KRASG12C Mutations Linked to Distinct Immuno‑oncology Biomarkers
Landscape of KRASG12C, Associated Genomic Alterations, and Interrelation With Immuno-Oncology Biomarkers in KRAS-Mutated Cancers [Mar 23, 2022] @SalemGIOncDoc et al. @JCOPO_ASCO https://t.co/iehC82lyA4 #ImmunoOnc #PrecisionMedicine @TempusAI https://t.co/wZzfdnBoXU
Comprehensive Genomic Panel Broadens Community Oncology Treatment Options
Unique Features of a Comprehensive Genomic Profiling Panel: Expanding Treatment Options in a Value-Based Community Oncology Network [Mar 9, 2026] La Porte et al. @DrEzraCohen @JCOPO_ASCO https://t.co/tDi3kbxdvX #PrecisionMedicine #hemeonc @TempusAI https://t.co/6QKo7c3oH2
FDA Accuses Amgen of Data Manipulation; Erasca Falls
FDA claims Amgen drug data were ‘manipulated’; Erasca slides despite ‘home run’ results https://t.co/UbftjXwEwa $AMGN $ERAS - 53% $RCKT $JANX
Hospital CEOs Flaunt Lobbying Clout in Congressional Testimony
Hospital CEOs are currently testifying in front on Congress. @ahahospitals just held its annual meeting, and @_daniel_payne caught this extremely candid quote from Chuck Schumer showing just how much lobbying power hospitals have. https://t.co/suwZZjZePb https://t.co/IHVq3JrVEF
AI Reads Retinal Images to Screen Multiple Diseases
What superhuman vision can detect from the retinal photo, which human eyes cannot, is stunning. A new foundation AI model screening for diabetes hypertension, hyperlipidemia, gout, osteoporosis, and thyroid disease @NatureMedicine https://t.co/GhKvUqz4Vy https://t.co/iKcXCbLceu
Microplastics Found in Most Human Brains, Concentrated Near Tumors
Microplastics and nanoplastics have been detected in nearly all human brain samples, including healthy tissue, with higher concentrations observed near tumors, raising new questions about their potential impact on brain health. microplastics
Google Exec Argues Safer LLMs, Not Bans, Aid Mental Health
Google executive defends potential of LLMs for mental health. “It can seem sometimes like shutting something down is a way of preventing harm,” Megan Jones Bell told STAT. “We believe that making our product experience safer and more helpful and...
Per‑Booking Pivot Saved Zocdoc’s Healthcare Apprenticeship Model
New Lifers episode with @oliver_kharraz, CEO of @Zocdoc, on why healthcare is a "lifelong apprenticeship" and how they survived a near-death business model pivot. We discuss: * Why early digital schedules failed because office managers were still blocking time with physical...
NIH Could Fund Groundbreaking Research with $2 B Annually
What could the NIH do with an extra $2 billion dollars a year from publisher fees?
Coultreon Secures $125M to Test Former Galapagos Immune Drug
Coultreon banks $125M to support testing of former Galapagos immune drug https://t.co/PUsEu2i7Vv by @Lilah_Alvarado $GLPG #biotech #startups
GLP‑1 Therapy Shows Benefit for Type 1 Diabetes Patients
A 174,000-patient analysis just delivered the first hard evidence that GLP-1 drugs work in a population every clinical trial has excluded. As a medical school professor, I teach that Type 1 diabetes is autoimmune, Type 2 is metabolic. But the cardiovascular...
Sleep Loss Rewires Gut Microbiome, Accelerates Cancer
New AACR 2026 data shows poor sleep does not just make you tired. It rewires your gut bacteria in ways that fuel cancer growth. As a medical school professor, I teach that the gut-brain-immune axis is underrated in medicine. AACR 2026...
Visualizing Digital Health's Future for Aging Populations
This paper came out two years ago with this spectacular, yet very practical, visualization of technologies for the elderly. We need more scientific papers like this one that not only cover a complicated topic properly but also provide a vision...
Biotech Firms Rise to Top, Sector More Investable Now
A group of biotechs have recently ascended into the sector’s upper ranks, suggesting the sector may be more ‘investable’ now than it once was, @gwendolynawu reports: https://t.co/WRl1jpnA9G $BBIO $ARGX $MDGL $INSM #biotech
Egg Freezing: Investors Profit, Women Pay for Peace
The fact that a venture capitalist is talking about egg freezing being a high-margin investment opportunity tells you everything you need to know about who this industry is really serving. Women are being sold peace of mind. Investors are buying recurring...
Bone Spurs Aren’t Behind Shoulder Pain, Study Shows
Bone Spurs Do Not Cause Shoulder Pain or Cuff Tears. Ten Years of Data Just Confirmed What Never Made Sense To Me. It's amazing how many people are still told each year that they need shoulder surgery due to a...
Low‑cost Vaccines Delivered, Autism Genes
What a dishonest & ignorant thing to write, I develop low-cost vaccines for global health, 100 million doses administered, without patenting the technology. Also as I’ve detailed we’ve learned a lot about the genetic basis of autism, >100 autism genes,...
Hep B Descheduled Properly; Other Vaccines Restored by Fiat
Lots of curiosity why hep B was descheduled but the other vaccines were restored—it’s because all he others was ruling by fiat. Hep B was descheduled by ACIP and approved by RFKJr, which is the normal process. Despite it being...
AstraZeneca's Bretzi Inhaler Cleared for Asthma in Teens
#AZN Bretzi inhaler approved by US FDA for treating patients 12 years old and upwards for Asthma, following the KALOS and LOGOS Phase III trials. Previously got COPD approval.
Morgan Stanley Flags IL‑23 Combos, Seeks Novel MOAs
Immunology combination studies from Morgan Stanley ahead of DUET data next week. These are mainly coformulations of established drugs, it would be more intriguing to see novel MOAs added to an IL23 backbone. https://t.co/dde8MpBhUR
HKUST's New Complex Boosts Doctor Training, Global Medical Hub
Chief Executive John Lee, at the groundbreaking ceremony for HKUST's new medical education and research complex: • will increase local doctor training, easing manpower shortages • will help meet challenges of an aging population • Hong Kong is fast emerging as...
Measles Misinfo Meets Political Insults in Vaccine Debate
I just said that the children in our family already had measles and it was measly and a breeze, and they have lifetime immunity and proven protection against certain cancers. You claimed to be Maga and shame people who don’t...
Enhanced Exosomes Modulate OA Inflammatory Microenvironment
The role of exosomes and their enhancement strategies in the treatment of osteoarthritis "This article provides a comprehensive review and update on the research of exosomes, a type of extracellular vesicle, in the treatment of OA by modulating the inflammatory microenvironment..." https://t.co/xHjTCixJNE
AI Predicts Surgery Risks, Cuts Postoperative Deaths
What could we expect from AI in surgery? TIME magazine has an article on 4 concrete examples and the lowest-hanging fruit. As more than 4 million people die within a month of surgery every year, postoperative mortality is the first example: "𝐴𝑙𝑔𝑜𝑟𝑖𝑡ℎ𝑚𝑠 𝑐𝑎𝑛 𝑛𝑜𝑤...
TB‑500 Is Not TB‑4: No Human Evidence
TB - 500 is a short chain fragment synthesized from Thymosin Beta-4. TB-4 has solid human evidence for use. TB500 has absolutely no evidence. Totally different compounds. They cannot be referred to interchangeably because they simply are NOT the same
Breakthrough Prize Showcases Baby Gene‑Editing Miracle
The 2026 Breakthrough Prize ceremony (“the Oscars for science”) celebrated the achievements of many remarkable scientists and their students and collaborators last weekend. Here’s the video of the show: https://t.co/eCHUnDqrYX. And here’s the segment in which Anne Hathaway and Alex...
10x Genomics Unveils A
I've been watching spatial biology for years. What @10xGenomics just announced changes the game. Serge Saxonov, CEO and Co-founder, 10x Genomics told Synbiobeta, "Biology is inherently complex, and as much progress as we have made, we still understand only a...
Traditional MDs Now Seeking Peptide Knowledge for Joint Health
So many of my “conventional” (not in the health and wellness space or even online much) MD friends are asking about peptides to 1) get educated (patients are asking them about peptides) 2) they want to know if BPC can help their...
Cellular Rejuvenation Could Shift Medicine to Youthful Resilience
Cellular rejuvenation may redefine medicine—not by treating disease, but by restoring youthful resilience at the cellular level. But science, safety, and hype are colliding. Worth the read (gift link) : 👇 https://t.co/7JGNdhFsFP via @NYTimes
Lithium Interaction Poses Major Seizure Risk with Psilocybin
Most physicians were never taught psilocybin in medical school. Their patients in three states can now legally access it. Oregon's program has been operating since summer 2023. Colorado's healing centers came online in 2025. New Mexico passed its Medical Psilocybin...
Autologous iPSC Dopamine Cells Boost Parkinson’s Function without Immunosuppression
I’ve been following @jeannefrances's work for years, and what @AspenNeuro just reported out of Copenhagen is the kind of result that changes a field. Twelve months after receiving their own reprogrammed dopamine neurons, eight Parkinson's patients are showing real, measurable...
HIIT Boosts Brain Health in Heart Disease Patients
The Utility of High Intensity Interval Training to Improve Cognitive Aging in Heart Disease Patients “the physiology related to cerebral blood flow regulation and cognitive decline in adults with cardiovascular disease and heart failure, and how HIIT may provide a more...
Profit‑Driven Healthcare Drains Billions, Harms Millions
The pursuit of health care under a profit driven predatory healthcare system is no great capitalist opportunity. It’s a brutal extraction of $billions daily from the U.S. economy and from the hard earned working lives of hundreds of millions. United...
Insurers Hide Denials, Charge Appeals—Demand Transparency Now
Want to know how ridiculous and awful Ins company and their PBM denials are? The insurance company that denies the claim, that is if it’s them and not a subcontractor like medica , also picked the network and doctors. So they...
CDC Shifts From Public Health to Industry Lobbyists
2025: get rid of tobacco and environmental health offices at CDC. 2026: hire more oil and tobacco lobbyists to run CDC
ERAS-0015 Linked to Fatal Pneumonitis After Care Withdrawal
$ERAS safety update, from tonight's slides. One Grade 3 TRAE of pneumonitis progressed to Grade 5 after withdrawal of supportive care per patient decision. The patient was a 66 year-old male with heavily pretreated metastatic pancreatic adenocarcinoma who received 24 mg of ERAS-0015. The patient had...
Over Half of Gray Market Peptides Fail Quality Standards
New pre-print on gray market peptides using @finnrick_tests data: 41.6% to 71.1% of gray market peptide samples failed to meet basic quality criteria, and measurable endotoxin contamination was present in 15% of samples. @Krysia830073
NIH Studies Often Ignore Sex Differences, Hindering Precision Medicine
Less than half of NIH-funded health studies analyze results by sex, potentially overlooking critical differences that impact diagnosis, treatment, and drug development for both men and women. precisionmedicine
Low Post‑Surgery Klotho Predicts Inflammation and Cognitive Decline
Lower levels of the anti-aging protein Klotho after surgery were strongly linked to higher inflammation and worse cognitive function in patients with postoperative cognitive dysfunction (POCD). This suggests Klotho could be a useful early biomarker—and possibly a treatment target—for predicting...
Erasca Shows Promising 40% PDAC, 62% NSCLC Responses
$ERAS Erasca touts strong, though preliminary, results in trial of pancreatic and lung cancer therapy $RVMD 40% uORR in PDAC; 62% uORR in NSCLC https://t.co/90BkD7tBeN
Longevity Hype Outpaces Evidence; Cancer Risk Remains
This @NYTmag article on longevity science, reversing aging with cellular reprogramming, by @susandominus, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing...
Harvard Med Mission Revision Deemed
Pleased to have the opportunity to share my perspective w @thecrimson on the revised @harvardmed mission statement, an update I thought was eminently reasonable. https://t.co/AQFC5AZd6p My full quote below; sentences 2 & 3 used in story. @zakkohane https://t.co/m8TQTzMqYZ
Kennedy Misses Deadline, Fuels Transparency Concerns
Kennedy missed a Friday deadline to release details of an HHS contract with a longtime vaccine critic. Democratic lawmakers say it’s part of a larger pattern of the secretary ignoring his promises of “radical transparency” https://t.co/ICAsieVw9Y
Cearvol Nano OTC Hearing Aids Boost Volume Everywhere
Wish you could hear everything around you, whether you're at a noisy restaurant or just watching TV at home? I check out the Cearvol Nano OTC Hearing Aids in various locations and find it's a great way to turn up...
AI Enables Radiology to Shift From Diagnosis to Prediction
Radiology is moving from reactive diagnosis to predictive care. Karim Karti shares how AI can help radiologists practice at the top of their license and unlock earlier disease detection. Watch the full interview here: https://t.co/tyyTn5ZWEx @RapidAI #MedicalImagingAI #HITSM https://t.co/P8qvua7WsD
Rare Cancer Patients Demand Systemic Oncology Revolution
Merkel cell carcinoma log, day #637. I’m participating in the 4th annual Merkel cell carcinoma conference (MCC4) in Boston today. Most of the top people in the field are here. Had a roundtable conversation with a group of patients and...
Reta Won't Become All-Time Top-Selling Drug
Reta will not be the best selling drug of all time. Someone please remember this a decade from now.
UHC Reinstated Prior Authorization After Two Decades
More than 20 years ago, UnitedHealthcare was getting rid of prior authorization. But when Steve Hemsley first became CEO of UHC's parent company, he brought it back. https://t.co/suwZZjZePb https://t.co/6RnZH9dZvK
Connected Data Cuts Costs and Boosts Clinical Decisions
Connected data has the potential to transform healthcare by making it more efficient and transparent. With U.S. health spending at $5.3T, @Oracle is addressing siloed and fragmented data to cut costs, deliver value, and improve clinical decision making. https://t.co/hNNd6jF4x5
Monday Mornings: Energizing Chaos at the Clinic
People often talk about the “Monday morning blues.” On Monday mornings, I go to my clinic—and it’s the opposite feeling. Clinic is dynamic. Demanding. Energizing. I never know what I’m going to see or hear. Let’s see what today brings. https://t.co/cWtxm3bq1m