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CircZBTB46 Targets miRNA-326/FGF1 to Combat Liver Disease

Researchers have identified the circular RNA CircZBTB46 as a potent regulator of liver pathology. By acting as a molecular sponge for miRNA‑326, CircZBTB46 restores fibroblast growth factor 1 (FGF1) signaling, which in turn attenuates hepatic fibrosis and improves liver enzyme profiles in pre‑clinical models. The study reported a 40% reduction in collagen deposition and a 35% drop in ALT levels after treatment, positioning CircZBTB46 as a promising candidate for non‑alcoholic fatty liver disease (NAFLD) and non‑alcoholic steatohepatitis (NASH) therapeutics. These findings open a new avenue for RNA‑based interventions in chronic liver disease.