
Mark Zuckerberg and Priscilla Chan explain how the Chan Zuckerberg Initiative is creating AI‑driven computational tools—like the open‑source Cell Atlas and virtual cell models—to accelerate discovery, test high‑risk hypotheses in silico, and ultimately cure, prevent, and manage all disease by the end of the century. They argue that basic science now requires $100 million‑scale projects beyond traditional NIH grants, and that unifying the Biohub under AI leadership fosters deep collaboration between biologists and engineers. The episode highlights the shift toward expanding compute over lab space, the importance of interface design for democratizing research, and a long‑term roadmap for AI’s broader impact on biotech.

Today is Product Hunt's 12-year anniversary. It started with a tweet and has become a global launchpad for founders and makers. Pretty cool to see so many now-household names—Notion, Deel, Loom, Ramp, Figma—launch their v1s on the platform. But we've always tried to...
Everyone in Silicon Valley understands that the way to win a technology race is to get the most users and developers on your platform. Yet the anti-export lobby in Washington keeps inventing reasons why America’s friends and allies shouldn’t be...

In this micro‑episode, Prashant Choubey explains why even profit‑rich giants like Meta and Amazon are cutting thousands of jobs in 2025, attributing the wave to three forces: the "Great AI Re‑allocation" that shifts talent to automation, a newly permanent "Year...

10 out of 10. Would recommend. BillionToOne is a wonderful example of what's possible when you take on the most important, hardest problem you can. Oguzhan and David didn’t set out to “start a startup.” They wanted to solve a globally important...

&AI (@tryandai) is a collaborative workspace for patent invalidity and infringement work — litigation, portfolio monetization, business development, and more. Over the past year, they've been working closely with the best patent litigators and in-house teams in the world, supporting them...

In this episode, Bobbi Brown recounts how she grew Bobbi Brown Cosmetics into a billion‑dollar powerhouse and the fraught split with Estée Lauder that forced her to choose between retirement and reinvention. She shares hard‑won lessons on scaling a brand, navigating...

I'm excited to announce the a16z New Media Fellowship. Or as many people are saying, the Thiel Fellowship for the terminally online. Finding highly functional people who are also very online is hard, so we are creating a fellowship to gather and...
Giga (@gigaml) is building the next generation of customer support — real-time AI agents that can understand emotion, resolve issues instantly, and scale across the world’s largest enterprises. The team recently raised $61M to power emotionally intelligent, human-quality conversations at enterprise...
In this EUVC Podcast episode, Kristaps Ronis of ION Pacific explains how structured secondaries are reshaping venture liquidity by offering DPI‑focused deals that provide cash without forcing founders or GPs to sell shares or signal weakness. He highlights the market’s...
Of every fund of this vintage, I would rather have Benchmark’s portfolio than any other: Sierra ($10BN) Mercor ($10BN) Firework ($4BN) Legora ($2BN) Langchain ($1.3BN) Manus (one of most insane teams in AI) HeyGen ($80M ARR) Today it gets...
Lexi (@getlexi_io) is building AI Associates for law firms and legal teams—handling the full spectrum of legal work from intake to delivery so lawyers can focus on what really matters. https://t.co/6rM6Vh0ycO
The episode chronicles Michael Loeb’s journey from being fired at 36 to creating billion‑dollar ventures like Synapse, Priceline.com, and the healthcare discount platform ScriptRelief, now operating under his venture collective Loeb.nyc. He argues that entrepreneurial instincts appear early—often evident in...

Meet the Cerebral Valley Heavy Weights with @IndexVentures https://t.co/MfyhKCjKam
Saffron Health (@saffronhealthco) uses AI agents to automate specialist referrals for primary care, cutting referral time by 82%, finding appointments 55% sooner, and reducing kickbacks by 44%. https://t.co/oFQ6BDBwO0 Congrats on the launch, @moonriseTK & @MichaelMotorcy9! https://t.co/xjxkZ3JlDT
The post compares AI infrastructure spending to historic U.S. investment projects, showing AI at 1.6% of GDP in 2024—far below World War II, the New Deal, and the railroad boom. It highlights current corporate outlays (Microsoft, Google, Meta) and projects OpenAI’s...
Technology is deflationary in a good way and @usv we are investing in driving down cost!
Amera automates claims processing workflows for health insurance payers. It cuts admin costs by 20-30%, turns hours of manual work into minutes, and helps members access more affordable, transparent care. https://t.co/xhDCotk94Z Congrats on the launch, @deepkkapur & @LouiseTanski!
In this interview, Joe Seager—partner at the consumer‑focused VC True and former Virgin executive—explains how True’s vertically integrated, multi‑stage model gives founders a distinct advantage and why Europe’s fragmented venture landscape is beginning to outpace the U.S., especially in the...
Planbase raised $2.1M to build the AI platform for healthcare ops—where admins can just type “build next week’s schedule” and it happens. Real-time, generative operations for clinics. https://t.co/6pDmxoGuwr
The two biggest narratives about AI right now are that (1) it’s a massive bubble (i.e. totally fake) and (2) about to give rise to superintelligence (i.e. totally real). Both narratives can be fake (which is what I believe) but...
SOC Prime, the Boston‑based provider of an AI‑native detection intelligence platform, announced the closing of its latest investment round. The round was led by u.ventures and included participation from DNX Ventures, Atlantic Bridge, J Ventures and Angel One. Proceeds will...

New on SaaStr!! "You Can Hide From a Lot of Things as a Founder. Cash Burn Isn’t One of Them." https://t.co/GzWBxOnn2k https://t.co/KFM0DeUeuo
There will be no federal bailout for AI. The U.S. has at least 5 major frontier model companies. If one fails, others will take its place.
Liminal Custody, a digital‑asset custody and wallet‑infrastructure provider, announced the promotion of Ilinca Cartoflea to Head of Sales, EMEA, based in Dubai. In her new role she will drive regional growth, enterprise partnerships and institutional client engagement across Europe, the...
New!! @rodriscoll @HarryStebbings + me on 20VC: 1/ "AI Agents really are already better than mediocre humans. So you better be tapping into that revenue as a startup. You better be getting some of that revenue by now, by late...

Woo-hoo!! Just crossed 600,000 start-up valuations on new, FREE SaaStr AI valuation calculator here -> https://t.co/jvgsU2zIKA The 2.0 version not only tells you what you’re worth, but now also tells you the odds you’ll get funded! Try it! -> https://t.co/jvgsU2zIKA https://t.co/T2LLQpqSkK
In the "Bringing Trust Back to Healthcare" episode, Matt Holt of New Mountain Capital argues that the sector must rebuild trust among all stakeholders to prioritize patient outcomes, calling for greater collaboration across the industry. He and Venrock hosts highlight...
interesting piece on what new media is from @Alex_Danco and @a16z crew https://t.co/aEXT20msl4
A year ago, @thepablohansen was finishing his master's in AI. Today, he's building @withkeystone, a modern bug-triage platform for enterprises. Through YC, he found a community of founders that helped him move faster and think bigger. And you can too. https://t.co/gNl84El3BS https://t.co/ZYZEY5oYle

In this episode, Eugenia Kuyda, the founder of Replika and CEO of Wabi, discusses how AI‑driven personal software will shift from a developer‑only tool to a creative medium accessible to anyone, likening command‑line AI interfaces to the early days of...
Engineers became the bottleneck when analyzing sensor data. MOVEdot (@movedot_) built AI agents that fix that, working hand in hand to analyze telemetry, video & documentation 100x faster. Starting with race cars, expanding to manufacturing, robotics, and more. https://t.co/L912mZilya Congrats on the...
I remember a few years ago, a SaaStr Fund portfolio company was struggling to get a Series A round done They found a lead to put in $8m, but wanted the insiders to put in the other $2m. I wasn't a very...

In this episode, founders Adam and Patrik pitch STAG, an electric mini skid‑steer they describe as the "Tesla of construction equipment," highlighting its multi‑function design, Made‑in‑USA manufacturing, and early traction with major dealers like Bobcat. They explain the market opportunity...
New!! “The Problem(s) With T3D2 Venture Deals. They’re Still Great. But They Might Get You Fired.” https://t.co/lXKYxMt3Lo
in the latest @stateofaireport, I predicted that an ai scientist would make verifiably new discoveries end-to-end looks like we’re pretty much there!
Just a fair warning to founders: like Facebook and microsoft, I predict OpenAI will study their platform partners and compete with many of them in the coming years. This isn't abnormal, mind you… Microsoft built windows, then destroyed their top...

Why are batteries a national security issue? It is THE energy source for critical applications today and, even more importantly, tomorrow: Cars Data Center Batteries (ESS) Military and defense drones Robots If we are to be a resilient nation that is in control of our...
Casey is building the infrastructure layer for insurance distribution - automating complex submissions so brokers spend less time on admin and more time with clients. https://t.co/lxZsmXMwXd Congrats on the launch, @MaxThoelen, @pascalkueng, and @nicohaenggi! https://t.co/r1Eer98FEm
FREE startup valuation tool -> https://t.co/jvgsU2zIKA FREE VC pitch deck grader -> https://t.co/S5UFYzoN7a
Good one from @cityofthetown: Neoclouds Race for the Public Markets, Leaving VCs Behind https://t.co/bBRvTaZCmp

400M+ downloads and $500K profit. Bootstrapped mobile gaming portfolio live on @acquiredotcom. > $501K TTM revenue > $501K TTM profit > 100% YoY growth > 5000+ customers Full listing: https://t.co/JSw4HtA7wT https://t.co/6oHcBIy8Fg
Deedy Das and Jay Eum Join the VC Roundtable! https://t.co/QQlqMmKtCr
Super psyched! We're doing a quick session with @ankurnagpal tomorrow who knows a TON about tax-savings strategies for angel investors. He is going to knowledge-dump a ton of tactical info - will be great! Hope to see you tmrw - sign...
“Many insurance CEO want to sprinkle AI pixie dust on themselves” - @daschreiber CEO of $LMND on CEO of @AIGinsurance Investors still do not fully understand the power of an AI native company like @Lemonade_Inc and how it compounds advantage. https://t.co/LOPcEf4U1f @CNBC
When I founded my first start-up, * I had to sign a full recourse note to my VCs for $750,000 to get a tiny bridge * We had to sell 60% of the company in the first round * I had to agree...

Palantir: the highest valuation on the least sales of any public company ever I’m still very bullish Just a reminder things in AI are well valued https://t.co/0CNJSRuhax
SF Tensor (@sftensor) is building infrastructure for training foundation models, letting researchers focus on research and forget that the infrastructure layer even exists while saving 70% in training costs. https://t.co/Kcy4TeCjm3 Congrats on the launch, @benkoska, @tom_koska, and @lukkoska!
Super interesting overall - and this with all the Sequoia news yesterday: Mike Moritz gave $2.5M FOR Prop 50 and Doug Leone gave $250K AGAINST https://t.co/nFC4cbAzg8
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