Red Wolf Controversy Deepens After Colossal’s Clone Claim
The red wolf has long been a contentious species. The debate over its preservation got even messier last year, when Colossal said it had cloned the animal.
AI Accelerates Small Molecule Synthesis, Says Martin Burke
Small molecule synthesis made faster for the AI era: Listen to Martin Burke on The Long Run. Sponsors: @AlphaSenseInc and Dash Bio. https://t.co/D990phgzg8
Biological Data Is Messy: Human Error Is Inevitable
1/ Biological data isn’t just messy. Humans generate it. And humans make mistakes. As a bioinformatician, this will be your reality 🧵 https://t.co/hjSOBVJvjM
Regulatory Hurdles, Not Tech, Slow Biotech Breakthroughs
"We need 6 'AlphaFold' moments to compress the drug delivery timeline from 10yrs to a few months" -Demis Yes and the FDA will still take 10yrs to approve it. Safetyism has throttled biotech unnecessarily and the only way to accelerate is to...
Nicotinamide Riboside Blocks Lasting Mitochondrial Damage Post‑asphyxia
Long-term region-specific mitochondrial respiration impairment after perinatal asphyxia is prevented by the NAD⁺ donor nicotinamide riboside: A real-time organotypic metabolic profiling approach https://t.co/ZGyAxcnNAC https://t.co/w0VJkAmlHT
Tortugas Neuroscience Launches to Develop Brain Disorder Drugs
Tortugas Neuroscience launches with hopes to develop drugs for brain disorders, other conditions https://t.co/zoM69VEQtV via @ADeAngelis_bio
Trump Order Boosts Psychedelic Biotech Stocks
Trump executive order lifts psychedelics biotechs https://t.co/3H00cxuF4A by @realJacobBell $GHRS $HRELP $DFTX $ENVB $COMP $ATAI #biotech
Serif Targets Revolutionary Genetic Medicine Platform
Serif, Flagship’s latest biotech, aims to make a new kind of genetic medicine https://t.co/kvmbF3xYKu by @gwendolynawu #biotech #startups @FlagshipPioneer
Celastrol Disrupts Hsc70‑Bim to Boost Longevity, Reduce Fibrosis
Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis https://t.co/Iv51QlhH5l
Time‑restricted Eating Matches Calorie Restriction for PCOS Weight Loss
Time-restricted eating for body weight management in women with polycystic ovary syndrome: a randomized controlled trial “Our results show that in women with PCOS, TRE induced greater weight loss than the controls and was comparable to that achieved with daily CR” https://t.co/fqogoSQpkd
Four Overlooked AACR Early-Stage Agents Worth Watching
While everyone was watching KRAS, some of AACR’s promising early stage pipeline agents were easy to miss. Here's an analysis on four examples which caught my eye and are well worth watching to see how they develop in the...
New RAS Cancer Drugs Aim to Beat RevMedicines’ Success
April20: Which RAS-based cancer drug developers are working to improve upon the dazzling pancreatic cancer results of @RevMedicines' daraxonrasib, whose stock surged 54%? Read about $RVMD plus updates on $MGTX and $TVTX in my latest StockWatch for @GENbio: https://t.co/9wQA7XsuLW
Tenofovir Alafenamide Cuts Biological Age in Adults
An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics 💫 https://t.co/FFvTmJv2zv https://t.co/DHHQ18nAmy
Epigenome Proteins Enable Precise Cellular Engineering Beyond On/Off Control
Epigenome proteins generate distinct gene expression patterns, influencing cellular behavior beyond simple on/off control and offering new avenues for precise cellular engineering. generegulation
HDAC7 Loss Predicts Poor DLBCL Outcomes; Restoration Stops Tumor
Loss of the HDAC7 protein in diffuse large B cell lymphoma is linked to poorer outcomes, while restoring HDAC7 in cancer cells halts tumor growth, highlighting its potential as both a biomarker and therapeutic target. bloodcancer
Gene Therapy Works Best for Deaf Children Aged 5‑8
AAV gene therapy for autosomal recessive deafness 9: a single-arm trial 🌟“Gene therapy for congenital deafness has shown promising results in children but lacks data in older populations… . An age-dependent therapeutic effect was observed, with optimal outcomes in 5- to...
Promising Longevity Molecule Stalled by Misaligned Incentives
The Longevity Drug You’ve Never Heard Of This is one of those stories that captures both the promise—and the frustration—of longevity science. In this preview episode, Dr. George Sutphin (@senmorteco ), Associate Professor of Molecular and Cellular Biology at the @uarizona @UAZCancer , walks...
Anktiva Needs Trial Data Before FDA Approval
For the umpteenth time, these posters have zero relevance to Anktiva unless, or until, $IBRX conducts/completes randomized clinical trials that demonstrate the drug improves outcomes for cancer patients w/ lymphopenia. @LoriMills4CA42 and the rest of you can idolize @DrPatrick ...
Funding Boosts AI for 3D Protein and RNA Mapping
Funding will support the development of advanced AI methods to map proteins and RNA structures in three dimensions. https://t.co/L6ZSpg8iMW #infrastructure #IoT #AI #5G #cloud #edge #futureofwork @virginia_tech https://t.co/7K7X1E9NpH
SynBioBeta Fuels Boom Capital’s Top Biotech Deals
@SynBioBeta draws one of the densest concentrations of biotech investors of any conference in the world. So what keeps them coming back? Celestine “Cee Cee” Schnugg has the answer. Cee Cee is the Founding Managing Partner of Boom Capital, an early-stage deep...
GLP‑1s Preserve Muscle Better Than Diet‑Only Weight Loss
Summary for patients on GLP-1 drugs and non-drug weight loss re: muscle mass impact @AnnalsofIM https://t.co/pSDhbKkXwb https://t.co/qM7OgVJwQg
JRT: LSD-Derived Antidepressant Boosts Brain Spines without Hallucinations
One dose: > 46% more dendritic spines in prefrontal cortex > 100x more potent than ketamine as an antidepressant What is it? LSD with a two atom swap. > no trip > no hallucinations > no schizophrenia signature It's called JRT. https://t.co/sozMqlJctc
Balaji Predicts Booming Market for Bro Biotech
.@theojaffee asks Balajis for his thoughts on Clavicular, Balajis says he’s cheering for Clavicular because he’s tapping into bro biotech/bro science and that’s set to be a major market. Peptides, etc https://t.co/CgSt6rg1zI
CRISPR Advances Outpace Ethics in Germline Editing Debate
In 2018, He Jiankui edited the genomes of two human embryos, brought them to term, and went to prison for it. The babies are now children. We don't know how they're doing. Seven years later, base editing and prime editing can...
Free Virtual Summit on Multiomics & NGS – Register Now
Join @julemieux1 and as we co-host THE STATE OF MULTIOMICS & NGS @Genbio virtual summit next Wednesday, April 29th: Sponsored by @illumina - registration is free. https://t.co/NJErGGe5qb https://t.co/dJuRqy8Np7
LLY's Second in Vivo CAR‑T Deal via Kelonia Buyout
Kelonia turns #ASH25 late-breaker into buyout, with $LLY's second move into in vivo Car-T. Via @ApexOnco -> https://t.co/NPhdnuhPu3 $AZN $GILD
Rejuvenated CD4 T Cells Promote Longevity, Infections Accelerate Senescence
Rejuvenated CD4 T cells--> longevity https://t.co/FH5XTQc3zl On the other hand, infection-->increased senescent T cells, shorter lifespan? https://t.co/wtsDnmIdnh
Key Overlooked Factors in Clinical Trial Design
New presentation on things we often forget to consider when designing a clinical trial: https://t.co/BVlSCIHdLu #Statistics #clinicaltrials
First Gut Microbiome Signature Predicts Parkinson’s Risk in Healthy Carriers
We've known the gut-brain axis is a key underpinning of Parkinson's disease. Today, for the 1st time, a gut microbiome signature denoting risk found in healthy individuals with genetic predisposition @NatureMedicine https://t.co/oDTItnis5L
2018 Study Predicts Psilocybin Should Move to Schedule 4
The psychedelic executive order requires government to "initiate and complete review of any product containing a Schedule I substance that has successfully completed Phase 3 clinical trials ... so that rescheduling ... may proceed as quickly as practicable". My 2018...
Israel's SynBio Surge: CEOs Reveal Scaling Success
Israel has built one of the most concentrated synbio ecosystems outside the US. The country's National Bioconvergence Program, run through the Israel Innovation Authority, is specifically designed to close the gap between lab-scale innovation and commercial biomanufacturing. This session at @SynBioBeta 2026...
AACR 2026 Unveils Merck Breakthrough and Lung Cancer Hope
AACR 2026: Revolution’s next prospect, Merck’s reveal and a lung cancer battle https://t.co/u2iwCd3DKv #AACR26 $RVMD $MRK $NUVL $NUVB
Biotech Must Prioritize Collaboration, Not Nationalism, for Patients
After a week in Washington DC at one of the best new annual events by @semafor , I came to China for just 2 nights to meet some of my friends from Washington. I even had to skip this year's...
PSIL Surges as Trump Fast‑tracks Psychedelic Research
Far Out Man: The Psychedelics ETF $PSIL has destroyed its daily volume record in first 30min of trading.. Trump just signed ex order expediting research/access to psyche drugs to cure depression. The sector has been in dog house, waiting for...
Molecular Glue Daraxonrasib Shows Promise Against Pancreatic Cancer
Good summary of the marked benefit of the molecular glue drug (daraxonrasib) vs pancreatic cancer, from Revolution Medicines, and other progress (adds to the neoantigen vaccine with 6-year survival) gift link https://t.co/qk7Ar9dCAQ https://t.co/SMiA51fiwX
Scientists Reverse Mouse Aging by 75%, Promising Human Breakthroughs
Dr. David Sinclair just dropped a two-hour masterclass on Tom Bilyeu's podcast. He shared 10 mind-blowing insights on how to reverse biological age in animals (and why it should work in humans too). 1) They already reversed a mice's age by 75%...
LLY Acquires Kelonia for $3.25bn After ASH25 Insights
It's official: $LLY buying Kelonia for $3.25bn + milestones. @ByMadeleineA take on the #ASH25 dataset that triggered this move: https://t.co/nVUNlq7YlO
GSK's Blenrep Approved in China for Multiple Myeloma
#GSK Blenrep (belantamab mafodotin) approved in China with a Bortezomib and Dexamethasone combo for treating Adults with a form of multiple myeloma.
AI-Driven Drug Discovery: Current Landscape and Future Promise
Cool review and perspective on the current state and the future of AI-powered drug discovery https://t.co/AgwqOlt4RU
Salt Harms Arteries via Immune‑driven Senescence, Not Direct Toxicity
Salt has been blamed as the culprit for damaging your arteries. A new mouse study puts salt-sensitive hypertension in context. Salt doesn't do it directly, it triggers your immune system to do it. 4 weeks on a high-salt diet (8% NaCl) cut...
Trump Cuts Crucial Health Research Funding, Fueling Crisis
This piece in the WaPo summarizes what I've been say. The feds under Trump are choking off research dollars -- particularly for women's health, cancer and mental health. Young researchers are particularly hard hit, steering scientists into other work. It's...
Boosting Mitochondrial NAD+/NADH Extends Life, Eases Alzheimer’s
Extension of Lifespan and Amelioration of Alzheimer's Disease Phenotypes by Genetic Manipulation of Mitochondrial NAD+/NADH Ratio https://t.co/m8K1Tm9sIR https://t.co/SU85G9FsgW
Zombie Immune Cells Linked to Fatty Liver, Inflammation, Aging
UCLA scientists identify zombie immune cells as a driver of fatty liver disease, inflammation and aging https://t.co/28Ql5er4kb https://t.co/IoAD5I6AJr
FDA Approves Breakthrough Therapy for Critically Ill Children
FDA says ‘yes’ to transformative therapy for sick children — and more media coverage of UCLA https://t.co/N6AJsRwCyX
Combined NMN and CD38 Inhibitor Rejuvenates Aging Muscles
Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration https://t.co/bnkkn0xblj Scheme 1: A novel synergistic drug combination (N + A) consisting of an NAD+ precursor (NMN) and an NAD+ consumption (CD38) inhibitor (API) promotes musculoskeletal regeneration in aging.
AI-Optimized Molecules Drive Clinical Interest and Expansion
#AACR2026 is in full swing and our posters are very popular. And some pharma companies realized that we have clinical data now and the molecules were AI-optimized to avoid the common liabilities. Finally, some genuine interest and we will have...
Stop Pipetting Yourself—Let Us Handle Experiments
Humans weren’t meant to pipette. Time to move on. Happy to run your experiments for you at https://t.co/b8gQiWKIwy https://t.co/skmzANp2Sl
Genome Sequencing Drops From Billions to Kitchen‑table Affordability
Human genome sequencing: 2003: $3,000,000,000 global effort years of research 2026: your kitchen table a few hundred $ Hard not to be excited for the future. https://t.co/0U5bXsHwt6 https://t.co/0U5bXsHwt6
Unexpected Insight Among 11 Lessons From AACR26
11 things I learned at #AACR26 Industry Partnering event – number 7 may well surprise you: https://t.co/T0ePbaIU1K https://t.co/CMh15HfnnG
Lung‑resident Memory B Cells Drive Lasting Flu Protection
Long-term flu protection may depend on lung-resident memory B cells, whose persistence is shaped by the strength of B cell receptor signaling, offering new directions for vaccines targeting immune defenses within lung tissue. immunology