory Multiple Myeloma [Sep 1, 2021] Ferron-Brady et al. Clinical Pharmacology & Therapeutics https://t.co/58kmDFKRwO #mmsm #oncopharm #caxtx
Anti‑BCMA CAR‑T Triggers Immunoglobulin Isotype Switching
Immunoglobulin Isotype Switch after Anti-BCMA CAR T-Cell Therapy for Relapsed or Refractory Multiple Myeloma [Nov 10, 2021] Liang et al. @BloodAdvances https://t.co/KfreDCvIDH #CARTcell #mmsm https://t.co/7qNQBEoqkX
Antigen Escape Drives Resistance to BCMA Therapies
Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma [Jul 25, 2024] @RossFirestone et al. @BloodJournal https://t.co/cOh0YC2u9H #mmsm #ImmunoOnc #CARTcell #PrecisionMedicine #lymphoidneoplasia #immunobiologyandimmunotherapy https://t.co/6sbEv5KtLY
Patients Prefer AI Over Frustrating Healthcare Appointment Process
the overall experience for patients from booking health related appointments to waiting ++ is so bad that they will gladly use AI first to avoid frustration
Clinical AI Offers Hope: More Impact, Less Complexity
"This is the first time where there's hope - there is a pathway to doing more with less. There is a pathway for the job of being a clinician, being a nurse, to be a fulfilling one. There is a...
DOJ and Ohio AG Charge OhioHealth with Price‑Gouging, Anti‑Competition
DOJ, Ohio attorney general accuse OhioHealth of driving up prices, crowding out competition https://t.co/oxxD0glykV via @statnews
Health Leaders Need Operational Agentic AI Strategies
Health leaders: your AI strategy may exist… but is it operational? Here’s how organizations are actually deploying agentic AI: https://t.co/iAzZysMNQp Meet NTT DATA at #ViVE2026 🤝 @NTT_DATA_NA #AgenticAI #HITSM
Monocyte IL‑10 Explains Sex Differences in Pain Duration
Sex differences in pain duration Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people) @SciImmunology https://t.co/fOsciwav7Y
Smart, Narrow, Trusted AI: Prenosis Sepsis Test Approved
Healthcare AI doesn’t need to be louder. It needs to be smarter, narrower, and trusted. Prenosis’ FDA-authorized sepsis diagnostic shows what that looks like in practice. 🔗https://t.co/JQBRCOKfO3 @PrenosisInc #patientsafety #HITSM
FDA Cracks Down as Novo Sues Hims over Semaglutide
This is the first reference which I heard directly from FDA commissioner Dr. Marty Makary regarding $HIMS, $NVO 🧵👇and the recent legal actions that the HHS had initiated against HIMs and Hers. When he was asked by @annikakimc - @CNBC’s...
Nasal Mucosa Targeted for Universal Respiratory Vaccine
How to get a universal vaccine vs respiratory threats? Block via the nasal mucosa @ScienceMagazine https://t.co/IjCkbF05LB @NatRevImmunol https://t.co/2W7SZ1fHSR https://t.co/XcEzcMeXrB
Teaching Your Own Work Feels Like Self‑Scrutiny
I always feel weird assigning things I'm in. It feels like a weird flex, even when it's actually a good teaching resource. Today my global health class is talking about "the fevers", colonialism, and the beginnings of global health. So I...
New Drug Discoveries Target Cancer and Autoimmunity
Discovering Drugs for Cancer and Autoimmunity. Listen to @Satpathology on The Long Run podcast. Sponsored by @AlphaSenseInc Dash Bio. https://t.co/02keVFdqzj
Madrigal Slides as Ex-Novartis Exec Joins Daiichi
Madrigal sees a stock sell-off; ex-Novartis exec heads to Daiichi https://t.co/ymSJ5qY8kq $MDGL $NVS $JNJ $ACIU #biotech
Creatine: Unexpected Longevity Boost Beyond the Gym
Creatine: The Longevity Supplement Hiding in Plain Sight For decades, I dismissed creatine as a "gym bro" supplement. Bodybuilders. Pre-workout shakes. Bigger biceps. Not relevant to a physician focused on metabolic health and longevity. I was wrong. https://robertlufkinmd.substack.com/p/creatine-the-longevity-supplement?r=6er0b
Most Health Systems Stall Patients' HIPAA Record Rights
HIPAA guarantees patients a right to their own medical records. In practice, most health systems require patients to fill out a release-of-information form designed for a different legal purpose; justify why they want their own data; and wait. I sampled...
Lymphopenia Reversal Won’t Secure Anktiva FDA Approval
Reversal of lymphopenia is not an acceptable endpoint for Anktiva FDA approval. $IBRX could file but if it did, the application would be rejected.
Cyborg Islet-Cell Implant Boosts Precision Diabetes Therapy
A cyborg pancreatic islet-cell implant takes the stem cell strategy to a new level of precision and potential future therapy for T1 diabetes @ScienceMagazine https://t.co/gkmsrzU1e4 https://t.co/qgegRPlEIl
Neutrophil Phenotypes and Spatial Patterns Mapped in Colorectal Cancer
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer https://t.co/0FLusa7vuB https://t.co/8MswWoLhCa
Screening Cuts Advanced Colon Cancer, Boosts Early Detection
Screening works for colon cancer. Largest trial ever done. Today @NatureMedicine A randomized trial of colon cancer screening by colonoscopy or occult blood (FIT) vs control in nearly 280,000 participants showed signficantly more early diagnosis (stage I-II) and less stage...
Exercise‑induced Liver Enzyme GPLD1 Restores Memory, Boosts Vascular Health
Liver enzyme GPLD1 produced during exercise reverses aging- and Alzheimer’s-related memory loss by improving vascular health https://www.cell.com/cell/fulltext/S0092-8674%2826%2900111-X
Allonic’s 3D Tissue‑Braided Robots Mimic Human Connective Tissue
The technology is undeniably impressive — but it carries a distinct 'Westworld' vibe. Anybody else feeling it? Allonic, a robotics startup based in Hungary, is developing humanoid robot bodies using a proprietary 3D "Tissue Braiding" system. The process weaves high-strength fibers, elastic...
Teens with Dogs Show Better Mental Health, Fewer Issues
Is it ok to let your kids kiss the dog? A new study found that teenagers who live with dogs show better mental health and fewer social difficulties. In a group of 343 teens, dog owners scored better across five behavioral measures:...
NKTR’s Alopecia Areata Play: Market Misprices Massive Upside
Ok, so I have finally gotten around to writing out my updated thoughts/thesis on $NKTR. Link in this post. I'm about as bullish on the stock now as I've ever been. The document is very long (sorry, but it's free...give me...
AZN's Calquence + Venetoclax Approved for CLL Treatment
#AZN Calquence combined with Venetoclax approved in US for treating Adults with Chronic Lymphocytic Leukaemia in a particular form.
Healthcare Confuses PE with VC; Transparency Needed
I've noticed that PE and VC are getting lumped together by healthcare industry folks that I know as if they're the same thing. I'm not sure how we solve this problem but I suspect having more transparent conversations about it...
Physicians Must Evolve Leadership Beyond Clinical Skills
What got you here won’t get you there: a physician’s guide to leadership http://dlvr.it/TR3W2k Physician #HealthIT
Galleri Test Misses Primary Goal, Shows Secondary Promise
A key study of $GRAL's Galleri test in the UK failed to reach its primary endpoint, but showed benefits on a secondary endpoint. Tell me what you all think. https://t.co/CDrvokqPop
Examining Vaccine Development Amid America's Science‑Anti‑Science Divide
Many thanks to Freedom Together Foundation medical research consortium for hosting my remarks this week @RockefellerUniv discussing our vaccine development program and my work on the history of medical science vs anti-science in America https://t.co/etbLqiezEA
EBV DNA Linked to Multiple Autoimmune Diseases in 800k Genomes
🆕@Nature Genome sequencing of >800,000 people finds Epstein-Barr virus reads and their association with other autoimmune diseases besides multiple sclerosis, including type 1 diabetes, inflammatory bowel disease, and hypothyroidism https://t.co/FKCV4OInT5
Altesa Secures $75M for Lung Drug, Led by Ex‑Trump Official
Altesa, run by former Trump official, raises $75M for well-traveled lung drug https://t.co/bUx5dcvNJy by @gwendolynawu #biotech #startups
New Drug Development Reforms Aim to Match China
These proposed reforms to pre-clinical drug development and to smoothing the transition to first-in-human studies could be the most consequential steps toward leveling the playing field with China. https://t.co/oVY6N3xo9Y
Adding Fragmentomics Boosts GRAIL’s Multicancer Detection Accuracy
The most used multicancer early detection (MCED) blood test (liquid biopsy) uses methylation (GRAIL). But combining that with DNA fragmentomics, as reported today @NatureCancer, improves early detection https://t.co/VkNDR4XuW3
FDA Proposes Single Pivotal Trial as Approval Standard
FDA leaders say one pivotal trial, not two, should be ‘default’ for drug approvals https://t.co/ADRb1miphf by Kristin Jensen #biotech
Tech Fails in Fee‑For‑Service, Aledade Shows Value‑Based Solution
What happens when you drop great tech into a fee-for-service system? Farzad Mostashari has a blunt answer—and it’s worth hearing. See what Aledade is doing to make the math work for value-based care: https://t.co/iMKzsdQSrl @AledadeACO #ValueBasedCare #HITsm https://t.co/lL49Ha2UHC
Deregulation Must Preserve Interoperability, AI Access, and Bulk FHIR Metrics
SMART Health IT team submitted formal comments on HTI-5. Feel free to read and borrow language. Briefly: Deregulation should not mean losing sight of whether interoperability is actually working. (HTI-5 risks eliminating the instrumentation ASTP/ONC needs to steer a successful...