GSK's Depemokimab Gains Chinese Approval for Nasal Polyps
#GSK Exdensur (depemokimab) approved in China for treating Chronic Rhinosinusitis with Nasal Polyps, following the ANCHOR trials.
Startup Pitches Brainless Human Clones for Organ Harvesting
Big news about a startup called R3 Bio that plans to create brainless human clones for the sole purpose of harvesting organs when people need them. They are just pitching the idea to investors now, but it is pretty wild (if...
Tiny AI Startup Outpaces Big Labs, Accelerates Discovery
I met with the founders of https://t.co/VDKFa8U1Su today. Building an AI scientist. About to launch something new that is beating all the evaluations. Their AI is next level. Evolves faster than competition that got a lot more money. Has a better memory. And...
Lithium Reverses ApoE4 Cellular Deficits, Merits AD Trials
https://t.co/r6JzHA1RxM with ApoE4/E4 from a sporadic Alzheimer's disease patient "Given the drug's demonstrated efficacy in reversing ApoE4-driven cellular vulnerabilities, lithium salt warrants further investigation for the treatment of AD." https://t.co/r6JzHA1RxM https://t.co/v2lE0XhN7n
Prediction Markets Could Overtake Biotech Stocks for Phase‑3 Bets
I think that one day soon that prediction markets are going to replace biotech stocks for how investors play key readouts...especially wrt larger companies. For example, if Novartis has a big phase 3, isn't it more interesting and efficient to...
Targeting Liver ApoE Boosts Bone Healing in the Elderly
Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing "Our work here identifies novel liver-to-bone cross-talk and a noninvasive, translatable therapeutic intervention for aged bone regeneration" https://t.co/KSzvkKOzZt https://t.co/1p0cXQlalT
Α‑Eleostearic Acid Acts as Senolytic via Ferroptosis
α-eleostearic acid as a senolytic via ferroptosis. Found in high concentrations in Tung oil (which is toxic) and in small amounts in Bitter Melon oil. https://t.co/FSCix3OZtD
Turmeric‑Ginger Coating Doubles Bone Bonding, Cuts Bacteria, Cancer Cells
Turmeric and ginger extract applied to titanium implants can double bone bonding in six weeks, eliminate 92% of surface bacteria, and sharply reduce cancer-causing cells, offering a promising advance for joint replacement and bone cancer patients. biomaterials
Plant Tissue Culture Constantly Reveals Surprising Cellular Tricks
Coolest part of plant tissue culture is that no matter how much experience you have, you will always learn something new about the strange things plant bits do when given some molecular encouragement.
Conjugated PUFAs Target Senescent Cells
Polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells “ Conjugated PUFAs α-ESA and its methyl ester selectively eliminate diverse senescent cells… These lipid senolytics reduce tissue senescence and extend health span in aged mice” 👉 Lipid peroxidation underlies selective vulnerability...
Hair‑Loss Pill Redefines Masculinity and Aging
The Hair-Loss Drug Rewriting the Rules of Masculinity A pill to cure baldness is changing the way men age — and how they see themselves. https://t.co/4OiLpmOwGR https://t.co/YQLBx61gVT
Follistatin: Dual Weapon Against Cancer and Muscle Loss
Follistatin protein, which plays a key role both in inhibiting tumors and promoting muscle tissue growth. https://t.co/OebCo6FSI7
KLF5 Drives Pancreatic Cancer Spread via Gene Rewiring
A gene called KLF5 may be a key force behind the spread of pancreatic cancer—but not in the way scientists expected. Rather than mutating DNA, it rewires how genes are turned on and off, helping tumors grow and invade new...
Fatty Acids Target and Eliminate Aging “Zombie” Cells
NEW STUDY finds certain fatty acids selectively kill senescent "zombie" cells. The molecules exploit a fundamental biophysical weakness in senescent cells, a totally new approach. Could we simply consume these moleculs to treat aging? ...🧵 https://t.co/EceCAfdlvz
Shingles Vaccine Beats Geroscience in Reducing Dementia
a different take: the shingles vaccine lowers dementia and all cause mortality and it’s targeted to a specific virus, not the process of aging so far the data say the score is shingles vaccine 1, geroscience hypothesis 0 and I could say the...
New Cytotoxic Targets Unveiled at AACR26
Time to head off the beaten track at #AACR26 with our latest preview exploring novel targets and cytotoxics. The long climb up the hill may be worth it for some of them: https://t.co/l9tkdWvpuF https://t.co/M5B3RTW1wf
Funding Hurdles Stall Needed Multi‑site BPC‑157 Trial
I can’t see any reason why a proper multi site RCT of BPC157 done by a few independent groups wouldn’t help clarify any real vs placebo effects. The challenge: no one wants to pony up the $ (more like $$$$...
Blueprint for Integrating Psilocybin Into NHS Mental Health Care
British Journal of Psychiatry Psychedelics in NHS services: exploring a model for real-world implementation of psilocybin https://t.co/6sgfqg66rt
First Human Trial Tests Cellular Age Reversal Therapy
This method to reverse cellular ageing is about to be tested in humans A burgeoning field is launching its first clinical trial to find out whether dialling back cell development can safely refresh aged tissues and organs. 💡"Technologies to refresh ageing tissue...
US Obesity Rates Dip in 2023, Drug Impact Suspected
BMI and obesity prevalence in the US decreased in 2023 for the first time in more than a decade. What s the reason? Are people 'exercising more and eating less' or are GLP-1 agonists starting to have an effect? https://jamanetwork.com/journals/jama-health-forum/fullarticle/2827712 @GatlanHealth
Gilead's $3.1B Deal Expands ADC Portfolio
Gilead continues M&A surge with $3.1B deal for ADC specialist Tubulis https://t.co/xEMXvDq2LL by @gwendolynawu $GILD #biotech
Top Experts Discuss Cutting‑Edge Longevity Strategies Live
Fund Longevity Live Stream Wednesday, April 8 11:00 AM - 12:00 PM EDT 🔗 https://t.co/gNCkMYxhfI @aubreydegrey — Combination therapy @LidskyPeter — New theory of aging Alexander Panchin — Gene therapy & science communication @longevion — Crypto & funding @cordeiro — Global longevity movement @ILAISRLA ...
Accelerating Early-Onset Cancer Cause Research for Prevention
Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers 🌟This roadmap aims to stimulate advances to accelerate cancer etiology research and prevention in the era of rising early-onset cancers. https://t.co/d0z6EHDpTh https://t.co/H6I76e4tFB
Peptide Vials Contaminated, Underdosed, and Unsafe
Besides the lack of data for safety or efficacy on peptides, or any assurance of sterility, here's what an independent lab found of samples: —The vial of BPC-157 contained lead —The vial of TB-500 contained endotoxins —The vial of CJC-1295 contained <42% of...
Fund NIH Trials to Validate Unapproved Peptide Safety
I thought this was an excellent, balanced article on the current state of unapproved peptides from a safety and regulatory perspective by @AnjeanetteDamon in @propublica https://t.co/DbA8cdvTY5 The fundamental problem is that we don't have quality data on safety or efficacy for...
SNY's Atopic Dermatitis Candidate Fails; NKTR Rem
$SNY next-gen atopic dermatitis drug failed in P2b. Missed primary endpoint. MOA was IL13xTSLP. Now what have they got to follow up dupi if (when?) they discontinue amlitelimab? $NKTR 👀 🤷🏻♂️ Remains the only new MoA...
Stay Grounded Amid Rapid Bioinformatics Advances
🧵Bioinformatics evolves fast. New tech. New data. New analysis. But here's how to stay grounded and not get overwhelmed: https://t.co/VdWFpeE93W
CEO Kazimi Explores Computation, Chemistry, Culture in Drug Discovery
Computation, Chemistry & Culture for Drug Discovery: Nimbus Therapeutics CEO Abbas Kazimi is the latest guest on The Long Run. Sponsored by @AlphaSenseInc and Dash Bio. https://t.co/XCysW6El1o
Tubulis Secures $5B Gilead Acquisition After CEO Vision
Last year I visited @Tubulis_GmbH in Munich, Germany. Here's what CEO Dominik Schumacher told me they were aiming to do. Congrats on today's acquisition by @gilead for up to $5B, and congrats to @schroederthilo who raved to me about this...
Four‑Month MDF Cuts NAFLD Liver Fat by 24%
"The 4-month intervention with this MDF was effective in reducing IHTC in patients with NAFLD by an absolute reduction of −5.89% and a relative reduction of −24.30% after adjusting for weight loss. Such effect was partly mediated by altered composition...
Real Progress Lies in 0‑to‑PCC Data, Not AI Hype
Check out my article in @FastCompany on AI drug discovery revolution. From one perspective, it may feel like I am turning into a version of Derek Lowe - AI skeptic. And when I read another interview with the IT...
Gene Therapy Poised to Redefine Obesity Treatment Landscape
1/GLP-1 obesity and weight-loss drugs - such as $NVO Ozempic & Wegovy and $LLY Zepbound & Mounjaro have long become a household name - making Obesity the fastest growing market in the BioTech and Pharma ecosystem and generating unprecedented revenues....
Probability of Success Integrates Development Risk Into Biotech Valuations
Incorporating Probability of Success (PoS) is a unique aspect of #biotech valuation investors must be aware of. It tries to factor development risk into revenue and cost assumptions. Here is a table of PoS values: #learnbiotechinvesting #investing #BiotechPrometheus https://t.co/GA3LVSmWFZ
Bootstrapped Cryo‑AI: LLMs Power Life‑Saving Freeze Tech
Meet Dr. Mark Woodward, undergrad and grad from Stanford, PhD from Harvard, Many years at Google as part of Google brain. One day he realizes that we need the enabling technology to pause biological time for patients that are about...
Digital Twins Simulate Psychedelic Effects for Consciousness Disorders
Digital twins allow virtual clinical trials of psychedelics for disorders of consciousness 🧠↔🧠 | Innovation | Tech for Good. 💬 Using magnetic resonance imaging (MRI), scientists have developed personalized, whole-brain computational models of patients with disorders of consciousness. Using these...
AI Meets Drug Discovery at NYC Meetup Tuesday
AI x Drug Discovery meetup next Tues (14) in NYC ! @ginkgo excited to host with @AAlphaBio — sign up here : https://t.co/GG5c7F4ogO
3D‑Printed Spanlastics Directly Target Tumors, Cut Side Effects
3D-printed spanlastics, microscopic carriers for cancer drugs, show potential to target tumors directly and reduce side effects by concentrating therapy at the tumor site rather than throughout the body. nanotechnology
Biotech M&A Poised for Second‑Busiest Year, Early Deals Surge
Biotech M&A on track to have 2nd most active year in history w/ more early stage deals. Nice summary of which funds have benefited from recent M&A from Stifel @TimOpler $XBI $IBB https://t.co/udCuhIcaIi
Creating Autonomous Health via Real-Time Multi‑Omic Monitoring
I've measured my body a lot. I'm about to dwarf what we've done by building real-time continuous multi-omic monitoring and intervention. Cars drive themselves. Software writes itself. I'm building Autonomous Health. First for me, then for you. > Peptides...
One Psychedelic Dose Quickly Eases Depression, Trial Shows
Single dose of a psychedelic drug can rapidly reduce depressive symptoms, clinical trial suggests https://t.co/c72qpfwQPm https://t.co/xR7hbj4v8e
Repurposing Approved Drugs: Small Trials Explore New Uses
Great reporting from @Philanthropy on our grantee @CuresWReach, which runs small trials testing whether existing, approved drugs might work for entirely different diseases.
AI Cancer Vaccines Thrive While Cities Reject Data Centers
incredible seeing (actual, live) AI-designed cancer vaccines one minute, and local city councils unanimously voting down data centers the next. cognitive dissonance.
Egg Bioreactors Replace CHO Cells in Biologics Production
We’ve optimized drug design with AI. Why are we still manufacturing with CHO like it’s the 1980s? Neion Bio is rethinking biologics production using chicken eggs as bioreactors. Excited to hear Sam Levin at #SynBioBeta2026. Visit the SynBioBeta website to read the full...
Autonomous Labs Revolutionize Research: Insights From Ginkgo, OpenAI, PNNLab
awesome talk about Autonomous labs from @Ginkgo, @OpenAI, and @PNNLab ! Check it out 👇
Study Shows Subcutaneous Tepezza Matches Infused Version
Under-the-skin Tepezza comparable to infused version in key study, Amgen says https://t.co/rOQqbRmEpL $AMGN $VRDN - 25%
Immune Training Against Senescent Cells Reduces Tumor Growth
Here's my take on your paper: Cellular senescence or "zombie cell" events happen when a cell experiences too much genetic or epigenetic noise, caused by cellular damage (e.g. DNA breaks) or telomere erosion Your study of a Lewis Lung Carcinoma (LLC) mouse...
Diabetes Drug Replicates Exercise Effects in Prostate Cancer Patients
How a Diabetes Drug May Echo the Benefits of Exercise in Prostate Cancer Care “From a clinical standpoint, seeing a metabolic signal that mirrors what we associate with intense exercise was striking… For patients whose treatments or symptoms limit physical activity,...
Resveratrol Alters Sperm Epigenetics, Boosts Offspring Metabolism
CRAZY IF TRUE PAPER: A new study in mice reports that resveratrol intake by old male mice (or directly treating their sperm) changes the metabolism of embryos & pups, "potentially through alterations in sperm telomere length and epigenetic modifications"...
Meta-Analyses Reveal Psychedelics Boost Brain Circuits
Two systematic, meta-analyses on psychedelic drugs today Brain Circuit Function @NatureMedicine https://t.co/nBmjreYEXU Depression @NatMentHealth https://t.co/zJR06AsC0Z https://t.co/qpWdjzBR4D
Cell Senescence Drives Cancer Risk, Yet Can Be Modulated
Cell senescence and how it predisposes to cancer, no less how we may be able to modulate it. An outstanding @CellCellPress review https://t.co/bmAXOS1Ybz
