BioTech Social Media and Updates

Myeloma Survival Breakthrough: Two Decades After Dalton’s Wish
SocialApr 6, 2026

Myeloma Survival Breakthrough: Two Decades After Dalton’s Wish

I remember interviewing Bill Dalton in 2005 about new developments in myeloma and how he wished for new regimens to take OS out beyond 3-4 yrs. Two decades on we've hit jackpot...

By Sally Church
Promoting OSKM Therapy with MYC Is Borderline Criminal
SocialApr 6, 2026

Promoting OSKM Therapy with MYC Is Borderline Criminal

The fact that some scientists are still touting OSKM as a therapy, which includes the cancer-causing oncogene MYC, is borderline criminal

By David Sinclair, PhD
FDA Backs Permanent Re‑authorization of Pediatric PRV Program
SocialApr 6, 2026

FDA Backs Permanent Re‑authorization of Pediatric PRV Program

FDA calls to permanently re-authorize the rare pediatric disease PRV program in Friday's 2027 budget plan -- far cry from the FDA that complained to the GAO about PRVs as distracting from their public health priorities https://t.co/i79F7X1ECw

By Zach Brennan
FDA Delay Shuts Down Small Biotech in Four Months
SocialApr 6, 2026

FDA Delay Shuts Down Small Biotech in Four Months

How a four-month FDA delay forced a small biotech company to close its doors https://t.co/6vMGJM5SjH

By Damian Garde
Rust Prototype Brings Terminal Transcriptome Browser to Life
SocialApr 6, 2026

Rust Prototype Brings Terminal Transcriptome Browser to Life

Almost done with a prototype Rust port of my Scriptoscope python app for transcriptome browsing, all in-terminal. Inspired by @Psy_Fer_'s ask to read from the holy books of Rust. https://t.co/OPr8rjFKj6

By Sebastian Cocioba
5-MeO-DMT Shows Remarkable Clinical Results and Unmeasured Benefits
SocialApr 6, 2026

5-MeO-DMT Shows Remarkable Clinical Results and Unmeasured Benefits

The clinical data for 5-MeO-DMT in $ATAI ‘s treatment-resistant-depression trials is outstanding. Yet beyond the measurable endpoints, there’s indeed an additional layer of impact - difficult to capture in standard metrics, but consistently reported. @bryan_johnson captured this beautifully. And I...

By Christian Angermayer
Oncology Revenue Dominated by Few Classes, KRAS Next.
SocialApr 6, 2026

Oncology Revenue Dominated by Few Classes, KRAS Next.

Great tables from Wedbush listing small molecule oncology and hemonc drugs ordered by approval date. I counted ~20 different classes for solid tumors and ~6 for liquid, most revenues are driven by a handful of classes that reached multi...

By Ohad Hammer
Wireless Oxygen Implant Powers Engineered Cells Inside Body
SocialApr 6, 2026

Wireless Oxygen Implant Powers Engineered Cells Inside Body

What happens when you give engineered cells their own wireless oxygen supply inside a thumb-drive-sized implant? https://spectrum.ieee.org/biologic-drugs-implant-bioelectronics-medicine?share_id=9322774

By IEEE Spectrum Threads
RA Capital Boosts Wave Stake Amid Clinical Setback
SocialApr 6, 2026

RA Capital Boosts Wave Stake Amid Clinical Setback

🚨Here is an interesting report from this week’s @barronsonline regarding a major investment made in $WVE by RA Capital - despite Wave’s recent disappointing clinical readout of its obesity candidate $WVE-007 🧵👇. According to the report RA Capital has raised...

By Yair Einhorn
Low‑Cost Covid Vaccine Tech Delivers 100M Doses, Bypassing Big
SocialApr 6, 2026

Low‑Cost Covid Vaccine Tech Delivers 100M Doses, Bypassing Big

So to clarify, Baylor Coll Med licensed our low-cost protein Covid vaccine technology to four entities: BioE (India), BioFarma (Indonesia), Incepta (Bangladesh), ImmunityBio (U.S./S. Africa). The first two produced and delivered 100 million vaccine doses as Corbevax for India and...

By Peter Hotez
Higher BMI Predicts Late-Life Mobility and IADL Disability
SocialApr 6, 2026

Higher BMI Predicts Late-Life Mobility and IADL Disability

Late-life disability following the action for health in diabetes (Look AHEAD) trial 😷Regardless of age, those with higher BMI had increased late-life mobility and IADL disability. https://t.co/QeU9TJhf9y https://t.co/zeCNrGcO7x

By David Barzilai, MD PhD
AI Reveals Aging Cells Lose Identity, Suggests Rejuvenation
SocialApr 6, 2026

AI Reveals Aging Cells Lose Identity, Suggests Rejuvenation

New paper @GladstoneInst @UCBerkeley @nvidia reinforces the Information Theory of Aging (ITOA). Looking at 175M single-cell gene expression patterns, AI found cells lose their identity over time. The model then predicted how to restore lost information to rejuvenate cells…🧵 https://t.co/oU3fYiqRzd

By David Sinclair, PhD
Psilocybin Single Dose Beats Nicotine Patches for Quitting
SocialApr 6, 2026

Psilocybin Single Dose Beats Nicotine Patches for Quitting

A single dose of psilocybin is more effective than nicotine patches for quitting smoking, study suggests https://t.co/APDQt1WYxp https://t.co/zDnXcUjFyG

By David Barzilai, MD PhD
Exercise‑linked Protein Target Could Rejuvenate Aging Blood‑brain Barrier
SocialApr 6, 2026

Exercise‑linked Protein Target Could Rejuvenate Aging Blood‑brain Barrier

Scientists Find a Mechanism for How Exercise Protects the Brain 🗣️Finding drugs to trim proteins like TNAP could be a new way to rejuvenate the blood-brain barrier, even after it’s been degraded by age. “We’re uncovering biology that Alzheimer’s research has largely...

By David Barzilai, MD PhD
SIRT1 Activation Shows Promise for Age‑related Brain Disorders
SocialApr 5, 2026

SIRT1 Activation Shows Promise for Age‑related Brain Disorders

SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential "...SIRT1 could be a promising pharmacological target for age-associated brain disorders, warranting more robust translational studies to validate these findings in humans..." https://t.co/hGVxZ4RErM

By David Barzilai, MD PhD
Optimizing Transcriptome Workflow with C Timing Tests
SocialApr 5, 2026

Optimizing Transcriptome Workflow with C Timing Tests

Now time to vibe some more. Working on some tests to see where I can speed up some steps to streamline the transcriptome workflow I'm envisioning. Asking the bot to do some wall-clock timings in C to peep a few...

By Sebastian Cocioba
Increasing Volume Drives Lower Biosimilar Medication Prices
SocialApr 5, 2026

Increasing Volume Drives Lower Biosimilar Medication Prices

We are just getting started. As our volumes go up, our prices go down. And we are adding more branded meds and soon more specialty meds. If you use humira, stelara or other meds that have biosimilars, we...

By Mark Cuban
Dermcidin Blocks Flu Entry via Conserved Hemagglutinin Site
SocialApr 5, 2026

Dermcidin Blocks Flu Entry via Conserved Hemagglutinin Site

Dermcidin, a natural antimicrobial peptide found in sweat, saliva, and tears, disrupts influenza virus entry by binding to a conserved region of hemagglutinin, suggesting a potential broad-spectrum antiviral defense mechanism. immunology

By Phys.org Threads
Dual-Assembly Hydrogel Enables Precise 3D‑Printed Regenerative Microfluidics
SocialApr 5, 2026

Dual-Assembly Hydrogel Enables Precise 3D‑Printed Regenerative Microfluidics

A dual self-assembly hydrogel enables precise 3D printing of stable, biocompatible structures with dynamic responsiveness and antimicrobial properties, advancing the creation of complex microfluidic channels for regenerative medicine. hydrogels

By Phys.org Threads
Obesity and Age Drive Peripheral Inflammation in Cognitive Impairment
SocialApr 5, 2026

Obesity and Age Drive Peripheral Inflammation in Cognitive Impairment

Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact "Peripheral low-grade inflammation was common, particularly in individuals with cognitive impairment; and obesity and age were the main drivers..." https://t.co/KvjFleW6t4

By David Barzilai, MD PhD
Cures Emerge From Incremental Advances, Not Single Breakthroughs
SocialApr 5, 2026

Cures Emerge From Incremental Advances, Not Single Breakthroughs

The media makes it seem like cures are one breakthrough away. In reality, cures come from smaller breakthroughs and improvements made by the work of thousands of scientists, drug developers and doctors. We’re witnessing this evolution in real time with...

By David Sinclair, PhD
AI Pathology Predicts Chemo Response in Small‑cell Lung Cancer
SocialApr 5, 2026

AI Pathology Predicts Chemo Response in Small‑cell Lung Cancer

An AI-powered pathology tool can predict whether extensive-stage small cell lung cancer will respond to platinum-based chemotherapy using standard biopsy slides, enabling more personalized treatment decisions without additional procedures. lungcancer

By Phys.org Threads
Daratumumab Boosts Revlimid Efficacy in Smoldering Myeloma
SocialApr 5, 2026

Daratumumab Boosts Revlimid Efficacy in Smoldering Myeloma

#EAonc EAA173 - Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM) - PI: @nsc_natalie https://t.co/VtBMJUjI5X Activated: Apr 30, 2019 #mmsm @eaonc #NCT03937635 @VincentRK @mweissmdphd https://t.co/fFVUqNssyX

By Mike Thompson, MD PhD
Phase 3 Trial Tests Daratumumab
SocialApr 5, 2026

Phase 3 Trial Tests Daratumumab

.@SWOG S2213 Ph3 RCT Dara-VC Induction Followed by ASCT or Dara-VCD Consolidation & Daratumumab Maintenance in Pts w/ Newly Diagnosed AL Amyloidosis [Activated: 12/1/23] https://t.co/OizUfJCc2c #mmsm #bmtsm https://t.co/ClwxVAhSy0

By Mike Thompson, MD PhD
Seeing Biological Age Data Drives Real Health Improvements
SocialApr 5, 2026

Seeing Biological Age Data Drives Real Health Improvements

Some doctors say wearables & epigenetic age tests aren’t useful because they aren’t clinically approved But a new study of 178 people over a year says otherwise When people saw their data & biological age, they changed behavior & saw measurable improvements...

By David Sinclair, PhD
Not All scRNA‑seq Zeros Are Dropouts—Distinguish Real Signals
SocialApr 5, 2026

Not All scRNA‑seq Zeros Are Dropouts—Distinguish Real Signals

Your scRNA-seq matrix is 90% zeros. You assume it is dropout. Some of those zeros are real biology. Some are your platform failing to capture transcripts. Treating them the same way will wreck your analysis. https://t.co/z9SDKz3ZZv

By Ming Tang
Congress Must Reform Broken IND Process for FIH Trials
SocialApr 5, 2026

Congress Must Reform Broken IND Process for FIH Trials

Great to see FDA & the administration prioritizing FIH (First in Human) reform. The current IND process is broken & has shifted FIH trials overseas. Countries like Australia have relied on a more flexible, notification-based pathway for years. Now Congress...

By Robert Nelsen
Levetiracetam Blocks Amyloid Beta via SV2a‑dependent APP Modulation
SocialApr 5, 2026

Levetiracetam Blocks Amyloid Beta via SV2a‑dependent APP Modulation

Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer’s disease models "...supporting the hypothesis that protein accumulation is a relevant pathogenic event in amyloid pathology..." https://t.co/bRqoZP1Qyf @ScienceTM

By David Barzilai, MD PhD
Future Peptide Therapy Needs Automated Multi‑dose Syringe
SocialApr 5, 2026

Future Peptide Therapy Needs Automated Multi‑dose Syringe

The peptide revolution will require a small (reservoir enabled) auto syringe that doses at intervals with multiple peptides throughout the day. Basically a parallel exo-somatic signaling system.

By Peter H. Diamandis
Targeted Antivirals and Vaccines Needed for CMV-Linked Cognitive Decline
SocialApr 5, 2026

Targeted Antivirals and Vaccines Needed for CMV-Linked Cognitive Decline

Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies 🔎"We advocate for targeted antiviral strategies and vaccine development to clarify its contribution to neurodegeneration." https://t.co/b7Qx9aj0K3 https://t.co/KMB9ITLEzW

By David Barzilai, MD PhD
Machine Learning Links Spironolactone to Reduced Fibrosis Risk
SocialApr 5, 2026

Machine Learning Links Spironolactone to Reduced Fibrosis Risk

Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics https://t.co/Ho2RL0RhO4 https://t.co/cHkogagDTt

By David Barzilai, MD PhD
GLP‑1s Linked to Lower Risk of Mental Illness Worsening
SocialApr 4, 2026

GLP‑1s Linked to Lower Risk of Mental Illness Worsening

GLP-1s appear to reduce the odds of mental illness getting worse. Another unlooked-for benefit. Caveats: 1. This is observational, not an RCT. 2. This is reduction of odds getting worse on each of these measures. Not reduction of existing mental illness....

By Ramez Naam
GLP‑1s Massively Marked up; LLMs Priced Near Cost
SocialApr 4, 2026

GLP‑1s Massively Marked up; LLMs Priced Near Cost

One observation here: GLP-1s are priced at maybe 25-50x production cost (not counting R&D). LLM usage is priced at perhaps 1x inference cost (not counting training). In any case, two great innovations that are rapidly catching on.

By Ramez Naam
China Competition Will Accelerate US Pharma, Cut Red Tape
SocialApr 4, 2026

China Competition Will Accelerate US Pharma, Cut Red Tape

This is great to see. Biotech and pharma competition with China is going to force us to sharpen and accelerate processes in the US, and cut red tape. And we'll get the benefit of Chinese drugs as well. Win/win.

By Ramez Naam
Biotech Survey Predictions Often Mislead Investors
SocialApr 4, 2026

Biotech Survey Predictions Often Mislead Investors

51.5% of you thought that $NVO was going to be delisted on $LLY Orforligpron approval day. It was not delisted. Not even a little bit. Are you guys dumb? (Here's a rudimentary example of why you should...

By Adam May
Intranasal EV Vaccine Shields Mice From H5N1, H7N9
SocialApr 4, 2026

Intranasal EV Vaccine Shields Mice From H5N1, H7N9

A potential universal flu shot? Intranasal EV vaccine protected mice from H5N1, H7N9 https://t.co/WroXpi6YP3 https://t.co/umAPlnRjbF

By David Barzilai, MD PhD
Adrenal Organoid Replicates Human Development and Hormone Production
SocialApr 4, 2026

Adrenal Organoid Replicates Human Development and Hormone Production

A new adrenal gland organoid accurately models human development and hormone production, offering a platform to study stress responses, disease mechanisms, and potential regenerative therapies for adrenal disorders. biotechnology

By Phys.org Threads
Key Frontier Biology Gaps Holding Back Civilization’s Leap
SocialApr 4, 2026

Key Frontier Biology Gaps Holding Back Civilization’s Leap

Some of the most underinvested areas in frontier biology that could accelerate civilizational progress: - Cheap, large-scale DNA synthesis (writing entire chromosomes or full organisms) - Real-time, non-destructive RNA sequencing in living cells - Highly accurate AI-powered polygenic scores for complex traits (disease...

By Brian Armstrong
Intermittent Fasting Cuts Crohn’s Disease Activity by 40%
SocialApr 4, 2026

Intermittent Fasting Cuts Crohn’s Disease Activity by 40%

As a medical school professor, I was never taught this: meal timing may be more powerful than medication for gut disease. A new clinical trial in Gastroenterology found that intermittent fasting reduced Crohn's disease activity by 40%. Patients who restricted eating to...

By Robert Lufkin, MD
GenAI Cryobiology Offers New Hope for Critical Patients
SocialApr 4, 2026

GenAI Cryobiology Offers New Hope for Critical Patients

Follow Wake Bio and its CEO, Mark Woodward, for cool news in high-throughput GenAI-driven cryobiology. P.S. I invested in this company personally and really like Mark and what he is doing. I hope that this technology will give patients we can...

By Alex Zhavoronkov, PhD
Silicon Valley's Immortality Bet Reaches 91‑year‑old
SocialApr 4, 2026

Silicon Valley's Immortality Bet Reaches 91‑year‑old

Longevity treatments for a 91-year-old. That's the kind of story that captures where Silicon Valley's immortality bet is actually heading. Great piece by @AmyDMarcus, who I had the chance to meet in Boston recently. She brings serious depth to this beat,...

By David Barzilai, MD PhD
37°C Causes scRNA‑seq Data to Mislead Researchers
SocialApr 4, 2026

37°C Causes scRNA‑seq Data to Mislead Researchers

37 degrees Celsius. That is the temperature where your scRNA-seq experiment starts lying to you. https://t.co/FXrk5fgWTQ

By Ming Tang
AlphaFold3 Boosts Engineered Toad Pathway 40‑fold in Tobacco
SocialApr 4, 2026

AlphaFold3 Boosts Engineered Toad Pathway 40‑fold in Tobacco

They ported the 5-MeO-DMT pathway from the Sonoran Desert toad into tobacco plants and then used AlphaFold3 to debug the protein structure, leading to a 40x yield increase. Prompt psychedelic design.

By Bryan Johnson
FGF21 Boosts Lactate Metabolism For
SocialApr 4, 2026

FGF21 Boosts Lactate Metabolism For

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice https://t.co/WInPF6Nm1C https://t.co/f9BxVAApln

By David Barzilai, MD PhD
Probability‑Adjusted DCF: Essential Tool for Valuing Pre‑Profit Biotechs
SocialApr 4, 2026

Probability‑Adjusted DCF: Essential Tool for Valuing Pre‑Profit Biotechs

When thinking about valuing #biotechs, especially those which are not yet profitable, a probability adjusted discounted cash flow model is perhaps the most important methodology Though it too has drawbacks #DCF #PoS #learnbiotechinvesting #investing #BiotechPrometheus https://t.co/1sfTMkZ6kO

By Biotech Investor
BLAST Integration Progressing; Tackling Self‑hits and API Slowdown
SocialApr 4, 2026

BLAST Integration Progressing; Tackling Self‑hits and API Slowdown

Internally pinged NCBI BLAST working nicely. Need to add a "this transcript" flag for any self-referencing BLAST hit, but all in all things are shaping up. Now to dig into some slowdowns and see where to optimize and where we're...

By Sebastian Cocioba
Marc Guell’s SynBio Lab Featured in Journal’s 30‑Year Highlights
SocialApr 4, 2026

Marc Guell’s SynBio Lab Featured in Journal’s 30‑Year Highlights

Great to see the SynBio work of @marcguellc lab getting featured as one of the highlights of 30 years of the journal

By Tom Ellis
Incretin Modulators Boost Health, Happiness, and Longevity
SocialApr 4, 2026

Incretin Modulators Boost Health, Happiness, and Longevity

Life is a marshmallow test. Incretin modulators help you win while staying happy. I often ask big audiences - "how many of you are on GLP1?" and only a couple hands go up. Sometimes, none. That's when I understood that...

By Alex Zhavoronkov, PhD
NBTXR3 Surpasses 70% Enrollment, on Track For
SocialApr 3, 2026

NBTXR3 Surpasses 70% Enrollment, on Track For

$NBTX update: Their lead cancer drug NBTXR3 is now over 70% enrolled in its crucial Phase 3 trial. Target: complete enrollment by end of 2025. With cash into late 2027, they're funded to reach this major milestone. Biotech

By periodtrader