Antigen Escape Drives Resistance to BCMA Therapies
Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma [Jul 25, 2024] @RossFirestone et al. @BloodJournal https://t.co/cOh0YC2u9H #mmsm #ImmunoOnc #CARTcell #PrecisionMedicine #lymphoidneoplasia #immunobiologyandimmunotherapy https://t.co/6sbEv5KtLY
Monocyte IL‑10 Explains Sex Differences in Pain Duration
Sex differences in pain duration Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people) @SciImmunology https://t.co/fOsciwav7Y
FDA Cracks Down as Novo Sues Hims over Semaglutide
This is the first reference which I heard directly from FDA commissioner Dr. Marty Makary regarding $HIMS, $NVO 🧵👇and the recent legal actions that the HHS had initiated against HIMs and Hers. When he was asked by @annikakimc - @CNBC’s...
Nasal Mucosa Targeted for Universal Respiratory Vaccine
How to get a universal vaccine vs respiratory threats? Block via the nasal mucosa @ScienceMagazine https://t.co/IjCkbF05LB @NatRevImmunol https://t.co/2W7SZ1fHSR https://t.co/XcEzcMeXrB
New Drug Discoveries Target Cancer and Autoimmunity
Discovering Drugs for Cancer and Autoimmunity. Listen to @Satpathology on The Long Run podcast. Sponsored by @AlphaSenseInc Dash Bio. https://t.co/02keVFdqzj
Lymphopenia Reversal Won’t Secure Anktiva FDA Approval
Reversal of lymphopenia is not an acceptable endpoint for Anktiva FDA approval. $IBRX could file but if it did, the application would be rejected.
Cyborg Islet-Cell Implant Boosts Precision Diabetes Therapy
A cyborg pancreatic islet-cell implant takes the stem cell strategy to a new level of precision and potential future therapy for T1 diabetes @ScienceMagazine https://t.co/gkmsrzU1e4 https://t.co/qgegRPlEIl
Neutrophil Phenotypes and Spatial Patterns Mapped in Colorectal Cancer
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer https://t.co/0FLusa7vuB https://t.co/8MswWoLhCa
Screening Cuts Advanced Colon Cancer, Boosts Early Detection
Screening works for colon cancer. Largest trial ever done. Today @NatureMedicine A randomized trial of colon cancer screening by colonoscopy or occult blood (FIT) vs control in nearly 280,000 participants showed signficantly more early diagnosis (stage I-II) and less stage...
Exercise‑induced Liver Enzyme GPLD1 Restores Memory, Boosts Vascular Health
Liver enzyme GPLD1 produced during exercise reverses aging- and Alzheimer’s-related memory loss by improving vascular health https://www.cell.com/cell/fulltext/S0092-8674%2826%2900111-X
NKTR’s Alopecia Areata Play: Market Misprices Massive Upside
Ok, so I have finally gotten around to writing out my updated thoughts/thesis on $NKTR. Link in this post. I'm about as bullish on the stock now as I've ever been. The document is very long (sorry, but it's free...give me...
AZN's Calquence + Venetoclax Approved for CLL Treatment
#AZN Calquence combined with Venetoclax approved in US for treating Adults with Chronic Lymphocytic Leukaemia in a particular form.
Galleri Test Misses Primary Goal, Shows Secondary Promise
A key study of $GRAL's Galleri test in the UK failed to reach its primary endpoint, but showed benefits on a secondary endpoint. Tell me what you all think. https://t.co/CDrvokqPop
Examining Vaccine Development Amid America's Science‑Anti‑Science Divide
Many thanks to Freedom Together Foundation medical research consortium for hosting my remarks this week @RockefellerUniv discussing our vaccine development program and my work on the history of medical science vs anti-science in America https://t.co/etbLqiezEA
EBV DNA Linked to Multiple Autoimmune Diseases in 800k Genomes
🆕@Nature Genome sequencing of >800,000 people finds Epstein-Barr virus reads and their association with other autoimmune diseases besides multiple sclerosis, including type 1 diabetes, inflammatory bowel disease, and hypothyroidism https://t.co/FKCV4OInT5
Altesa Secures $75M for Lung Drug, Led by Ex‑Trump Official
Altesa, run by former Trump official, raises $75M for well-traveled lung drug https://t.co/bUx5dcvNJy by @gwendolynawu #biotech #startups
New Drug Development Reforms Aim to Match China
These proposed reforms to pre-clinical drug development and to smoothing the transition to first-in-human studies could be the most consequential steps toward leveling the playing field with China. https://t.co/oVY6N3xo9Y
Adding Fragmentomics Boosts GRAIL’s Multicancer Detection Accuracy
The most used multicancer early detection (MCED) blood test (liquid biopsy) uses methylation (GRAIL). But combining that with DNA fragmentomics, as reported today @NatureCancer, improves early detection https://t.co/VkNDR4XuW3
FDA Proposes Single Pivotal Trial as Approval Standard
FDA leaders say one pivotal trial, not two, should be ‘default’ for drug approvals https://t.co/ADRb1miphf by Kristin Jensen #biotech
Group 3 Medulloblastoma Shows Diverse Lipid Dependencies
Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma https://t.co/tpjJiRa08t https://t.co/z7aIYerTqO
Intronic Reads in Bulk RNA‑seq: Common and Multi‑Faceted
Why are there intronic reads in your bulk RNA-seq data? You're not alone—it's common, and the reasons are more layered than you think. Let’s break it down. 🧵 https://t.co/SNJnohqHUM
Former Psilocybin Trial Participant Shocked by New Findings
"I took part in a 2012 psilocybin trial. What I’m seeing now horrifies me" https://t.co/T1BLv6n59X via @statnews
Blood P‑tau217 Test Predicts Alzheimer’s Symptoms 20 Years Ahead
Predicting when symptoms of Alzheimer's disease will occur with elevated p-tau217 blood test and a person's age, even 20+ years in advance @NatureMedicine https://t.co/EYaGglBh1H
Gossamer Lung Trial and ProMis Alzheimer Therapy Spotlight
This week's Biotech Scorecard newsletter: -- What to expect from $GOSS Gossamer Bio’s late-stage lung disease study -- A better, safer Alzheimer’s treatment? ProMis $PMN takes its shot https://t.co/YaA8kvUR4Z
Profusa Enables Real‑Time Tissue Biochemistry Monitoring
👍Profusa is my pick for 2026. Fascinating technology to measure real time tissue biochemistry. This is a fundamental shift from blood to tissue to shine a new light on cellular status and metabolism. https://t.co/gfduGvgJTX @ProfusaInc #medicine $PFSA #diabetes
INSM Projects 2026 Brinsupri Sales Minimum $1B
$INSM guides to 2026 Brinsupri sales of "at least $1B" in line with consensus. https://t.co/o7JhPKU3m1
Shape‑conformal 3D Frameworks Enable Full‑surface Neural Organoid Electrophysiology
If you’re interested in organoid biology and/or 3D bioelectronics, then check out our paper published today in Nature Biomedical Engineering, titled ‘Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology,’ at https://t.co/Y7MzvRQKTm. This work introduces a technology...
Reversing Nerve Cell Age to Combat ALS, Alzheimer’s
Super proud of Dr. Kelly Rich, senior postdoc in our lab who's pioneering nerve cell epigenetic age reversal to treat diseases such as ALS and Alzheimer's 🪨⭐️ https://open.spotify.com/episode/7nWkEH5li36oW9monEIG8B
US Vaccine Policy Shift Boosts MRNA Stock Appeal
Macro: US vaccine-policy swing heightens regulatory risk; FDA will review Moderna’s flu shot. Key: public dispute, amended filing; decision by Aug 5. Risk: political oversight. Trade: Buy MRNA. — Viktor Kopylov, PhD, CFA More insights: t.me/si14Kopylov
AI Automates Cytology, Streamlining Cell Pre‑Screening
AI automates cytology, which is a laborious, manual, human subjective task, for pre=screening cells for abnormalities and making initial diagnoses today @Nature https://t.co/ZI3F2pkMxE https://t.co/WsUcRjkHFN https://t.co/mdz1DM6xs7
Finalizing Top 100 Biotech VCs, Join 2026 Webinar
We're wrapping up the fact checking process for our annual Top 100 biotech VCs list and prepping for our companion webinar on VC investing in 2026. If this is a topic near and dear to your heart, be sure to...
Conversational AI Unlocks Hidden Value in Scientific Literature
So cool to see the focus on really mining the scientific literature from @EdisonSci — it’s where a ton of valuable information is waiting and having models conversant in it is a big deal 👏👏👏
Brain’s Venous Sinuses Patrol Immune Cells and Drain Fluid
What's ruffling? Large veins interfacing the skull (venous sinuses) that patrol immune cells and help drain the brain https://t.co/WsML3Jd1yA
FDA Chief: Most Drugs Belong Over‑the‑counter
FDA chief Marty Makary says 'everything should be over the counter' unless drug is unsafe or addictive https://t.co/HiYBuxvyWC
Federal Vaccine Panel Meeting Delayed After HHS Missed Deadlines
Upcoming meeting of federal vaccine panel may be postponed after HHS missed deadlines https://t.co/zfAl7owoQg via @statnews
MRNA Vaccines Advance Triple‑negative Breast Cancer Therapy
The unfounded move by @HHSGov against mRNA vaccines will hurt our future potent immune therapy vs cancer. Another point of progress for triple-negative breast cancer with individualized neoantigen mRNA vaccines today @Nature Adds to successful pancreatic, renal cell, melanoma reports...
Listen to Biology’s Early Whispers to Prevent Disease
We could prevent diseases so much better but we haven't learned to listen to when biology whispers long (10 + years) in advance. A key theme in Super Agers, too. https://t.co/0pSap3f32N @NathanPriceSci @ @nrappapo @BuckInstitute example below for Type 2...
Agentic AI Enables Accurate Rare Disease Diagnosis via DeepRare
Another good use case for agentic AI in medicine: diagnosis of rare diseases. Exemplified by DeepRare https://t.co/XBd68V3iDl https://t.co/rBl5yn95sI
Pharma Demands FDA Stability as Leadership Sparks Drama
The pharmaceutical industry needs stability & clear guidance from #FDA as it attempts to bring through licensure new drugs & vaccines. Vinay Prasad, FDA's head of biologics, has brought drama to a setting where it's not welcome, @matthewherper.bsky.social writes. https://t.co/Qaw1QmYNpL
FDA's Erratic, Unpredictable Decisions Undermine Drug Regulation
The FDA keeps spinning, spinning, spinning round and round. Just what you want from a drug regulator: Erratic decision-making and complete unpredictability. https://t.co/q5abiPwgkW
V‑plot TF Binding May Be Artifact of Fragmentation
🧵 That V-plot showing transcription factor binding? It might be an artifact. New research shows chromatin fragmentation methods create patterns even on naked DNA. Here's what went wrong. https://t.co/79B5c0ulgD
Claude Code Fabricates Fake ENSEMBL IDs for Gene Plots
1/ Claude Code just hallucinated ENSEMBL IDs for my volcano plot. (it happened last week for real) I asked it to highlight specific genes. The data matrix uses ENSEMBL identifiers. Instead of flagging that it couldn't map the gene symbols, it invented...
10 Free Bioinformatics Tools to Save Time & Money
🧵 10 free bioinformatics tools you should know in 2026. These will save you time, money, and headaches. https://t.co/t8amdLE4MX
FDA's Moderna U‑turn Highlights Agency Chaos
The FDA’s Moderna $MRNA pirouette is one more sign of chaos at the agency https://t.co/zThJqhT2BS via @matthewherper
FDA Relents, Agrees to Review Moderna's mRNA Flu Vaccine
#FDA backs down on #Moderna: The agency had refused to review the company's licensure application for an mRNA flu vaccine, but after significant pushback has relented. https://t.co/omo7bEBQGW
Moderna's Flu Vaccine Review Set for August 5
$MRNA says FDA will now review its flu vaccine. PDUFA date is Aug. 5. https://t.co/npZzeEa5nk
FDA Splits Moderna Flu Vaccine Review by Age
FDA agrees to review Moderna flu vaccine application, splitting review into standard approval for those under 65 and accelerated approval for those 65 and above. $mrna https://t.co/HMMlPm0PGh
AI Transforms Unknown Genetic Variants Into Actionable Insights
A “Variant of Unknown Significance” is a genetic finding that can’t yet be interpreted, leaving families with uncertainty instead of answers. Now, AI agents can help connect sequencing data with scientific literature and biological context to turn VUS into traceable, evidence-backed...
Resveratrol Activates SIRT1 to Shield Kidneys From Fat
Resveratrol protects kidneys from fat accumulation and diabetic kidney disease by activating SIRT1, similar to its effects on fatty liver 🐁 www.sciencedirect.com/science/article/abs/pii/S1098882326000067
PRC2 Links Embryonic Methylation to Age Reversal
Embryos and old people have a lot in common: the PRC2 protein complex, which controls DNA methylation during embryogenesis, is a key participant in age reversal via epigenetic reprogramming link.springer.com/content/pdf/10.1038/s44320-026-00195-9.pdf
