Know What's Happening in Healthcare
Know What's Happening in Healthcare
FDA approves KRESLADI, first CIRM‑backed gene‑editing therapy
The FDA cleared KRESLADI, a gene‑editing treatment from Rocket Pharmaceuticals for severe leukocyte adhesion deficiency‑I in children, eliminating the need for a bone‑marrow donor. It is the first product directly funded by California’s Institute for Regenerative Medicine to receive approval.
Also developing:
By the numbers: Syneron Bio raises $150M Series B
Manufacturers concentrate patient support on the launch window, emphasizing financial aid and onboarding within the first 30‑60 days. Tina Valbh highlights that this front‑loaded model neglects the evolving barriers patients face throughout long‑term therapy. Without a holistic, multi‑phase strategy, programs risk falling short of patients’ ongoing needs. The interview underscores an industry opportunity to redefine success beyond initial access.
Patients with obesity undergoing transcatheter aortic valve replacement (TAVR) who received tirzepatide before and after the procedure experienced significantly lower rates of subclinical leaflet thrombosis (HALT) and paravalvular leak. In the randomized TAVR‑MET trial of 260 patients, tirzepatide reduced HALT...
Dermatology Partners, a large physician‑owned dermatology group, deployed EliseAI's agentic voice AI to handle its 2,000‑4,000 daily inbound calls. The system integrates with AdvancedMD and Modernizing Medicine EHR, allowing the AI to schedule appointments and capture simple clinical tasks. Early...
A retrospective series of 5,317 pediatric spinal deformity surgeries (1992‑2024) found intraoperative neuromonitoring (IONM) alerts in 4.2% of cases, most often during correction. The study recorded 237 alerts and 348 interventions, with raising mean arterial pressure (MAP) being the most...
A phase‑3, double‑blind trial of over 500 patients showed the ustekinumab biosimilar CT‑P43 achieved equivalent PASI75 response at week 12 and maintained comparable PASI50/75/90 rates through week 52. Safety, adverse‑event profiles, and antidrug‑antibody incidence mirrored those of reference ustekinumab. Patients who switched...
The Covid‑19 inquiry finds the NHS was on the brink of collapse as pandemic waves overwhelmed hospitals and ambulance services. Critical shortages of oxygen, PPE and staff forced intensive‑care ratios to deteriorate, while the “Stay Home, Protect the NHS” slogan...
CMS is piloting a new patient‑centric data exchange model that uses biometric authentication to unlock electronic health records and QR codes to transmit them securely. Amy Gleason, administrator at U.S. DOGE Service and CMS strategic advisor, outlined how the approach...
Sarepta Therapeutics will submit a supplemental NDA to the FDA seeking to convert the accelerated approvals of its Duchenne exon‑skippers Amondys 45 and Vyondys 53 into traditional approvals, despite the confirmatory ESSENCE trial failing to improve motor function. The company bolsters its...
Providers struggle to verify lifestyle‑medicine outcomes because behavior changes occur outside the exam room. The article argues that remote patient monitoring (RPM) can supply objective, real‑time data to validate nutrition, exercise, and stress‑management programs. CMS’s MAHA ELEVATE model and new RPM...
I read from an influencer nurse that measles is “going around”. She is selling vitamin A supplements. Having measles is not inevitable. Especially if a population is vaccinated. And that has been proven in the US for the past 30...
Heart Rhythm Advocates (HRA) outlined six policy issues that could shape electrophysiology in 2026, led by Medicare payment reform and a new 2.5% efficiency adjustment that threatens physician reimbursement. The group highlighted a reintroduced Medicare Patient Access and Practice Stabilization...
Senior editor Jim Parker has launched Inside Hospice, a Substack platform that delivers in‑depth analysis of hospice industry trends, personal narratives, and behind‑the‑scenes insights. While Hospice News remains a traditional journalistic outlet, Inside Hospice offers longer‑form commentary and direct engagement...
The Defense Health Agency (DHA) has launched a five‑year data strategy to create a secure, interoperable AI ecosystem for the Military Health System. Partnering with Red Hat, DHA is building cloud‑native infrastructure, data lakes, and governance frameworks that can safely scale...
Dr. Christie Mulholland challenges the entrenched binary that medicine must be a self‑sacrificial calling, proposing instead a two‑dimensional matrix of calling intensity and job satisfaction. The model creates four quadrants—The Calling, The Craft, The Wound, and The Wall—each describing a...
Glaukos announced that Epioxa™ HD/Epioxa™ is now commercially available, marking the first FDA‑approved, incision‑free topical drug for keratoconus. The therapy uses a riboflavin solution with the O₂n™ System and Boost Goggles, eliminating the need to remove the corneal epithelium. By...
Pfizer announced that the Phase 3 TALAPRO‑3 trial met its primary endpoint, showing that TALZENNA (talazoparib) combined with XTANDI (enzalutamide) significantly improved radiographic progression‑free survival (rPFS) in patients with HRR gene‑mutated metastatic hormone‑sensitive prostate cancer. The combination achieved a hazard ratio...
The NHS has partnered with AstraZeneca, Chiesi, GSK and Sanofi in a £10 million Respiratory Transformation Partnership (RTP) to improve care for asthma and COPD patients. The co‑funded programme will use data analytics and digital tools to identify high‑risk patients, expand...
In this episode of Healthcare Uncovered, hosts Joe Rettino and former Cigna insider Wendell Potter dissect the 2025 earnings of the seven biggest for‑profit insurers, which together generated $1.7 trillion in revenue and $54 billion in profit despite covering 10 million fewer people....
Researchers at Graz University of Technology unveiled VRSpi, a neuroadaptive virtual‑reality system that reads EEG and heart‑rate signals to automatically adjust spider exposure intensity. The prototype uses frontal alpha asymmetry to gauge real‑time anxiety, ensuring stimuli are neither too weak...
Let's look at how the FDA is treating $SRPT and $QURE differently. The FDA grants accelerated approval to Amondys and Vyondys to treat Duchenne muscular dystrophy. Sarepta conducts a post-marketing confirmatory study that fails to show a benefit for either...
The article explains how physicians must balance financial risk by distinguishing between risk capacity—their ability to absorb setbacks—and risk tolerance—their personal comfort with uncertainty. It outlines four common physician profiles and offers targeted strategies such as debt reduction, reserve building,...
U.S. blood banks are reporting critically low inventories of O‑negative red cells, prompting a coordinated call for donations and revised emergency transfusion protocols. Anesthesiologists, who deliver roughly 60% of the nation’s blood transfusions, are urging hospitals to start with O‑positive...
Excalipoint, a biotech focused on cancer T‑cell engagers, announced the close of a $68.7 million seed financing round. The capital, raised from leading venture firms and strategic investors, will fund the development of its bispecific antibody platform targeting solid tumors. The...
AI-powered handheld X‑ray devices and molecular diagnostics are rapidly reshaping tuberculosis detection in low‑resource settings. The Global Fund now backs AI‑driven screening in more than 22 countries, while Indonesia has moved treatment initiation to over 460 primary health centers, reducing...
When side effects are actually a cry for help with medication costs http://dlvr.it/TRZqBj Physician #Cardiology
Recent data from the New York Federal Reserve shows that employer‑sponsored health insurance premiums have surged roughly 20% since 2022, while wage growth in the Fed’s region has slipped from about 6% to 3% this year. The economists estimate that...
The U.S. Food and Drug Administration granted Breakthrough Device Designation to Nia Therapeutics’ Smart Neurostimulation System (SNS) for treating episodic memory loss in adults with moderate to severe traumatic brain injury. The fully implantable, closed‑loop system records neural activity from...
This week’s corporate round‑up highlighted several pivotal moves: Novo Nordisk’s semaglutide patent lapses in India, prompting more than 40 firms to launch over 50 generic weight‑loss brands; BP agreed to sell its Gelsenkirchen refinery, targeting roughly $1 bn of operating‑cost savings;...
Artificial intelligence is rapidly entering clinical workflows, from diagnostic algorithms to administrative tools, but its adoption creates a new attack surface for cybercriminals. Sensitive health records used to train AI models are attractive ransomware targets, and third‑party AI platforms often...
Researchers analyzing Fitbit heart‑rate data from 14,489 participants in the All of Us study found that people who regularly exercised between 7 a.m. and 8 a.m. had significantly lower odds of cardiometabolic diseases. Morning exercisers were 31% less likely to have coronary...
A UK Biobank analysis of 340,924 adults tracked over 13 years found that high alcohol intake raises all‑cause, cancer, and heart disease mortality. At low to moderate levels, wine consumption was linked to lower cardiovascular death risk, while spirits, beer...
A new ACC study reveals that deaths from hypertensive heart disease among U.S. women aged 25‑44 have quadrupled, climbing from 1.1 to 4.8 per 100,000 between 1999 and 2023. The increase is driven by stark racial and geographic disparities, with...
45% of Seniors Got Better With Age (Yale / Geriatrics) Nearly half of adults over 65 got BETTER with age -- not worse. And mindset was the biggest predictor. As a medical school professor, I was trained to see aging as inevitable...
The essay chronicles how a succession of U.S. health‑care statutes—from the 1946 Hill‑Burton Act to the 2010 ACA provision—has incrementally constrained the industry. It quantifies each law’s impact, noting $4.6 billion in Hill‑Burton grants, 36 states retaining Certificate of Need (CON)...
Quintessence Biotech introduced DACS, the first "living" artificial cell designed to streamline bio‑separation in cell and gene therapy (CGT) manufacturing. The lipid‑particle platform mimics cell size, deformability and antigen presentation, enabling a gravity‑based flotation method that replaces magnetic‑bead workflows. DACS...
Swedfund has pledged $600,000 to Jacaranda Maternity, a Kenyan provider of low‑cost maternal care, to accelerate its network expansion. The funding will finance new hospital openings, upgrade neonatal units, and improve existing facilities serving Nairobi’s low‑ and middle‑income neighborhoods. Jacaranda...
Novo Nordisk has launched an oral version of its semaglutide weight‑loss drug Wegovy, expanding GLP‑1 therapy beyond weekly injections. Clinical data show the pill, dosed at 25 mg daily, achieves blood‑level exposure comparable to the 2.4 mg weekly injection, resulting in 13.6 %...
Eli Lilly’s investigational injectable retatrutide achieved a 1.9‑point HbA1c reduction versus 0.8 points for placebo after 40 weeks, while participants on the highest dose shed 15.3% of body weight compared with 2.6% on placebo. The weight loss was still progressing at...
Value-based care was supposed to save healthcare. In some cases, it created a new incentive: getting rid of the sickest patients. In a recent episode of The Podcast by KevinMD, Dr. Jonathan Bushman reveals the dark side of healthcare analytics. He...
AL‑S Pharma released Phase II (AP‑101‑02) data evaluating intravenous AP‑101 every three weeks in 73 ALS patients, including 52 with sporadic disease and 21 with SOD1 mutations. The trial met its primary safety and tolerability endpoint and demonstrated disease modification,...
In this in‑between episode, host Stacey reflects on listener feedback and highlights LinkedIn posts from community members Ken Woosina and Michelle Burnaby, emphasizing that better healthcare decisions stem from transparent, actionable insights rather than theory. She discusses how transparency data,...
Yet another account that does not know the law. Pills for terminations cannot be obtained from the NHS after 10 weeks gestation. The vanishingly small number of cases of drug-induced late termination involved pills illegally obtained from a foreign online...
Please stop telling people with osteoporosis not to lift anything heavy... I've heard it from docs, PTs, Trainers, etc... This might seem protective... but it's not. This risk calculation... A hip fracture in an older adult carries a one-year...
Finance Minister Peter Bethlenfalvy said Ontario will table its 2026 budget on March 26, projecting a $13.4 billion deficit and flagging a $1 billion structural shortfall for hospitals. The announcement underscores tension between fiscal prudence and rising health‑care costs.
This won't show up in any market data, but it's a profound hollowing-out and weakening of America. "Nearly one in 10 people who had Affordable Care Act plans last year dropped health insurance altogether, after premium costs rose sharply" https://t.co/LfNP8wRTD1
Many interesting conversations ahead today at #STATBreakthrough — including on CMS and FDA, both at critical junctures: https://t.co/aThGw2QEfw
Unlocking the full potential of cancer care starts with connected data. Proud of how Oracle is helping to bring adaptive, evidence-based oncology insights directly to the point of care.
Multiple vaccines offer benefits beyond protecting the vaccinated individual from the disease the vaccine targets. Some protect fetuses in the womb, some protect people who are immunocompromised, some protect seniors. As vax rates fall, these benefits are threatened. https://t.co/zmiws8gAnw
Exclusive: Clarissa Desjardins' newest biotech has put its first drug in the clinic + raised $40M more. Congruence also expects to put 2 more molecules into clinic in early 2027, seeing its platform driving its R&D efficiency: https://t.co/pzxcnmKFBj
Linking adiposity and inflammation with all-cause and cardiovascular mortality https://t.co/JXj1WDWHHx via @medical_xpress #health #lifestylemedicine #CardioTwitter #MedTwitter #hearthealth
