Continuous Glucose Sensor Outperforms HbA1c in Predicting Disease
Continuous glucose sensor (GGM) foundation model predicts Type 2 diabetes and cardiovascular deaths better than the standard blood biomarker, HbA1c
Stop Blaming Time—Make a Decision, Not an Excuse
If you keep saying “I don’t have time,” start with a 2 hour offer. Time is not the issue. Decision is.
Artemis II Wet Dress Rehearsal Slated for Jan 31
NASA says the Artemis II Wet Dress Rehearsal is now as early as Jan 31. https://t.co/bj6ypJWE9L
TikTok Developing World Models for Robotics—Watch This
Of course @tiktok_us is building world models to run robotics, and other things. An effort to watch.
AI Agents Simulate Real Humans for Customer Research
Now your AI agents can do customer research by using simulated humans that are based on real humans. In other words, a new way of building your business is here. @runrehearsals cofounder @liambolling gives me one of the most interesting conversations about...
Skip SaaStr AI, Watch Rivals Leap Ahead
Your competitors are sending their whole leadership team to SaaStr AI 2026. You can skip it. But don't be surprised when their AI roadmap is 6 months ahead of yours by June. May 12-14. SF Bay. https://t.co/4U2DOAE1gc
AI Researchers Mimic Human Brain in New Study
The AI researchers are emulating the human brain and here's an interesting report about it. (From my neuroscientist list).
Replit Expands Enterprise AI, Hiring GTM Talent Now
Replit is now known as one of the fastest-growing AI companies in the world, but what's less recognized is our adoption in the enterprise. Our sales team officially started last year, and since then we've closed some of the largest...
Artemis II Crew Begins Quarantine, Awaiting Launch Timeline
Still no date for the WDR or launch, but Artemis II crew is getting ready. They entered quarantine on Friday in Houston. Pending outcome of the WDR or other operations considerations they can come out and reenter 14 days before...
Brands Must Prioritize Analytics over High CPM Confidence
$60CPM's... No conversion tracking... "confident in unique ad value despite limited analytics" Ugh. Brands need to learn from AppLovin's rollout to new ad channels. https://t.co/v4qSx7wveH
PhD Students: Register Now for CMU 3‑Minute Thesis Competition
Attention Ph.D’s!🚨🔔 Registration for the CMU 3 Minute Thesis Competition ends next week. All Ph.D students regardless of year are welcome to compete. Get started below 👇👇 https://t.co/yXFM6UMc0q https://t.co/dsVieQDeWI
Ask “What Made You Cancel?” To Uncover True Reasons
My biggest takeaways from Jason Cohen : 1. “Too expensive” is never the real reason customers cancel. They already saw your pricing and decided to buy, so something else changed. When customers cite price, dig deeper—the actual reason might be...
Double Down on Winners: Increase Ownership Every Round
I'm a co-investor with a mega VC fund we don't talk about as much here but they are wildly successful in many top IPOs and top decile returns. And they have a really simple way they do follow-on checks: ✅If the company...
Oman Signs Artemis Accords, Hosts Regional Space Summit
The Sultanate of Oman is the latest Artemis Accords signatory. Oman is hosting the Middle East Space Conference this week. https://t.co/vdZQAZ2n6w
Hospital Group Challenges Eli Lilly's 340B Data Policy
Hospital group seeks to have new Eli Lilly policy on 340B claims data blocked https://t.co/Uz0lDrgL1y
Zoom Jumps 10% as Anthropic Stake Finally Priced
Zoom is up 10% today, or about what its Anthropic position would be worth (I'd guess closer to 50x than 85x). It's trading at a $28B market cap as of right now, and its Anthropic position is probably worth ~$2-3B. Insane this...
Pre‑order Ads Succeed only for Truly Unique Products
I had a friend recently ask me if he should run ads for pre-orders while he's out of stock until March. His raw material sources are backed up from Chinese New Year, and he can't manufacture again for weeks. But when it...
Bill Nye Steps Down as CEO, Becomes Ambassador and Vice Chair
After 15 years heading The Planetary Society, Bill Nye "The Science Guy" is transitioning from CEO to a new role as Chief Ambassador as well as Vice Chair of the Board of Directors. Current COO Jennifer Vaughn will be...
Moon Spacewalks Far Harder than ISS, Astronauts Say
That *is* an excellent report abt the realities of spacewalking on the Moon, esp v the ISS, and Axiom's suits. Incl stmts by astronauts Kate Rubins (ret) and Mike Barratt to the Natl Academies recently (plus an interview w/Rubins). Snip:...
GEO Anxiety Replaces FOMO as AI Search Disrupts Marketing
GEO anxiety is the new FOMO. And it's everywhere. We just surveyed 50 mid-market B2B marketing leaders through Wynter platform. Everyone is scrambling to figure out AEO/GEO. Why? Because the old playbook is bleeding out. 46% of these leaders are actively pulling back...
Canada-Korea MoU to Jointly Develop K‑LEO Military
Canada's @MDA_space and Korea's #Hanwha Systems Co sign MoU to explore collaborating on Korean govt K-LEO military constellation using MDA's Aurora software-defined satelite platform. https://t.co/6vSjdppt4v
Lead Content Engine for AI Adoption at Pragmatico
My friends at Pragmatico are hiring a Head of Content Marketing, and it's a super interesting role. Outside of working with Randy Stocklin and Santiago (Santi) Jaramillo (which should be enough), this is a super interesting role because it's more...
Claude Adds MCP Apps, Enabling Box File Previews in Chat
Claude now supports MCP Apps, which means you can get interactive experiences in Claude responses. We're excited to partner with Anthropic to support Box file previews for nearly any file type directly in your Claude chat experience.
Founders: Content Is Your Ultimate Business Landing Page
Every founder should be creating content and that’s a hill I’ll die on. Your content is a landing page for literally everyone. - Investors - Agencies - Partners - People you want to hire They are all going to your profile to figure out what...
AI Turns First Sales Hire Into Pure Discovery Role
Nailing the first sales hire has historically been one of the biggest hurdles in kicking off the scaling process. They’re a unique breed: half Account Executive, spending all week in conversations with prospective customers, and half Product Manager, distilling those...
Launching an AI‑First Startup Accelerator After 3 Years
very excited to share a project i've been iterating on for 3+ years: an AI-powered startup "accelerator" inspired by my time at Techstars and seeing similar programs, I've wondered what an AI-first version could look like check out what i made this weekend...
From Blurry Beginnings to 4x Faster, 3x Cheaper HD
I've been watching this company since its very beginnings. Back then it could barely make blurry photos with hands that had an unnatural number of hands. I tried to get some investors interested in it and they passed. Now 4x faster...
Robotic Packaging Cuts Labor, Costs, and Complexity
High-speed food packaging only makes sense if automation actually changes the economics. At Anı Bisküvi A.Ş., a robotic box-filling system from Robentex now runs two lines at a combined 800 products per minute. They moved to a tray-and-lid concept instead...
Purpose over Features: Simpler Product Drives Massive Sales
Bombas made $100M selling socks with ONE differentiator: donate one pair per purchase. Meanwhile you're adding 15 features nobody asked for. That's the gap.
AI's Adolescence Threatens Security, Economy, Democracy—Defend Now
The Adolescence of Technology: an essay on the risks posed by powerful AI to national security, economies and democracy—and how we can defend against them: https://t.co/0phIiJjrmz
Launching a Billion‑Dollar SaaS: Episode One Begins
I’m building the next billion-dollar SaaS. (At least that’s the goal) I’m documenting the whole thing so you might be able replicate it. Welcome to episode 1.
IonQ's SkyWater Access Claim Faces Feasibility Questions
Will IonQ really allow other QC companies to use SkyWater, as the press release claims? What if someone asks to tape out a device superior to what they have at a given time?
Prioritize AI by Decision Bottlenecks, Not Feature Lists
🧠 The ABC of AI use cases is useful—but incomplete. Lists like this help name opportunities. Leaders need help prioritizing and sequencing them. Here’s the strategic reframe: 🔹 Most use cases collapse into 4 enterprise intents 1. Predict (risk, demand,...
Journalists Should Use Signal Usernames, Not Personal Numbers
A number of Washington Post journalists asked for tips from government workers last year and posted their personal phone numbers for @signalapp. Please know that Signal allows you to create a username, meaning you can keep your phone number private....
Shared Vaccine Decision‑making Isn’t the Enemy, Says Sandman
I think you should always listen to Peter Sandman, even if you don't agree. "Shared decision-making on vaccines is not the enemy," one of the great experts on medical decision-making writes in STAT. https://t.co/1XZnI9JZ1m
AI Must Learn When to Pause, Not Just Answer
AI is getting better at answers. The next step is knowing when not to rush one. New research argues for artificial metacognition: giving AI systems the ability to reflect on their own thinking, detect uncertainty, spot conflicts, and slow down when...
Beware: Clawdbot Could Unleash Unaligned AI Risks
Rahul warns us about Clawdbot. I'm not too worried about the nerds here who load it, but it got so popular over the weekend that non-techies will get drawn in. And that's where the trouble starts. I don't know how...
Remember William Foege: Smallpox Eradication’s Rational Hero
I don't know how to ask for a moment of silence amid the madness that is X. But please take a moment to reflect on the heroism of William Foege. Foege, who died Saturday at 89, was a key architect of...
New AI Tool Attracts 1,400+ Companies, Challenges Claude
Developers: fresh meat. Added to my AI developer tools list. Now more than 1,400 companies. My friends say this one is a good one, will it get you to change off of Claude?
AI Assistants Boost Output, Spark New Micro‑anxiety
As @jasonlk said a few days ago, it won’t be long until most of us have at least one agent working for us almost 24/7. More and more, I give an agent (usually coding or research) a task before jumping on...
ESA Backs Iris2 Low-LEO Expansion with NRE Reimbursements
.@defis_eu Iris2 multi-orbit network expands low-LEO component to allow more industry experimentation; @esa agrees to modify its rules to permit reimbursement of NRE expenses needed to scale tech to constellation-level production rate. https://t.co/oxaKaZk6Vf
AI Fashion Tools Must Cut Returns, Not Just Show Off
NRF is drowning in “AI for fashion” demos, from styling assistants like Ask Ralph to one-click shopping via Copilot/Gemini/ChatGPT. Do customers want this… or is it just retail tech cosplay? If AI doesn’t reduce returns or improve trust, it’s innovation theater. https://t.co/Lym3BLrso4
Origami-Inspired Robot Arms Enable Button Pressing, Heavy Printing
A recent Science #Robotics study describes an interlaced origami-based structure that enables mobile robots to extend arms to press elevator buttons or form frames to support heavy 3D printing systems. https://t.co/fgD4ZjcnPp https://t.co/M4GVUcZKYH
OHB and Rheinmetall Discuss Multi‑billion Bundeswehr Broadband Project
.@OHB_SE confirms it's in talks with @RheinmetallAG "regarding a cooperation for participation in possible public procurement processes," which @handelsblatt reported was the proposed multi-billion $ broadband constellation for the German @bundeswehrInfo. https://t.co/npkoQGwWoo
Phone‑First AI: Simpler Text Access Over Complex Setup
I’m gonna be honest about Clawdbot. I’ve seen dozens of tweets on it, watched tons of videos, read whatever docs and guides I could find, and I’m with @omooretweets on this one. I’m glad tinkerers are loving it. I’m glad...
Ethiopia Declares First Marburg Outbreak over After 42 Days
This is good news indeed. Ethiopia has declared its first recorded #Marburg outbreak is over, after going 42 days without new cases. There were 14 confirmed cases & 9 deaths.
Kontigo's Neobank Facade Leaves No Clear Accountability
Kontigo looks and acts like a neobank, but there’s no bank standing behind it. At least with BaaS middleware, the end user had a legal and contractual relationship with a bank. So, there's a clear line of responsibility (whether the issue was...
Turn Customer Wow Moments Into Your Best Sales Tool
Most B2B SaaS companies are sitting on a goldmine. (they just don't know it). Here's what I see: A customer gets their first win. They're excited. They tell their team "this works." That's a wow moment, but nobody captures it....
Get Real Drive Data Instantly via OPC UA
🎥 OPC UA instead of guesswork – access real drive data Everyone talks about data – but how do you actually access process data from modern drives? In my new video, I show you hands-on how to easily access process...
Lower‑Middle Market M&A Thrives;
I’ve had so many conversations with founders who tell me they almost sold during ZIRP, then decided to wait because they were sure the market would only get better. They expected multiples to keep rising, capital to stay cheap, and buyers...