Quantifying Pathway Identifiability Under Partial Metabolomics for Measurement Prioritization
The study introduces an operator‑based framework to assess pathway identifiability when metabolite coverage is incomplete. It aligns condition‑specific pathway graphs using a Johnson‑Lindenstrauss stabilized fused Gromov‑Wasserstein (JL‑FGW) operator and quantifies ambiguity via a composite functional that blends transport entropy, alignment instability, and structural risk. Measurement prioritization is formulated as an optimization over this functional’s sensitivity, yielding a next‑best metabolite estimator without exhaustive enumeration. Synthetic and real‑world evaluations show low regret versus baselines and tractable runtimes for curated and genome‑scale models.
Drones Aim to Detect and Extinguish Wildfires Early
What if we could use technology to identify wildfires, then extinguiwh them before they spread? That’s what Crossfire, a research team, is trying to accomplish with drones. There’s a multi-million dollar contest awarding the best wildfire-dousing tech. #wildfire #drones #tech #fire
A Fish a Day: More than 300 Freshwater Species Described in 2025
Taxonomists documented 309 new freshwater fish species in 2025, the highest annual count since 2017 and the third‑highest since records began in 1758. The discoveries span five continents, with Asia leading (165 species) followed by South America and Africa. Many...
This Masterpiece by Rembrandt’s Star Pupil Has a New Owner
Willem Drost’s 1654 tronie *Man With a Plumed Red Beret* was sold at TEFAF Maastricht through Agnews Gallery to the privately‑held Leiden Collection. The painting, once owned by the Rothschild family and recovered by the Monuments Men after World War II,...
“Who’s That Little Pisser?”: Dolly Parton Addresses Health, Dating Rumors During First Major Public Appearance of the Year
Dolly Parton made her first major public appearance of the year at Dollywood's 41st‑season kickoff, addressing recent health setbacks and the loss of her husband, Carl Dean. She confirmed postponing her Las Vegas residency and other engagements to focus on...
Fans Believe They Just Found Drake’s Instagram Burner Account
Fans of Drake have spotted an Instagram profile called @quilteddiamonds that appears to be a new burner account, featuring 115 posts and a single follower – the rapper himself. The account’s minimal activity and exclusive connection to Drake have sparked...
Buick Is Reportedly Considering a New Sedan for the United States
Buick is reportedly evaluating a new sedan for the U.S., potentially built on GM's Alpha II platform that underpins the Cadillac CT4 and upcoming CT5. The brand has not offered a domestic sedan since the Regal ended production in 2020, though...
Why Men Need Therapists Who Aren’t Afraid of Them
Therapists who can sit with men’s anger, regret, and aggression without flinching are essential for genuine therapeutic breakthroughs. Men quickly assess whether a clinician can handle their raw truth; when they sense steadiness, they begin to disclose suppressed emotions. The...
Keisha Scarville Awarded Brooklyn Museum’s $25,000 UOVO Prize
The Brooklyn Museum announced photographer and collage artist Keisha Scarville as the winner of its sixth UOVO Prize, awarding her a $25,000 unrestricted cash grant. Scarville will mount a solo show titled “Where Salt Meets Black Water” at the museum’s...
Newborn Sneezes: Normal Airway‑Clearing Reflex
Have you ever noticed how much newborns sneeze? It's because they're clearing their nasal passages. Newborns have tiny little nostrils and breathe almost exclusively through their nose for the first few months. Every little bit of dust, milk, or mucus makes...
SHINEDOWN's Upcoming 'Ei8ht' Album Was 'a Year And A Half In The Making': 'We Really Pushed Ourselves This Time Around'
Shinedown’s eighth studio album, “Ei8ht,” arrives on May 29 via Atlantic Records, featuring 18 tracks that the band describes as a double‑album. The record, a year and a half in the making, sees bassist Eric Bass taking the production helm,...
The Ins and Outs of Zubin Mehta
Zubin Mehta, born in Bombay to the founder of India’s first symphony, rose from Vienna studies alongside Claudio Abbado to early posts in Liverpool and Montreal. He later led the Los Angeles Philharmonic, gaining worldwide attention for his energetic conducting...
Rumblings of an iPod Resurgence—Young Music Listeners Look to Distance Themselves From Streaming
A noticeable resurgence of Apple’s discontinued iPod line is underway, driven largely by Gen Z listeners seeking a break from algorithm‑driven streaming and smartphone overload. Google Trends and eBay data show searches for classic iPods and iPod Nano up 25%...
Walking Vs Running: Which Activity Is Right For You? Experts Explain The Benefits Of Each
Experts explain that both walking and running satisfy the CDC’s 150‑minute weekly activity recommendation, but each offers distinct advantages. Walking provides a low‑impact, beginner‑friendly option that can be intensified with hills, weighted vests, or intervals, supporting cardiovascular health and chronic...
A Design Lover’s Travel Guide to Seoul (2026): What to See, Eat, Drink
Seoul’s design scene is spotlighted in a new travel guide that pairs expert recommendations with curated itineraries for design‑focused visitors. The guide highlights four key neighborhoods—Sogyeok‑dong, Seongsu‑dong, Jeong‑dong and Hongdae—alongside boutique hotels, high‑end restaurants and concept stores that showcase the...
Get a Sneak Peek Of The Ozarks BDR-X Route Coming Soon
Backcountry Discovery Routes (BDR) is set to unveil the Ozarks BDR‑X, a 480‑mile loop that begins and ends in Jasper, Arkansas. The route weaves through the Boston Mountains, Ozark‑St. Francis National Forest, and features iconic spots like the Arkansas Dragon...
It’s Time for Men to Step Down and for Women to Lead the Way
The article reviews Daniel Constantinou’s book *The Holy Grail and Her Knights*, arguing that humanity thrives when women lead with compassion and men step back from power. It claims that female leadership would end wars because mothers would never send...
Salmokji: Whispering Water Trailer by Lee Sang-Min
Director Lee Sang-min returns to horror with his solo feature debut, “Salmokji: Whispering Water.” The film follows a film crew investigating a mysterious figure captured at the remote Salmokji reservoir, where they encounter escalating supernatural phenomena. Starring Kim Hye‑yoon alongside...
The Oracle of Dublin
Clare McAndrew’s latest annual art market report confirms a rebound, with total sales reaching an estimated $59.6 billion in 2025 – a 4 percent rise over the prior year. The recovery is most pronounced in the auction segment, which has rebounded strongly since...
New Book Alert (and No, It's Not What You Think)
Sara Blackard announces her debut poetry collection, *My Uterus Is in Her Chaotic Era*, which candidly chronicles her perimenopause journey. The book blends humor, raw emotion, and lyrical insight to give voice to a phase often left unspoken. Blackard markets...
Align Your Destination with Belief to Prioritize Effectively
Knowing your destination lets you self-prioritize and make decisions about what you're doing and how you're doing it. But, it's also bigger than that. You want to make sure the direction you're headed in still feels right-that you still believe...
Webinar to Discuss How Leaders Strengthen Clinical Workforce
The American Hospital Association will host a webinar on March 19 at 1 p.m. ET to examine how health‑care leaders are strengthening the clinical workforce. The session will focus on improving retention, physician well‑being, and coverage stability across hospitals. Attendees will...
Embrace Telehealth Early or Lose Clients Forever
Six years ago today, on Friday, March 13, 2020, I sent the email switching all my clients to telehealth. Some of them didn’t want to do online sessions; they said they’d rather wait a little, until things blew over. I...
Gemini Powers Google Maps with AI-Driven Personalized Routing
We’ve reimagined the way our Gemini models power @GoogleMaps. Here are some use cases you can try (and the advancements that make them possible): “Find a well-lit pickleball court that’s usually less busy on Tuesday nights” ➡️ Maps performs multi-step reasoning across...
The KPop Demon Hunters’ Tourism Wave Is Just Getting Started
Netflix’s animated hit *K‑Pop Demon Hunters* has become the platform’s most‑watched original, surpassing 500 million views and sparking a new wave of Korean travel. In the three months after its June 2025 release, global flight bookings to South Korea jumped 25 % and...
Case Report: Optimizing Wound Care: Tailored Nutritional Strategies with Immune- Modulating Enteral Nutrients
A dietitian‑led case series of four critically ill patients with advanced pressure ulcers implemented personalized enteral nutrition, targeting progressive energy and protein goals, glycemic control, and selective immunonutrient supplementation (arginine, glutamine, HMB). Over several weeks to months, each patient showed...
The Milpa Diet: A Functional, Sustainable Pattern for Human and Planetary Health
The Milpa diet revives a Mesoamerican polyculture of maize, beans, squash and chili, combined with traditional processing like nixtamalization, to create a nutrient‑dense, bioactive‑rich food system. Agroecologically, the intercropping maximizes land equivalent ratio, cuts water use and curtails deforestation, while...
Gut Microbiota Mediates the Anti-Obesity Effects of Gnaphalium Affine Methanol Extract in HFD-Induced Obesity
A methanol extract of the traditional plant *Gnaphalium affine* (GAE) markedly reduced weight gain, visceral fat, and metabolic dysfunction in high‑fat diet mice. The treatment restored antioxidant defenses, improved glucose tolerance, and reinforced intestinal tight‑junction proteins. Multi‑omics revealed GAE reshaped...
Immunomodulatory Effects of Short-Chain Fatty Acids and Immune-Supporting Nutrients on Slice Cultures of Head and Neck Tumors
Researchers used patient‑derived organotypic slice cultures from nine head and neck squamous cell carcinoma (HNSCC) tumors to test short‑chain fatty acids (SCFAs) and an immunonutrition (IN) blend containing glutamine, alanine and omega‑3 fatty acids. IN alone or combined with SCFAs...
One-Month Early Time-Restricted Eating Enhances Cognition via White Matter–Cortical Pathways in Males with Metabolic Syndrome: Evidence From TBSS and SBM...
A one‑month early time‑restricted eating (eTRE) regimen in 21 male patients with metabolic syndrome led to significant reductions in weight, BMI, fasting glucose, insulin and HOMA‑IR. Neuroimaging revealed increased fractional anisotropy in the left anterior thalamic radiation and cortical thinning...
Age and Alcohol Dramatically Shift Sleep and HRV
World Sleep Day. We're marking it the best way we know how: with data. We just released https://t.co/wj0FotCsjN. 10.2 million nights from 23 countries. One year of continuous measurement. Some findings confirmed what we expected. Others didn't. - REM sleep peaks in...
Coffee and Tea Linked to Reduced Neurodegenerative Disease Risk
Consumption of coffee and tea and the risk of developing neurodegenerative diseases: a cohort study in the UK biobank https://t.co/bv0q79xKni
Gerry Lopez Designed a Board for Assisted Hydrofoil Surfing
Legendary surfer Gerry Lopez has partnered with North Action Sports (NSP) to launch the Pelican, a lightweight foilboard built for the Foil Drive electric‑assist system. The board features a rounded, forgiving shape and a subtle nose vee that promotes quick...
Inside Kevin Feige’s USC Dedication with Coogler,
...an exclusive inside report from last night's Kevin Feige USC dedication that brought out Ryan Coogler & Shawn Levy...Plus: SOMETHING IS KILLING THE CHILDREN: the novel. And VISIONQUEST finds its composer. https://t.co/PrULgqINGy
Stop Working on Autopilot: Manage Yourself Intentionally
To survive in the current workplace we need to be more thoughtful and intentional about how we manage ourselves. That means we cannot be on autopilot. https://t.co/SanqGOwq3T https://t.co/Lf8czbZW9b
China Is Developing Low-Cost Lunar Cargo Options for Its Expanding Moon Program
China’s Shanghai Academy of Spaceflight Technology unveiled an “economical lunar cargo transport” concept at the CACE 2026 exhibition. The cylindrical lander family would deliver 120 kg to 5,000 kg using a methane‑liquid‑oxygen engine, marking a shift from hypergolic propellants. The system is positioned...
Program Your Brain with Kindness, Joy, and Optimism
Install positive emotions in your neural circuity. Consistently focus on kindness, compassion, generosity, joy, patience, and optimism. https://t.co/zjc850yFse
Finding Pollo Huaxmole with Mexican Market Seedpods
In my Substack today, where to get pollo huaxmole, made with those green seedpods you see in Mexican markets. [link in first comment] https://t.co/k5GapZkTAi
15 Stunning Airbnbs Near Portugal’s Top Surf Breaks
Jessica Chapel’s March 13, 2026 guide showcases 15 hand‑picked Airbnbs that sit within walking distance of Portugal’s premier surf breaks, from Nazaré’s giant waves to the Algarve’s quieter points. Each property was selected for Superhost status, guest ratings, amenities, design and proximity...
Boost Book Club Sessions with Author Q&A and Guides
🎉 Want a fun way to kick off or wrap up your book club? 🗣️ I shared ideas like an author visit for a final session Q&A. 📚 I also mention study guides as a planning tool, including my free EdTech Essentials...
VR Lets Hospital Patients Explore Beauty Beyond Walls
A hospital room can feel very small. But the mind doesn’t have to stay there. At Cedars-Sinai, we’re using VR to help patients explore beautiful places beyond the four walls of the hospital room. Not to escape life… but to contemplate its beauty in...
Early Exposure to a High-Fat Diet Alters How the Adult Brain Reacts to Junk Food
A study in Nutritional Neuroscience shows that rats exposed to a high‑fat, high‑sugar (Western) diet during gestation and lactation retain metabolic imprints into adulthood. Even after months on a healthy diet, these animals exhibit elevated blood glucose and protein levels....
Testing Ubiquitin Promoter for Stable Petunia Transformation
Alright, Alice 24-0001 petunia bits co-culturing with Agribacterium strain Gv3101 carrying a PcUBI4::RUBY::THSP construct. Testing out this ubiquitin promoter for stable transformation to avoid silencing. These will bake at 30°C until Monday and then transfered to selection. 🤞 https://t.co/SO1EKELMgU
Hollywood's Oscars: Six Years of Existential Crisis
For the sixth year in a row, Hollywood enters the Academy Awards in some stage of an existential crisis. https://t.co/jozy6DM9bL
14 Work Blazers to Wear This Spring
Fashion outlet The Cut has compiled a spring‑ready list of 14 blazers, ranging from $75 Amazon basics to $429 designer pieces. The selection emphasizes fit, versatility, and inclusive sizing, covering oversized, cinched‑waist, and double‑breasted silhouettes. Brands featured include Gap, Uniqlo,...
NAD⁺ Controls Aging Hallmarks, Offering Therapeutic Paths
NAD⁺ as a central hub regulating the hallmarks of aging: Mechanisms and therapeutic implications https://t.co/Mw45GF0QhL https://t.co/pvAGRxXQZv
How to Watch Best Picture Nominee The Secret Agent
Brazil’s *The Secret Agent* has earned two Oscar nominations – Best Picture and Best International Feature – marking a historic moment for the nation’s cinema. Actor Wagner Moura becomes the first Brazilian male to receive an acting nomination, recognized for his...
Visionary Hotelier Rami Fustok’s Art-Filled London Apartment Is Up for Rent
Visionary hotelier Rami Fustok has listed his 5,500‑square‑foot, art‑filled London residence for about £5,000 (≈$6,600) per week. The apartment occupies New River Head, a former early‑20th‑century civic building in Clerkenwell, retaining grand boardroom spaces, high ceilings and Doric columns. It...
How This Groovy 1976 One-Hit Wonder Reflected a Major Musical Shift Happening From the 1970s to 1980s
In 1976 Wild Cherry turned a casual audience comment into the hit "Play That Funky Music," capturing the seismic shift from hard‑rock to disco. The single surged to #1 on the Billboard Hot 100 and cracked the top ten in multiple...
Earth’s Days Are Getting Longer. Climate Change Is to Blame
A new study shows Earth’s rotation is slowing faster than in any of the past 3.6 million years, lengthening the average day by about 1.33 milliseconds per century. Researchers linked this unprecedented slowdown to rising sea levels caused by melting glaciers and...