CellRank Maps Trajectories From Destructive Single‑cell RNA‑seq
🧵 Single-cell RNA-seq is destructive. You sequence the cells, they're gone. So how do you reconstruct cellular trajectories? Like tracking stem cells as they differentiate? Enter CellRank. https://t.co/HqHnErHYNy
Stay Grounded Amid Rapid Bioinformatics Advances
🧵Bioinformatics evolves fast. New tech. New data. New analysis. But here's how to stay grounded and not get overwhelmed: https://t.co/ZyxcLRExC6
CMPS Leads Psychedelic Push; HELP Gains Momentum
$CMPS first-in-line for potential psychedelic approval for Treatment Resistant Depression (TRD) . Likely war between "Old School FDA" and MAHA movement. Will be exciting to see the outcome. $HELP with strong data for Major Depressive Disorder (MDD) and Breakthrough Therapy Designation. New...
FDA Rejects Review of Moderna’s Experimental Flu Vaccine Data
Here the Moderna flu data the FDA refused to review. This is the most important slide from the company's study of its experimental flu vaccine-- exactly the data FDA said it wouldn't even review. And below is a thread of...
Capital Markets Reshape Translational Therapeutics Landscape
The Catalyst Machine | Ep. 931 How Capital Markets Quietly Rewired Translational Therapeutics https://t.co/lWNRxW0wuQ https://t.co/l14X2JfrLX
Affordable Duckweed Lines & Stellar Service From Rutgers
I had such a fantastic experience with the Duckweed archivists at the Rutgers Duckweed Stock Cooperative. Many of their lines are open for commercial entities too for just $170+ship. Got some great duckweed for rapid prototyping in and customer service...
Biotech IPOs Deliver Median -15% Return, Outperforming Losses
Humbling 30 year Biotech stats shared by @verdadcap in a recent report: Just over 1,000 biotechs hit $200M mkt cap at some point. Of those, 67% have lost value (had cumulative negative returns), vs 48% for all other US companies....
Biotech Earnings: Neurocrine Drops, Alnylam Faces Skepticism
Earnings roundup: Neurocrine slumps, Alnylam battles skeptics and Ascendis eyes a competitor https://t.co/kU1ex80A24 by @realJacobBell $NBIX - 10% $ALNY - 4% $ASND - 2% $BBIO #biotech
Semaglutide Linked to Higher NAION Risk in Veterans
Among US veterans (mean age 60) with T2 diabetes who received semaglutide (Ozempic) there was a risk of 0.3% in the first 2 years of NAION, a serious vision loss event, that exceeded SGLT-2 inhibitor drugs (graph) @JAMAOphth https://t.co/c3zDHa7OQB https://t.co/hYTxAs6ThH
Global Vaccine Market Persists, but Innovation May Falter
“Yes, the rest of the world can maintain a market for vaccines. But will it be as innovative and as vibrant as it has been? That’s a different question.” https://t.co/jB38FWfglo
Exercise Rewires Brain, Boosting Endurance in Mice
How exercise rewires the brain to promote endurance https://t.co/h7fiahzoAn as demonstrated in the mouse model https://t.co/DfUWadNKgt https://t.co/vhrsv1pkUs
FDA Approved Pembrolizumab Using Single‑Arm Trials Across Tumors
It would be highly instructive to read the pembrolizumab paper highlighted by @DrPatrick. Of course, he doesn't expect anyone to do that. This is what it says IN THE FIRST PARAGRAPH: The FDA approved pembrolizumab on May 23, 2017, for...
Bioresorbable Implant Uses Heat to Block Pain
Our latest paper appeared today as a cover (inside front) feature article in Advanced Functional Materials, titled “A Bioresorbable Neural Interface for On-Demand Thermal Pain Block.” The focus is on a bioresorbable, implantable form of neural electronics that supports precisely...
Daré Bioscience Launches Reg A Crowdfunding for Women's Health
Daré Bioscience with an approved product and a pipeline in women’s health is raising money from investors in a crowdfunding like construct (reg A offering with minimum investment of $250). https://t.co/NA3JKe6Irg haven’t seen too many of these
Molecular Mimicry Links J&J Vaccine to Rare Clotting
Cracking the case: how did adenoviral vector vaccine such as the J&J's Covid induce very rare and potentially fatal clotting, bleeding? An elegant proof of molecular mimicry—genetic background + rogue antibodies https://t.co/yp6TNE8ZQC https://t.co/NhhYDvntmT @rkhamsi @TheAtlantic https://t.co/xY7f6MVkx9 @kakape @GretchenVogel1 @ScienceMagazine
Monthly CEO Talks Launch on BiotechTV Featuring New Leaders
From Kendall Square - @MassBio’s @KendalleOC will be doing monthly CEO discussion shows on @BiotechTV this year. Leslie Williams and Ed Kaye (who both have new companies) are in the house today. https://t.co/MTSeqemxgc
FDA’s Prasad‑Era: Rules Shift, Rare‑Disease Drugs Stalled
This week's Biotech Scorecard newsletter: The old Vinay Prasad never left. He just changed jobs Submissions to the FDA are handled by teams of reviewers, of course. But when I look across all of these recent cases, I see a...
When to Merge Vs. Separate Single-Cell Datasets
🧵 Should you integrate single-cell RNA-seq datasets or not? You've got PBMCs from multiple donors. Merge them—or keep them separate? Let's break it down. https://t.co/s7PmZrvalM
Bioinformatics Demands Matrix Thinking—Most Never Learned It
1/ If you're in bioinformatics, you're staring at matrices all day. RNA-seq? Gene x sample. scRNA-seq? Gene x cell. Everything is a matrix. But I never learned how to think in matrices. And I regret it. https://t.co/ygbY31AfMe
Terray's Non‑diffusion AI Beats Boltz
NEW: Terray has taken a contrarian AI approach, building a non-diffusion-based model for binding affinity predictions They shared some H2H results against Boltz-2, a popular open-source model, showing 20% more accuracy + 26x faster to run: https://t.co/BFZU8y6qI8
AI Models May Cheat on Molecular Binding Predictions
The Utah-based startup Leash Bio is warning of the potential for AI models to be cheating on tasks like predicting binding affinities of molecules I talked with @allmeasures about how its "Name that Chemist" quiz relates to the goal of generalization:...
Sanofi's Board Ousts Hudson, New CEO Faces Dupixent Gap
So Sanofi's board strikes again. Paul Hudson gets the old Paris boot 6 years after taking on the task of remaking the pipeline. It hasn't gone well. Next: Belen Garijo. She has a few years to get ready for the...
FDA Defends Skipping Review of Moderna's mRNA Flu Shot
FDA defends its decision not to review Moderna's mRNA flu shot. My comments with @NBCNews @BerkeleyJr https://t.co/h8PlaEUC3v
ASCO GU26 Highlights Litespark, Keynote B15, Flare
Key late-breakers at Asco #GU26 include Litespark-011 & 022, Keynote-B15... and who's heard of Flare Therapeutics? Via @ApexOnco -> https://t.co/bXcANMQu5m $MRK $PFE $ALMPF $CGON $VIR
90% Want Free AI Mammograms, Yet None Receive It
Over 90% of responders believe it's time for mammography to incorporate AI for every readout, whereas close to 0% who get screened are getting that interpretation now, and at no out-of-pocket charge https://t.co/hITOBNd7pg https://t.co/x1I6Ffxfio
Scientists Overstate Precision by Ignoring Significant Figures
Pet peeve: why do "scientists" forget about the concept of significant figures? Happens all the time, in biotech & beyond. Too many decimal places scream lack of credibility. "Sig figs" is a simple concept: measurement readings should not push beyond instrument...
Successfully Cloned Infernal Arabinose Promoter Despite Synonymous Mutation
Infernal arabinose inducible promoter finally cloned. Two of the positive colonies had the same point mutation, but luckily it was synonymous and the affected Tyrosine is still intact. Cloning promoters into modular part libraries is always a pain even with...
US Stalls Flu Vaccine, Lags China on Nasal COVID
Not only has the US blocked a significant advance for a flu vaccine, but it has done nothing, unlike China, to advance a nasal Covid vaccine that achieves mucosal immunity to block infections https://t.co/FXnaWjxkWV https://t.co/WABn5324U8
ICE Enables Accurate Senescence Detection From Sparse Single‑Cell Data
ICE: robust detection of cellular senescence from weak single-cell signatures using imputation-based marker refinement https://t.co/PDp6oK5s3W https://t.co/8cPgIQEuID
Boost R Scatter Plots with Scattermore for Million Cells
R is slow in plotting tens of thousands of points. How to speed up for a million cell scRNAseq data? check out scattermore https://t.co/tGPHObuK9S https://t.co/TfsRb5V9Xs
Collaboration Between Bioinformaticians and Wet Biologists Unlocks Science
🧵The most underrated superpower in science: Bioinformaticians and wet biologists working together. Here’s why it matters. https://t.co/YNDqsvyu6A
MRNA Companies Must Educate Public to Spark Outrage
I stand by this comment from last fall. Moderna and others need to take their messaging to the general public. There’s not going to much public outrage about yesterday’s flu news because there’s been no meaningful public education on mRNA...
Open AI Breakthroughs Unlock Progress Beyond the Breakthrough
There is a moment in AI history I keep thinking about. In The Thinking Game, someone tells Demis Hassabis that AlphaFold could predict every known protein structure in about a month. He looks up and says, “Why don’t we just do that?” That decision...
Learn With Me: $2M Insight, Fractional Cost
In 2020, I hired McKinsey to teach me about the global energy transition. I learned a lot, but it cost me more than $2M. After that experience, I decided to build my own internal research project at Social Capital called Learn...
Exploring Cutting-Edge Automated Lab Gear at SLAS Boston
SLAS is going on in Boston right now. We’re checking out a lot of cool automated lab equipment this week. https://t.co/CSFO1oGnt7
Rezpeg Shows Higher 1‑Year EASI75 Rates Than Dupixent
Lot's caveats to this as it's a rough calculation, but given higher maintenance of EASI75 responses on $NKTR Q12W regimen and a very similar absolute rate of EASI75 on induction when compare to Dupixent... ...A higher proportion of patients achieve EASI75...
AZN Drops Relaxin mAb, Boosting TENX over TECX
It’s going to be a bad day for $TECX as $AZN has removed their relaxin mAb from their pipeline in their earnings slides this morning. It doesn’t really affect $TENX POS, but I’d definitely call it a positive for them overall....
HIMS' Safety Scandal Ignored by Bullish Retail Investors
$HIMS is absolutely ON A ROLL …bugs in their manufacturing facility and failing to report major adverse events (3 nights of hospitalization) from their glp1 to the FDA as required by law. Of course, the company’s legendary retail investor base will...
DOJ Targets Entire GLP‑1 Market, HIMS in Trouble
Fresh CNBC interview with head of DOJ on $HIMS. Please watch this if you still think that they’re only coming for the oral. This makes it very clear they’re going after the whole GLP-1 operation. Catastrophic for $HIMS. https://t.co/57dc3L1O3A
NVO Vows Aggressive Patent Enforcement; Danes Cheer Newfound Spine
$NVO exec: "Anybody who is infringing our patents should be very, very much on notice that we take that seriously, and that we will enforce our patents.…If anybody out there thinks we will not, this should be a wake-up...
Computational Biology: Beyond Coding to Data Detective Work
🧵 So You Want to Be a Computational Biologist? 1/ Bioinformatics is more than just coding. It’s data analysis, modeling, pipelines, and detective work. Here’s what you must know. 👇 https://t.co/oJxsWkBYzP
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So $LLY not interested in oncology applications of Orna's in vivo Car-T? $ABBV $AZN $BMY $GILD https://t.co/wB3rR5LID8
Novo Nordisk Joins DOJ, FDA to Target Hims
There you go - $NVO ***FINALLY*** going after $HIMS themselves. DOJ, FDA, $NVO all on board now. Time for $HIMS to get what they deserve.
All Pharma Will Secure Chinese Clinical Development Partner Soon
Within the next 18-24 months every Pharma will have a partner to access the China fast clinical development engine https://t.co/zpLV1XJbvB https://t.co/h5CyXUNO82
Doctors Overprescribe Personalized Semaglutide, Raising Legal Red Flags
Oh and it’s been a while since this topic has come up, but, to the $HIMS-employed doctors/nurse practitioners etc who have been writing millions of “personalized” doses of semaglutide nonstop in order to help the company skirt intellectual property rights: Do...
Inspect Your P‑value Histogram After DESeq2 Analysis
How is your p-value histogram look like? chatomics blog post: Downstream of bulk RNAseq: read in salmon output using tximport and then DESeq2 https://t.co/zGjobde9TO https://t.co/aCJaxto5tS
FDA Clears First Human Cellular Reprogramming Trial
Fascinating interview with Chief Scientist Sharon Rosenzweig-Lipson about working with the FDA, prepping for clinical trials, and what's next lifespan.io/news/first-human-cellular-reprogramming-trial-cleared-by-the-fda/
Regulators Target Hims After Misleading GLP‑1 Ads
Coincidence that $HIMS has suddenly taken down all ads touting “the same active ingredient as Wegovy”? $HIMS may have finally called enough attention to their bullshit antics to get regulators to finally crack down on them. This could...
Flu B Surge Kills 8 More Children, 90% Unvaccinated
1. Some news about #flu & #measles in the US: 8 more kids have died from flu this winter. That brings the pediatric death toll to 60 & flu season isn't over. Flu B activity seems to be increasing & flu...
IMMX Poised for Rise After Feb ’26 Enrollment Completion
$IMMX looks like it wants to move higher. Enrollment completion in Feb ’26 is the next key catalyst, setting up the path toward a filing-grade dataset in AL amyloidosis. Market starting to sniff it out. Check out the AL Amyloidosis success story here: https://t.co/1ei6kat25y
