Longevity Revolution: Are We Truly Aging Slower?
Are people actually aging slower today? Or are we just cherry picking the data? We are in the beginning of a longevity revolution.
Bispecific Autoimmune Therapies Set to Transform 2024
"Dual Wielding in I&I: A Pivotal Year Ahead" - new blog - Atlas EIR Cody Tranbarger with a tour de force on the bispecific opportunities in autoimmune... https://t.co/StQJX0vgfx
FDA's New Move Undermines mRNA Flu Vaccine
https://open.substack.com/pub/pauloffit/p/weaponizing-the-fda-against-vaccines?utm_campaign=post-expanded-share&utm_medium=web A closer look at the FDA's recent kill shot against an mRNA influenza vaccine.
Ambiguous CPT Codes Threaten Physicians with Criminal Charges
I interviewed a dual-boarded psychiatrist and internist who warns that the ambiguity of CPT codes is being used to criminalize physicians. Dr. Muhamad Aly Rifai joined me to discuss the chilling case of Dr. Ron Elfenbein. During the COVID-19 pandemic, Dr. Elfenbein...
Future Docs Must Master Digital Health and AI
I'll give a presentation today to medical students at Semmelweis Medical School about the rise of digital health and AI, as part of the 𝐷𝑖𝑠𝑟𝑢𝑝𝑡𝑖𝑣𝑒 𝑇𝑒𝑐ℎ𝑛𝑜𝑙𝑜𝑔𝑖𝑒𝑠 𝑖𝑛 𝑀𝑒𝑑𝑖𝑐𝑖𝑛𝑒 course that I co-launched. 𝐈𝐟 𝐭𝐡𝐞𝐫𝐞 𝐢𝐬 𝐨𝐧𝐞 𝐦𝐞𝐬𝐬𝐚𝐠𝐞 𝐲𝐨𝐮 𝐰𝐨𝐮𝐥𝐝 𝐫𝐞𝐚𝐥𝐥𝐲 𝐥𝐢𝐤𝐞...
Koushicare Device Offers Relief for Dry Eye
Can you guess what this device is for? It is made by Koushicare, and it helps people with dry eye. https://t.co/FilgMQ1JEy
GSK
#GSK Exdensur (depemokimab) approved in EU for treating "severe asthma with type 2 inflammation and chronic rhinosinusitis with nasal polyps". Follows from the SWIFT and ANCHOR phase III trials.
No‑Compression Breast CT Approved, Yet Still Rare
Pain that comes from mammography has been a common challenge in screening. But what if a device can change that experience? Here is a no-compression breast CT. As far as I know, no-compression dedicated breast CTs like the Koning Vera exist...
Danaher Nears $10 B Acquisition of Masimo
Big deal scoop by @sindap and @mroliverbarnes - US healthcare manufacturer Danaher is closing in a $10bn deal to buy medical tech group Masimo. A deal could be announced as early as Tuesday provided it does not hit any last-minute...
Plasmid Injection Triggers Immune Attack on Cancer Survival Protein
What if a physician could inject you with a plasmid that would induce an immune response against a protein needed for cancer cell survival? This novel strategy is being tested and looks promising for refractory cancers. Talking Biotech 488 ...
HTML Comments Reveal Vendor’s Intentional Export Method Distinction
Your human users might only read the visible content in your page, but bots read the HTML comments :-) I appreciated this nugget from my EHI Export analysis, and I have to say that I agree with "kendra/sli", they had...
Question Sensational Medical Claims; Scientists Must Champion Truth
Be aware there is a rising number of posts using blatantly false medical & scientific information, with misquoted and twisted interpretations of articles, taking videos by others without permission and warping the facts to suit their own purposes, and making...
Free, Ad‑free Biomed Insights Reaching 200k Globally
Ground Truths are free essays and podcasts on the hot topics in biomedicine and health. Mostly things the media doesn't cover or adequately highlight. No ads or sponsors. Join ~200,000 subscribers from 212 countries https://t.co/ZgnO2Y0P4L
Pre‑market Rallies Set for Tomorrow’s Data Releases
Two Major Data Readouts Coming Tomorrow: $OCUL ripped in after-hours, +26% to ~$11.16, clear positioning into retina data. $CMPS has been quietly bid into its Phase 3 TRD readout, steady accumulation with mild pre-market strength. Both leaning long into the print. Now it’s...
B‑Cell Depletion: Rebooting Immunity to Cure Autoimmunity
"Immune Reset" Rebooting the immune system by depletion of B cells, like a reboot of a computer, to achieve cures vs autoimmune diseases https://t.co/253NtyFmCN
Women Show Higher P‑tau217 Levels and Tau Deposition
p-tau217 is a breakthrough blood test for risk of developing Alzheimer's disease. Important to know there are sex differences for this biomarker, with women having higher values at baseline and more tau deposition. @JAMANeuro https://t.co/Xrr8SjsiVY https://t.co/eyDt6mgSqR
Psychedelic Shows Rapid Depression Relief in Small Trial
A psychedelic quickly reduced depression (in patients with major depression disorder) in a small, double-blind placebo randomized trial @NatureMedicine https://t.co/vvug72VGBi https://t.co/Tn58rP0ufS
Bionic Eye Mimics Animal Pupils for Sharper Focus
A new Science #Robotics study describes a #bionic eye that can simulate irregular pupils such as a cat’s vertical pupil for precise focus while hunting and a toad's heart-shaped pupil for improved depth perception. https://t.co/p1uZy6rbky https://t.co/X4pzdrnoIi
LLM-Edited Radiology Reports Boost Patient Understanding, Preserve Accuracy
When the LLM rewrites the radiology report, patient understanding is increased and clinical accuracy is maintained. @LancetDigitalH @curtlanglotz @smrabd https://t.co/q2UHebBQG7 https://t.co/IwZAx59brY
AI Subtyping Boosts HR+/HER2‑ Breast Cancer Therapy
Precision treatment with artificial intelligence assisted subtyping enhances therapeutic efficacy in HR+/HER2− breast cancer: The LINUXtrial https://t.co/UF4Lt3g5QK https://t.co/LWuJYD2qGh
China’s Biotech Boom: 5 Hidden Drivers & Future Forecasts
5 Hidden Themes Driving China’s Biotech Surge | Ep. 314 ...and 5 Bold Predictions for What’s Next https://t.co/TxBhvw5PG8 https://t.co/jTR63o431j
Physicians Evolve Into AI‑Guided Medical Orchestrators
Think AI will reduce demand for doctors? Consider this: Claude writes 100% of its own code, yet Anthropic's engineering team is exploding. We aren't looking at the end of the physicians, but the birth of Medical Orchestrators. When asked why Anthropic...
120 Biomarkers for $99 and Nationwide CT Calcium Scans
This is how I test 120 biomarkers for $99 and get CT calcium scans anywhere nationwide. Vitals Vault. https://www.vitalsvault.com/
Modern Bluetooth Pacemakers Continuously Broadcast When Disconnected
Regarding this, there was a couple questions on does the pacemaker continue to advertise - most BLE implantable devices go into a sleep type mode. In this case, we are lucky - it does not. We know based on law enforcement...
15‑PDGH Inhibition and Ozempic May Restore Cartilage
Two things that may help restore cartilage —15-PDGH inhibition https://t.co/chCj9Lj5qk —Semaglutide (Ozempic), independent of weight loss https://t.co/fqbrQQYfRt https://t.co/6CRdY1QtC1
Insurance Doesn't Prevent Massive Medical Debt, Even for Celebrities
When a celebrity tragically dies with massive medical debt, I’m left with the questions. Did they have insurance? People with insurance absolutely have medical debt, but out-of-pocket costs are capped. Debt may be from out-of-network care, claims denials, or unocvered...
Saudi‑US Biotech Tie Is Just a Pay‑for‑promotion Scheme
This is not a Saudi-USA Biotech Alliance, it’s a Saudi @DrPatrick $IBRX “you pay we pay” marketing campaign. Anktiva is stalled in the US because he can’t generate the clinical data to move the drug forward, so he goes to...
3D‑Printed Brain Phantoms Replicate Gray and White Matter
Printing brain phantoms in a support gel and selectively replicates gray and white matter https://t.co/9rIVOPCjd2 https://t.co/LFwa9Qlqjc
AI Docs Tools Expand Into Health System Enterprise
Those “direct-to-physician” CDS AI tools like OpenEvidence and DoximityGPT? They're now going after health systems too. My 5 thoughts on how this will all play out: First, the gist of what was announced: → Sutter Health will integrate OpenEvidence with Epic, allowing...
Age‑Restricted Longevity Drugs: Accept Risks After 70
We should have a class of drugs you can only sell to people over 70 —super aggro longevity stuff, muscle regeneration, etc - tolerate more possible bad side effects given you don’t have much time left for effects to manifest...
US Infectious‑Disease Center Halts Pandemic Preparedness Efforts
But this is such treachery. Doesn’t our govt understand pandemic threats? New waves of zoonotic flu, SARS-3 coronavirus; arboviruses from climate change; bioweapons from our enemies: Russia, DPRK, Iran; return of measles, pertussis, soon polio. What’s going on? Exclusive: Key US...
Flu Kills 66 Kids; 90% Were Unvaccinated
1. Time for a #flu & #measles update. Six more kids have died from flu, bringing the year-to-date total to 66. Sadly there will be more deaths reported but hopefully this year doesn't approach last year's dreadful pediatric death toll. #CDC...
Disc CEO Updates
This was over two months ago at ASH, so ages, but here's how Disc's CEO said the bitopertin review was going back then. $IRON https://t.co/9SvSML6th8
FDA Rejects IRON Disc’s Rare Disease Therapy, CNPV Stumbles
FDA rejects rare disease therapy from $IRON Disc Medicine, early recipient of commissioner’s voucher CNPV program falters out of the starting gate... https://t.co/w4ptB2ecRS via @LizzyLaw_ and me
NIH Shifts Funding Away From Pandemic Preparedness
#NIH to deprioritize pandemic preparedness and biodefense research, @nature.com reports, saying director Jay Bhattacharya wants to focus on known diseases, not possible future threats. What could possibly go wrong? https://t.co/6TpLr6pY3B https://t.co/7rVzvkOzkT
Healthy Diet Adds 2‑3 Years Lifespan, Especially Early
A healthy diet, accounting for longevity-related genes, associated with 2-3 more years of life expectancy from >100,000 people followed 10.6 years, max benefit for starting at youngest age (Figure) @uk_biobank @ScienceAdvances https://t.co/Ji7Wlhj9ZA https://t.co/B6UxuE97xG
PET Scans Miss Cancer; System Needs Diagnostic Overhaul
Merkel cell carcinoma log, day #566. Completed my 6th PET scan at Dana-Farber yesterday. The radar, such as it is, doesn’t reflect any Merkel cell carcinoma. Lymph nodes look clean. The more I do PET scans, though, the more I...
IMMX Gains Momentum as CAR‑T Landscape Heats Up
$IMMX momentum continues >Mizuho analyst initiates $14 PT >Lily acquisition of Orna Therapeutics $2.4 billion >AbbVie acquired Capstan Therapeutics $2.1 billion CAR-T heating up >Next milestone: imminent enrollment completion >Could NXC-201 be an eventual front-line therapy for AL Amyloidosis? >BLA submission projected Q3’26 https://t.co/cPpiiFHQal
AI Is Adding Work, Not Reducing Clinician Burden
Working on a story about where AI is actually creating more, rather than less, work for clinicians. (As in, adding additional grunt work or even creating entirely new and tiresome workflows.) Reach out if you'd like to contribute.
Stable FDA Rules Essential for Patient Safety and Investment
To invest the billions it costs to make new medicines, companies need to be able to trust the word and actions of the FDA. To capaciously change the rules at the end of the game ultimately hurts patients.
Genetic Evidence Shows BMI Directly Shapes Gut Microbiome
A successful hunt of human genome variants identifying some (with MR) that provide causal evidence that BMI affects microbe composition @NatureGenet https://t.co/1uxvnFNrbK https://t.co/SuItRHAnFe
AAP Leads Fight to Reverse RFK Jr.'s Vaccine Policies
The American Academy of Pediatrics has become a leader in the effort to reverse RFK Jr.'s vaccine policies. The success — or failure — of the group's approach will have consequences for kids' health nationwide. Inside the AAP's plan for the MAHA...
CMPS Leads Psychedelic Push; HELP Gains Momentum
$CMPS first-in-line for potential psychedelic approval for Treatment Resistant Depression (TRD) . Likely war between "Old School FDA" and MAHA movement. Will be exciting to see the outcome. $HELP with strong data for Major Depressive Disorder (MDD) and Breakthrough Therapy Designation. New...
Bluetooth Pacemakers Could Be Tracked via War‑Driving
For the Nancy Guthrie case, an idea and maybe a crazy one but she had a pacemaker which often implantable devices use bluetooth such as Medtronic's. Couldn't you war-drive (drones even better) with a high gain antenna with amplifiers -...
Biotech Earnings: Neurocrine Drops, Alnylam Faces Skepticism
Earnings roundup: Neurocrine slumps, Alnylam battles skeptics and Ascendis eyes a competitor https://t.co/kU1ex80A24 by @realJacobBell $NBIX - 10% $ALNY - 4% $ASND - 2% $BBIO #biotech
Clean Air Essential for All Lungs, Despite Expert Opposition
For my book Allergic, I went to Cincinnati Children's Hospital and talked to asthma experts that vehemently argued otherwise...with decades of data behind them. Young (and old) lungs especially need the cleanest air we can manage. This is one of the...
TEFCA Enables 500M Health Record Exchanges, Cutting Costs
#TEFCA, America’s National Interoperability Network, Reaches Nearly 500 Million Health Records Exchanged as @HHSGov + @HHS_TechPolicy Leverages #Technology and #AI to Lower Costs and Reduce Burden #ASTP2026 https://t.co/0iBnnjnNR3 https://t.co/oFI2brZmfq
Global Vaccine Market Persists, but Innovation May Falter
“Yes, the rest of the world can maintain a market for vaccines. But will it be as innovative and as vibrant as it has been? That’s a different question.” https://t.co/jB38FWfglo
FDA Approved Pembrolizumab Using Single‑Arm Trials Across Tumors
It would be highly instructive to read the pembrolizumab paper highlighted by @DrPatrick. Of course, he doesn't expect anyone to do that. This is what it says IN THE FIRST PARAGRAPH: The FDA approved pembrolizumab on May 23, 2017, for...
Seres Cuts Staff and Pauses Flagship Program
Seres to lay off staff, pause top program in latest reboot https://t.co/yJRtypSN3d by @Lilah_Alvarado $MCRB - 37%