Finding Calm at VISTEC's Global SynBio Symposium
Back at peaceful campus of VISTEC 🇹🇭 all this week for their SynBio/Biocatalysis symposium with speakers from around the world. Nice to escape the heat and hustle of Bangkok. https://t.co/s9ZRM3uyDu
PCSK9 Drives Vascular Aging, Offers New Therapeutic Targets
PCSK9 in Vascular Aging and Age-Related Diseases Comprehensive summary of PCSK9's regulatory functions in vascular aging, highlighting potential therapeutic targets for combating age-related cardiovascular diseases. https://t.co/uo3PaSJLCb https://t.co/w8UZgIduPV
China’s GM Crops Remain Silent, Limited to Feed
Genetically modified crops are the dog that never barks in China. People are wary and there's very little of it outside animal feed. The next FYP is ambiguous. https://t.co/ixkR3lGCCI
Aged Grandmothers Pass Metabolic Shifts to Grand‑Offspring Oocytes
Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice 👉 “ Our findings indicate a remodelling of lipid homeostasis in oocytes of female mice derived from AMA great-grandmothers and highlight the need to take a closer look at the inheritance...
AI‑Driven Lab Loop Cuts Protein Cost 40%
OpenAI ran 86,000 experiments in 2 days. AI is talking to robotic labs in a tight loop. Result: a protein synthesized at 40% lower cost. This is the new scientific method.
IPV Doesn’t Block Infection, but Stops Paralytic Polio
Actually he has it a bit backwards, those vaccinated with IPV can still acquire poliovirus and shed virus, but it prevents the virus from entering the bloodstream + protects almost 100% paralytic polio, just like the Covid vaccine protects 80-90%...
Vertex Drug Cuts Kidney Disease Marker in Late-Stage Trial
Vertex $VRTX says its drug successfully reduced marker of kidney disease in late-stage trial https://t.co/TbEkcHVYBB via @Jasonmmast
AI Predicts Asymmetric Cross‑coupling, Slashing Lab Time and Cost
A new AI-driven workflow predicts the outcomes of asymmetric cross-coupling reactions, enabling chemists to efficiently identify optimal molecular structures while significantly reducing laboratory time and costs. drugdiscovery
Bristol Myers Reports Positive Results for Next‑Gen Blood Cancer Drug
Bristol Myers claims success in study of another next-gen blood cancer drug https://t.co/fqPbZ2Szv8 by @gwendolynawu $BMY
De‑risking Synthetic Biology: From Lab to Market
What does it actually take to bring a biological product to market? For more than 20 years, Ingenza Ltd has helped teams avoid the most common failure points in synthetic biology. Freedom to operate issues. Low productivity. Fragile processes. Late CMC...
New Study Examines Psychedelic Use–Schizophrenia Connection
Exciting & important new study from my lab. Have you ever wondered how strong that alleged connection is between psychedelic use and #Schizophrenia? This project aims to point the telescope there & give it a focused look. Please share widely. @AlexaM_Molinaro...
FDA Draft Guidance Streamlines Low‑Cost Biosimilar Approval
New FDA draft guidance outlines important streamlining of path to getting low-cost biosimilars to the market - could reduce cost of pharmacokinetic studies and allow ex-U.S. comparitor products to be used for proving biosimilarity to U.S.-licensed drugs https://t.co/ErjNOga0qo
Combat Aging Now: Common Longevity Concerns Overstated
Why is it vital for humanity to fight aging? Why are common longevity worries not big problems? My new review: https://t.co/tIcXYBFE7U a preprint of a book chapter for the upcoming radical longevity book that many in the field have contributed to. https://t.co/NFTYSMALzD
New $8M Funding Enables Aging Biomarker Trials
A much needed effort that @Danbelsky and I have now been funded for to support the FAST initiative ($8 million over 18 months): https://t.co/aZsaZuEpoo The goal of this is to provide a set of biomarkers that will tell a person if...
UniQure Sparks Gene Therapy Rally After Prasad Departs
UniQure leads genetic medicine biotech rally after news of Prasad’s exit https://t.co/zu1CtJfj29 by @realJacobBell $QURE $RGNX $ATRA $LXEO #GeneTherapy
FDA Slashes Advisory Panels, Threatening Drug Safety Oversight
I've covered most of the big controversies the FDA has faced over the past 25 years: Vioxx, drug-coated stents, and Aduhelm all spring to mind. In all of these cases, the FDA's advisory panel system, in which the agency calls together...
Multivitamin Modestly Slows Epigenetic Aging; Cocoa Doesn’t
Just published @NatureMedicine A daily multivitamin (MVM) slowed epigenetic aging in a randomized trial after 2 years; effect was small (~2 months) and not seen with cocoa extract supplement (vitamin was Centrum Silver) https://t.co/snOMNsTzW7 https://t.co/a6MhMuRhJb
Foundation Models Set to Transform Drug Discovery
Would you like to hear an opinion on how the future of drug discovery will look like as foundation models become more capable in drug discovery tasks? Check out our dialogue and the first pilot with the foundation model genius @ramin_m_h...
Retinal Implants Let Blind See, BCI Future Looms
Max Hodak (@maxhodak_) is the co-founder of Neuralink and founder of @ScienceCorp_, a company building brain-computer interfaces that can restore sight. Science has developed a tiny retinal implant that stimulates cells in the eye to help blind patients see again. More...
Harnessing Immune System: New Frontiers in Cancer Therapy
The new Huberman Lab episode is out: Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson 0:00 Alex Marson 2:21 Diseases & Current Biological Landscape; AI & Computational Tools 5:56 Immune System, Innate vs Adaptive Immune System 10:55 Thymus, T...
FMT Triples the Boost to Cancer Immunotherapy
Not just replication, but triplication of the benefit of revving up cancer immunotherapy with FMT (Yes💩) https://t.co/rXyQdO74FJ
FDA's Turbulent Leadership and Shift Away From Advisory Panels
Two terrific #FDA related pieces by @lizzylawrence.bsky.social & @matthewherper.bsky.social. Matt's is a look at lessons to be drawn from Vinay Prasad's chaotic tenure; Lizzy's delves into the FDA's turning away from adcomms. https://t.co/gC5GNTiPm1 & https://t.co/ygvylHi0uz
Five Key Lessons From Vinay Prasad’s FDA Tenure
. @matthewherper is so damn reasonable. Smart, too. 5 lessons from Vinay Prasad’s turbulent tenure at the FDA https://t.co/R65vPj5ep5
Undermanned VRBPAC Meets to Pick Flu Vaccine Strains
The #VRBPAC committee is scheduled to meet Thursday to advise #FDA on #flu vaccine strain selection. VRBPAC is supposed to have at least 15 members. It currently has 7 voting members & no chair. It has met only twice since...
TopTown SuperDNA Aims to End Aging by 2028
We will solve aging or will die trying. Check out the TopTown SuperDNA project. It is no longer a concept - projected launch in Q3 2028. Fully-integrated residential-biotechnology-clinical infrastructure is key to longitudinal AI-powered drug discovery. https://t.co/LK5XaTci29
RLMD's Strong Bladder Cancer Data Hits IBRX Valuation
The $RLMD bladder cancer data (phase 2) reported this morning look very good. Another competitive blow to $IBRX particularly at its bloated valuation. https://t.co/wYThfwIpG8
QURE-FDA Turbulence Highlights Market Volatility, MRNA Settlement Relief
9March: What a roller-coaster ride with $QURE and @US_FDA ! I sum up a wild week--plus $MRNA's could've-been-worse settlement with $ABUS & $ROIV (w/ insights from CEO Matt Gline) and updates from $DAWN and $TNGX in my latest StockWatch for...
GSK Secures $300M Upfront for Linerixibat Deal
#GSK to get $300m upfront and $100m upon US FDA approval plus $20m for EU approval and up to $270m sales based payments from Alfasigma who will acquire rights to Linerixibat, a bile acid transporter inhibitor, currently under development.
Mitochondrial Quality Control Drives Senolytic Resistance
Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance "findings suggest that mitochondrial quality control is a key determinant of resistance to ABT263-induced and ARV825-induced senolysis, providing a possible framework for rational combination senotherapies." https://t.co/xB0wFkzIW9
Vinay Prasad Mocked for Hosting Controversial HHS/FDA Call
Too funny. @emilyakopp (below) outs Vinay Prasad as the host of Thursday’s HHS/FDA media call to discuss $QURE.
OSK Gene Combo Reverses Joint Damage via Epigenetics
Osteoarthritis & back pain affects millions of people. Instead of managing symptoms, imagine rebuilding joints by making them young New study shows the reprogramming gene combo OSK regrows joints in mice & effect depends on TET2 so it's epigenetic...🧵 https://t.co/AlOIwcEXEQ
Whale Protein Boosts DNA Repair, Slowing Aging
DNA breaks are a potent accelerator of epigenetic drift, which some researchers think drives aging. Great work by the Gorbunova lab 👏
NR/NMN Lack Human Anti‑Aging Proof, Only PAD Benefits
stated as a critique but what does this mean as no drug has been demonstrated to have anti-aging effects in human clinical trials NR is active versus inflammaging and PAD, which is an age-related conditions affecting 10s of millions of americans you...
Antibiotic‑induced Microbiome Depletion Revives Aging Brain Function
Microbiome depletion rejuvenates the aging brain 👉"We confirmed that antibiotic treatment improves vascular density, promotes myelination, enhances neurogenesis, and reduces microglial reactivity. Functionally, microbiome-depleted mice showed improved hippocampal memory performance." https://t.co/XYuJ2kPVbi
Human‑neuron Bio‑computer Learns to Play Doom
Today in #postdigital technology: Australia-based @CorticalLabs’ bio-computer with 200,000 human neuron cells basically “learned” how to play Doom. https://t.co/Uq2JKzG04z
Four Genes Can Reprogram Cells to Reverse Aging
I teach future physicians this uncomfortable truth: "aging" is not just time—it's biology we can potentially reprogram. NIH highlights a PNAS study where researchers screened 200 transcription factors to "reset" old human fibroblasts toward a younger gene-expression pattern. They narrowed it to...
DBiTplus Merges Imaging and Sequencing Spatial Omics
Integration of imaging-based and sequencing-based spatial omics mapping on the same tissue section via DBiTplus https://t.co/YtsDFQNt9H https://t.co/ffKPWLDViY
Lifestyle Choices Link to DNA Methylation Aging Rates
Lifestyle factors and DNA methylation-based aging clocks: cross-sectional and longitudinal associations in the Singapore diet and healthy aging cohort https://t.co/x0zpRxwOXX
Proliferation Stress Drives Human Stem Cell Aging
Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging https://t.co/3mjdKHKcPc
Magnesium Balances Vitamin D: Boosts Deficiency, Lowers Excess
As a medical school professor, I've watched patients take vitamin D for years with zero improvement in their blood levels. Now a Vanderbilt clinical trial explains why: they're missing magnesium. Key findings: > Magnesium RAISED vitamin D in people who were deficient > But...
Consumer Biotech Set to Outgrow Disease‑Focused Pharma
GLP-1s already have market cap close to 1/3 of the top 10 biopharma companies combined. Consumer health biotech products will dwarf disease-focused biotech products.
Prasad’s Missteps as CBER Chief Spark Criticism
On Prasad’s last few weeks as CBER chief: 1. It was absurdly inappropriate to bring a large group of reporters together and rail on a pending application “on background” 2. The walk back of the Moderna RTF was a bad...
Patent Battles and GLP‑1 Turf Wars Prompt FDA Crackdown
Patent Fights, GLP-1 Turf Wars, and the FDA Tightens the Screws | Ep. 952 https://t.co/v0fulR3NfB https://t.co/9gGdkAVvlv
Consumer Biotech Undervalued, Ripe for Cyberpunk Trends
Consumer biotech is perpetually slept on because it doesnt have the returns of pharma. Thats like saying don't build wooden chairs; carpentry is reserved only for yachts. Make. Good. Products. People. Want.
Cures for some Autoimmune Diseases Now a Reality
One of the most impressive advances we've ever seen for some autoimmune diseases: cures https://t.co/OZDuq4Iooy
Fragmentomic Liquid Biopsy Detects Early Breast Cancer, Subtypes, Nodes
Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment https://t.co/RC5rTrFO4l https://t.co/s0Z6lc7Jeb
AlphaFold Isn’t the Drug‑development Silver Bullet
Even with AlphaFold, protein structure is not a solved problem. And protein structure was never the bottleneck for drug development anyway. Let me explain.
Japan Leads Stem Cell Revolution Since Yamanaka’s 2006 Breakthrough
Not many are aware but Japan 🇯🇵 is a true powerhouse when it comes to Stem Cells research & the field of regenerative medicine since 2006 - when stem-cell biologist Shinya Yamanaka, working at Japan’s @KyotoU_News identified a handful of...
Bitter Compounds Protect Brain in Diabetic Cognitive Decline
Bitter Compounds as Multifunctional Agents against Diabetes-associated Cognitive Dysfunction: Bridging Metabolic Regulation and Neuroprotection https://t.co/Xv3xItlP20
Seasoned Scientist Still Innovating Vaccines and Writing
Baylor did some new pics photos by my friend Agapito Sanchez Jr. Gosh I’m old, estoy viejo, but still making new vaccines, hope to have results of our hookworm anemia vaccine soon, hoping to reproduce our low cost Covid vaccine...
