Probiotic L. Paracasei DG I1572 Combats Vascular Inflammaging
Gut Microbiota Manipulation by Probiotic Lacticaseibacillus paracasei DG I1572 as New Therapeutical Strategy to Counteract Vascular Inflammaging https://t.co/91dumlTNgU https://t.co/tkL0m8P6nd
New Tissue Models Accelerate Liver Disease Drug Development
New tissue models could help researchers develop drugs for liver disease by Anne Trafton @MIT Learn more: https://t.co/hkeRZ0W47B #HealthTech #EmergingTech #TechForGood #Innovation https://t.co/LNvft8iX9M
Niclosamide Combats Frailty by Dampening mTORC1 Hyperactivation
Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models https://t.co/U8LALaiz9D https://t.co/67rsM0g0pP
Gut‑brain Signaling Fixes Age‑related Memory Loss
Intestinal interoceptive dysfunction drives age-associated cognitive decline "We leverage this pathway to define interventions that enhance memory in aged mice, such as phage targeting of Parabacteroides, GPR84 inhibition and restoration of vagal activity. These findings indicate a key role for interoceptive dysfunction...
Phase 2 Trial Compares Dara‑Bor
EAA241 - Ph 2 RCT Dara-Bor-Dex vs Cy-Bor-Dex in the treatment of Newly Diagnosed Multiple Myeloma with Light Chain Cast Nephropathy (LCCN) [Study activated 8/11/25] @keruakous https://t.co/1NgvVZ3fTA #NCT07085728 #mmsm @eaonc https://t.co/IvK3UNeem9
Phase 3
#EAOnc EQUATE EAA181 Effective Quadruplet Utilization After Tx Evaluation: Ph3 RCT NDMM Not Intended for Early ASCT [Activated: 10/27/20] PI= @myelomaMD https://t.co/qD26HMx3J8 #NCT04566328 #mmMRD #mmsm @eaonc @mweissmdphd @VincentRK @LynneWagnerPhD Wei Snyder Kostakoglu @mtmdphd https://t.co/FLK0sJ0N1w
Daratumumab Boosts Revlimid Efficacy in Smoldering Myeloma
#EAonc EAA173 - Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM) - PI: @nsc_natalie https://t.co/VtBMJUjI5X Activated: Apr 30, 2019 #mmsm @eaonc #NCT03937635 @VincentRK @mweissmdphd https://t.co/ikQKjHjscU
Phase 3 Trial Tests
.@SWOG S2213 Ph3 RCT Dara-VC Induction Followed by ASCT or Dara-VCD Consolidation & Daratumumab Maintenance in Pts w/ Newly Diagnosed AL Amyloidosis [Activated: 12/1/23] https://t.co/OizUfJCc2c #mmsm #bmtsm https://t.co/FoT3i0xGcL
Mapping Genomic Alterations in Multiple Myeloma Precursors
Genomic landscape of multiple myeloma and its precursor conditions [May 21, 2025] Jean-Baptiste Alberge et al. @IrenemGhobrial @NatureGenet https://t.co/DDWGRrpI4Y #mmsm #PrecisionMedicine #cagenome https://t.co/LY1MzFXSBN
Multiple Myeloma Evades GPRC5D T‑Cell Engagers via Multim
Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma [Jan 15, 2026] @hollyleeYJ et al. @NBahlis @NatureMedicine https://t.co/mz393mPMAq #mmsm #PrecisionMedicine #tcellrx THREAD: https://t.co/lNX9b7LsnR HT @AuclairDan https://t.co/2qih7LwP1c
First In‑Utero Stem Cell Surgery Cures Spina Bifida
In a First, Researchers Use Stem Cells and Surgery to Treat Spina Bifida in the Womb by @ShellyFan https://t.co/4xO4I0iLJL https://t.co/HV1CGzlMXU
Sequencing Hematologic Cancers Reveals Germline Variant Candidates
Identifying potential germline variants from sequencing hematopoietic malignancies [Dec 4, 2020] Ira L. Kraft, Lucy A. Godley @ASH_hematology Education Book https://t.co/L09eJ55sNW #geneticcounselors #PrecisionMedicine #hemeonc https://t.co/Ggq8IEzQEa
Regulation Will Push Peptide Market to Clean Providers
Consider this arc: peptides were around in niche communities, GLPs from Pharma then exploded, people realized they could take less or source them elsewhere, regulation enters & now gray & black market are going bye-bye & companies like HIMs &...
Day 3 Tackles Extending Healthspan and Achieving Longevity Escape Velocity
The @abundance360 Day 3 is at full force, covering one of the most important topics for humanity: how do we extend human healthspan & achieve LEV. We have a powerful lineup of speakers, including my friend @davidasinclair ! https://t.co/SLfeDlbo5f
Engineering Meat: Science Drives Next Agricultural Revolution
For 12,000 years, humanity has produced meat the same way: grow crops, feed animals, convert plants into protein. From a biomanufacturing perspective, it is one of the most complex and least optimized production systems on the planet. What happens when we start...
Black Stripe Marks Successful Agroinfiltration, Red
More agroinfiltration tests. Black sharpie stripe indicates injecred bloom. Right lobe is positive control. Should turn red in the next 72hrs. https://t.co/2lRTbwAjhq
Emerging KRAS Combo Therapies Show Promising Progress
The KRAS niche has been a deluge of new selective and pan/multi inhibitors. Now there are combos to watch out for – we may be making progress. Here are insights on 7 of them: https://t.co/F9HmM8A4ud https://t.co/IqWw6n2m3k
GLP‑1 Drug Linked to Longer Survival in Brain Metastases
Another potential GLP-1 drug benefit seen in people with diabetes and brain metastases for improved survival; a retrospective study that needs further assessment but intriguing https://t.co/nZm3xEYQMH https://t.co/V76S7o1MJb
Alzheimer’s Blood Markers Also Flag Certain Amyloidosis Types
The blood neuromarkers p-tau181 and p-tau217 that can predict and diagnose Alzheimer's disease are also abnormal in certain types of amyloidosis, indicating both some non-specificity and potential help in diagnosis of these conditions https://t.co/jodvMY6TNK
Severe COVID/Flu May Boost Lung Cancer Risk
A causal link between severe Covid or flu and lung cancer risk by impairing immunity and promoting inflammation, as shown in multiple murine models https://t.co/NvE6uIYFZh
DNA Repair Gene Changes Shape NSCLC Immune Landscape
DNA damage repair gene alterations influence the tumor immune microenvironment in advanced non-small cell lung cancer [Feb 14, 2025] @KamyaSankar et al. @ReckampK Lung Cancer https://t.co/mXZ80zYke3 #lcsm #ImmunoOnc #PrecisionMedicine @TempusAI https://t.co/UJwZnw4qnc
BRAF Class II/III Mutations Represent Unmet Clinical Need
Real-world clinical genomic analysis of Pts w/ BRAF mutated cancers identifies BRAF class II & III as a population of unmet medical need [3/7/22] Severson et al #ESMO2240P @TempusLabs https://t.co/s5PEBEczlv @Annals_OncologyDOI: https://t.co/c3wxWyUuX0 #PrecisionMedicine #caxtx
Targeting Mitochondrial Redox Balance to Create Geroprotectors
Mitochondria and Aging: Redox Balance Modulation as a New Approach to the Development of Innovative Geroprotectors (Fundamental and Applied Aspects) https://t.co/TcG9GjMVg7 @IJMS_MDPI https://t.co/gxCC9SsO7z
Vima Raises $100M to Develop Oral Movement Disorder Drug
With $100M, Vima pursues an oral drug for movement disorders https://t.co/gLrhlYDMSy by @gwendolynawu #biotech #startups
Vitamin D Triggers Autophagy, Improves Diabetes Metabolism
As a medical school professor, I teach students that vitamin D does far more than build bones. This new study shows just how much more. Researchers found that vitamin D supplementation significantly improved glucose tolerance, lowered fasting blood sugar, and reduced...
Average-Onset CRC Shows Higher BRAF Mutation Rates
Genomic Landscapes of Early-Onset vs Average-Onset Colorectal Cancer Populations [Feb 28, 2025] Storandt et al. @Cancers_MDPI https://t.co/as7Jolal12 #crcsm #PrecisionMedicine most significant difference b/w eoCRC & aoCRC was higher rates of BRAF mutation among Pts w/ aoCRC https://t.co/7qB4b3A1WK
Biotech Winter: Funding Freeze, IPO Surge, Path to Thaw
Biotech Science at Less Than Zero | Ep. 955 https://t.co/4DXKsaKXdO [00:49] Biotech capital winter deep dive [01:17] Scientific leaps vs frozen markets [02:31] The 2020–2021 biotech bubble [03:42] Crossover funds fuel IPO surge [04:56] Interest rates freeze biotech funding [07:58] Negative enterprise value phenomenon [10:37] Why Big Pharma...
New Nonprofit Secures $500M to Upgrade Science for AI
New nonprofit launches with at least $500 million to modernize scientific process for AI era https://t.co/yuypno6rVY via @ADeAngelis_bio
MIT Professor Hired by RFK Jr Fails Scientific Standards
The MIT professor who has been appointed by Robert F Kennedy Jr to review the safety of Covid-19 vaccines has failed to meet basic scientific standards in his own research on the topic, according to more than a dozen scientists...
No RCTs for BPC‑157: Patent Dead, Profit Absent
Correct. There will likely be no RCTs on BPC. Unless a new variant can perform better and be patented and Rx’d… and THATs happening.
Senescent Cells Fuel Atherosclerosis; Senolytics Offer Hope
The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolytic Strategies in Cardiovascular Diseases "Cellular senescence and SASP drive chronic inflammation and vascular dysfunction central to atherosclerosis pathogenesis, with senescent endothelial cells, VSMCs,...
Lab-Grown Teeth Could Replace Traditional Dental Fillings
Lab-grown teeth might become an alternative to dental fillings by @Khulood_Almani #HealthTech #Healthcare #Technology #Innovation #TechForGood https://t.co/S4x8tYCjaq
AI Augments, Not Replaces, Human Insight in Complex Biology
"AI will not replace biological reasoning, but it may become indispensable for navigating biological systems whose complexity exceeds human intuition." A perspective on future applications for cancer neuroscience https://t.co/TnDFZ7NRFN @scisignal https://t.co/ijbhfbjXcs
Stretchable Electronics Turn Pancreas Organoids Into Glucose Sensors
Crazy cool > Embedded soft, stretchable electronics into tiny clusters create cyborg islet organoids. Miniature pancreas-like tissue can eavesdrop on the electrical charging of individual lab-grown cells, learning to sense glucose and release hormones. https://t.co/0ntJ3cJ16n
Leucovorin Approved for Limited Autism Subgroup, Not Mass Treatment
Last fall the administration was talking about leucovorin as a potential treatment for large numbers of people with #autism. Today's approval suggests the evidence supports its use in a much smaller group of people, @rosebroderick_ reports. https://t.co/NlJR8KlaqP
Agentic AI Tackles Biology’s Exploding Complexity
Is biology finally becoming too complex for static models? For decades, biological modeling has relied on fixed equations, narrow simulations, and local approximations. That works until it doesn’t. Once you move into real systems, gene regulation, signaling cascades, protein networks, the...
BioNTech Founders Leave to Launch New mRNA Venture
BioNTech founders to step down and helm new mRNA startup https://t.co/yjvsVRQH2D by @Lilah_Alvarado $BNTX - 20%
Xenon Scores Epilepsy Win; FDA Revives Duchenne Cell Therapy Review
Xenon hits a ‘home run’ in epilepsy; FDA restarts review of Duchenne cell therapy https://t.co/l40xYeW2Xh $XENE $CAPR + 15% $REGN $PFE $ABBV $GSK #biotech
BBIO, ALNY Surge on Pfizer Tafamidis Patent Win
$BBIO $ALNY moving higher on apparently good news re: Pfizer's tafamidis patent defense. If you have access to Umer Raffat's research, he has all the details.
Seeking Reports of BPC-157 Adverse Events From Gray Market
Has anyone experienced or is anyone aware of a documented adverse event from taking BPC157 (that was obtained from gray market or compounding pharmacy sources)? If so, please let me know.
Blood Test Predicts Alzheimer's up to 25 Years Early
Predicting Alzheimer's disease up to 25 years in advance of any symptoms with the p-tau217 biomarker blood test, among 2,766 women mean age 70 https://t.co/aOActAUN27 https://t.co/Bxl2YZxnlf
DNA Repair Mutations Predict Response to Chemo‑Immunotherapy in Pancreatic Cancer
DNA Repair gene alterations and efficacy from gemcitabine and nab-paclitaxel with/without durvalumab and tremelimumab in metastatic pancreatic ductal adenocarcinoma https://t.co/v39bOreJwu
ATAI: Top‑Positioned Psychedelic Biotech Leader
Good moment to resurface this blog post explaining why I believe $ATAI is the best-positioned company in the psychedelic biotech sector 😉🚀
Whole‑cell Cycle Simulation Demands Years, GPUs, Six Days
Why simulating an entire cell cycle took years, multiple GPUs and six days per run https://t.co/41xr8Bnn4C https://t.co/9LcRqDswYT
FDA Adds Six Former Members, Total Nine Voters
Correction: I took down a post about Thursday's #VRBPAC meeting because it contained an error. #FDA has named 6 temporary voting members (not 2), which will bring the number for the meeting to 9. The temps are all former members....
FDA Accepts CAPR's Deramiocel Resubmission, Decision Aug 22
$CAPR resubmission of the deramiocel application accepted by the FDA. New decision date: Aug. 22. https://t.co/mWSyyXg8di
Coding Beats Pipettes: The Biologist’s Ultimate Lab Tool
1/ Your most powerful lab tool isn't a pipette. It's a keyboard. If you're a biologist who hasn't learned to code yet, here are 10 rules that changed everything for me: https://t.co/DhSXBXGitk
BioNTech Founders' Exit Needed as Sales Plunge
This morning's BioNTech news strikes me as very odd. Certainly, founder Ugur Sahin and Ozlem Tureci shouldn't feel compelled to run the company forever, and they may not be the right people to manage both the continued decline of Covid-19...
CRISPR's Natural Blueprint Powers Gene‑Therapy Breakthroughs
How CRISPR works (in nature) and how it’s being leveraged as a tool for gene editing to cure and prevent diseases. Dr Alex Marson MD PhD of UCSF on the Huberman Lab podcast out now. https://t.co/fiL48JHxSL
GSK Secures Approval Yet Refuses to Produce Drug
$GSK is ostensibly the "sponsor" that won the approval but is once again saying it won't produce the drug.
