AI's Real Bottleneck: Accelerating Human Processes, Not Tech
Our bottleneck for some of the biggest change ahead may be humans. I shared the story of Paul Conyngham and his dog Rosie on my Instagram when it broke. When I read the coverage, my shock was less that ChatGPT finding a possible treatment (though to be sure, I loved it) and more that UNSW scientists got on board and were somehow able to get the vaccine made and used in 2 months. The companies who gain the most value with AI will also have the leaders who figure out how to speed up human and physical processes. Think: trials, approvals, testing, drug manufacturing, and dog belly rubs. Though I believe I’m fastest in market on that last one.
GIP Drives Subcutaneous Fat Storage; Tirzepatide Leverages This
GIP preferentially enhances glucose storage and triglyceride deposition in healthier subcutaneous fat, particularly under conditions of hyperinsulinemia and hyperglycemia. Tirzepatide contains a GIP agonist. https://doi.org/10.2337/db10-0098 https://www.gatlan.com/ @GatlanHealth
Bicycle Cuts 30% Staff, Abandons Padcev Challenger
Bicycle to lay off 30% of staff, pivot away from Padcev challenger https://t.co/m3JFu2mwoB @ByJonGardner $BCYC $PFE $MRK
World's Largest In‑Vivo CRISPR Data Engine Unveiled
From Prof Jin and my colleagues @scrippsresearch the largest in vivo CRISPR data engine, nearly 8 million cells, in collaboration with @nvidia and featured at GTC
Pfizer's Ibrance Successor Advances with Fresh Study Data
Pfizer’s Ibrance successor moves forward with new study data https://t.co/ozXAZYmc3M by Kristin Jensen $PFE $LLY $NVS $RHHBY $ONC
GLP‑1 Weight Loss Shows No Extra Muscle Loss
A study asserts lack of disproportionate loss of muscle mass or strength cf weight loss from GLP-1 drug treatment, in mice and a small short term (12 weeks) trial in men The issue remains unsettled and counters the efforts by companies...
Single-Cell Analysis Advances Neurodegenerative Disease Understanding
Neurodegenerative diseases at the single-cell level, a powerful tool to differentiate and better understand https://t.co/Pkz4qW0ELM @jclinicalinvest https://t.co/LiJ4FojRYZ
CytomX CRC Data Demand Double‑Take, Not Clear Verdict
Some clinical updates tell you exactly what they are. Others ask to be read twice. CytomX’s latest CRC data belong firmly in the second category. Is the die cast? https://t.co/dfdPxx4zXs https://t.co/y9QAoahMut
Co‑varying Residues in MSAs Predict Protein Contact Points
A great read: What we can learn from evolving proteins "A signal hidden in Mulitple Sequence Alignments (MSAs): amino acid positions that tend to co-vary in the MSA tend to interact with each other in the folded structure, often via direct...
Hidden Mistakes, Not Bad Data, Threaten Genomics
1/ You think the biggest danger in genomics is bad data. More than that. It's the mistakes you make—without knowing. Here are the ones I learned the hard way. 🧵 https://t.co/3oj9cseVq7
FreezOpt Controls Ice Nucleation, Preserves Cells in Cryopreservation
I've always been fascinated by animals that can survive being frozen—cell walls are delicate and can be destroyed by ice crystals. HOHCells just launched FreezOpt, which is designed to keep cells intact during cryopreservation. It enables controlled initiation of ice...
Peptide Drugs Require Robust Safety and Efficacy Evidence
In response to suggesting peptide drugs should have good evidence on safety and efficacy in order to weigh the risks and benefit…
R1 Secures $78M to Advance Kidney Drug Development
R1 starts up with $78M, aiming for a better kidney drug https://t.co/PQQjX47ODM by @gwendolynawu #biotecjh #startups
New Drug Could Eradicate Sleeping Sickness, Says NPR
Sleeping sickness could be wiped out with this new drug: my comments @NPR @NPRGlobalHealth https://t.co/T0mAeX8P0A
Modified Lipid Nanoparticles Boost Immunity and Cut Vaccine Inflammation
Engineered lipid nanoparticles with modified ionizable lipids enhance immune cell metabolism, improve mRNA vaccine delivery to lymph nodes, and reduce inflammatory side effects in preclinical models. vaccinetechnology
Vote for the Top Engineered Yeast Bioart
It’s time for the annual vote for best engineered yeast bioart from the @ImperialBioeng undergrad #SynBio students. Help us decide among these beautiful final 4 with your votes. 🗳️ ⬇️ https://t.co/2fo1XaGCmL
Seeking Examples of Overly Negative Biotech Trade Press
Will ask colleagues to respond because I haven’t been tracking all the tickers. Pls reply with examples of biotech trade press being called too negative
Broken Chromosomes Repaired with Fragments Spark Cancer‑driving Mutations
Researchers at Cardiff University found that severe DNA mutations called chromoanasynthesis happen when broken chromosomes are repaired using small DNA fragments, causing chaotic duplications that can drive cancer and genetic diseases. 🧬https://t.co/Q9j2hRezTs
Judge Stalls Kennedy Childhood Vaccine Overhaul Meeting
Kennedy childhood vaccine overhaul stalled by judge The next meeting of the Advisory Committee on Immunization Practices was scheduled for this week, but has been postponed due to the ruling https://t.co/0cUIXEVgyV
Methionine Restriction Cuts Alzheimer Pathology via FGF21 Signaling
A study in Alzheimer's & Dementia found that late-life methionine restriction reduces Alzheimer’s pathology and neuroinflammation in mice by activating the liver–brain FGF21–FGFR1 signaling pathway, independent of metabolic improvements. 🧠 https://t.co/A9kEqNv8pO
Semaglutide Boosts Metabolism, Reduces Anxiety in Obese Mice
Beyond the Weight Loss: The Effects of Semaglutide on Standard and Diet-Induced Obese Mice 🤔"..semaglutide improved glucose metabolic health inboth diet groups..while chronic semaglutide treatment appeared to exertanxiolytic effects in obese mice, opposit[e] effects were observed in lean animals.." https://t.co/doU6EkwT7z
FDA Urges IRB Overhaul to Match China's 60‑day Trials
FDA commissioner Makary at a CMS conference today in Baltimore calls for “big and different” IRB reforms to catch China's speedy trial starts - pre-IND phase can run 380 days in the US, he said, while China is pushing for...
CytomX Jumps 66% on Promising Colorectal ADC Data
CytomX surges on positive data for ‘masked’ ADC in colorectal cancer https://t.co/PxQMISvyri by @Lilah_Alvarado $CTMX + 66%
Structure's GLP-1 Pill Shows Best-in-Class Obesity Results
Structure’s GLP-1 pill shows ‘best-in-class’ potential in obesity trial https://t.co/j0fzAg6GRV @ByJonGardner $GPCR $LLY $NVO $AZN $MRK #obesity
Multi-Ancestry Polygenic Score Predicts T2D, Obesity, GLP‑1 Need
A polygenic risk score that predicts Type 2 diabetes, obesity, and likelihood for requiring a GLP-1 drug. Across 6 ancestries. https://t.co/5hTVv8kqlK https://t.co/IgXhx8vFA6
Biotech IPOs Falter as Companies Pull Planned Listings
16March: Which companies recently withdrew their planned IPOs? And how much have the stocks of this year's #biotech IPOs risen or fallen this year? Read about the IPO market plus updates on $BNTX, $IXHL, and $INKT in my latest StockWatch...
AI-Driven Digital Biology Delivers Custom Cancer Vaccine for Dog
The era of digital biology, exemplified by making a bespoke and effective vaccine for cancer in a dog, is taking off. Access to the AI-Coscientist. A new feature @NatureMedicine https://t.co/AR9lqne7E1
Placenta: Century‑Old Medical Resource Beyond Waste
Actually yes. The placenta has been used in medicine for over 100 years. The amniotic membrane is used in eye surgery for corneal reconstruction. It's used as a graft for burn treatment and wound healing. It's used in dental and orthopedic...
Aged Blood Stem Cell Mutations Drive Aortic Aneurysm Growth
Just weeks ago we didn't know that mutant clones of our aged blood stem cells could be linked to expansion of an aortic aneurysm. No less how. And so much more https://t.co/YuEmJPkdg2 https://t.co/qQq2dgAfWf
Sarepta Tests Elevidys Safety, Sana
Sarepta tests new Elevidys safeguards; Sana advances diabetes cell therapy https://t.co/hkixuANCCV $SRPT $SANA $INO $BAYRY #biotech
Psychedelic Medicine Shifts From Stigma to Scientific Momentum
1/6 Excited to join @START_Global this week in Switzerland for a fireside chat on the psychedelic medicine opportunity. As co-founder and former CEO of one of the first psychedelics-focused biotechs, I’ve had a front-row seat to this field’s move from stigma...
Structure's Obesity Pill Shows Phase 2 Weight‑Loss Promise
Pretty impressive data from $gpcr, which remains my favorite ticker. Structure's obesity pill shows weight loss promise in Phase 2 trial https://t.co/T0JU2UuftY
Aging Can Be Treated, Says Harvard Scientist Sinclair
The scientist trying to reverse aging in humans: David Sinclair. This Harvard researcher spent 30 years studying aging—and now says it's a treatable medical condition. He reveals how on the World Governments Summit: https://t.co/VRgBFtCiRW
EU Approves Imfinzi‑chemo Combo for Gastric Cancers
#AZN Imfinzi (durvalumab) combined with 'standard-of-care' Chemotherapy has been approved in the EU for treating Adults with forms of Gastric and Gastroesophageal Junction Cancers, following the MATTERHORN Phase III trial.
Cell Painting Images Predict Cellular Age Without Methylation
A model that predicts cellular age from Cell Painting microscopy images alone. No DNA methylation needed. The model captures morphological aging hallmarks across nuclear and cytoplasmic compartments, correlates with chronological age AND epigenetic clocks. The promise: screen for rejuvenation compounds...
Single‑cell Methylation Reveals Age
Epigenetic aging happens at different rates in individual cells within the same tissue. Using single-cell DNA methylation analysis, Hagit Masika, Tommy Kaplan, Howard Cedar, and colleagues show polycomb CpG island methylation creates 'young' vs 'old' cell subpopulations even at fixed...
12-Year AI Drug Expert Unfamiliar
In my 12 years in AI drug discovery, I have not heard of this company, have you? Original Bloomberg post by @AmberTongPW https://t.co/9C4LY1c5Um and full text by China Dailly https://t.co/z3xG5Y5HBI https://t.co/fnddeGtdEW
Aging Driven by DNA Instability and Mitochondrial Decline
So great to see the OG work that helped spark the longevity revolution taken to the next level: New paper confirms two main causes of aging: 1. DNA instability -> epigenetic noise 2. Mitochondrial decline ...independently causing failure of the cell Is this relevant to...
Graph AI Accelerates Longevity Drug Discovery in New Alliance
Solve Aging: Biophytis and LynxKite are expanding their alliance to use graph-based AI to speed discovery of new longevity drugs, aiming to map complex aging biology and surface novel targets for age-related disease. The “AI x longevity” stack is quietly...
Open‑source Hermes Agent for mRNA Vaccine Design
Has anyone built full open source tooling for Hermes Agent @NousResearch for Bioinformatics (mRNA vaccine design is the target)? It'll need new agent skills too. Would you use it if I built it? I have a few hours left to...
AI Beats FDA, Prompting DIY Drug Use
AI's capabilities have outpaced the FDA's capabilities to regulate it There are literal cures that can be designed and synthesized but have no way to reach the market due to regulatory/ethics blocks People will, like with Peptides, start dosing themselves & their...
Low‑Cost Vaccines Fight Pseudoscience, Yet Remain Unaccepted
Please @X I make low cost vaccines to help humanity and debunk pseudoscience. This is unacceptable
GLP‑1 Drugs: Promising yet Unproven Healthspan Extension
GLP-1 drugs for extending healthspan? Intriguing but we're a long way off from evidence Discussed at length in Super Agers as a candidate drug beyond lifestyle + factors @TheEconomist gift link https://t.co/A2dpfcnApF https://t.co/3gY8iACeGs
Variant Bio Hunts Rare Traits For
From a tiny idea in our Lux office to deal after deal... ...@VariantBio finding outlier people, with outlier traits, in outlier parts of the world to make outlier drugs. organ by organ ... https://t.co/I5fK8nzZb4
Chemical Tools Uncover Active Microbes in Complex Ecosystems
🔎 Chemical biology tools reveal which microbes are truly working behind the scenes 🔗 https://t.co/oFvPY4Uz95 🌐 #INPST #Biotech #CRBIOTECH https://t.co/tGA5P30yM1
Approve Longevity Drugs for Disease First, Then Expand to Aging
The only sustainable path to development of longevity therapeutics is to get the potential longevity drug approved for a disease, then go for indication expansion and study it in the context of aging at different doses and regimens. To be...
Consumer Biotech Will Eclipse Tech, Health Is Ultimate Value
Consumer biotech will ultimately be bigger than consumer tech. What’s more valuable to people than health and wellness?
Deconstructing Psychedelics to Engineer Non‑Hallucinogenic Therapies
How do you break psychedelic molecules into parts, like cars in a chop shop, and build new ones? A look into non-psychedelic psychedelic medicine by Clayton Dalton, an ER doc and Ferriss-UC Berkeley Psychedelic Journalism Fellow @ucbsoj & @SciPsychedelics https://t.co/b7R4aTNdyf
AI Converts Standard Slides Into Spatial Proteomics, Cutting Costs
We’ve trained a multimodal AI model to turn routine pathology slides into spatial proteomics, with the potential to reduce time and cost while expanding access to cancer care. https://t.co/OCptXdsUm1
Never Trust Bulk RNA‑seq without These 7 QC Checks
1/9 Every bulk RNA-seq experiment I run goes through the same 7 checks before I trust the results. I've been burned enough times to know: if you skip QC, you will find out the hard way. Usually during a meeting with...
