Trump Ties Gavi Aid to Phasing Out Thimerosal Vaccines
Reuters reports the Trump adminstration wants to condition any future funding to @gavi on the organization agreeing to phase out use of vaccines containing the preservative thimerosal. I wrote late last year about how unnecessary & impractical that would be. https://t.co/uHTBFZnE7V
Model Failures Stem From Data, Not Algorithm Power
1/ You think your ML model fails because it’s “not powerful enough”? No. It’s your data. Garbage in, garbage out. Here’s what most AI scientists miss when using public RNA-seq or single-cell data 👇 https://t.co/dVezFRLHkW
UK Trails Peers in Newborn Disease Screening Policies
Why is the UK so far behind peer countries in terms of the diseases it screens babies for at birth, diseases for which early treatment makes an enormous difference? @statnews 's @DrewQJoseph explores why. https://t.co/stNqZdcV94
Immune Synapse Crosstalk Directs T Cell and Dendritic Cell Functions
How crosstalk at the immune synapse shapes T cell and dendritic cell biology https://t.co/DtqWi1PWhU https://t.co/Yw3sO2UgSX
Inherited Messy Bioinformatics Code? Learn Better Practices
You inherit someone else’s bioinformatics code. No comments. No structure. Variable names like x1, foo, temp2. And now it’s your problem. Let’s talk about that experience—and how to do better. https://t.co/RqCDNPwhMD
CT‑388 Dual GLP‑1/GIP Shows Potent, Durable Weight Loss
Didn’t know $RHHBY was in obesity? They are. Genentech’s CT-388 (dual GLP-1/GIP) showed Ph2 data (n=469) & it might be differentiated (TBD): >48w: −22.5% PBO-adj (efficacy est) / −18.3% treatment-regimen >BMIpreDM to normoglycemia: 73% vs 7.5% >d/c: 5.9% vs 1.3% >No plateau; clear dose-response 💡Mechanistic...
Continuous Glucose Sensor Outperforms HbA1c in Predicting Disease
Continuous glucose sensor (GGM) foundation model predicts Type 2 diabetes and cardiovascular deaths better than the standard blood biomarker, HbA1c
Hospital Group Challenges Eli Lilly's 340B Data Policy
Hospital group seeks to have new Eli Lilly policy on 340B claims data blocked https://t.co/Uz0lDrgL1y
Shared Vaccine Decision‑making Isn’t the Enemy, Says Sandman
I think you should always listen to Peter Sandman, even if you don't agree. "Shared decision-making on vaccines is not the enemy," one of the great experts on medical decision-making writes in STAT. https://t.co/1XZnI9JZ1m
Remember William Foege: Smallpox Eradication’s Rational Hero
I don't know how to ask for a moment of silence amid the madness that is X. But please take a moment to reflect on the heroism of William Foege. Foege, who died Saturday at 89, was a key architect of...
Ethiopia Declares First Marburg Outbreak over After 42 Days
This is good news indeed. Ethiopia has declared its first recorded #Marburg outbreak is over, after going 42 days without new cases. There were 14 confirmed cases & 9 deaths.
FeNNix-Bio1 Delivers Quantum‑Accurate MD, Open for Academia
#compchem #compbio 🚀 𝐅𝐞𝐍𝐍𝐢𝐱-𝐁𝐢𝐨1 enables to perform extremely fast molecular dynamics simulations at hashtag#quantum accuracy under various #GPU-accelerated frameworks. 🚀 As some people asked me, the 𝐅𝐞𝐍𝐍𝐢𝐱-𝐁𝐢𝐨1 #machinelearning foundation model is fully available for academic groups (ASL licence) at various places: - 👉...
Future Oranges May Come with Built‑in Biodegradable Packaging
One day in the future our plant scientists will engineer oranges to have their own biodegradable packaging. Until then… https://t.co/IpqaTyuiJN
Deal Flow Quality Trumps Picking Skill for VC Success
Deal Flow Quality beats “picking skill” The figure below is a reminder that most VC chest-thumping is aimed at the wrong variable. In venture, outcomes are driven by two levers: >Pool quality (base rate): how many real winners exist in what you see >Picking...
Billionaire Sid's Cancer Escape Highlights Access Inequality
Fantastic read. How a billionaire saved himself (for now) from cancer. Not everyone has resources like Sid. https://t.co/73Oj3KF4RP This imposes a bigger question on how we can bring therapeutics to every patient. https://t.co/NyekRQUoND
Batch Effects Create False Cross‑Chromosome Variant Signals
Batch Effects Are Hiding in Your Variant Calls I thought my QC was solid. Then I found thousands of "variants" that weren't real. The signal? Variants on different chromosomes showing linkage disequilibrium. That's impossible in real biology. https://t.co/QK4BVSpbsh
Five 2026 Biotech Black Swans Threaten Industry Stability
🧨 5 Potential Black Swan Biotech Events in 2026 Low probability. Massive impact. Worth thinking about. 😲Multiple deaths from incorrect AI health advice One high-profile event could trigger lawsuits, regulation, and an overnight sentiment flip on AI-in-healthcare. 😲Sudden safety, supply, or reimbursement shock...
AI Could Slash Primary Care to $5 Copay
Predictions for the future of AI - the one that catches my attn most is the $5 copay Today; You wake up with a sore throat and grab the first primary care slot you can find. Ten minutes with a rushed clinician...
New Study Shows Telomeres Reset in First Week
Did you know that we begin life the same age as our parents? Then during the first week of life we undergo a reset. A new study has just mapped how telomeres are also reset during this process https://academic.oup.com/reproduction/article/171/1/xaaf005/8424158
Consistent Sleep Beats Length in Predicting Mortality
Sleep regularity appears to be a stronger predictor of mortality risk than sleep duration https://elifesciences.org/articles/88359
Biotech Shifts: New Masks, Diversification, AI‑Driven Trials
A few key takeaways from this week’s top biotech news: $BMY & $JANX: Tackling T-cell toxicity with tumor-activated masks. $PFE & $NVAX: Diversifying beyond mRNA for strategic risk hedging. $JNJ: projecting >$100B revenue post-Stelara patent cliff. $RHHBY: Building manufacturing moats for obesity market dominance. FDA:...
US Measles Surge 2026: 94% Unvaccinated Cases
1. Looks like 2026 will be a big year for #measles in the US. The #CDC reports there have already been 416 confirmed cases in 14 jurisdictions; only 3 of those have been imported. 94% of the cases this year...
Fundamental Flaw Identified in Cloud Lab Business Model
My take on issue w cloud lab biz model so far — I have some ideas to improve this coming up, but this is fundamental issue from my standpoint.
Autonomous Labs Will Redefine Biotechnology Within Five Years
I used my talk at the JPM conference this year to deep dive on @Ginkgo's future direction - building autonomous labs that replace traditional manually-operated laboratories. Wherever you see a lab bench today you will see one of Ginkgo's autonomous labs...
TSniffer Enables Unbiased De Novo RNA Editing Detection
TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data https://t.co/uQRXdipF88 https://t.co/yeOxSvxrl2
Learning Skills Turns AI Advice Into Useful RNA‑seq Tools
Claude keeps suggesting outdated tools for my RNA-seq analysis. Then I learned about skills. Now it actually helps instead of creating work. https://t.co/yiFbouglo2
Sequencing Artifacts Masquerade as Rare Disease Mutations
1/ Your genome report says you have a disease-causing mutation. Reanalysis 13 months later: it was a sequencing artifact. MedSeq found 164 "rare variants" appeared in >10% of their patients. Population databases missed them all. https://t.co/S0hc1TRr18
AI-Designed Drugs Double Phase‑I Success Rate
Phase I AI-discovered molecules show an 80-90% success rate in Ph1-to-Ph2 transition. *vs historic benchmark ~50% https://t.co/rC03gNjOPo https://t.co/AcK2XxfrW0
ACIP Chair Calls for Reassessing Polio Vaccine Necessity
So we are the point of questioning polio vaccines. The chair of ACIP: “I think also, as you look at polio, we need to not be afraid to consider that we are in a different time now than we were then....
New ACIP Chair Questions Polio Vaccines, Rejects Established Science
The new chair of the #ACIP was on the Why Should I Trust You? podcast. The interview was ... enlightening. Among other things, Kirk Milhoan seemed to question whether kids still need to be vaccinated against polio & said he...
U.S. Exit From WHO Undermines Global Pandemic Preparedness
The US withdrawal from #WHO became official today, leaving the world less prepared for dangerous disease outbreaks. “When that will bite us in the ass, it’s impossible to predict. But there is a 100% certainty that it will bite us...
KNN in scRNA‑seq: More Art than Science
Everyone talks about KNN (K nearest Neighbor) like it’s a simple algorithm. But in practice, especially in single-cell RNA-seq—it’s art, not science. https://t.co/BCreDmtKwZ
Progress in Cancer Fight, Yet GBM, Colorectal, Liver
Great progress update on the war on cancer “GBM, colorectal and liver still look very challenging...” See below for detail point down 👇🏼 https://t.co/UTFZSsDVcX
CORT Shows 30% Pre‑market
$CORT +30% pre-market Still room to run? >OS met: HR 0.65 (-35% death risk), mOS 16.0 vs 11.9 mo (+4.1) >PFS (prior): HR 0.70 (-30%) >n=381, safety ≈ control, no biomarker needed What’s next: full dataset at a med meeting; FDA PDUFA Jul 11, 2026...
NTLA Rises Despite FDA Hold; Hy’s Law Remains Core Risk
Reminder that at $14 $NTLA is *already* trading higher than when the FDA hold was put in place. Novice retailers getting this twisted. There’s no “take backs” on a Hy’s Law case. That is the real problem...
Highly Cited Cancer AI Models Rarely Reach Patients
1/ Your cancer prediction model has 1,000 citations, but It's never been used on a patient. "Some models are wrong, yours are useless." A Cambridge researcher analyzed why most clinical AI tools die in academic journals instead of helping people. https://t.co/mIXS32qDr3
Autonomous Labs Enable Diverse Overnight Experiments, Not Just Repeats
What’s exciting now with autonomous labs is you can get the closer to the flexibility of the bench but automated. So you could design 200 different experiments to run overnight and read out for you in the morning. ...
Record-Breaking Audience of Bacterial Cellulose Experts at Chulalongkorn Seminar
Was great to give a seminar today to the Dept. Food Technology at @ChulalongkornU University, Bangkok 🇹🇭 I present regulary on our lab's work on engineered materials based on bacterial cellulose (BC), but I think today breaks the record for the...
CDC Deputy Downplays Losing US Measles Elimination Status
Would the #CDC's principal deputy director view it as a public health loss for the US if the country loses its #measles elimination status? "Not really," Dr. Ralph Abraham said at a press conference today. https://t.co/JXb3tlOrsu
Bipartisan Deal Paves Medicare Path for Grail's Cancer Test
In case you missed it, one apparent winner in today's bipartisan healthcare deal is the diagnostics firm Grail. $GRAL The company’s "multi-cancer early detection" test is already available, but in order to succeed it must leap multiple hurdles, including receiving...
RFK Jr. Seeks Overhaul of Vaccine Compensation Panel
RFK Jr. is moving to remake a panel involved in that compensating people who are injured by vaccines. It could have big consequences. By @ChelseaCirruzzo. https://t.co/S98hMN6Vd0
Longevity Biotech Shifts Focus to Root Causes
Longevity biotech now targets root causes rather than single diseases. This is a paradigm shift in medicine
Mapping Tumor‑Immune Spatial Interactions in Solid Cancers
Decoding the spatial dynamics of tumor and immune cell interactions in solid cancers https://t.co/AHgt77Ee2t https://t.co/1Xxkt45JlD
Use Repetition to Slash Bioinformatics Analysis Time
Are you ready to level up your bioinformatics skills? Let’s talk about repetition—a key concept that can save you hours in real-world data analysis. https://t.co/2Dtc9hz46e
Shared Decision Making Misused to Question Vaccine Science
Shared clinical decision making was devised to help patients & their doctors make choices when the answer isn't clear cut. People who devised the approach fear it's being hijacked to undermine decades of study supporting #vaccines, @EricBoodman writes. https://t.co/JMmaHTI7eg
Kennedy's Push Could Drive Vaccine Makers Out
Vaccine proponents worry that Kennedy will drive manufacturers from the US market by adding autism to the vaccine injury compensation program & unleashing a flood of litigation. The path to that change is through a committee he's currently "acip-ing." (clearing...
Intronic Reads in 10x 3′ UMI Data Explained
You’re analyzing 10x Genomics single-cell RNA-seq and notice lots of intronic reads. Wait—wasn’t this a 3′ UMI-based assay for mature mRNA? Let’s unpack why introns show up—and why they matter. 🧵 https://t.co/cDeb8dfLAS
CRVS Shows Promising AD Efficacy, Needs Tissue Validation
$CRVS +57% premarket on AD Cohort-4: randomized PBO-controlled signal (EASI-75 75%, mean EASI −72% vs −40% PBO; p=0.035) with clean safety, real but fragile (n=12 vs 12; 10 PBO-evaluable). 📝No skin-biopsy disclosed. While exiting progress serum PD != tissue reversal....
CRVS Shows Promise Yet Remains Early, Uncertain
Lots of haters on $CRVS and yes the way they’ve disclosed data over time is a little iffy but 🤷🏻♂️. Active drug. New data looks solid. They ought to be able to fund the P2. They’ve got...
Out‑of‑the‑Money ABVX Calls Hint at Genuine Deal
I know (and understand why) there’s a lot of speculation around the credibility of the La Lettre articles on $ABVX M&A. I have no idea whether the reporting is legit. Could it be made up BS as part of some...
