Pfizer Scrubs Trillium Pipeline, CD47 Concept Proves Bust
Sometimes in biotech you can get lucky and win even though you were dead wrong. $PFE just dumped the rest of the Trillium ( $TRIL) pipeline - it all came to naught. I made out nicely when PFE bought TRIL, but seems the once-promising CD47 concept turns out to be a complete bust. I still don't know exactly why it didn't work - was a neat concept (blocking tumor's "don't eat me" signal).
Biotech Poised to Create Universal Anti‑venom Breakthrough
Day 1 @SynBioBeta first panel on building a universal anti-venom "We haven't innovated in 125yrs, since injecting horses with venom worked okay" We're now on the cusp of a universal anti-venom thanks to modern biotech https://t.co/wNbPwXjHPi
Orexin Therapies Unlock New Horizons Beyond Narcolepsy
Orexin drugs for narcolepsy and more. Listen to Richard Pops @popsalks discuss the emerging opportunity, and his 35-year-career, on The Long Run. Sponsored by @AlphaSenseInc & Dash Bio. https://t.co/Qr6oJ8AwzB
New Brain Pathway Protects Women From Parkinson’s Progression
A newly identified brain pathway strengthens dopamine-producing neurons and slows Parkinson’s progression, but this protective effect was observed only in females, highlighting the importance of sex-specific approaches in future therapies. neuroscience
The $200M‑$500M Leap Is Healthcare’s Toughest Scale
Scaling a healthcare unicorn looks a lot different from the inside. @_KateRyder and I go deep on why the $200M–$500M jump is the most challenging phase, the absolute absurdity of pitching postpartum care to rooms full of "trolls", and why...
Group Visits Elevate Lifestyle Medicine Outcomes
In 2016, I gave a workshop on the power of group lifestyle medicine interventions with Drs. Wayne Dysinger, Beth Morris Motley + Deepa Sannidhi. Then, we published in the American Journal of Lifestyle Medicine: The Art and Science of Group...
Single 25 Mg Psilocybin Dose Triggers Month-Long Brain Changes
A single 25 mg dose of psilocybin leads to brain structural changes that were seen at 1 month. From a cross-over study of 28 healthy volunteers, no prior psychedelic, who also were also assessed after 1 mg. Behavioral results in...
Payers May Price Risk Pools by City or ZIP
“High-risk cities” could see double-digit PMPM growth above national averages. This means that Payers may begin pricing city-level or even ZIP-level risk pools. https://t.co/B9YFDKiXoX
MRI Body Composition Predicts Diabetes, Heart Events, Mortality
Body composition from MRI of 66,000 people was linked to diabetes, major cardiovascular events, and all-cause mortality @radiology_rsna https://t.co/KUkMppvorA https://t.co/FdyHjpWqW1
Cytospire Secures $83M to Develop Novel T‑Cell Engager
Cytospire hauls in $83M for a new type of T cell engager https://t.co/19BkL5JiHk by @gwendolynawu #biotech #startups
Quantum Breakthrough: 10-Year Partnership Yields Discovery Accelerator
Next up - Quantum with @ClevelandClinic's Serpil Erzurum - talking about the discovery accelerator - result of a 10 year partnership. #IBMThink https://t.co/LwGwuFTvgf
US Exit From WHO Risks Missing Outbreak Alerts
As an outbreak, #hantavirus on a cruise ship is more interesting than alarming. But it should serve as a warning sign to the US, which by withdrawing from #WHO has cut itself off from WHO's outbreak intelligence network, writes @KrutikaKuppalli. https://t.co/WdEaLOWf1f
Multivitamins Show No Overall BP Benefit, Help Low‑Diet Individuals
Long-Term Effect of Multivitamin Supplementation on Incident Self-Reported Hypertension and Blood Pressure Changes in the COSMOS Trial "MVM supplementation versus placebo did not reduce hypertension incidence or lower BP overall. Exploratory analyses showed greater reduction in hypertension risk and BP changes...
AI Powers Around-the-Clock Healthcare Member Services
Next up - what AI can do in Healthcare - Ratnakar Lavu of @ElevanceHealth in a conversation with @IBM' @ArcindKrishna - Benefits, Member Services 24x7. #IBMThink https://t.co/yv4a1KSyio
ADHD Misdiagnosis: Recognizing Hidden Cases Beyond Hyperactive Boys
Why does everyone suddenly have ADHD now? Because we spent decades only recognizing it in hyperactive little boys who couldn't sit still in class. The quiet girl who daydreamed constantly? Missed. The high-achieving adult whose internal world was chaos? Missed. The person who masked...
Oracle Brings AI and Cloud Expertise to Poland's Healthcare
Loved spending a couple days in Poland last week, where I had the privilege of meeting with Tomasz Maciejewski, @USAmbPoland Tom Rose, Hon. Stuart Andrew MP, and other leaders working to advance Poland’s healthcare ecosystem. We at @Oracle are keen to share our...
Few Hospitals Rely on Gifts; Most Earn Fees
My analysis of IRS data found only 10 hospitals (out of 2,100) that received more than 50% of their income from gifts. The typical nonprofit hospital receives 94% of its income from fee-for-service payments and just 3% from gifts. This $1.3...
Tech Disruption Varies by Specialty: Task Type Matters
An analysis of what impact digital technologies could have on the top 20 medical specialties, based on how repetitive vs creative and interaction-based vs data-based tasks those specialties entail. This and many more inforaphics and detailed analyses in our e-book: The...
Genetic Variant Determines Individual GLP‑1 Drug Response
As a medical school professor, I get asked why GLP-1 drugs work miracles for some and barely budge for others. A new Nature paper from 23andMe gives part of the answer: your genes. Researchers ran a genome-wide association study in 27,885...
Gallium Needle Softens at Body Heat, Boosts Injection Safety
KAIST Develops Gallium Needle That Softens at Body Temperature for Safer Injections by @tweetciiiim #MedTech #HealthTech #Tech #TechForGood https://t.co/g8iTdzNeF9
ApoB, Not LDL, Predicts True Heart Attack Risk
Lie I was taught in medical school: your LDL cholesterol number is the gold standard for heart attack risk. Reality: a normal LDL with high ApoB is far more dangerous than a "high" LDL with low ApoB. ApoB counts the actual...
Agents Without Moats Will Falter in Fierce Market
Pointed ironies in the SERD wars, plus ADC hype, and what really works in breast cancer... How agents with no moat, no differentiation, and no clear advantage will struggle in a tough competitive market: https://t.co/2Efcy5ItNM https://t.co/FBDM2eDJd4
Male‑dominant Dementia Risks Highlighted in 2024 Lancet Report
Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework Your dementia risk profile may differ by sex. Which risk factors matter most for you? 🤔👇👨⚕️ "The 2024 report identifies 14 modifiable risk factors for...
Myqorzo ACACIA Study Achieves Dual Primary Endpoint Success
$CYTK Here we go! Myqorzo ACACIA study results in nHCM --> BOTH co-primary endpoints hit with statistical significance. There may be debate about magnitude of improvements for Myqorzo via KCCQ-CSS and peak V02. But, if you were dreaming for a...
Patents Hide Life‑Saving Drug Clues Await Discovery
What if the next life-saving drug is buried in a patent diagram? In early drug discovery, progress can hinge on a single decision. The evidence exists, but some of the most valuable insights stay invisible to conventional search, especially inside...
Integrated Care Platforms Redefine Post‑Telehealth Healthcare
Beyond Telehealth: The Rise Of The Integrated Care Platform by Manjula Iyer @Forbes Learn more: https://t.co/zUONBCm5Oz #MedTech #Healthcare #HealthTech #Tech #TechForGood https://t.co/uFU9tfj0zu
Lawmaker Blames AMA Billing Codes in Fraud Fight
Top lawmaker takes aim at doctor lobby, linking AMA’s billing codes to fraud fight https://t.co/cgDIvQHPti via @statnews
Surgeon Prioritizes Preventing Unnecessary Rotator Cuff Operations
I am a shoulder surgeon. I have been repairing rotator cuffs for 30 years. And the most important thing I do in my office is try to talk people out of surgery they do not need. https://t.co/GKyxAP0J34
Full Asset Acquisitions Avoid Margin Drag of Royalties
Seedy is not long enough $ABVX, however I’m old enough to remember when $ABBV spent $21B to buy half of ibrutinib.
Coauthoring Landmark EU Study on Longevity Research
Very proud to be one of the authors of this important paper to support longevity research in the European Union, with many of the leading experts in our region. https://t.co/RpsdF5zmXD #healthylongevity #ageing #longevitydividend #geroscience #healthpolicy https://t.co/HRCphTuY3Q
Life‑saving Epilepsy Drug Denied by NHS; Sign Petition
Ben has severe epilepsy and used to have up to 300 seizures a day. A medicine changed his life. But his family still have to pay for it privately every month because there’s no NHS access. That’s not right. There’s a petition that...
Kennedy Launches Initiative to Reduce Antidepressant Use
Bad timing, guy. You are one reason among many why the nation is so depressed. Kennedy Starts a Push to Help Americans Quit Antidepressants https://t.co/nSnwWeUqcW
New Trial Compares Dara‑Bor‑Dex vs Cy‑Bor‑Dex in MM with LCCN
EAA241 - Ph 2 RCT Dara-Bor-Dex vs Cy-Bor-Dex in the treatment of Newly Diagnosed Multiple Myeloma with Light Chain Cast Nephropathy (LCCN) [Study activated 8/11/25] @keruakous https://t.co/1NgvVZ3fTA #NCT07085728 #mmsm @eaonc https://t.co/Jrh4teOxUK
Daratumumab Boosts Revlimid Efficacy in Smoldering Myeloma
#EAonc EAA173 - Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM) - PI: @nsc_natalie https://t.co/VtBMJUjI5X Activated: Apr 30, 2019 #mmsm @eaonc #NCT03937635 @VincentRK @mweissmdphd https://t.co/oQzEYsPoU4
Phase 3 Trial
.@SWOG S2213 Ph3 RCT Dara-VC Induction Followed by ASCT or Dara-VCD Consolidation & Daratumumab Maintenance in Pts w/ Newly Diagnosed AL Amyloidosis [Activated: 12/1/23] https://t.co/OizUfJCc2c #mmsm #bmtsm https://t.co/zWMK1RfCFW
AI's Echo Chamber: Validation Vs. Reassurance in Healthcare
One of the biggest problems with AI is it so often tells us what we want to hear. In healthcare, I can’t figure out if that means telling a patient they have a likely diagnosis — or that they don’t....
FDA Likely to Fast‑Track KRAS Drug for PR Boost
To try to offset this, I predict the FDA will approve the $RVMD KRAS drug in record time. Not just much quicker than usual. FDA needs a public relations win, and this will be their vehicle.
Gene Therapy Targets Childhood Blindness by Fixing Retinal Gene
Jean Bennett and Albert Maguire developed a gene therapy approach to correct a gene in the retina to treat childhood blindness. https://t.co/WJ99qvcUT1
CDC Director Echoes Vaccine Aluminum Risks Amid Sc
Well, thankfully the CDC Director follows me here on X and is speaking out about the dangers of vaccines. Not as much as I would like, but injecting aluminum into your body is never healthy. And we know the OLD...
Invest in Biosecurity Now to Counter AI and Pandemic Threats
We should absolutely take AI risks to biosecurity seriously. And we shouldn't panic. Now is the time to strengthen our overall biosecurity regime. The same investments in monitoring, preparation, and technology development will reduce risk from natural pandemics, lab leaks,...
Leroy Hood Unveils Dark Proteome Frontier at SynBioBeta 2026
“I am interested in deciphering human complexity in terms of wellness and disease. I guess you would describe me as a multi-disciplinary human biologist.” That is Dr. Lee Hood @ISBLeeHood in one quote. We're excited and honored to have Dr. Leroy Hood...
Healthy Habits Boost Odds of Living Past 100
Healthy lifestyles and survival beyond age 100: Evidence from a national cohort of Chinese centenarians https://t.co/FsfcGUzlFV
TSH Alone Misses Thyroid Issues Affecting Fertility
Your TSH alone does not tell you if your thyroid is doing its job. Most providers run TSH, see it within range, and call it normal. But TSH is a pituitary hormone. It does not measure what your thyroid is...
Integrated AI Care Partner Unites Communication, Evidence, Workflow
We don’t need another app—we need systems that ✨work together.✨ Heidi’s approach integrates communication, clinical evidence, and workflow into a single AI care partner. Details 🔗 https://t.co/M92fxaSATd @tryHeidi #HIMSS26 #HITSM
Prevent Billing Errors Upfront by Moving Left in EHR
"The best denial is the one that never happens.” Instead of fixing billing after the fact, what if your EHR prevented errors upfront? This interview breaks down what “moving left” really looks like. 👉 https://t.co/3wq0xwo8al @greenway #HIMSS26 #healthtech
Senator Lummis Softens Stance After MS Patients Benefit
“I have friends that have multiple sclerosis and they can get some relief from medical marijuana,” she said. “Because of that, my personal feelings about it have softened a little bit.” Sen. Cynthia Lummis (R-WY). https://t.co/WK8CtFhecG
The Hidden Reason Doctor Appointments Are Impossible to Schedule
"In the real world, the post-it notes happen." @oliver_kharraz shares the surprisingly simple reason your doctor's appointment is so hard to book. FULL EPISODE ON LIFERS: Spotify: https://t.co/W086iI8W11 Apple: https://t.co/L6HSxNxiAf Youtube: https://t.co/sQrkMS3W9g https://t.co/bY9CAF9gTB
One Hepatic Failure Case Sparks LLY vs Novo Debate
$LLY $NVO So one case of hepatic failure reported with $LLY Foundayo. To put this in perspective, with the injectables in this class, the reported hepatic incidents have been well under 1 in 100,000. Other oral GLP-1 agonists have also...
Deviation Capital Launches $300M Fund, Seeks Bio‑tech Founders at SynBioBeta
Deviation Capital just launched with a $300M fund target, and founding partner Dusan Perovic will be at #SynBioBeta2026 this week in San Jose looking for the next generation of founders to back. Deviation spun out of @TwoSigmaVC with a clear thesis:...
Trump Lifts Visa Freeze, Easing Hospital Staffing Shortage
JUST IN: Trump administration lifts visa freeze for foreign physicians, easing US hospital staffing shortages