
Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial “Treated groups had remarkable improvements in physical performance measures and inflammatory biomarkers, both of which characterize the frailty syndrome. Given the excellent safety and efficacy profiles demonstrated in this study, larger clinical trials are warranted to establish the efficacy of hMSCs in this multisystem disorder.” 🔑 Key findings “ The CRATUS trial is a randomized, double-blind, placebo-controlled evaluation of allo-hMCSs to treat the signs and symptoms of frailty. The results support the safety and feasibility of administering allo-hMSCs in this population. With regard to efficacy, there was a preferential effect towards improvement of functional capacity and patient reported outcome measures in patients receiving lower dose MSCs, although immunologic bioactivity was evident with both doses. Together, these findings suggest that allo-hMSCs may be an effective biological modifier of aging frailty, and support ongoing investigation of allo-hMSCs alone or as an adjunct to current physical training strategies for aging frailty.” https://t.co/BKh5TaWT1J

The Whiteboard Windfall: A Lesson in NHS Negotiations by @Timothy_Hughes https://t.co/2JqnBxsbKP @DLAIgnite #SocialSelling #DigitalSelling #Sales #SalesTips #SalesLeader #Salesforce #SalesEnablement #RevOps #Leadership #Marketing #SalesNegotiation https://t.co/QfAUP3Lf1B
A Multidomain Lifestyle Intervention Is Associated With Improved Functional Trajectories and Favorable Changes in Epigenetic Aging Markers in Frail Older Adults: A Randomized Controlled Trial https://t.co/8Ex1caVyLp

DEFEATING ENTROPY hackathon at @fiftyyears London HQ. Focus areas: Biomaterials for neural repair Engineered neural cells Tissue replacement AI for surgical robotics Advanced cryo methods Biostasis https://t.co/gMDDoo6Io4

Your Thymus and Your Healthspan https://t.co/ENhIn2A2l3 High vs Low Thymic Health Scores and Outcomes https://t.co/oOz9sOK8RV
Wow... Power training and longevity Araújo et al. followed 3,899 people — mostly middle-aged and older adults — for a median of nearly 11 years. They compared two metrics head-to-head: muscle strength and muscle power. Men in the lowest power category were...
Please write the app that tells me how long 2 TAVRs will last if the first is installed in me soon....
How do you build a company that $JNJ will buy for $15 billion? Listen here.

It's important to celebrate the interoperability wins just as often as leaning in on all the drama. To that extent, let's start the clap as @eClinicalWorks just dropped 9 new FHIR APIs, including full CRUD on Coverage and e-prescribing data...

Every 1% BMI Drop Cuts Cancer Risk Every 1% drop in BMI lowers your cancer risk. The data now proves it in the real world. As a medical school professor, I have taught for years that obesity drives cancer through metabolic dysfunction....
Can quantum computers now solve health care problems? We'll soon find out. | MIT Technology Review https://t.co/fQ3aSQxhdd
The Impact of Fatigue on Health, Function, and Survival Between Ages 70 and 100 "Our findings highlight the clinical importance of recognizing fatigue by health care professionals throughout the entire aging life span and raise the possibility that fatigue may serve...
most of us chose medicine for the love of healing and the satisfaction of seeing patients recover, not for ego or glory, and money was meant to be a by-product. But after years of hard work, investment, and burnout, if...
🧵 The biggest mistake doctors make isn’t choosing the wrong branch. It’s choosing the safe life without questioning it. You study for years. Get the degree. Take the job. Everything looks right. But slowly: • Income plateaus • Workload increases • Freedom decreases
I bet on uniQure thinking it was an obvious win win win. HD wins with expanded access. FDA wins by narrowly expanding authorization while vigorously monitoring follow up data. Investors win as the company proves what doctors are saying. Instead...

Use of SGLT2 Inhibitors in Frail Older Adults is Associated with Increased Survival: A Retrospective Study https://t.co/tsJ5qJLBap https://t.co/4EvBWDftJ4

A new study of more than 340k British adults finds that moderate wine drinkers (1-3 glasses/day) have a 21% lower risk of dying from cardiovascular disease versus people who never drink or do so occasionally. I will be accepting no...
Researchers found that shorter telomeres and DNA changes in kidney cells may signal faster biological aging of the kidneys and help predict risk for Chronic Kidney Disease earlier than current methods. 🧬 https://t.co/JKRM7xhOnh

Effect of henagliflozin on aging biomarkers in patients with type 2 diabetes: A multicenter, randomized, double-blind, placebo-controlled study 🔎"Our results suggest that henagliflozin may exert anti-aging effects by influencing multiple pathways, including the IGF-1 system, glucose metabolism, the immune system, and...

It takes the human brain two years to fully recover from burnout. Yet many physicians are in denial, assuming their absolute exhaustion is just normal. Dr. Tomi Mitchell hit her absolute limit. She was running a massive medical center, raising two...
Des and Nurses are underpaid. Independent doctors are getting ripped off to the point of barely getting paid after fees The biggest insurance companies are awful for beneficiaries and for employers. One example ? What good is insurance if patients...

Vaccines save lives. Ask in the comments if you have questions. As a subscriber to my Substack you get a vaccine resource guide available for download and as a paid subscriber a 64 page guide on vaccine preventable diseases.
Some of this healthcare fraud video stuff is of course performative and bad use of data. But a lot of it isn't. Yet, not a single Dem that I'm aware of at national/state/big city level is making the case for...

There is a similar study for thigh circumference - turns out that thin legs are one of the best predictors of mortality. https://t.co/v6H3jYNXrY https://t.co/PkaQPvyrpX https://t.co/0cOR1L7ZnM
Interesting collection of YCombinator biotech startups this batch. I had been skeptical that YC could work at all in biotech, but I've been proven wrong over the last couple of years.

Loved sitting down with @DrSharma_NY earlier this month for a fireside chat at Health Tech Summit 2026! Grateful for the opportunity to share how Oracle is working with our customers and partners to advance AI-driven innovation in healthcare. Thanks to the The Health...

Delighted and honored to speak to the over 1,000 participants in the Brigham Women's Hospital CME course titled Office Practice of Primary Care Medicine yesterday, via Zoom at 4:55 pm, at their last session of a powerful week of presentations. The...
Wastewater Detects Colorectal Cancer Biomarkers What if your city's sewage could detect cancer before your doctor does? As a medical school professor, I find this remarkable. Researchers tested neighborhood wastewater in Kentucky for colorectal cancer biomarkers using droplet digital PCR. They detected CDH1...
There's a $101 million competition happening right now to extend human healthspan. Not in mice. Not in worms. In people. https://x.com/robertlufkinmd/status/2035318955821375489
Great review of the idea of potential enrollment right into Medicare Advantage (though doesn’t consider Chris’ added twist of competition between Traditional Medicare ACOs and MA) https://t.co/rcquVZ8zxn it would be fun to compete head-head (but would need level playing field)

A 100 percent patient satisfaction score does not always mean you are a great doctor. Sometimes it just means you are a people pleaser. Physicians are conditioned to panic over negative feedback. One bad review can trigger a complete nervous system...
When I was talking to Sergiy Velychko, a former postdoc from George Church's lab, about the future of human genome engineering, we discussed: “We're now at this point where we can engineer ourselves. We can do stem cell therapies. We can...
Frailty and inflammation predict prolonged stay in post-emergency geriatric units: a retrospective cohort study https://t.co/92P3HSm6LS
The Republican efforts to dismantle the ACA absolutely made things worse but even if they’d left it alone the legislation still wouldn’t have fixed our health care system
Physical exercise and health-related quality of life in mid- to late-adulthood: a multi-group chain-mediation analysis https://t.co/vd6yqa45rx
Over half of all lumbar fusions fail. They’re still covered by insurance. Conservative care that actually works — exercise, PT, load management — gets denied or severely limited. We don’t have a back pain problem. We have a financial incentive problem.
Read “Bottle of Lies.” FDA needs to perform spot checks of generics - not just inspections.

I've been a dad for five days - and somehow, it's already made me question what I thought about AI and the patient experience. Lemme explain… We had an incredible experience in the hospital. Not because of any Tech… but because...

Endometriosis and Oocyte Quality: Morphological Alterations, Developmental Competence, and Modifiable Strategies for Reproductive Longevity https://t.co/I2ZrtJkguK https://t.co/LkH3LXzkcg
Automatic enrollment in Medicare Advantage plans under consideration, top Trump health official says https://t.co/Bgv6WBeo2u via @statnews
How the new DOT ruling on food allergies threatens air travel safety http://dlvr.it/TRcKjc Conditions #AllergiesImmunology
Fun day .. “You’re my 5th opinion.” Knee injury These are usually a problem. Previous 4… -Only one exam -All repeated X-rays -2 MRIs. - One Special NY hospital often insists their MRIs...
To appeal or not to appeal (yet): The potentially politically dicey situation facing HHS over a preliminary court ruling this week on #ACIP and the rewritten childhood vaccination schedule. By @ChelseaCirruzzo. https://t.co/3P1PW1lDFT

I will NEVER miss an opportunity to call out medical misinformation so people know how to protect themselves and rally for change. On this particular panel, we got into the hype and hope of stem cells in an honest and cathartic...
Some interesting comments from Jacob Van Naarden, $LLY head of business development, at STAT's Breakthrough Summit East event yesterday: On deal volume: Jake, himself, is seeing approx 10 deals per week, ie deals that are important enough, or diligenced enough,...

One of the questions I get asked most often is how to tell the difference between a longevity clinic built on evidence and one built on marketing. It's a question that deserves a honest, detailed answer. Grateful to be sharing the...
If you care about the future of the CDC or public health, you need to read this piece and watch this video on how leadership is thinking about the search for a new director. Definitely watch the 10 minute video in...
If you've been following the situation at #CDC — specifically the agency's lack of a director for most of the past 15 months — you'll want to listen to Chris Klomp, chief counsellor to HHS, discuss the administration's search for...
The question in health IT isn’t who has the best roadmap It’s who can execute fast enough. David Cohen’s perspective from the Greenway User Conference: https://t.co/N0sw9cW6oH @greenway #EHRstrategy #HITSM
In hectic settings like emergency departments, clinicians shouldn’t have to choose between caring for patients and keeping up with documentation. @OracleHealth Clinical AI Agent is designed for the realities of emergency and inpatient care. https://t.co/P3gcSvXwCJ