SIRT6 Overexpression Reverses Liver Chromatin Aging
SIRT6 overexpression counteracts chromatin aging in the male murine liver “Furthermore, AAV-mediated SIRT6 overexpression in aged male mice demonstrates that SIRT6 not only slows age-related chromatin changes but can also reverse them, rejuvenating chromatin accessibility to a youthful state.” https://t.co/fpGJtiOjvL @NatureComms
CRISPR Shows How Curiosity-Driven Science Sparks Revolutions
Good reminder from Erik Sontheimer: “CRISPR genome editing is a quintessential example of a technological revolution arising unexpectedly from basic, curiosity-driven discovery science.” #asgct2026 https://t.co/ytoKRcevN5
Senolytic ABT‑263 Cuts Lung Inflammation, Flu Severity in Aged Mice
Senolytic Treatment Reduces Acute and Chronic Lung Inflammation in an Aged Mouse Model of Influenza "Overall, ABT-263 therapy partially mitigates influenza severity in aged mice, primarily through dampening acute and chronic inflammation. Most of these effects were age-dependent, suggesting a role...
GLP‑1/GIP/Glucagon Drugs Target New
Just a few conditions being pursued for secondary prevention or treatment by GLP-1/GIP/Glucagon drugs in a new and comprehensive review @NatRevDrugDisc https://t.co/pjfc2jkAGU
Lilly Highlights Maintenance Strategies for GLP‑1 Weight Loss
Lilly data point to ‘maintenance’ strategies for GLP-1 weight loss https://t.co/LGyx82AJKf by Kristin Jensen $LLY $NVO
Gene and Cell Therapies Surge: Over 2,000 Projects in 2026
This excellent @Citeline 📊👇shows the exponential rise in the Gene & Cell Therapy field over the past 30 years. 2026 continues show strength with 2,115 Gene Therapies currently being developed to cure genetic diseases & 2,610 Cell therapies in different...
Gene Therapy Virus Implicated in Boy's Tumor, Study Finds
Scientists link boy’s tumor to gene therapy viruses, in rare finding https://t.co/d2jWn0zs9C via @statnews By @Jasonmmast
New mRNA‑nanoparticle Vaccine Boosts Cancer Potency, Durability
An innovation taking mRNA-nanoparticle cancer vaccines to the next level for potency and durability @NatureBiotech https://t.co/6wBToMGgEA
AI Enables Creation of Minimalist Organism Under 20 Amino Acids
Scientists just made the first ever observed organism with fewer than 20 amino acids in its make-up, and it was made possible by AI. https://t.co/ZCkvq4Rdas
Sub‑minute, Low‑power Device Prevents Kidney Ice Formation
getting through the danger zone for ice formation in under a minute, with a device that only draws a few kW (work done on a pig kidney, same scale as a human kidney) https://t.co/bQooglhqBU
LSD Triggers Region‑Specific White Matter Plastic
Curious. Opposite DTI/FA findings to those we recently published on. Region specific? Neuroplastic white matter changes in patients with major depression following lysergic acid diethylamide treatment: Cell Reports Medicine https://t.co/sIXRAZumie
16‑Hour Fast Enhances Cancer Immunotherapy via Metabolic Shift
A 16-hour fasting regimen may boost cancer immunotherapy. Transient nutrient stress reshapes tumor metabolism, increasing isoleucine in the TME and enhancing CD8+ T cell function. In mice & patients, short-term fasting improved immune response—offering a feasible way to strengthen treatment. #Fasting,...
XBI Sees Modest Boost After Anticlimactic FDA Decision
$XBI getting small lift (so far) from the Un-Martying of the FDA. It's all very anticlimactic. https://t.co/q4ta0bkJh4
Programmable Drug Targets Cancer Cells via DNA Recognition
FinalDose is building the first programmable drug platform - a single smart drug molecule that finds diseased cells by their DNA and destroys them. They're starting with all cancers. Congrats on the launch, @Jeffliu6068Liu, @sklin_lite, and @liyaohuang2! https://t.co/uKJgl7lpmR https://t.co/l4b1hS2mn7
Metformin May Lower Glucose via Gut, Not Liver
New paper on a proposed mechanism for how metformin lowers glucose, in Nature Metabolism. For such a widely used drug, the picture has been surprisingly murky. We've thought metformin works in the liver by enhancing glucose metabolism/utilization. But biodistribution and new...
Personalized Neoantigen Vaccine Shows Promise Against Glioblastoma
Personalized neoantigen vaccines vs cancer: we've seen benefits for pancreatic, renal and melanoma. Today initial, encouraging results vs glioblastoma in 9 patients with this deadly brain cancer @NatureCancer https://t.co/ACdCjiXnjJ
CAG-170 Bacterium Abundant in Healthy, Scarce in Illness
A Gut Bacterium Quietly Linked to Good Health As a medical school professor, I've watched the microbiome field generate countless conflicting findings. This one stood out. A large international study from Cambridge, published in Cell Host & Microbe, identified an obscure group...
Intronic Reads in 10x scRNA‑seq Reveal Hidden Biology
You’re analyzing 10x Genomics single-cell RNA-seq and notice lots of intronic reads. Wait—wasn’t this a 3′ UMI-based assay for mature mRNA? Let’s unpack why introns show up—and why they matter. 🧵 https://t.co/tbfkhNDmtQ
From “Undruggable” To Hope: KRAS Breakthrough
When “undruggable” meets “indefatigable” — the long, “impossible” journey from academia to industry that led to the discovery of KRAS and a potential breakthrough for pancreatic cancer patients. https://t.co/Fj85ry9thu
RIGL to Sell Approved Veppanu for ARVN, PFE
$RIGL will sell the newly approved Veppanu for $ARVN and $PFE. Modest financial terms https://t.co/9RsbSMzxBf
Tomatidine Boosts Memory and Cuts Cellular Aging in Mice
Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice https://t.co/jVfshXgzxQ https://t.co/6l86CBdoBC
EnGene's Phase II Data Triggers 83% Sales Forecast Plunge
11May: How much have peak sales forecasts nosedived after $ENGN reported updated Phase II data for detalimogene? Read about enGene Therapeutics' 83% plunge plus an IPO roundup and updates on $ATRA, $TRDA, $MRNA, & $VRDN in my latest StockWatch for...
Digital Twins of Human Lungs Personalize Therapy Assessment
Digital twins of ex vivo human lungs enable accurate and personalized evaluation of therapeutic efficacy https://t.co/0FMBqmiMyM https://t.co/3MrdTqK82w
Merging AI Pattern Recognition with Mechanistic Models Enables Virtual Cells
Minimal life by computer 👉 Progress toward a true virtual cell will depend on uniting AI’s pattern-finding power with the causal rigor of mechanistic models. https://t.co/2VYeaYCEUj @NatureNano https://t.co/nQGCjX7cna
DOSE Trial Reveals Best Heart Failure Infusion Strategy
Bolus or drip? What the DOSE trial actually showed about heart failure [PODCAST] http://dlvr.it/TSV5l4 Podcast #Cardiology
New AI Target Discovery Paper Sets Benchmark
New Paper Alert 🚨: A collaboration with the leading target ID experts in Nature Reviews Drug Discovery. If you are looking to teach your AI target discovery - this is a good place to start. Thanks Peter Kirkpatrick for giving...
Yutrepia Delivers Dramatic Cough Relief and Titration Benefits
“… when we go back to them and they begin prescribing Yutrepia, they come back with their own anecdote around that they're seeing a night and day difference, particularly around the cough and the ability to titrate and drive outcomes.” -...
Proteins Can Directly Template Sequence‑Specific DNA Synthesis
For 50+ years, molecular biology followed one golden rule: DNA ➜ RNA ➜ Protein 🧬 This new Science paper just added a shocking new twist: 🧪 Proteins can DIRECT sequence-specific DNA synthesis — without a nucleic acid template. 🤯⚡ Yes, you read that right. A...
Questioning CDC's Current Primer Design Standards and Tools
Jokes aside, what's the current CDC protocol for primer design? Are they using Primer3? Are they using a modern thermodynamic model? Still with that GC clamp juju? I keep hearing primer issues being brought up but thats practically solved...
Dog Drug Flavor Loved, but Owners Smell Vomit
from the trenches of dog drug development: last week we had to change the flavoring in one of our drugs because, while the dogs LOVE it, to dog owners it smells like ........ vomit
GLP‑1 Drugs Boost Survival, Cut Recurrence in Obese Breast Cancer Patients
In women with breast cancer and obesity or T2 diabetes, a large propensity matching retrospective analysis reports association of GLP-1 drug therapy with improved survival and reduced risk of recurrence https://t.co/GjimCr97S0
GNPS2 Enables Comprehensive Drug Metabolism Toolkit
Nature Protocols: A versatile toolkit for drug metabolism studies with GNPS2: from drug development to clinical monitoring https://t.co/lEejrO6gXT https://t.co/qlybcRgD9V
Tech Advances Redefine IVF and Our View of Reproduction
Tech advances not only made IVF safer and more effective; they fundamentally changed the way we think about our reproduction.
China Ranks Third Globally in AI-Driven Life Sciences
China ranks third in global index for AI competitiveness in life sciences China listed behind only the US and UK, reflecting the country’s ‘major scale’ in AI, biotechnology and talent, says data consortium https://t.co/IqiWdO5hea via @scmpnews
FDA Embraces AI: Radiology Leads 1,400 Approvals via 510(k)
The FDA, a global leader in healthcare regulation, is adapting its framework to include AI-based medical devices, with 1400 approvals and clearances to date, indicating an acknowledgment of AI’s expanding role in healthcare. Radiology leads in AI device approvals reflecting deep...
Fractyl Secures Dutch CTA for First GLP‑1 Gene Therapy Trial
Fractyl Health today announced that it has received Clinical Trial Application (CTA) authorization in the Netherlands to initiate the Phase 1/2 first-in-human study of RJVA-001 - $GUTS first clinical candidate from its Rejuva 🧵👇 GLP-1 Gene Therapy platform and the...
Rare Disease Community Gains New Treatment Hope After Five Years
Five years after disaster, a rare disease community gets new chance at treatment Yet another heart-rending story from @Jasonmmast. https://t.co/9vgOKpInL3
Epic 175‑Tweet Deep Dive Into Embryonic Stem Cell History
This lab is drum rolling an upcoming epic tweet storm of 175 tweets on the history of stem cells (embryonic). Can we get a postscript chapter on synthetic embryos/embryoids?
POD24 Signals Urgent Need for Wise Management
POD24 in follicular lymphoma: time to be “wise” [Mar 17, 2022] @JohnPLeonardMD @BloodJournal https://t.co/jLMd14D4Ur #lymsm https://t.co/991dNQe3JH
Zoledronic Acid Prevents Bone Loss in Lymphoma Therapy
Zoledronic Acid for Prevention of Bone Loss in Patients Receiving Primary Therapy for Lymphomas: A Prospective, Randomized Controlled Phase III Trial [Dec 29, 2012] @Lymphoma_Doc @mtmdphd et al. CLML https://t.co/iPOYSXEA1M #lymsm #SuppOnc #BoneHealth #NCT00352846 https://t.co/UlaqHyy65d
GLP‑1 Cash‑pay Users Set to Triple by 2030
In its initiation on $HIMS, The J.P. Morgan healthcare team estimates the long term GLP-1 cash pay addressable market to be over 120M individuals in the US, with only ~3M of those currently utilizing compounded or branded GLP-1s (~2.5% penetration)....
New Patent Covers Short-Acting Monoamine Releasers
Short-acting monoamine releasers D Nutt, A Borthwick, R Tyacke - US Patent 12,590,077, 2026 https://t.co/P99hvyXiil
Decoding Epigenetic Clocks: Pathways Behind Accelerated Aging
How epigenetic clocks tick: Unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging https://t.co/MU3R25TEu3
GrimAge Predicts Mortality in Centenarians Beyond Immune Aging
Advances in precision geriatrics. GrimAge methylation clock works in centenarians. Striking new preprint from the Henne Holstege lab (Yaran Zhang et al., 100-plus Study) in n=247 cognitively healthy Dutch centenarians: GrimAge predicts mortality at extreme old age (HR ≈ 1.6...
Glutamic Acid Boosts Quality of Aged Mouse Oocytes
Supplementation of old female mice with glutamic acid (an amino) enhances the quality of aged oocytes
Underpowered Trial Misleads: Non‑significant Trend, Not Failure
One of my pet peeves is a headline saying "This trial showed drug X doesn't work in condition Y" when in actuality what was demonstrated was a non-significant trend to efficacy in a severely underpowered trial.
AI's Promise in Biomedicine Hinges on Quality Data
AI is transforming our lives and science, but we need to be realistic about both its promise and its limitations. In biomedicine, one major bottleneck remains data. We need more high-quality data to unlock AI-driven advances. It was a pleasure to speak...
MANE Secures Patent, Launches Trials to Address Minoxidil
Turns out I was dead wrong in this thread from some four years back. $MANE managed to get a patent (US 12,268,688 ) and is conducting full-scale trials to assuage the obvious safety concerns with the approved Minoxidil oral dose.
Pandemic‑Driven Stocks Set to Surge Amid Volatility
Thoughts? We discuss four stocks that could potentially surge if another global pandemic causes market volatility similar to We break down why Thermo Fisher Scientific, Abbott Laboratories, Pfizer, and Gilead Sciences could be smart plays, highlighting their roles in testing,...
Finally, a Seamless Golden Braid Plasmid Editor
This is all I wanted from a plasmid editor: a way to quickly run Golden Braid cloning using parts from my library, with overhang sanity checks. I have not found a single tool that made it this easy. No visual...