One Blood Test Detects Multiple Cancers and Diseases
Detecting multiple cancers and other diseases from a single blood sample https://t.co/6gjjYY50dm via @medical_xpress #cancer #research
Aging Shares Disease Hallmarks, May Be Treatable
Is aging a disease? These authors reflect: “Disease is commonly defined as an abnormality of bodily structure or function, distinct from direct physical injury (Bulterijs et al., 2015). Whether ageing itself constitutes a disease has long been debated in the fields of...
Therapeutic Phlebotomy Restores Bone Marrow, Reverses Aging
Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function “our work provides preliminary evidence suggesting that periodic therapeutic phlebotomy exerts anti-aging effects by restoring bone marrow function and mitigating aging phenotypes, subsequently driving peripheral blood functional restoration.” 👉 “...
Safe Cell Reprogramming Restores Identity, Nature Reports
You're confused. Let me explain: My student @Y_Ryan_Lu worked for years to find a SAFE way to reprogram cells so they'd only RE-GAIN identity, not LOSE it, as Prof Yamanaka showed We tried innumerable combos to find the solution Story is @Nature...
High‑dose Dexamethasone Improves Outcomes in Newly Diagnosed Myeloma
Lenalidomide + high-dose dexamethasone (RD) vs lenalidomide + low-dose dexamethasone (Rd) as initial therapy for newly diagnosed multiple myeloma: an open-label RCT [10/22/2009] @VincentRK et al. @TheLancetOncol https://t.co/hXxlFINejC #NCT00098475 #EAonc E4A03 #mmsm #caxtx #ctsm https://t.co/GnehXu71Td
NMN Reverses Ovarian Aging in Mice, Human Trials Needed
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓 https://t.co/oVeGUZSaQ0
P&G Brings Biotech Ingredients to Mass‑market Consumer Products
P&G doesn't move on new ingredients unless the science is bulletproof and the consumer performance is there. They're moving on biotech. Three R&D leaders from Procter & Gamble are at SynBioBeta 2026 to talk about how bio-derived ingredients are making it into...
Seeking Experiences with GTWY Peptide From Β‑Lactolin
New smart drug peptide alert… (Possibly): who has experience with GTWY peptide isolated from β-lactolin? Research here: https://t.co/Sg7twStXvr
Combating Rising Anti‑Vaccine Activism Through Science Advocacy
Many thanks @uiowa for hosting my lectures this week, on our vaccine development program and the dangers of accelerating antivaccine activism in America, also the history of American anti-science movements and latest book #ScienceUnderSiege with @MichaelEMann @PeterHotez https://t.co/3r0XH08iMu
Light‑Powered Nanorobots Capture and Relocate Bacteria Precisely
Light-driven nanorobots, smaller than a micron, can now hunt, capture, and relocate bacteria with precision, offering new possibilities for targeted manipulation in microbiology and biomedical research. nanotechnology
Weekly Biotech Roundup: Top Insights From X's Best Accounts
Here is my favourite weekly 🧵- made by my dear friend @BiopharmIQ. This post is a comprehensive recap of the past week in BioTech and gathers the best related posts written by some of the smartest & brightest 𝕏 Bio...
AI‑Designed Enzymes Break Evolution’s Limits for Biomanufacturing
Nature never designed enzymes for industrial manufacturing. It designed them to survive. That mismatch is one of the biggest bottlenecks in biomanufacturing — and most of the industry has been working around it with incremental fixes for decades. Matthew Thompson from Biomatter...
Poor Drug Selection Hampers Stroke Treatment Breakthroughs
1,026 experimental treatments in acute stroke (2006) "The results question whether the most efficacious drugs are being selected for stroke clinical trials. This may partially explain the slow progress in developing treatments..." https://t.co/WllAIz3Xul
Epigenetic Clock Detects Aging and Cancer via Blood Test
This is the future: An epigenetic clock for the simultaneous assessment of biological aging and cancer from a simple, cheap blood test 👏 https://t.co/uzGoZWos9C
Spatial Biology, Single‑cell Profiling, and AI Map T‑cell Immunity
Towards Spatial Medicine for individualized cancer immunotherapy @SciImmunology "The convergence of spatial biology platforms, single-cell immune profiling, and machine learning is positioning the community to decode how T cell immunity is spatially organized in human tissues and to exploit that organization...
Progerin Bridges Premature and Natural Aging, Biomarker Potential
Progerin expression in humans: implications for natural ageing "These insights may collectively position progerin as a mechanistic link between premature ageing and physiological ageing, positioning it as a potential component of biomarker strategies." https://t.co/KZuV0c7TOK
Cell‑free DNA Manufacturing Eliminates Cloning Bottlenecks
Your DNA synthesis workflow is probably slowing you down more than you think. Cloning introduces delays, contamination risk, and hard limits on what you can build. Most of the field is still living with these constraints — even as mRNA therapeutics,...
Stool Test Detects 90% of Colorectal Cancers
As a medical school professor, I've watched colorectal cancer screening rely on colonoscopies for decades. That era may be ending. Researchers at the University of Geneva just published a breakthrough in Cell Host & Microbe: a simple stool test that detects...
Real‑time Biological Data Is the Missing Link for AI
🧵 Unlocking the true potential of AI and bioinformatics hinges on one missing link: real-time biological data. I saw that Prof. Nikolai Slavov posted this, and that reminds me of how complicated a single cell is. https://t.co/UCUeL2Bdge
Choosing Cutoffs for P‑values, Log2
🧵“What cutoff should I use for p-value, log2FC, or mito content?” This is the most common question I get. Here's why it’s not simple: https://t.co/A4P37eEwdc
China's Biotech Surge Threatens Western Drug Dominance
Big Pharma Is Turning to China for the Newest Drug Ideas—China’s biotechs are faster and have lower costs, and its drug research threatens to soon overtake the West’s @Loftus https://t.co/YszgDfNlwc https://t.co/YszgDfNlwc
IL6R Protects, IL6 Harms: Genetic Proof of Survival Impact
Causal effects of inflammation on long-term mortality: A mendelian randomization study 🔑"The IL6/IL6R axis has a causal impact on human survival through cardiovascular mechanisms: IL6R exerts a protective effect, whereas IL6 is detrimental." https://t.co/0TwQldDrQe
One‑sentence AI Pipeline Transforms Drug Discovery Workflow
What if your next drug discovery pipeline started with one sentence, not 6 months of scripting? In this latest deep dive with @scispace, I saw a shift that feels bigger than incremental AI gains. Upload single-cell data and get clustered cell types,...
Aging
RIP Dr Skulachev who made serious contributions to the ROS theory of aging. Unfortunately, no FDA-approved drug out of his work yet. One of my goals is to have several FDA approved drugs before or after I die. Papers and...
Human Cells Lag Far Behind Yeast in Large DNA Integration
“Ultra large” in this paper is 8 kb 😭 > shows how far we are from achieving the sort of SynBio we routinely do in yeast in primary human cells. 50 kb integrations are fairly routine in yeast
MIT Discovers Hundreds of Bacterial CRISPR-Like Tools
MIT Mined Bacteria for the Next CRISPR—and Found Hundreds of Potential New Tools https://t.co/n4cJpB8dVk https://t.co/Vq57AKw6XD
Self‑immunized Man’s Blood Yields Universal Antivenom
A truck mechanic from Wisconsin spent 18 years injecting himself with venom from the world's deadliest snakes. 700 doses. 200+ bites. He taught himself immunology from a textbook. His name is Tim Friede. His blood may end up saving hundreds of...
Longevity Strategies Miss Deeper Levels of Aging
Are we targeting aging the wrong way? In this interview with Peter Fedichev (@fedichev), CEO of Gero, we discuss why many longevity interventions may only be tackling “level 1” aging. https://t.co/jRnuYr3dFN
Dynamic Enzyme Complex Maps Nicotine Biosynthesis in Wild Tobacco
The complete biosynthetic pathway of nicotine in wild tobacco has been mapped, revealing a dynamic enzyme complex that orchestrates the final steps and transport of this alkaloid, offering new insights for synthetic biology and plant defense mechanisms. plantbiology
Reprogrammed Tregs Turn Pancreatic Tumors Immunotherapy‑Friendly
Reprogramming regulatory T cells within pancreatic tumors may transform them from immune suppressors into supporters of anti-tumor activity, offering a potential strategy to enhance immunotherapy effectiveness in this challenging cancer. immunotherapy
Biotech IPOs Open as Hemab Goes Public
Biotech IPO gates are opening. Congrats also to @JMaraganore (Chair) and Benny Sorensen (CEO) of Hemab, and best of luck.
Explore Rapamycin's Role in Aging at UArizona
If you’re in Tucson next week, I’ll be giving a talk at the University of Arizona College of Pharmacy (@UAZPharmacy) on the science behind rapamycin and aging. We’ll cover what we know, what we don’t, and where the field is...
REPL RP1 Melanoma Trial Flawed; New CRL
I've never covered the REPL RP1 data in melanoma, mainly due to dislike of the trial design w/ its lack of a monotherapy arm. Sometimes you can see where things are likely headed and kicking a dog when it's down...
FDA Approves First Gene Therapy for LAD‑I Children
FDA approves first gene therapy, Kresladi, offering a breakthrough treatment for children with the rare immune disorder LAD-I https://t.co/ezWPPEgtd0
Live CEO Interviews From Raymond James Biotech Symposium
Programming note: On Tuesday of next week I'll be broadcasting @BiotechTV interviews from the Raymond James Biotech Symposium in New York. Current confirmed CEO interviews: $SEPN $AKBA $WVE $VERA $DYN $KRRO (and maybe more). Let me know any questions for...
Ezetimibe Shows Unexpected Potential to Prevent Alzheimer’s
Ezetimibe might help prevent Alzheimer's disease... but not in the way that you think. These data really caught me off guard. But the data are the data. (long-form video linked below)
OCE's Objections Caused Rejection, Not Vinay Prasad
$REPL my read of the RP1 CRL suggests OCE (CDER) took the lead in the review. Their objections led to the first rejection, as I previously reported, and nothing Replimune submitted for the second review was enough to support...
Replimune's FDA‑targeted Skin Cancer Drug Faces Another Rejection
Replimune $REPL skin cancer drug that became FDA flashpoint is rejected again https://t.co/7aOfKy8vC7 via @Jasonmmast
Psychedelic Therapies May Outpace GLP‑1s Commercially
I believe the commercial potential of #psychedelic therapies is likely to exceed that of GLP-1s. $ATAI $CMPS $DFTX
Optical Genome Mapping Enhances AML Classification and Treatment
Optical genome mapping [OGM] improves the accuracy of classification, risk stratification, & personalized treatment strategies for Pts w/ acute myeloid leukemia [Jul 17, 2024] @sanamloghavi et al. @AjHematology https://t.co/R5ZLgolhuj #AMLsm #leusm #PrecisionMedicine #oncopath https://t.co/kX7KUJLK0L
Sex Drives Distinct Immune Aging Patterns and Disease Risks
The way our immune cells age differs substantially by sex, from single-cell analysis of ~1,000 people. Implications for propensity for autoimmune diseases (women), vulnerability to cancer (men), immunosenescence and inflammaging @NatureAging https://t.co/GjcuZ8luNM
Personalized CRISPR Fixes Baby KJ’s Genetic Defect
In just 6 months a team at @ChildrensPhila & @PennMedicine designed a personalized CRISPR based Rx to correct the single misspelled letter in Baby KJ’s DNA that results in CPS1 deficiency. Recent advances in mRNA science & CRISPR gene...
Biotech IPO Surge Expected; List on NYSE
Getting to know the @NYSE and Johanna and Eric has been a highlight of mine since their earliest support of BiotechTV. I have no doubt we will see a strong IPO pipeline for biotech this year, and I hope you...
Ultrasound Enables Non‑Invasive Control of Body Cells
"Sonogenics" is an emerging scientific field that uses ultrasound to non-invasively control and manipulate specific cells in the body, such as neurons or heart cells
NMN Daily Restores NAD, Supports Healthy Aging
David Sinclair takes 1 gram of NMN every single day. Here's why. As you age, your body loses up to 50% of a molecule called NAD. NAD is a molecule that acts like fuel powering your sirtuin genes - the genes responsible...
Young Mitochondria Transplants Could Reverse Aging and Disease
What if aging, ALS, Parkinson's, stroke, and diabetes all share a single upstream cause — and the fix is a transplant the size of a bacterium? Dr. Catherine Baucom and Van Hipp of MitoSense explain how injecting healthy young mitochondria...
Regeneration Depends on Environment, Oxygen, and Epigenetics
Awakening latent regeneration in mammals “regeneration is not simply a fixed genetic trait but rather a state that is dependent on the extracellular environment, oxygen sensing, and epigenetics.” https://t.co/HtTXENUEur
Blocking 15-PGDH Reverses Age‑Related Cartilage Loss
As a medical school professor, I was taught that lost cartilage is gone forever. Stanford just proved that wrong. Researchers discovered that blocking a single protein (15-PGDH) -- which rises as we age -- can actually REGROW joint cartilage in aging mice. The...
New GLP‑3 Drug Reta May Target Fat, Spark Hunger
Like it or not, GLP-1-based weight loss drugs are here to stay. 1/2) What's more, people are experimenting with newer evolutions, like "reta" (retatrutide/GLP-3). As an MD PhD & metabolism scientist, I decided to start my own experiment to help answer...
Decoding ORR: What RECIST v1.1 Means for Investors
Investors will often see ORR quoted or displayed for oncology clinical trial results for solid tumors Here's what the CRs/PRs/SDs mean at a high level These are assessed on scans I'm using RECIST v1.1 definitions #learnbiotechinvesting #biotech #investing #BiotechPrometheus https://t.co/eZb86TcoLL
