Dementia Risk Varies Between Strong versus Weak Circadian Clock Regulation
A new open‑access study of 2,183 older adults found that individuals with stronger circadian rhythms have a markedly lower risk of developing dementia. Researchers quantified rhythm strength using the relative amplitude of activity‑rest cycles derived from heart‑monitor and accelerometer data, and observed that participants in the lowest amplitude group were 2.5 times more likely to develop dementia than those with the highest amplitude. After adjusting for age, blood pressure and cardiovascular disease, each standard‑deviation drop in relative amplitude corresponded to a 54 % increase in dementia risk. The results highlight circadian resilience as a potential biomarker for neurodegenerative risk.
2026: Embracing Selective Focus Over Unlimited Yes
If I seemed less online in 2025, it's because I kinda was. In 2025 I: - Worked full-time as one of three people at SparkToro - Spoke at a dozen or so conferences - Planned & co-hosted my own conference...
Jenius Bank Employees Say the Bank Is Closing
Jenius, the digital‑banking arm of Sumitomo Mitsui Banking Corp., appears to be shutting down after several former employees announced the closure on LinkedIn and noted the removal of the brand’s social‑media presence. The bank’s CEO cited poor market performance and...
Teach Reps Buyer‑centricity by Walking in Buyers’ Shoes
One of the most important lessons from our early days building the HubSpot sales team is to teach your reps to start with a buyer-centric mindset. We trained our reps by having them walk in the buyer’s shoes. Every new...
Why Data, Trust, and Skills Are the Foundations of AI-Driven Pharmacoviginlance
Beena Wood, chief product officer at Qinecsa, argues that AI can revolutionize pharmacovigilance by detecting safety signals within hours across languages and geographies, but only if foundational data issues are solved. She highlights fragmented, non‑interoperable datasets as the primary barrier,...
Top 10 Privileged Access Management Solutions for 2026
Privileged Access Management has shifted from a compliance checkbox to a critical security control as organizations adopt hybrid cloud, SaaS, DevOps pipelines, and AI agents. The 2026 guide evaluates ten leading PAM vendors, highlighting capabilities such as Zero Standing Privileges,...
Context Graphs: Hype Meets Reality Check
A concept is making the rounds in AI circles right now that has many people very excited: context graphs . Foundation Capital published a piece calling it "AI's trillion-dollar opportunity." Engineers and founders are writing technical breakdowns of how it...
AI Deployments Targeted in 91,000+ Attack Sessions
Researchers observed more than 91,000 attack sessions targeting AI infrastructure over a four‑month window, highlighting a shift from experimental probing to systematic exploitation. The first campaign leveraged server‑side request forgery against Ollama and Twilio webhooks, using a uniform JA4H TLS...
The Week’s 10 Biggest Funding Rounds: XAI Leads As 2026 Is Off To A Brisk Start
The week’s biggest funding round was Elon Musk’s xAI, which closed a $20 billion Series E, bringing its total financing to $42.7 billion. Other notable deals included $305 million for Parabilis Medicines, $200 million for Soley Therapeutics, and $150 million for AI‑model evaluator LMArena. Two companies...
Boltz PBC Launches with $28M to Democratize AI Platforms for Drug Discovery
Boltz, a public benefit corporation founded by MIT CSAIL researchers, announced a $28 million seed round led by Amplify, a16z and Zetta Venture Partners. The company aims to democratize AI‑driven drug discovery by offering Boltz Lab, an end‑to‑end platform that reduces...
Vendasta Shows Why Platforms Become Operating Systems for AI Agents
The episode explains how Vendasta pivoted from a traditional SaaS marketplace to an AI‑driven platform that functions as an operating system for digital agents, enabling SMBs and partners to automate core business tasks and deliver enterprise‑grade customer experiences. Key takeaways...
Commercially Viable Biomanufacturing: Designer Yeast Turns Sugar Into Lucrative Chemical 3-HP
Scientists at the University of Illinois and Penn State have engineered the acid‑tolerant yeast *Issatchenkia orientalis* to convert plant sugars into 3‑hydroxypropionic acid (3‑HP) at commercial‑grade yields and titers. The strain achieved a 0.7 g 3‑HP per g glucose yield and 92 g 3‑HP...
People First: Manifesto Drives Never‑Stop‑Learning Brand
Your only competitive advantage is your people. That belief shaped how we approached the Docebo rebrand from the very beginning. Because (as a marketer) it's your duty to give your company a damn opinion in the market. So, before any...
NTLA’s 8‑K Reveals Liver Failure Death From Sepsis
Context: $NTLA just 8K'd (not a PR, hmmm wonder why) that their Hy's Law patient's autopsy showed ruptured GI ulcer and sepsis as the ultimate cause of death. Anyone saying this is not related to the liver failure is showing...
Tonic.ai Product Updates: January 2026
Tonic.ai’s January 2026 release adds Guided Redaction in Textual, a beta human‑in‑the‑loop workflow that couples AI detection with manual review for high‑risk data. The platform also expands model‑based custom entity types, letting users train detectors for niche business vocabularies. A...
PREDICT 2026: Finextra’s US Regulation Pulse Check 2026
Finextra’s 2026 US Regulation Pulse Check surveys financial institutions on a slate of overlapping compliance deadlines, including Treasury clearing mandates, ACH fraud rules, the GENIUS Act and new AML/CFT program designs. The study finds firms are turning to AI, automation...
My Top AI Tools for Every Workflow
My favorite AI models/tools for different tasks right now: 1) Go-to starter: Claude Opus 4.5 - I continue to be stunned by its capabilities. It gets me. It passes the vibe check with flying colors. It matches my writing at 85-93%....
Corporate Payouts Platform Onbe Appoints Kevin Ryan CFO
Onbe, a corporate payouts platform, announced Kevin Ryan as its new Chief Financial Officer, effective immediately. Reporting to CEO Bala Janakiraman, Ryan will lead FP&A, accounting and treasury, shaping the firm’s financial strategy. He brings 24 years of fintech finance leadership, most recently...
Precision Motion Control Solutions Trusted by OEMs for 25 Years
Midwest Motion Products (MMP) marks its 25th anniversary as a leading OEM supplier of precision motion‑control hardware, including DC motors, gearmotors, and controllers. The company differentiates itself with “Lightning‑Fast” same‑day delivery of standard planetary gearmotors and a #1 rating for...
MMP D22-376D-24V GP52-408 (Brushed 24V DC Gearmotor Capable of Producing up to 443 In-Lbs Continuous Torque with an Output Speed...
Midwest Motion Products introduced the MMP D22-376D-24V GP52-408, a brushed 24 V DC gearmotor delivering up to 443 in‑lbs continuous torque at 10 RPM. The unit is compact—under 2.5 in diameter and 9 in long—and carries an IP54 protection rating. Midwest emphasizes rapid availability, offering...
'Chaotic Web' Of Tech Keeps Bank Fraud Victims in Limbo
The article recounts a consumer’s six‑week ordeal after a smishing attack led her bank to block both credit and debit cards, while fraudsters continued to use the compromised account. It highlights how legacy mainframe cores and fragmented software across branches,...
MMP D33-455F-36V GP81-068 (Brushed 36V DC Gearmotor Capable of Producing up to 245 In-Lbs Continuous Torque and 1079 In-Lbs Peak...
Midwest Motion Products (MMP) introduced the D33-455F-36V GP81-068, a brushed 36 V DC gearmotor delivering up to 245 in‑lb continuous torque and 1,079 in‑lb peak torque at 47 RPM. The compact unit measures under 3.5 in diameter, 10 in length, weighs 13 lb, and carries an IP54...
5 Essential Skills Every Project Manager Needs During a Data Center Transformation to the Cloud
Organizations accelerating data‑center to cloud migrations face enterprise‑scale complexity that demands more than technology. Five core capabilities—systems thinking, elastic governance, stakeholder coordination, technical fluency, and resilience—are identified as essential for project managers leading these transformations. By mapping interdependencies, adapting governance,...
Dedicate a Day to Automate Every Team Workflow
Your team needs a Systems Hack Day. I know the name isn’t perfect, but I’m talking about dedicating one day entirely to rethinking how a process gets done. If you haven’t built Claude skills you’re using regularly... If you haven’t...
Flight Engineers Give NASA’s Dragonfly Lift
NASA’s Dragonfly mission is advancing toward its 2028 launch after successful full‑scale rotor testing at the Transonic Dynamics Tunnel (TDT) at Langley Research Center. Engineers from Johns Hopkins Applied Physics Laboratory fabricated the rotors from massive aluminum blocks, refined the...
Free Cheatsheet Guides Practical Agent Architecture Decisions
We created a free Agents Architecture Cheatsheet. Here’s why 👇 A lot of people are building agent systems without a clear reason to do so. They mix tools with agents, over-complicate architectures, and struggle to move from demos to production. This cheatsheet is designed to be...
Aragen Launches CHOMax Cell Line Development and Manufacturing Platform
Aragen Biologics introduced CHOMax, an integrated cell line development and early manufacturing platform for standard IgG monoclonal antibodies. Refined across more than 200 CHO programs, the platform combines cell line creation, process development, analytics, and GMP manufacturing to move projects...
China Reports Progress On Xuntian Telescope Data Simulations
China’s research team has completed a full data‑simulation workflow for the Chinese Space Station Telescope (CSST), also known as the Xuntian Space Telescope, publishing the results on 7 January. The end‑to‑end suite generates realistic pixel‑level mock observations that mirror the telescope’s...
Fiserv Launches Unknown Shopper to Help Merchants Understand In-Store Customers
Fiserv has introduced Unknown Shopper, an analytics tool that transforms in‑store card‑present transaction data into actionable customer insights. Leveraging billions of historical payments, the platform enriches raw data with demographic attributes, allowing merchants to build segments without loyalty program enrollment....
Flu Deaths Rise as Child Vaccination Rates Fall
1. There's a new FluView report from #CDC. Let's dive in. CDC was informed of 7 more kids who've died from #flu, bringing the season's toll to 17. Sadly, this number is going to rise. Vaccine uptake among kids has been...
Drone Production Hits Automotive-Scale Standardization, Faces Complexity Limit
Modern drone production. An assembly line in China shows how far drone manufacturing has been industrialized. Conveyor systems move the airframes between stations. Each worker performs a narrowly defined step, closer to poka-yoke than to classic workshop assembly. • Highly...
Personalized Medicine Vs. Precision Medicine
Dr. Jennifer Levin Carter of Medzown clarified the distinction between personalized medicine, which tailors care to individual circumstances, and precision medicine, which leverages genetic and molecular data to design disease‑specific therapies. She highlighted oncology’s 15‑year transformation through genomics, enabling targeted...
Building Credit From the Ground Up: How Credit-Building Cards Actually Work
Credit‑building credit cards are designed for consumers with thin or damaged credit, offering low limits, simplified approvals, and reporting to major bureaus. By encouraging regular, low‑balance usage and on‑time payments, they help improve payment history, utilization, and credit mix, key...
Is CSGOFast a Scam or Legal?
CSGOFast is a skin‑wagering platform that offers provably‑fair betting mechanics, transparent round histories, and a documented withdrawal process. While users can lose money due to the inherent risk of gambling‑style games, the site provides the verification tools scammers typically avoid....
Landspace Secures Launch Contracts for China’s Megaconstellation Projects
Landspace has secured formal launch contracts for China’s two flagship megaconstellations, Guowang and Qianfan, using its reusable Zhuque‑3 methane‑liquid oxygen vehicle. The contracts, detailed in the company’s Shanghai Stock Exchange IPO prospectus, include an 18‑satellite launch for Yuanxin Satellite in...
Susannah Streeter Joins Wealth Club as Chief Investment Strategist
Wealth Club, the UK‑focused investment platform for high‑net‑worth individuals, has appointed Susannah Streeter as chief investment strategist. In the role she will head the firm’s market commentary, decode economic and monetary trends, and guide clients toward opportunities in venture‑capital trusts,...
A Bioinspired Hydrogel Patch with Controllable Adhesion Properties for Enhanced Soft Tissue Repair
Researchers from Shenzhen University, the Chinese Academy of Sciences and Hong Kong Polytechnic University have created a bioinspired hydrogel patch with controllable adhesion for soft tissue repair. The dual‑sided device combines a suction‑cup‑like adhesive layer that can be repositioned and...
Slow Down to Break the Urgency‑Error Cycle
Your team isn't slow. They're too fast, and that's the problem. The operational doom loop: Urgency creates errors. Errors create escalations. Escalations create churn. Churn creates panic. Panic creates more urgency. Urgency creates new errors. You're not moving fast. You're...
Proteomics at Scale: Current Approaches and Emerging Technologies
The new eBook "Proteomics at Scale" examines how emerging and traditional proteomics platforms balance protein coverage with analytical detail. It highlights the inherent trade‑offs between detecting a broad protein repertoire and accurately quantifying proteoforms. The publication introduces Nautilus™’ Iterative Mapping...
BIO Investment Council Will Bring Together VC and Small Biotechs to Boost Innovation
The Biotechnology Innovation Organization (BIO) launched the BIO Investment Council (BIC) on Jan. 7 to bridge venture capital and small‑to‑mid‑size biotech firms. BIC aims to align early‑stage companies with the right investors as clinical‑stage funding now outpaces preclinical for the first...
Build Stories From Real Audience Insight, Not Buzzwords
“Storytelling” gets tossed around so much can end up meaning ... nothing. In this clip, John Elbing , author of Storybuilding, helps us move past story as a buzzword and into something more useful: building stories from real audience insight....
Biotech TV Takes Over Union Square with Industry Leaders
Biotech TV is going to blanket Union Square this year. Starting Sunday, we'll have @ByAmyBrown @RS_Flinn @chloeckirk and myself hustling around town with the industry's top leaders. Please tune in. https://t.co/mtJTzUF5Sd
Parkinson’s Outcomes Compared: With Vs. Without Deep Brain Stimulation
A recent comparative study evaluated Parkinson’s patients receiving deep brain stimulation (DBS) against those managed with medication alone. The analysis found that DBS recipients experienced a 40% reduction in OFF‑time and a 30% decrease in levodopa dosage, while motor scores...
Add a Revenue Filter to Claude Code for Growth
Claude Code lets you build anything. Most founders are using it to make $0. I almost did the same - until I added a revenue filter. Here’s how I use it to drive retention, expansion, and net-new revenue ↓
Predicting $20B+ Biotech M&A Deal by 2026
One of my #JPM26 predictions for 2026 is that we'll see a $20B-plus M&A deal in biotech. So here's hoping any RevMed deal comes after Monday morning. https://t.co/5pe4ymAILt
Sepsis Often Leads to Death In
Hey @grok is sepsis a common proximate cause of death in patients with drug induced liver failure?
AI Prompts Boost OT Cybersecurity Expertise
20 ChatGPT prompts for OT / ICS cybersecurity 👇 From asset inventories to threat hunting, tabletop exercises, IR plans, and secure remote access. AI won’t replace OT experts — but it can scale the few we have. Credit: Mike Holcomb #OTSecurity #ICSCyber #CriticalInfrastructure #CyberSecurity
AI‑Driven GTM Built in 180 Days: Key Wins
1/ Personio's CRO Phil Lecor built an AI-powered GTM in 6 months. From nothing to all-in in 180 days. $8.5B company. 400 salespeople. 15,000 customers. Here's what actually worked (and the mistakes to avoid): 🧵 https://t.co/qhDbuFmAxS
Modernizing Core Delivers Speed, Flexibility, Resilience
Core modernization is not about appearances. It is about speed, flexibility, and resilience that legacy systems cannot deliver. We unpack what this means with Sai Rangachari of @Temenos. Watch the full video: https://t.co/u3T8bi10eb https://t.co/nTrfg3ms91
Chinese Hospital's Blood‑Drawing Robot Hits 94.3% Success
Chinese Hospital Deploys Blood-Drawing #Robot Achieving a 94.3% Success Rate by @Khulood_Almani #Robotics #MachineLearning #ArtificialIntelligence https://t.co/lg80dWYLHD