10‑Marker Bioage Score Outperforms Chronological Age
As a medical school professor: chronological age is a tax bracket. Biological age is the actual bill. Aging Cell paper from MARK-AGE (Moreno-Villanueva, Burkle et al, U Konstanz, 2026) screened 362 biomarkers in ~3,300 adults across 8 European countries, then distilled a 10-marker "bioage score" by sex. Findings: - W... https://www.youtube.com/@RobertLufkinMD BiologicalAge #Longevity #MetabolicHealth #Biomarkers https://medicalxpress.com/news/2026-03-body-blood-biomarkers-biological-age.html
High Hs‑CRP, Not LDL, Drives Statin Benefit
"But my cholesterol is normal." JUPITER trial (NEJM): 18,000 people, normal LDL, high hs-CRP. Statin → cardiac events ↓44%, heart attacks ↓54%, strokes ↓48%. 322,000-person UK Biobank: hs-CRP outranked LDL. Full episode 🎙 https://youtu.be/FBLB1CQGBPM
Longevity Genes Can Switch From Benefit to Harm
As a medical school professor, I tell students: be careful with "longevity gene." Prof. Nikolai Slavov (Northeastern) just argued that single "longevity genes" are oversimplified. The same gene's effect on lifespan can flip sign with age -- helpful early, harmful later....
Invasive Nanowire BCIs Needed, Non‑Invasive for Biomarkers
I love brain-to-computer interfaces and one of my first papers and granted patents was in AI/ML for BCI. And I was very much impressed with BrainCo's non-invasive BCIs and artificial limbs and sensing fingers (that they sell to Tesla btw)....
Catalyst Poised as Florida’s First Multi‑Billion Biotech Exit
Is Catalyst (based in Coral Gables) the first Florida biotech to have a multi billion exit?
Extracellular Vesicles Deliver SASP, Fuel Aging, Offer Therapies
Extracellular Vesicles as Key SASP Carriers Driving Cellular Senescence, Inflammaging, and Therapeutic Opportunities in Aging and Age-Related Diseases https://t.co/SURS5ZbTD9 https://t.co/IXM2BkdurZ
Targeted Therapies Resurge; some Phase 3 Trials Risk Obsolescence
With a rapid fire raft of trial updates coming out of #esmobreast26, one thing stood out... targeted molecules are back in fashion and a few companies might be left holding the baby if their phase 3 trials have already started: https://t.co/jlKDLsecVZ...
Polynucleotide Implants Promise Hair Regrowth for Complete Baldness
Looks like polynucleotide implants can save even a fully bald head by @IntEngineering #Tech #TechForGood #EmergingTech https://t.co/CtDKGSBbcb
Oncology Care Ignores Patient Survival vs QoL Preferences
"Patient preference for extending survival or maintaining QoL was not associated with up-front treatment modifications or downstream outcomes, suggesting a possible lack of responsiveness of the current oncology care delivery system to patient preference." https://t.co/0RXf4h2dr3 In: Outcomes of Older Adults With Advanced...
Japan's TMS-007 Shows Promise for Stroke Treatment
@ej23ny @BiotechXGuru @biotech_cash @Ceazar_Black Anyone here look at Japan Biotech? I'm far from an expert, but I think 4891.T (TMS) is worth looking into. Its a nano cap with dilutive equity warrants (and a smallish cash runway) but their main...
Unfunded $24B Could Have Delivered 100‑Day Prototype Vaccines
Every so often I think about how, in 2022, for $24B we could had "prototype vaccines ready for each of the 26 known viral families that cause human disease" so they can be deployed in 100 days if there was...
MRNA Flu Shot Cuts Illness in 50+, Raises Reactogenicity
Prasad wanted high-dose flu vaccine comparator - hence the original Refusal-to-File. FDA then agreed to a split application for over-65's and under, and accepted the revised application.
SIRT6 Shields Aorta by Cutting Inflammation and Aging
SIRT6 appears protective in aortic disease, as higher levels reduce vascular inflammation and smooth muscle cell aging, thereby helping prevent both aortic aneurysm and dissection progression. https://t.co/eXuKrR7oNF
AI Speeds Dangerous Bio Design; Economics Drive Safety Race‑to‑bottom
"What keeps me up at night is the fast pace of acceleration of open weight models in the ecosystem. They do not prioritize the same type of safety refusals." - Yunyun Wang, @OpenAI We just ran a biosecurity panel at...
Even a Dog Loves Scaling Virtual Biology Panel
Not all our #SynBioBeta2026 attendees walk on 2 legs 🐶 Taco here found the "From Cells to Patients: Solving the Scale Mismatch in Virtual Biology" Main Stage Panel particularly interesting. https://t.co/6xMHnozSqd
First‑in‑class Molecular Glue Shows Breakthrough Pancreatic Cancer Results
We're seeing major advances vs pancreatic cancer. Today @NEJM data for daraxonrasib @RevMedicines https://t.co/IinceclK6w Context for this first-in-class molecular glue https://t.co/IinceclK6w https://t.co/odhmXQqzMF
Quick Turnaround: Good Longevity Trial News Arrives
I post about working around longevity clinical trials and an hour later @j_n_justice tells me good news about longevity clinical trials... 😍
Inflammatory Genes Link Obesity, Diabetes to Pancreatic Cancer
Shared inflammatory genes are active in both pancreatic cancer and metabolic diseases like obesity and diabetes, providing insight into why metabolic conditions worsen cancer outcomes and highlighting potential targets for improved prediction and treatment. cancerbiology
Trump Drug Strategy Clashes With New Funding Policies
Trump administration’s drug strategy is at odds with recent actions on funding, policy https://t.co/UDiuVnEMDZ via @statnews
Staying the Course: TMDX’s Long‑Term Thesis Remains Intact
Excellent post (below) on $TMDX, I'll do another detailed post in the next few days however in the meantime I'm doing calls with sell-side analysts and management. Here's what I'll say for now... Today is obviously frustrating for long-term shareholders but I...
Peptides Boost Hormones, Yet Trigger Serious Metabolic Side Effects
People mistakenly believe peptides are only good. Peptides can be bad, too. They can cause adverse effects. Some dangerous. I did a peptide experiment and measured its effects in my body. The results are complicated. I tried a peptide called CJC-1295....
Hamilton Unveils Integrated Glucose Sensor, Marks Decade Milestone
Hamilton Company has been coming to @SynBioBeta for years. This year, they showed up with something new. Tyler Schweder from Hamilton's process analytics team walked Gary George through their full upstream workflow: pH, dissolved oxygen, viable cell density, total cell...
80+ Therapeutic Peptides Approved Across Major Disease Areas
Did you know... over 80 therapeutic peptides have been approved to treat a wide array of diseases, ranging from infectious diseases, cardiovascular, dysmetabolic diseases, and cancer: https://t.co/kW4zgAcmE3
Scientists Remove Essential Amino Acid, Redefining Life's Code
All Life Uses 20 Amino Acids. Scientists Just Deleted One in Bacteria The synthetic bacteria push the limits of life and could open the door to designer proteins and new medicines https://t.co/mVZrQ0z7vz https://t.co/zFzSpnrk6h
Briumvi’s Optional Subq Gives It Market‑share Edge
On the $TGTX call the following was casually mentioned in response to a question about subq: "We feel actually very confident in our ability to deliver a quarterly product." It's important to understand that Briumvi will be the only product that...
Dark Proteome Research Redefines Human Disease Understanding
This, from @MeganMolteni, is frickin' cool. "How a global effort to explore the ‘dark proteome’ is upending our understanding of human disease." I remember when everyone was shocked that there were only 30,000 protein-coding genes found by the Human Genome Project. This...
Pill GLP‑1 Drugs Activate Amygdala Reward Circuit, Not Hypothalamus
Discovery of a new brain reward circuit in the amygdala for small molecule (pill) GLP-1 drug effect, unlike the injectables (hypothalamus), as shown in mice https://t.co/3lkfxROh5Z
Blood Test Now Gauges Tumor Microenvironment Non‑invasively
We've known how important the tumor microenvironment is for cancer progression and treatment, but we never had a non-invasive blood test to assess it. Today, as reported @nature, one has been discovered https://t.co/rDaF5YUwTq
Chicago Trip Reveals GLP-1 Adoption Still in Infancy
being in Chicago for a few days has made me realize how insanely early we are in the GLP-1 adoption cycle
Gene Therapy Field Focused on FDA Shifts in Rome
Even at a meeting in Rome, FDA shifts are top of mind for gene therapy field https://t.co/J9WXJqzqTY via @statnews
GLP‑1 Use Surges, Unlocking $100B Anti‑obesity Market
i think roughly 40% of Americans are significantly overweight so still plenty of upside for GLPs. $LLY
Harvard-Backed Trials Still Face Skeptical Disagreement
Have a team at Harvard Medical School, and drug pipeline in human trials, and scientific papers dating back to 2008 challenging that assumption No - I don’t agree 🤣
Self‑Destructing Plastic Degrades Completely in Two Weeks
Plastic pollution doesn’t seem to be getting better. But what if we could engineer plastics to get rid of themselves? A team of scientists in China recently demonstrated this somewhat comically idealistic solution, reporting their findings in a recent paper published in...
Direct Protein Reading Platform Ends Proteomics Blind Spot
🐠 Everything we know about biology has been built on an incomplete picture. DNA tells us what a cell might do. Proteins tell us what it’s actually doing. Pumpkinseed announced their $20M Series A today (led by Future Ventures and NfX)...
Nastent Nasal Insert Outperforms CPAP in Compliance
Your doctor will not tell you this. Most CPAP patients hate it and abandon it within months. Their oxygen crashes at night. Their mitochondria suffer. Their glymphatic system cannot clear amyloid beta. A clinical trial just completed on Nastent. It is...
Blocking IGF1 Senescence Reverses Hair Follicle Aging
Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging - Wang - 2025 - Aging Cell - Wiley Online Library https://t.co/LwbNFih66G
FDA Blocks Proven Therapies, Permits Untested Peptides
So let me get this straight - this FDA 1) won’t approve life saving melanoma and Huntington’s disease drugs based on BS objections related to control groups that would not be ethical 2) blocks large study showing exquisite safety of...
Bees Trained to Detect Explosives, Security Breakthrough
Bees Trained to Detect Explosives: A Breakthrough in Biotech Security by @zackdfilms1 #EmergingTech #Technology #Innovation https://t.co/LKDx2dGVFM
CD47 Blocks Mouse but Not Human Macrophage Phagocytosis
"the classic “don’t eat me” signal CD47 has minimal impact on human macrophage phagocytosis. By contrast, CD47 strongly suppressed mouse macrophage phagocytosis."
Awaiting Faster
Looking forward to the implementation of quicker/less bureaucratic path to first in human and only one pivotal study required for approval. Question is when these changes will happen and will all FDA offices/divisions support.
BioNTech's Remarkable Vaccine Supply Chain: A Bittersweet Legacy
For those of us (OK, mainly me) obsessively tracking the details of BioNTech's *INCREDIBLE* vaccine supply chain buildout during COVID-19, this piece is bittersweet. What BioNTech achieved for humanity in 2020-21 is simply an incredible story. https://t.co/H0YcTszLjr
FDA Approvals for Aging Therapies: Updated Insights
My 20min talk on FDA approvals of aging therapies & more coming soon from the Dec 2025 Longevity Summit at the Buck Institute is now on YouTube: https://t.co/L024jUz9iT It's an updated version of the one I gave at Vitalist Bay May'25. I'll be...
Viridian Data Boosts Thyroid Eye Disease Drug Prospects
Viridian data lift prospects for thyroid eye disease drug https://t.co/fjfkebQ99D by @Lilah_Alvarado $VRDN + 28% $AMGN
Pfizer Scrubs Trillium Pipeline, CD47 Concept Proves Bust
Sometimes in biotech you can get lucky and win even though you were dead wrong. $PFE just dumped the rest of the Trillium ( $TRIL) pipeline - it all came to naught. I made out nicely when PFE bought TRIL,...
Biotech Poised to Create Universal Anti‑venom Breakthrough
Day 1 @SynBioBeta first panel on building a universal anti-venom "We haven't innovated in 125yrs, since injecting horses with venom worked okay" We're now on the cusp of a universal anti-venom thanks to modern biotech https://t.co/wNbPwXjHPi
Chemical Reprogramming Triggers Toxic Lipid Droplets In Vivo
https://t.co/F6dZ4lFcUZ problem is that most groups don't publish negative results here's a recent paper from @gladyshev_lab showing that chemical reprogramming (yes, different thank OSKM) causes lipid droplet formation and significant in vivo toxicity
Orexin Therapies Unlock New Horizons Beyond Narcolepsy
Orexin drugs for narcolepsy and more. Listen to Richard Pops @popsalks discuss the emerging opportunity, and his 35-year-career, on The Long Run. Sponsored by @AlphaSenseInc & Dash Bio. https://t.co/Qr6oJ8AwzB
Single 25 Mg Psilocybin Dose Triggers Month-Long Brain Changes
A single 25 mg dose of psilocybin leads to brain structural changes that were seen at 1 month. From a cross-over study of 28 healthy volunteers, no prior psychedelic, who also were also assessed after 1 mg. Behavioral results in...
From Telecom to Longevity: Big Science Aging Talk
TODAY @ 10AM PT: LBF Conversation with Todd White @DToddWhite (Director @ Thalion Initiative). We'll be discussing Big Science for Aging Biology, fundraising, and his founder story pivoting from a career in telecom to longevity biotech. 👉 RSVP: https://t.co/UJP8xs8nrc
Cytospire Secures $83M to Develop Novel T‑Cell Engager
Cytospire hauls in $83M for a new type of T cell engager https://t.co/19BkL5JiHk by @gwendolynawu #biotech #startups