Resveratrol Activates SIRT1 to Shield Kidneys From Fat
Resveratrol protects kidneys from fat accumulation and diabetic kidney disease by activating SIRT1, similar to its effects on fatty liver 🐁 www.sciencedirect.com/science/article/abs/pii/S1098882326000067
PRC2 Links Embryonic Methylation to Age Reversal
Embryos and old people have a lot in common: the PRC2 protein complex, which controls DNA methylation during embryogenesis, is a key participant in age reversal via epigenetic reprogramming link.springer.com/content/pdf/10.1038/s44320-026-00195-9.pdf
Blood Test Maps Organ Age for Early Intervention
.@Vero_Bioscience is working to end age related chronic disease. With a simple blood test, Vero uses proteomics and machine learning to measure the biological age of each organ, revealing where the body is aging fastest so people can intervene early...
European ADC Agents with Novel Targets Gain Momentum
With all the attention on China for TOPO-I ADCs of late, how about the potential for European agents, especially ones involving novel targets? Our latest expert interview drops with some hard hitting and candid opinions from a battle hardened...
GLP‑1 Therapies Improve Metabolism Beyond Weight Loss
Incretin (GLP-1) based therapies have dramatic effects on many aspects of metabolic disease. Can this occur independent of the effect on obesity? https://www.nature.com/articles/s44324-024-00030-5
BRD4's Extra‑terminal Domain Drives Recruitment to ASXL1 Targets
Recruitment of BRD4 to the ASXL1 genomic targets depends on the extra-terminal domain of BRD4 https://t.co/sRbcAAMqPx https://t.co/IbD0EM56SS
GLP‑1 Safety: New Data Highlights Retinal Risks
A short thread on GLP-1s based on new publications. 1. The safety story Table of potential side effects and very good description of mechanisms, especially w/r to retina https://t.co/L5GNZyArrn https://t.co/MyXVOF3SYv
Retrieve Mouse Gene Lengths with Bioconductor TxDb
🧵 Need gene lengths for every mouse gene? Bioconductor annotation packages make this simple. Here's how to get gene lengths using TxDb.Mmusculus and https://t.co/FiqDAsSPa0.db. https://t.co/VyE36hp3om
MAHA: Pseudoscientific Scheme Undermining Medicine for Profit
As I’ve written @BakerInstitute MAHA = a system of pseudoscience designed to undermine scientific biomedicine in America for the benefit and profits of the wellness influencer industry. It’s incredibly corrupt and endangers the health of Americans. Vaccines are just the...
Bispecific Autoimmune Therapies Set to Transform 2024
"Dual Wielding in I&I: A Pivotal Year Ahead" - new blog - Atlas EIR Cody Tranbarger with a tour de force on the bispecific opportunities in autoimmune... https://t.co/StQJX0vgfx
FDA's New Move Undermines mRNA Flu Vaccine
https://open.substack.com/pub/pauloffit/p/weaponizing-the-fda-against-vaccines?utm_campaign=post-expanded-share&utm_medium=web A closer look at the FDA's recent kill shot against an mRNA influenza vaccine.
GSK
#GSK Exdensur (depemokimab) approved in EU for treating "severe asthma with type 2 inflammation and chronic rhinosinusitis with nasal polyps". Follows from the SWIFT and ANCHOR phase III trials.
Plasmid Injection Triggers Immune Attack on Cancer Survival Protein
What if a physician could inject you with a plasmid that would induce an immune response against a protein needed for cancer cell survival? This novel strategy is being tested and looks promising for refractory cancers. Talking Biotech 488 ...
Free, Ad‑free Biomed Insights Reaching 200k Globally
Ground Truths are free essays and podcasts on the hot topics in biomedicine and health. Mostly things the media doesn't cover or adequately highlight. No ads or sponsors. Join ~200,000 subscribers from 212 countries https://t.co/ZgnO2Y0P4L
Pre‑market Rallies Set for Tomorrow’s Data Releases
Two Major Data Readouts Coming Tomorrow: $OCUL ripped in after-hours, +26% to ~$11.16, clear positioning into retina data. $CMPS has been quietly bid into its Phase 3 TRD readout, steady accumulation with mild pre-market strength. Both leaning long into the print. Now it’s...
B‑Cell Depletion: Rebooting Immunity to Cure Autoimmunity
"Immune Reset" Rebooting the immune system by depletion of B cells, like a reboot of a computer, to achieve cures vs autoimmune diseases https://t.co/253NtyFmCN
Women Show Higher P‑tau217 Levels and Tau Deposition
p-tau217 is a breakthrough blood test for risk of developing Alzheimer's disease. Important to know there are sex differences for this biomarker, with women having higher values at baseline and more tau deposition. @JAMANeuro https://t.co/Xrr8SjsiVY https://t.co/eyDt6mgSqR
Psychedelic Shows Rapid Depression Relief in Small Trial
A psychedelic quickly reduced depression (in patients with major depression disorder) in a small, double-blind placebo randomized trial @NatureMedicine https://t.co/vvug72VGBi https://t.co/Tn58rP0ufS
LLM-Edited Radiology Reports Boost Patient Understanding, Preserve Accuracy
When the LLM rewrites the radiology report, patient understanding is increased and clinical accuracy is maintained. @LancetDigitalH @curtlanglotz @smrabd https://t.co/q2UHebBQG7 https://t.co/IwZAx59brY
Respecting the Meticulous Skill Behind Biolab Hardware Design
Started my day with a peer review duty for Hardware X. Another cool build landed on my desk and it's delightful to see folks really take the minutiae and nuance of designing a tool seriously. People often make wild assumptions...
AI Subtyping Boosts HR+/HER2‑ Breast Cancer Therapy
Precision treatment with artificial intelligence assisted subtyping enhances therapeutic efficacy in HR+/HER2− breast cancer: The LINUXtrial https://t.co/UF4Lt3g5QK https://t.co/LWuJYD2qGh
Essential Bioinformatics Curriculum: Top Courses to Master
10 courses for my dream bioinformatics curriculum: 1. Unix Commands with Greg Wilson https://t.co/83VHvTqbMt 2. statistics and R with Rafael Irizarry https://t.co/ofYSIiChoW https://t.co/1GogvjAbAA
Graphene Quantum Dots Show Promise as Antioxidant for Injuries
📰 🧪 James Tour Group in the News: Graphene quantum dots could yield an effective antioxidant for various traumatic injuriesThe research of James Tour, the T.T. and W.F. […] https://t.co/nZF8XBp9zL
China’s Biotech Boom: 5 Hidden Drivers & Future Forecasts
5 Hidden Themes Driving China’s Biotech Surge | Ep. 314 ...and 5 Bold Predictions for What’s Next https://t.co/TxBhvw5PG8 https://t.co/jTR63o431j
120 Biomarkers for $99 and Nationwide CT Calcium Scans
This is how I test 120 biomarkers for $99 and get CT calcium scans anywhere nationwide. Vitals Vault. https://www.vitalsvault.com/
15‑PDGH Inhibition and Ozempic May Restore Cartilage
Two things that may help restore cartilage —15-PDGH inhibition https://t.co/chCj9Lj5qk —Semaglutide (Ozempic), independent of weight loss https://t.co/fqbrQQYfRt https://t.co/6CRdY1QtC1
Immune System Drives the Biological Process of Aging
Our immune system is the driver of the biologic process of aging. A new and comprehensive review @NatRevImmunol https://t.co/0Fm9w7U341 https://t.co/alPoABMozO
Squidiff Predicts Cell Development and Perturbation Responses
Nature Methods: Squidiff: predicting cellular development and responses to perturbations using a diffusion model from single cell data https://t.co/MqJxhiRJDD https://t.co/cV0IwwFABZ
Saudi‑US Biotech Tie Is Just a Pay‑for‑promotion Scheme
This is not a Saudi-USA Biotech Alliance, it’s a Saudi @DrPatrick $IBRX “you pay we pay” marketing campaign. Anktiva is stalled in the US because he can’t generate the clinical data to move the drug forward, so he goes to...
Pick a Bioinformatics Tool and Just Start
🧵 Stop searching for the "perfect" bioinformatics tool. You're wasting time. Here's why picking something and moving forward beats endless comparison. https://t.co/cffR3dJaoQ
NKTR's <1% ISR Discontinuation: Legal FUD Overblown
$NKTR bears will still look at you with a straight face and tell you that an adverse event (ISRs) that led to a ***LESS THAN 1%*** discontinuation rate is the bear thesis… The ISR brain damage done to y’all by those...
Validate Drugs Against Human LOF Genetics for True Efficacy
This principle hit OX40 hard - $SNY $AMGN $APGE What about $CRVS and ITK…? 🤔 https://t.co/gvLcqVgrpk
3D‑Printed Brain Phantoms Replicate Gray and White Matter
Printing brain phantoms in a support gel and selectively replicates gray and white matter https://t.co/9rIVOPCjd2 https://t.co/LFwa9Qlqjc
AI Speeds Biology Discovery, Scientists Still Steer Ethics
AI is not taking over biology, at least not now—it's accelerating discovery, not replacing scientists; humans still ask the questions, validate results, and steer ethical choices. https://t.co/l8KCQGNd4Y
Data Hygiene Precedes AI Success in Biotech
1/ You can't bolt AI onto chaos. In biotech, if your data is a mess, your AI won't save you. Build the data strategy first. Here's how. https://t.co/HM7qddrCsC
Defending Climate and Vaccines From Anti‑Science Attacks
Moving Climate Change And Vaccines Out Of The Anti-Science Crosshairs | many thanks @AngelaKShen @Health_Affairs for the thoughtful review our book #ScienceUnderSiege @MichaelEMann @PeterHotez @public_affairs https://t.co/DbXijUsYnB
Age‑Restricted Longevity Drugs: Accept Risks After 70
We should have a class of drugs you can only sell to people over 70 —super aggro longevity stuff, muscle regeneration, etc - tolerate more possible bad side effects given you don’t have much time left for effects to manifest...
US Infectious‑Disease Center Halts Pandemic Preparedness Efforts
But this is such treachery. Doesn’t our govt understand pandemic threats? New waves of zoonotic flu, SARS-3 coronavirus; arboviruses from climate change; bioweapons from our enemies: Russia, DPRK, Iran; return of measles, pertussis, soon polio. What’s going on? Exclusive: Key US...
Flu Kills 66 Kids; 90% Were Unvaccinated
1. Time for a #flu & #measles update. Six more kids have died from flu, bringing the year-to-date total to 66. Sadly there will be more deaths reported but hopefully this year doesn't approach last year's dreadful pediatric death toll. #CDC...
Tricot Snapdragon Mutant Reveals Triple Leaf Pattern Mechanism
Some fun observations: Ive been growing this tricot mutant of my snapdragon line. Note the triple leaf pattern. I cut off the apical meristem and the new lateral buds formed normal dicot branches. So cool to explore the mechanism of this lil...
Disc CEO Updates
This was over two months ago at ASH, so ages, but here's how Disc's CEO said the bitopertin review was going back then. $IRON https://t.co/9SvSML6th8
FDA Rejects IRON Disc’s Rare Disease Therapy, CNPV Stumbles
FDA rejects rare disease therapy from $IRON Disc Medicine, early recipient of commissioner’s voucher CNPV program falters out of the starting gate... https://t.co/w4ptB2ecRS via @LizzyLaw_ and me
NIH Shifts Funding Away From Pandemic Preparedness
#NIH to deprioritize pandemic preparedness and biodefense research, @nature.com reports, saying director Jay Bhattacharya wants to focus on known diseases, not possible future threats. What could possibly go wrong? https://t.co/6TpLr6pY3B https://t.co/7rVzvkOzkT
Healthy Diet Adds 2‑3 Years Lifespan, Especially Early
A healthy diet, accounting for longevity-related genes, associated with 2-3 more years of life expectancy from >100,000 people followed 10.6 years, max benefit for starting at youngest age (Figure) @uk_biobank @ScienceAdvances https://t.co/Ji7Wlhj9ZA https://t.co/B6UxuE97xG
Must‑Follow BioTech & Finance Accounts for Creators
Part of being a content creator on 𝕏 should be to promote other valuable creators as much as possible. So, here is a list of top tier accounts who create exceptional content & who are A MUST FOLLOW in BioTech...
PET Scans Miss Cancer; System Needs Diagnostic Overhaul
Merkel cell carcinoma log, day #566. Completed my 6th PET scan at Dana-Farber yesterday. The radar, such as it is, doesn’t reflect any Merkel cell carcinoma. Lymph nodes look clean. The more I do PET scans, though, the more I...
IMMX Gains Momentum as CAR‑T Landscape Heats Up
$IMMX momentum continues >Mizuho analyst initiates $14 PT >Lily acquisition of Orna Therapeutics $2.4 billion >AbbVie acquired Capstan Therapeutics $2.1 billion CAR-T heating up >Next milestone: imminent enrollment completion >Could NXC-201 be an eventual front-line therapy for AL Amyloidosis? >BLA submission projected Q3’26 https://t.co/cPpiiFHQal
User Feedback Beats Accolades: PCR Primer Guide Shared
Nothing means more to a toolbuilder than knowing their tools and tutorials are helpful to someone. I'll take a comment like this over a million accolades and degrees worth of institutional validation any day. PCR Primer Design Guide here if...
Stable FDA Rules Essential for Patient Safety and Investment
To invest the billions it costs to make new medicines, companies need to be able to trust the word and actions of the FDA. To capaciously change the rules at the end of the game ultimately hurts patients.
Genetic Evidence Shows BMI Directly Shapes Gut Microbiome
A successful hunt of human genome variants identifying some (with MR) that provide causal evidence that BMI affects microbe composition @NatureGenet https://t.co/1uxvnFNrbK https://t.co/SuItRHAnFe
