Consumer Longevity Research Gains Momentum with Ginkgo Cloud Lab
Really excited about the use of @Ginkgo Cloud Lab for consumers to do research in longevity and other consumer apps. These areas are less well-studied than you'd expect as US research funding is largely oriented towards disease. Fun chatting with @LongevityTech about it!
US Patients Access Zegfrovy via Apex Oncology
Another win for Dizal, but how do US patients get hold of Zegfrovy? Via @ApexOnco -> https://t.co/4GVjyHS9vz https://t.co/bjjrnZkNL6
Pfizer's Lyme Vaccine Data Remains Ambiguous, FDA Review Looms
As someone who lived in Vermont and still spends the summer there, it's disappointing to see the ambiguity in Pfizer's data on a new Lyme disease vaccine. It's a serious threat. Now we can move on to speculating on the...
Thymus Gland Emerges as Key to Healthy Aging
Don't take the time to read about the new landmark studies that put our thymus gland at center stage for healthy aging https://t.co/ENhIn2A2l3 https://t.co/oY2PLSenmf
FDA OKs Fecal Transplants, Yet Access Declines
Paradox: The FDA approved some fecal transplants for C. difficile. But accessing treatment got harder. https://t.co/AFFyCGPeKW
Phase 3 Lyme Vaccine Shows Mixed Preliminary Results
The news is mixed in the preliminary results from a Phase 3 trial of a needed #Lyme disease vaccine, @matthewherper reports. https://t.co/bcbfeXchk1
Real Bioinformatics Data Is Messy, Not Perfect
1/ Every bioinformatics tutorial is lying to you. They give you clean data, perfect sample names, and zero missing values. Then you open a real dataset and nothing works. Here's what they don't teach you.
Lyme Vaccine Hits 70% Efficacy, Misses Confidence Threshold
The $PFE/ $VALN Lyme vaccine was a product for which there was a lot of hope. Results today show OK efficacy. Vaccine efficacy landed at 70%; investors hoped for 80% but thought as low as 60% would be relevant. But the...
Portable DNA Tests Map Cave Microbes in Real Time
Field-portable genetic assays now enable rapid, on-site mapping of cave microbial ecosystems, offering near real-time insights into biodiversity and potential health threats without reliance on traditional lab methods. microbiology
CtDNA Drives Next‑stage Risk Stratification in TNBC
From Prognosis to Action: Circulating Tumor DNA and the Next Phase of Risk Stratification in Triple-Negative Breast Cancer [Mar 18, 2026] Schneider & @StoverLab @JCO_ASCO https://t.co/6jPBxQe9QP #bcsm #PrecisionMedicine #LiquidBiopsy https://t.co/MOG73iTcNl
New Guidelines Add Testing, Therapy for ESR1‑mutated Metastatic Breast Cancer
Guideline Update Provides New Testing & Tx Recx for Pts w/ ER-Positive, HER2-Negative Met Breast Cancer w/ ESR1 Mutations [May 17-18, 2023] @ASCO Daily News - https://t.co/3ZVrEkQEN5 @DrHBurstein et al. @JCO_ASCO https://t.co/68e7D0CSgU #bcsm #PrecisionMedicine #LiquidBiopsy https://t.co/KBx2hq2BDW
Low‑
Lenalidomide + high-dose dexamethasone (RD) vs lenalidomide + low-dose dexamethasone (Rd) as initial therapy for newly diagnosed multiple myeloma: an open-label RCT [10/22/2009] @VincentRK et al. @TheLancetOncol https://t.co/hXxlFINejC #NCT00098475 #EAonc E4A03 #mmsm #caxtx #ctsm https://t.co/3Pa2TRMntk
Personalized Therapy Improves Outcomes in Residual TNBC
BRE12-158: A Postneoadjuvant, Randomized Phase II Trial of Personalized Therapy Versus Treatment of Physician's Choice for Patients With Residual Triple-Negative Breast Cancer [Dec 15, 2021] Schneider et al. Radovich @JCO_ASCO https://t.co/oJm6BJrMtA #bcsm #PrecisionMedicine
Genetic Links to Aromatase Inhibitor Musculoskeletal Side Effects
Genome-Wide Associations [GWAS] and Functional Genomic Studies of Musculoskeletal Adverse Events in Women Receiving Aromatase Inhibitors [Sep 20, 2010] Ingle et al. @DrWeinshilboum @JCO_ASCO https://t.co/1NJcXkWy8c #bcsm #Supponc
Circulating DNA/Cells Predict Recurrence Post‑Chemo in TNBC
Assoc of Circulating Tumor DNA & Circulating Tumor Cells After Neoadjuvant Chemotherapy w/ Disease Recurrence in Pts w/ Triple-Negative Breast Cancer: BRE12-158 RCT [Jul 9, 2020] Radovich et al. @JAMAOnc https://t.co/XxH9kTT9d5 #bcsm #cactc #NCT02101385 https://t.co/kgV0yM2I1f
Pfizer's Lyme Phase 3 Cut by One‑Third Over Contractor Issues
Pfizer's phase 3 for its Lyme trial was supposed to be 18k patients -- but issues with a contractor at the start of the trial cut the size by a third, and @ky_lahucik + I reported a long time ago...
P7C3 Boosts NAD Enzyme, Improves Mouse Alzheimer Model
P7C3 is an activator of an enzyme that makes NAD called NAMPT. Cool that it’s working in a 🐁 model of AD 👏
China Transforms From Free Rider to Drug Innovator
New @nberpubs: "From Free Rider to Innovator: The Rise of China's Drug Development" https://t.co/cQpEqRC1jy https://t.co/pSL5kCzlnO
Pfizer Lyme Vaccine Effective yet Misses Crucial Statistical Benchmark
Pfizer’s Lyme vaccine shows efficacy, but misses key statistical hurdle There is a set up for drama here. $Valn $pfe Valneva stock is down 14% in premarket trading. https://t.co/WN0KOl4Nqh via @statnews
Advanced Biotech Diagnostics Enable Precise Disease Detection
Accurate Disease Detection with Advanced Biotech Diagnostics by @antgrasso #MedTech #Healthcare #HealthTech #Tech #TechForGood https://t.co/VRXzThHgeq
Only Seven Proven Longevity Compounds After Massive Mouse Trials
7 Drugs. 30,000 Mice. 20 Years. The Only Longevity Compounds With Real Evidence. https://t.co/BzdoDZeicb @agingroy https://t.co/uM5QMpIAS6
Open‑source Super‑intelligent Model Accelerates Drug Discovery
Very important paper from our & @liquidai teams - deeply honored to have published with the geniuses @ramin_m_h & @xanamini . Take the super flexible model with high density of intelligence, post-train and fine-tune for basic...
Stem Cell Dose Boosts Walk Test, Cuts Frailty
Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty 🌟Performance on the 6-minute walk test improved in a dose-response fashion 🌟Improved 6-minute walk test distance correlated with patient-reported outcomes 🌟The percentage of study subjects classified as frail decreased...
Single Stem Cell Dose Boosts Strength, Reverses Frailty
Stem cell therapy shows promise for reversing aging-related frailty in new clinical trial 🗣️A clinical trial reports that a single dose can significantly improve physical strength and key signs of aging in older adults with frailty. https://t.co/5mw5r64imb https://t.co/uI88QpTEIa
FDA Staff Hear Peptide Plan via Rogan Podcast
“At least two career staffers at the FDA whose work includes compounding drugs said they learned of the health secretary’s plans to take action on peptides only from his appearance on Rogan’s podcast.” https://t.co/vpTDqstpDZ
Allogeneic Stem Cells Safely Boost Function in Frail Adults
Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial “Treated groups had remarkable improvements in physical performance measures and inflammatory biomarkers, both of which characterize the frailty syndrome. Given the excellent safety and efficacy...
Hackathon Targets Neural Repair, AI Surgery, Cryo Innovations
DEFEATING ENTROPY hackathon at @fiftyyears London HQ. Focus areas: Biomaterials for neural repair Engineered neural cells Tissue replacement AI for surgical robotics Advanced cryo methods Biostasis https://t.co/gMDDoo6Io4
Inhibiting MARCHF8 Revives Immune Attack on HPV Tumors
HPV-positive head and neck cancers evade immune detection by using the protein MARCHF8 to remove key cell markers; blocking MARCHF8 restores immune response and may make resistant tumors treatable with immunotherapy. cancerimmunology
Multiple Drugs Fail to Extend UM-HET3 Mouse Lifespan
Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice https://t.co/k0vERH4LSg
Low‑cost Patent‑free Vaccines Challenge Big Pharma, Expose Uninformed Freedom Rhetoric
But…I develop low-cost often patent free vaccines that bypass big pharma and provide access to people who can’t afford them. In the past people who espoused freedom were learned and read books. Now they’re just lazy mindless dummies who think...
AI Aims to Slash Biotech’s $3B, 13‑year Drug Timeline
The biotech industry spends $3 billion and 13 years to bring one drug to market. If you're still searching for a treatment that works, it exists but the process discovering it is too slow to actually help you in time. How Marc...
Scientists' Risk Fuels Life‑Saving Medicines, Not COI Fear
Scientists who stick their necks out and make medicines are my heroes There’s too much concern about COI for seasoned scientists with exemplary records Without commercial activity, we’d have zero medicines and ER-100 would still be in mice, not FDA cleared for...
UniQure Bet Turns Into FDA Shitstorm and Short‑sell Speculation
I bet on uniQure thinking it was an obvious win win win. HD wins with expanded access. FDA wins by narrowly expanding authorization while vigorously monitoring follow up data. Investors win as the company proves what doctors are saying. Instead...
SGLT2 Inhibitors Boost Survival in Frail Seniors
Use of SGLT2 Inhibitors in Frail Older Adults is Associated with Increased Survival: A Retrospective Study https://t.co/tsJ5qJLBap https://t.co/4EvBWDftJ4
Henagliflozin Shows Potential Anti‑Aging Effects in Diabetes
Effect of henagliflozin on aging biomarkers in patients with type 2 diabetes: A multicenter, randomized, double-blind, placebo-controlled study 🔎"Our results suggest that henagliflozin may exert anti-aging effects by influencing multiple pathways, including the IGF-1 system, glucose metabolism, the immune system, and...
Vaccines Save Lives—Get Free Resource Guide
Vaccines save lives. Ask in the comments if you have questions. As a subscriber to my Substack you get a vaccine resource guide available for download and as a paid subscriber a 64 page guide on vaccine preventable diseases.
YC Proves Its Worth in Biotech Startups
Interesting collection of YCombinator biotech startups this batch. I had been skeptical that YC could work at all in biotech, but I've been proven wrong over the last couple of years.
AI Speeds up Therapeutic Drug Discovery and Design
3 Questions: Using AI to accelerate the discovery and design of therapeutic drugs | MIT News | Massachusetts Institute of Technology https://t.co/CZ4waA5IGg
Biotech IPOs Show Strong Avg Gains, Weak Median
Quick Biotech IPO stats for 2026, with six offerings: $AKTS $AGMD $EIKN $SGP $MANE $GENB - Average post-IPO stock performance (offer price to 3/20/26 close): +38%. Without $MANE, avg is negative. - Median post-IPO stock performance: -24% - Total IPO gross proceeds:...
Contaminated Cell Line Turns Liver Cancer Papers Retracted
1/ A researcher spent 2 years studying liver cancer biology. Published 3 papers. Then discovered the "liver cancer" cell line was actually HeLa -- a cervical cancer line that contaminated their stock decades ago. Those papers? Retracted. https://t.co/q3a9g0G04s
We’re on the Brink of Self‑directed Human Evolution
When I was talking to Sergiy Velychko, a former postdoc from George Church's lab, about the future of human genome engineering, we discussed: “We're now at this point where we can engineer ourselves. We can do stem cell therapies. We can...
SIRT1: Longevity Gene Proven to Suppress Cancer
Fun fact: in 2008, when we published that NAD-dependent SIRT1 suppresses cancer, almost no one believed us. How could a longevity gene suppress cancer? they asked https://t.co/aPAG3zf470
Lab Celebrates Progress While Students Head to Grad School
Celebrating another week of amazing progress at the Sinclair lab and farewell to a couple of our beloved students, Yifan and Hanyu, both headed off to graduate school 👩🏻🎓 This morning we had our usual three hour lab meeting, but it...
Senolytics May Harm Brain Myelin, Use Supplements Cautiously
It's studies like this why I treat supplements are a secondary, and last resort, not a primary approach Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum https://t.co/t3jMFTcKcL
Low‑cost Vaccines Saved Half‑million Lives, Ignored for Joke
Seriously? I make low-cost vaccines that reached 100 million people, bypassed big pharma, didn’t make a dime, and saved 300,000-500,000 lives, and they focus on a junk food joke I made 6 years ago, this Rogan crowd, a bunch of...
Neuregulin‑2 Predicts Venetoclax Sensitivity in Non
Identification of a Novel Drug Sensitivity Biomarker Neuregulin-2 for Venetoclax in Non-t(11;14) Multiple Myeloma [Dec 12, 2021] Dai et al. Abstract 459 #ASH21 https://t.co/mnXEThuKgy #mmsm #PrecisionMedicine https://t.co/zx7d29Jzpk
Living-Cell Robots Gain Self-Contained Nervous Systems
Robots Made From Living Cells Get Upgraded With Their Very Own Nervous Systems https://t.co/ctQ64b45O4 https://t.co/ye1TV6VwCn
Companies Hide Device Risks, Harm Thousands
This is a recurrent fiasco. Health care companies that now the serious risk of their device or drug but keep selling it and do not acknowledge the hazard. Until so many people are harmed. Today's front page @nytimes by @katie_thomas @bostonsci...
Biotech Godfather Stelios Papadopolous Joins Garde on Podcast
This week's Readout LOUD podcast is now available on all your favorite podcast outlets -- Stelios Papadopolous, the ‘godfather’ of biotech, in conversation with @damiangarde https://t.co/RHh5Qv9OyT via @statnews
Deubiquitinase Complex Protects Oocyte Epigenome, Fertility
Polycomb repressive-deubiquitinase complex safeguards oocyte epigenome and female fertility by restraining Polycomb activity https://t.co/M6JjHH2JG2 https://t.co/dnHknjJmJy
