DNA Breaks Speed Aging; Cloning Reveals Epigenetic Loss
Introducing controlled DNA breaks accelerates biological aging without mutations, and animals can be cloned from old adult cells, suggesting aging is caused by information loss at the epigenetic level
IBRX Quilt-3.092 Study Mandates Pre‑
The $IBRX Quilt-3.092 CAR-NK study also requires patients to undergo lymphodepleting chemotherapy prior to cell therapy infusion. https://t.co/fPMR7Jhwht
Study Finds Frequent BRCA1 Test Errors, Risking Unnecessary Surgeries
1/ Women scheduled surgery after being told they had rare BRCA1 variants. The genetic test was wrong. University of Exeter analyzed 50,000 samples to find out how often this happens. The results should worry anyone who's downloaded their 23andMe raw data. https://t.co/F1QALvi4H4
South Carolina Measles Surge Eclipses U.S. Annual Totals
The number of confirmed #measles cases in South Carolina has hit an astonishing 558 in an outbreak that started in October. For context: that is more cases in 4 months than the entire US racked up most years in...
ECDC Rejects Doxy‑PEP Over Resistance, CDC Supports It
Citing concerns it could drive antibiotic resistance, @ECDC_EU opts not to advise general use of doxy-PEP, where doxycycline is taken after unprotected sex to lower the risk of acquiring several types of STIs. #CDC recommends it for high-risk individuals. https://t.co/AVosEtcALT
CRISPRTX Unveils 2026 Roadmap: In‑Vivo
1/@CRISPRTX recent #JPM26 presentation emphasised the company’s strategic priorities and planned milestones for 2026. Here’s my 🧵👇which focuses on CRISPR’s In-Vivo and siRNA extended pipeline, the progress of CASGEVY’s launch and $CRSP current corporate status. $XBI #JPM2026 https://t.co/octkTAE5h4
Accelerated & Breakthrough Save Time; Fast Track Doesn't
How much time do FDA expedited designations save? Accelerated approval and Breakthrough status save a statistically significant amount of time. But Fast track does not Investors should keep this in mind #learnbiotechinvesting #biotech #investing #BiotechPrometheus https://t.co/tmxBBt7Izi
Autonomous Labs Free Scientists From Bench Work
Great article from @packyM and @evanbeard -- I agree with this distinction between automation and autonomy. We've been working on autonomy with our autonomous labs at @Ginkgo -- much needed to get scientists off the lab bench, more in...
Low Air Pressure Clears Senescent Cells, Extends Mouse Lifespan
Intermittent bouts of low air pressure prevent hair loss, weight gain, osteoporosis, and extend the lifespan of mice. Ascribed to selective lysosomal killing of senescent cells. Could aerobic exercise or high altitudes mimic this effect? 🧵 https://doi.org/10.1038/s41551-025-01584-5
Meta‑Contrarian Biotech Thesis: Consensus Locally, Ignored Globally
Great article altogether by @KevinLMak on how he arrives at an $ABVX bull thesis as a generalist. You should read the whole thing, but the lines below are far too good not to share: 👉"The result is an unusual dynamic....
MEK Inhibitor Trametinib Boosts
Trametinib is an approved drug for melanoma. It inhibits MEK1/2 thereby shifting cells away from “grow at all costs” to maintenance & repair🐁Trimetaprib extends lifespan ~15% & with rapamycin a whopping 30%
Stop Wasting Hours Matching Sample IDs Across Assays
1/ How many hours do bioinformaticians lose matching sample IDs across assays? Too many. And it’s avoidable. Let’s talk about why this happens—and how to stop it. https://t.co/ZIcF1bUzFF
Biotech Pre‑funded Warrants Raise Cash, Delay Dilution
Since most biotechs aren't profitable they often use warrants (including pre-funded) to raise capital while mitigating short term dilution But what is a warrant and what are their implications? #learnbiotechinvesting #biotech #investing #BiotechPrometheus A warrant is a security that gives the...
DUD‑E Bias Inflates Deep‑learning Virtual Screening Results
Hidden bias in the DUD-E dataset leads to misleading performance of deep learning in structure-based virtual screening https://t.co/NEAe3zdQrq
AI Diabetes Prevention Program Matches Human-Led Outcomes
#AI-Powered Diabetes Prevention Program Shows Similar Benefits to Those Led by People by Rebekah Mikeasky @HubJHU Learn more: https://t.co/4Xs9wCHAPf #ArtificialIntelligence #MachineLearning #ML #MedTech #HealthTech https://t.co/OryFWrOc5O
US Drops Rotavirus Vaccine Despite Preventable Illness
In affluent countries with accessible healthcare, most kids survive #rotavirus infection. But that doesn't mean kids & their families should have to go through a nasty illness. Rotavirus vaccine was one of those recently dropped from the US "recommended for...
T‑bet+ CD8 T Cells Predict Neoadjuvant PD‑1 Response
Antigen-specific profiling identifies T-bet+ melanoma-specific CD8+ T cells associated with response to neoadjuvant PD-1 blockade https://t.co/VSwMpdqjqO https://t.co/DXc8P28oIZ
One Year In, Code Works—Beware Self‑Deception
1/ A year into bioinformatics, your code starts to work. But that’s also when it gets dangerous. Because now you can fool yourself. https://t.co/7QCMSpI30A
Biotech Success Now Hinges on De‑risking and Speed
We asked the biotwit some interesting industry questions. The answers were telling... 5 takeaways from last week’s biotech polls: 1️⃣ When efficacy ceilings are hit, risk wins. Safety, tolerability, and long-term risk profile now beat novelty and precision once drugs work “well enough.” 2️⃣...
IBRX Surge Fueled by 700% Revenue Forecast, Not Anecdote
$IBRX is trending on the TL - but the +40% pop more likely driven by prelim 2025 net product revenue of ~$113M, up ~700% y/y and not this tiny N CD19 CAR-NK + ritux anecdote in a rare lymphoma. https://t.co/64wkMTGX9v
SIAE Variant Linked to Autoimmunity Lacks Control Evidence
1/ Eight patients had a genetic variant. Zero controls did. That 2010 Nature paper claimed SIAE variants increased autoimmune risk 8-fold. The mouse data was clean. The functional assays checked out. https://t.co/tFKXjXEr1y
Plan Biotech Catalysts Early to Capture Stock Moves
Investors should know WHAT will move a stock and WHEN, especially in biotech with the outsized moves. Build your catalyst calendar ahead of time. You won't have time to thoughtfully analyze the data when it hits #learnbiotechinvesting #biotech #investing #BiotechPrometheus https://t.co/iFc6oc4jll
Inflammation Speeds DNA Methylation Aging, Impairing Cognition
Systemic inflammation is associated with cognitive impairment. New paper suggests this relationship is caused by an acceleration of DNA methylation age https://www.tandfonline.com/doi/full/10.1080/17501911.2025.2595905
Sequencing Boom Drives Quantity over Quality in Biology Publishing
Anyone else feel that since next-gen sequencing and bioinformatics, publishing a paper in biology has become increasingly about quantity than quality?
Tylenol Use in Pregnancy Shows No Increased Neurodevelopmental Risks
Tylenol during pregnancy is safe without increased risk of autism, ADHD, or intellectual disability of offspring A new review of the evidence just out https://t.co/Kjwp1h3PBP
Cheap Generic Antibiotics Deliver Massive Healthcare Savings
Correct. This is why we should push more of healthcare towards medicine. By far the highest leverage technology in healthcare. Consider the $5 generic antibiotic you take that saves a hospital stay. Insane savings.
Autonomous Microsurgical Robot Delivers Precise Retinal Injections
Scientists have developed a #microsurgical robot that can perform #autonomous and precise retinal injections in animal models. Learn more in Science #Robotics: https://t.co/EdjxTYp5lA https://t.co/WrUZgKjYOT
Most Pediatric Flu Deaths Unvaccinated as Toll Rises
1. Time for a #flu update. 🧵 #CDC was informed of 15 more pediatric flu deaths in the week ending 1/10, which brings this season's total to date to 32. This number, sadly, will continue to climb because kids & teens...
Top JPM26 Highlights: Weekly BioTech Recap
Here is my favourite weekly 🧵- made by my dear friend @BiopharmIQ, which is a comprehensive recap of the past week in BioTech. This time he gathered the best posts - written by some of the brightest BioX accounts, about...
Longevity Demands Whole‑Life Habits, Not One Simple Fix
I’m often asked what the one thing to increase longevity. If it were that simple, many more people would already live to 100 Here are some tips: 1. Avoid sugar, simple carbs, alcohol 2. Lose your breath for 10 min 3x/week...
Super Agers Show APOE‑ε4 Reduction, Like Healthy Controls
Super Agers with intact cognitive function and the frequency of the APOE-ε4 and APOE-ε2 alleles compared with controls and people with Alzheimer’s disease https://t.co/vMYcSTVCDS
Intentional GenAI Use Can Reduce Global Health Inequities
GenAI has the potential to worsen health inequities. In a new review @NatureHealthJnl we show that with intent, confronting the challenges, it could be just the opposite, globally @nliulab https://t.co/jwmslSVIV1 https://t.co/5q3gq9mnez
BiotechCH's Space: Must‑Watch for BioTech & Pharma Enthusiasts
I highly recommend attending @BiotechCH’s upcoming space today - which in my opinion is the most interesting space on 𝕏 for those interested in BioTech, Pharma, Life Sciences & everything in between….If you can’t attend it’s also available on the...
Lynch Syndrome Vaccine Shows Strong Immune Response, Safety
A vaccine to prevent colon cancer. Proof-of-concept for strong immune response and safety via neoantigens given to people with mutations for Lynch syndrome https://t.co/EfXDlTJlIz https://t.co/RtxfB4oGZ1
Longevity Gene Claim Debunked: Study Proves Wrong
1/ A 2010 Science paper claimed they'd found genetic variants strongly tied to living past 100. New York Times covered it. Media went wild. One problem: The results were wrong.
Bioinformatics Blends Code with Intuition for Insight
1/ Bioinformatics isn't just code. Intuition plays an important role too. You run the stats, but you feel when something’s wrong. That feeling is a clue. https://t.co/pV5SxvYuFL
JPM Week 2026 Highlights: Why It Was Fantastic
My latest Biotech Scorecard newsletter, post #JPM26 edition. JPM Week 2026 is over. It was fantastic. Here’s why https://t.co/uwgz7J4WRk
Mega‑Fund Returns Require Unrealistic Share of Biotech Exit Pie
The Mega-Fund Math vs Reality Below is a simple case study on fund math. People are asking if a16z can really do a 3-5x on a $15B fund. To 3x net on $15B, you need ~$45B back. Assume ~5% ownership at exit. 👉 That...
Oncology M&A: Early‑Stage Deals Still Command Higher Multiples
In #oncology #M&A higher 5-yr forward revenue multiples occur for earlier stage companies, though P3 is an exception Recently multiples have declined reflecting lower valuations, later stage acquisitions, and smaller market opportunities What are some other reasons? #learnbiotechinvesting #biotech #investing #BiotechPrometheus
AI-Created Sensors Pave Way for Early Cancer Detection
#AI-generated sensors open new paths for early cancer detection by Anne Trafton @MIT Learn more: https://t.co/udkbd5V4cP #MedTech #Healthcare #HealthTech #Tech #TechForGood https://t.co/0SpKlYQsVA
Approved CD19 CAR‑T Cures Lymphoma; NK Therapies Lag
Currently approved CD19 CAR-T therapies extend lymphoma patient survival for years. These treatments are basically curative. Available right now for patients. On the other hand, experimental NK cell therapies have never worked because the cells aren’t persistent. @DrPatrick acts like...
Gene Therapy Leads Durable Clinical Value in Five Years
Which modality has the cleanest path to durable clinical value over the next 5 years?
Acute Infections May Reopen Investment Door for Anti‑Infectives
1/ The Back Door Is Open How Acute Infection Could Make Anti-Infectives Investable Again Anti-infectives never died. The business model did. Low prices. Short courses. High resistance risk. Pharma walked. Now look at Alfasigma stepping into HSV encephalitis. Small deal. Narrow indication. Big implication....
Obesity Rewires Macrophages, Triggers NLRP3 Inflammation
How does obesity lead to immune system dysregulation and chronic inflammation? Macrophage metabolism is rewired, with activation of the NLRP3 inflammasome @ScienceMagazine https://t.co/bkAUgOE1c2 https://t.co/It6YaXT1b5
Multimodal AI Promises Patient‑centric Mental Health, Needs Validation
New @ScienceMagazine A thoughtful and comprehensive review on how multimodal AI can transform mental health, with emphasis on a patient-centric approach "The successful translation of AI into clinical practice will require robust validation" https://t.co/xSACrFI0tW https://t.co/8jiV6P1vdj
Qilu Mirrors JNJ with New CD79b‑CD20 Trispecific
Qilu appears to be aping $JNJ in trispecific T-cell engagers. First BCMA x GPRC5D, now CD79b x CD20. Via @ApexOnco -> https://t.co/d4pBcl0MuF
IBRX’s Dilutive ATM Funding Fuels Pump‑and‑Dump Tactics
$IBRX Anktiva q/q sales growth slowed, cash balance decreased. How much dilutive cash did the company raise from its adjusted ATM in January? https://t.co/UTKcVOAs4x Classic: Issue lots of press releases, pump stock higher, sell stock.
Apply NMF to Single‑Cell RNA‑seq with Our Tutorial
Non-negative matrix factorization is a commonly used technique in genomics data analysis. Read my tutorial on how you can use it for single-cell RNAseq data https://t.co/2SA1JdLfkT https://t.co/6kI1gcqyOe
Twitter Transformed My Bioinformatics Career and Keeps Me Current
Bioinformatics is a fast-moving field, how to stay current? 👇 The answers are different in different times. I read Stephen's post around 2012 and I hopped on Twitter; followed a bunch of bioinformaticians, Journals and professors. It changed my career trajectory. https://t.co/QYV5vKFQgP
US Must Shift to Robotic Labs to Stay Competitive
This is happening because scientific research in the US is done by hand at the lab bench. China is very good at having lots of skilled, manual labor. We need to move our paradigm for doing science off the lab...
