Glioblastoma's Immune Microenvironment Blocks Checkpoint Therapy
The glioblastoma tumor immune microenvironment (TIME) is an immunosuppressive barrier to therapy that encumbers glioblastoma responses to immune checkpoint inhibition (ICI). https://t.co/rgIKZ8N0Q4
Synthetic Biology Localizes Drug Production, Ending Fragile Supply Chains
Most pharmaceutical APIs still travel thousands of miles through fragile global supply chains before they reach a patient. COVID and the Russia-Ukraine war showed exactly what that fragility costs. Synthetic biology offers a different model: program cells to manufacture the molecules in...
30 Top Media Leaders at SynBioBeta Can Make You Viral
📰 𝟯𝟬 𝗝𝗼𝘂𝗿𝗻𝗮𝗹𝗶𝘀𝘁𝘀 𝗮𝗻𝗱 𝗣𝗿𝗲𝘀𝘀 𝗰𝗼𝗺𝗽𝗮𝗻𝗶𝗲𝘀 𝗮𝘁𝘁𝗲𝗻𝗱𝗶𝗻𝗴 𝗦𝘆𝗻𝗕𝗶𝗼𝗕𝗲𝘁𝗮 𝟮𝟬𝟮𝟲 𝘄𝗵𝗼 𝗰𝗼𝘂𝗹𝗱 𝗺𝗮𝗸𝗲 𝘆𝗼𝘂𝗿 𝗰𝗼𝗺𝗽𝗮𝗻𝘆 𝗴𝗼 𝘃𝗶𝗿𝗮𝗹 📰 With a combined reach of 500M+ monthly visitors, the journalists in the room at @SynBioBeta know how to get your work in front...
Bergamottin Reduces Cancer‑related Cachexia via Multiple Pathways
A Novel Role of Bergamottin in Attenuating Cancer Associated Cachexia by Diverse Molecular Mechanisms https://t.co/pr3d4kg0hB #mdpicancers
Mutated TP53 Turns Tumor Suppressor Into Cancer Promoter
The TP53 gene makes the p53 protein, which normally helps prevent cancer by controlling cell growth and triggering damaged cells to die, but when it’s mutated it not only loses this protective role but can also help tumors grow. https://t.co/wPedodwV2U
Early GLP‑1 Rodent Studies Showed Weight Loss Before Diabetes Focus
I don't think this is correct from @nytimes op-ed on GLP-1s - wt loss known from early rodent studies involving injection into CSF as I recall. DM2 more tractable as initial pharma indication, esp at that time - many still...
New NEJM Review Links Hormone Therapy to Cardiovascular Risk
Sex hormones, clotting disorders, and cardiovascular risk An important new @NEJM review for MHT and testosterone latest data https://t.co/UNqXAwjsKM https://t.co/4ckJsc4YyE
FDA Reverses Ban on 12 Peptides for Review
So... @SecKennedy just announced that 12 peptides the Biden FDA shoved into "Category 2" — effectively banning them from regulated compounding pharmacies and driving people to the black market - are being pulled back for legitimate scientific review. Here's what each one...
Retatrutide Poised to Become History’s Biggest Drug
Not s hot take, but I think retatrutide could be the largest drug in history @TravisHoium makes a great case on why the best way to play the emerging peptide market is $HIMS
Engineered Brain Cells Erase Alzheimer’s Proteins in Mice
Enhanced brain cells clear away dementia-related proteins New cellular immunotherapy approach for Alzheimer’s disease shows promise in mice https://t.co/YBoqUZLvJo https://t.co/FjG699Etga
IPSC Tissues Supply Causal Data to Power Simulations
A general-purpose biological simulator, one that can predict how the human body responds to any intervention, isn't blocked by compute. It's blocked by data. Not data in general. Causal, human-relevant data. The kind where molecular interactions actually produce functional outcomes you...
Discover Cutting‑Edge Stem Cell Advances at BEYOND 2026
The best place to learn about the latest stem cell research is at BEYOND, Austin, TX, May 27-29, 2026. Learn all the new ways stem cell research is growing and becoming more available from @stemcellchristian at the BEYOND Biohacking Conference. https://t.co/e04Xnfyjwa
AI-Driven Precision Oncology Breakthrough From Korean Researchers
One unexpected but very insightful paper in Nature BJC from a leading institution in Korea on precision oncology and AI-driven drug discovery. I read it with great pleasure and you should read it too. https://t.co/vpxofjt9Mn https://t.co/SXs4n72CcY
Elon Bets, GLP‑1 Relevance, and Consumer Sentiment Slump
🆓 Wednesday links: betting on Elon, why GLP-1 pills matter, and what's driving poor consumer sentiment. https://t.co/wCKQe3osVm image: https://t.co/QkWrhkJpqj https://t.co/aCwEbtyhzI
Practitioner Input Needed: AI Can't Perfect Cloning Tools
Cloning tools suck so much I decided to make my own, lol. Low hanging fruit yes, but without input from people who actually regularly do molecular cloning its the same like any other tool not made by practitioners of said...
Promolytics: Targeting Cancer‑Promoting Clones to Halt Progression
A new review on tumor promotion and the evolution of cancer with the concept of "promolytics" —drugs that could prevent potentially dangerous clones and/or their progression https://t.co/IFah5gi8ZK @Nature
Moderna's Cancer Therapy Rename May Mislead Physicians
Moderna mRNA cancer treatment used to be called a "cancer vaccine" but in 2023 they switched to "individualized neoantigen therapy." Some docs think the name change is misleading. https://t.co/UIn2djdDAv
AI Agents Power Future Biotech Labs and Organizations
Live in 15 minutes — I'm talking with Stanford's @james_y_zou on his latest research in building laboratories and biotech orgs made of hundreds or even thousands of AI agents Register now to watch live, for free: https://t.co/xSa5NXkX4A
Statins Don't Harm Muscle Health in Older Adults
Statin use does not impair muscle health in older adults: findings from the SCOPE study https://t.co/WKjk9Ov0rG https://t.co/xTo9mk3vbw
AI Designs Lab-Ready Antibodies From Text Prompts
Drug discovery has always meant finding. Screening libraries. Keeping what survives. Semiconductors don't work that way. Neither do aircraft. You design them computationally before anything gets built. @saakohl left @GoogleDeepMind after co-developing AlphaFold2 to do the same thing for biologics. @LatentLabs_ Latent-X2...
Chinese Biotechs Lead Licensing as M&A Surges
M&A is sizzling right along, with the Q1 numbers looking good for biotech. IPOs got started on the year with a spike in offerings and some mixed results on the Street. Dealmaking remains solid. And shall we just call it...
FDA Peptide Meeting Signals $100B Market Boom
I wish this FDA meeting to discuss peptides was happening a little sooner but I'm glad it's finally on the calendar so we don't have to keep guessing. Looks like they're going to start with 7 peptides (BPC-157, TB-500, KPV, Mots-C,...
Synthetic Biologists' Mirror‑image Microbe Dream Hits Complexity
Synthetic biologists were tantalized by the idea of making mirror images of microbes. Then things got complicated.
Two‑Month Dosing Likely Beats Monthly in PK Trial
As I commented before, they have Phase 2 PK data and they still took both 2 months and 3 months into Ph 3. The primary endpoint is purely a PK non-inferiority one (AUC through week 24). That means that 2...
Muscle Atrophy Driven by Intrinsic Aging, Not Nerve Damage
I teach medical students that nerve damage causes muscle wasting. New research says we had it backwards. Scientists at MDI Biological Lab engineered "atrofish" -- zebrafish that compress DECADES of human muscle aging into weeks by activating the Atrogin-1 gene. What they...
FDA Panel to Consider Expanding Peptide Access
FDA panel will meet to discuss allowing broader access to certain peptides https://t.co/PDWKvmvvUH via @LizzyLaw_
WSJ Defends Replimune Drug Amid Mounting Criticism
@WSJ is not giving up the fight for Replimune's cancer drug. Second CRL draws another rebuke and a direct attack on @MartyMakary (Prasad gets another swipe as well, but he's about out the door now.) I often disagree with the...
AI-Driven Global Collaboration Needed for Longevity Research
Great speaking with @SpeakerPelosi at @semafor . In my opinion, drug discovery for cancer and age-related diseases should be a global effort. Nations need to strive to collaborate to extend healthy productive life. Please through longevity. It is the best...
Electromagnetic Gene Switch Extends Lifespan in Progeroid Mice
Wow, a technique that allows electromagnetic control of gene expression in vivo 🤯 And they tested their system with OSK partial reprogramming, showing it extends lifespan in progeroid mice. In normal mice, they report health improvements and a small reduction in mortality...
Liquid AI Launches Foundation Model for Drug Discovery
@semafor World Economy brought together most of the global CEOs to Washington, DC. And it is a pleasure and honor to meet our amazing partner @ramin_m_h of Liquid AI . We just published the Liquid Foundation Model capable...
AI Agents and Next‑Gen Alzheimer’s Drugs Beyond CRISPR
Endpoints' Drug Discovery Day is today — our own @RLCscienceboss will be talking about beyond CRISPR & future of Alzheimer's drugs I'm excited to talk with Stanford's @james_y_zou on his escalating research in building AI agents into co-scientists, labs, and now biotechs...
RVMD and ALLO Illustrate Biotech's Enduring Success Struggle
Why $RVMD & $ALLO are a microcosm of biotech's historic struggle for success. Some musings from me on @ApexOnco -> https://t.co/3lWgzQplvc
MRNA Nanoparticles Teach Beta Cells to Prevent Type 1 Diabetes
As a medical school professor, I can tell you: what we've been doing for type 1 diabetes is managing, not curing. University of Chicago scientists just changed the game. They developed mRNA-loaded nanoparticles that deliver genetic instructions directly to insulin-producing beta cells,...
Today's Teen Could Become First 150‑year‑old
David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has...
Advisory Committee Needed to Vet RP1/Replimmune Melanoma Data
I haven’t dug into the specifics of the RP1/Replimmune data in melanoma, but isn’t this an example of where a good old-fashioned Adcomm could help vet the data and overall risk-benefit? https://t.co/qAxtU9pUeF
AllogeneTx Stock Plummets After $2 Share Offering
I saw that a lot of people on 𝕏 are surprised by the sharp decline in $ALLO stock price - from $4.3 to $2.2 in one day despite the company’s excellent cema-cel readout 🧵👇. The reason for this decline is...
New Drug Boosts Survival for Platinum‑Resistant Ovarian Cancer
Combining a new drug with #chemotherapy extends the survival of platinum-resistant ovarian #cancer patients in #clinicaltrial https://t.co/JE4r8nISUq
Robotic Phlebotomy Achieves 94% Success, Low Complications
I've been following Vitestro for years. They have been developing robotic devices to collect patients' blood samples. They have big news now as the results of a multicenter ADOPT clinical trial have been published in Clinical Chemistry. That is the...
Lab Success Doesn't Guarantee Real Cancer Drug Efficacy
Just a reminder. Killing cancer cells in a lab is very easy. Almost anything will kill cells. Even water (because of osmotic damage). Inside our bodies killing cancer cells is extremely hard for many reasons so things that kill...
Brain Age Gap Predicts Lifestyle Impact on Mental Health
Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health https://t.co/kgvgyZ9v4S
Fear of ‘Vibebioterror’ Overstates Threat, Defends SynBio Education
@strnr do you sincerely think that vibebioterror will be a thing? I honestly think this is fear mongering at its highest caliber. You can go to a community college right now and learn all you need to work with microbes...
Young Microbiota Restores Cognition and Sperm Health via Bifidobacterium
Young Human-Derived Microbiota Ameliorates Cognitive Decline and Reproductive Senescence in Aged Mice This approach "increased intestinal Bifidobacterium levels and effectively restored hippocampal metabolomic profiles and cognitive behavior." Additionally, yFMT-based treatments "mitigated structural damage to the seminiferous tubules [and] improved sperm quality. 👉These findings...
FDA Introduces Standardized Framework for Gene Therapy Safety
New FDA guidance on evaluating the safety of gene therapies will establish a more predictable development process as these measures are implemented They provide a standardized, layered framework for uncovering off-target effects and other safety issues https://t.co/D7lsBeZybT
Natural Compounds Boost Gut Butyrate, Increase Muscle Mass
Computational Screening and Experimental Validation of Natural Compounds that Enhance Butyrate Production in Gut Bacteria and Promote Muscle Cell Mass https://t.co/YgZdtWly4n
Exposing Antivaccine Rhetoric Masquerading as Real Science
1/n Here’s a thread on why this is nonsense. I think it’s important to debunk bc increasingly the antivaccine activists and their rhetoric are trying to sound more like real science even though it’s fake.
Patent‑Free COVID Vaccine Reaches 100 Million at $2‑3
Except the opposite, I make low cost vaccines that actually bypass big pharma, our patent-free COVID vaccine reached 100 million people at $2-3 per dose. It’s sad to see so many give up their critical thinking skills for conspiracy sites,...
EMF‑Controlled Gene Switch Reverses Aging In Vivo
EMF-inducible gene switch gene switch enables in vivo rejuvenation by reversing aging phenotypes Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression https://t.co/yeIDzXChWV
AI Models Map Worm Brain, Scale to Synthetic Biology
The C. elegans nervous system has exactly 302 neurons and 7,000 synaptic connections. Scientists have had the full wiring diagram since 1986. What they haven't had: a computational model that captures how those neurons actually develop and wire themselves up. Eric Wasiolek...
Grapefruit Compound Bergamottin Blocks STAT3, Triggers Tumor Cell Death
Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells https://t.co/cLRxHMFBCJ
One Injection Restores Hearing via OTOF Gene Therapy
A single injection uses an engineered AAV virus to deliver a healthy OTOF gene into cochlear cells, enabling them to produce otoferlin and restore the ear’s ability to convert sound vibrations into signals the brain can interpret. https://t.co/Lk34jpnRBe
